Pancreatic cancer: pathogenesis, prevention and treatment

scientific article

Pancreatic cancer: pathogenesis, prevention and treatment is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1016/J.TAAP.2006.11.007
P3181OpenCitations bibliographic resource ID458880
P932PMC publication ID2094388
P698PubMed publication ID17174370
P5875ResearchGate publication ID6626463

P50authorFazlul H. SarkarQ56648717
P2093author name stringYiwei Li
Sanjeev Banerjee
P2860cites workWidespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumoursQ28206040
Cancer chemopreventive activity of resveratrol, a natural product derived from grapesQ28300555
Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genesQ28307762
Overexpression of urokinase-type plasminogen activator in pancreatic adenocarcinoma is regulated by constitutively activated RelAQ28371975
Nuclear factor-kappaB in cancer development and progressionQ29547879
Hedgehog is an early and late mediator of pancreatic cancer tumorigenesisQ29614405
Cancer statistics, 2006Q29615133
Antitumor activity of epidermal growth factor receptor-related protein is mediated by inactivation of ErbB receptors and nuclear factor-kappaB in pancreatic cancerQ46902076
Cisplatin-induced antitumor activity is potentiated by the soy isoflavone genistein in BxPC-3 pancreatic tumor xenograftsQ46941754
Mitogenic and antiapoptotic role of constitutive NF-kappaB/Rel activity in pancreatic cancerQ47887187
Down-regulation of Notch-1 contributes to cell growth inhibition and apoptosis in pancreatic cancer cells.Q53631737
The Notch signaling pathway is related to neurovascular progression of pancreatic cancer.Q54628566
Notch-1 down-regulation by curcumin is associated with the inhibition of cell growth and the induction of apoptosis in pancreatic cancer cellsQ56749698
Modulation of pancreatic carcinogenesis by antioxidantsQ73132219
Abrogation of the Rb/p16 tumor-suppressive pathway in virtually all pancreatic carcinomasQ73555144
Notch mediates TGF alpha-induced changes in epithelial differentiation during pancreatic tumorigenesisQ73614651
Epidermal growth factor receptor blockade with C225 plus gemcitabine results in regression of human pancreatic carcinoma growing orthotopically in nude mice by antiangiogenic mechanismsQ73803447
Overexpression of cyclooxygenase-2 in carcinoma of the pancreasQ78206842
Dietary intake of lycopene is associated with reduced pancreatic cancer riskQ81448492
Down-regulation of notch-1 inhibits invasion by inactivation of nuclear factor-kappaB, vascular endothelial growth factor, and matrix metalloproteinase-9 in pancreatic cancer cellsQ82698906
Molecular pathogenesis of pancreatic cancerQ82888824
Molecular analysis of the p53 gene in pancreatic adenocarcinomaQ30430851
Suppression of human pancreatic carcinoma cell growth and invasion by epigallocatechin-3-gallateQ31097458
Cetuximab, a monoclonal antibody targeting the epidermal growth factor receptor, in combination with gemcitabine for advanced pancreatic cancer: a multicenter phase II TrialQ33361488
Green tea in chemoprevention of cancerQ33814275
Inactivation of nuclear factor kappaB by soy isoflavone genistein contributes to increased apoptosis induced by chemotherapeutic agents in human cancer cellsQ34439326
Molecular prognostic markers in pancreatic cancer: a systematic reviewQ34560651
Vitamin D intake and the risk for pancreatic cancer in two cohort studiesQ34567226
The genetics of pancreatic cancer.Q35208669
Indole-3-carbinol and prostate cancerQ35966641
Recent advances on the molecular mechanisms involved in pancreatic cancer progression and therapiesQ36300992
A review of erlotinib and its clinical use.Q36376408
Targeting multiple signaling pathways by green tea polyphenol (-)-epigallocatechin-3-gallate.Q36410856
Gene therapy developments for pancreatic cancerQ36426211
Molecular biomarkers: their increasing role in the diagnosis, characterization, and therapy guidance in pancreatic cancer.Q36464111
Clinical implications of the mechanism of epidermal growth factor receptor inhibitorsQ36565941
Molecular pathogenesis of pancreatic adenocarcinoma: potential clinical implicationsQ36581391
Inhibition of basal and mitogen-stimulated pancreatic cancer cell growth by cyclin D1 antisense is associated with loss of tumorigenicity and potentiation of cytotoxicity to cisplatinumQ37377431
Gene therapy based on gemcitabine chemosensitization suppresses pancreatic tumor growth.Q40227847
Epidermal growth factor receptor-related protein inhibits cell growth and invasion in pancreatic cancerQ40248519
Nuclear factor-kappaB contributes to hedgehog signaling pathway activation through sonic hedgehog induction in pancreatic cancerQ40254051
Antitumor and antimetastatic activities of docetaxel are enhanced by genistein through regulation of osteoprotegerin/receptor activator of nuclear factor-kappaB (RANK)/RANK ligand/MMP-9 signaling in prostate cancerQ40284981
Molecular evidence for increased antitumor activity of gemcitabine by genistein in vitro and in vivo using an orthotopic model of pancreatic cancerQ40365695
Overexpression of cyclin D1 promotes tumor cell growth and confers resistance to cisplatin-mediated apoptosis in an elastase-myc transgene-expressing pancreatic tumor cell lineQ40382268
Potentiation of the radiation effect with genistein in cervical cancer cellsQ40387923
Epidermal growth factor receptor-related protein inhibits cell growth and induces apoptosis of BxPC3 pancreatic cancer cellsQ40427648
Genistein, a soy isoflavone, enhances necrotic-like cell death in a breast cancer cell treated with a chemotherapeutic agent.Q40462950
Inhibition of nuclear translocation of nuclear factor-{kappa}B contributes to 3,3'-diindolylmethane-induced apoptosis in breast cancer cells.Q40467145
Selective growth regulatory and pro-apoptotic effects of DIM is mediated by AKT and NF-kappaB pathways in prostate cancer cellsQ40485942
Cyclooxygenase-2-dependent and -independent effects of celecoxib in pancreatic cancer cell linesQ40492311
Nuclear factor-kappaB and IkappaB kinase are constitutively active in human pancreatic cells, and their down-regulation by curcumin (diferuloylmethane) is associated with the suppression of proliferation and the induction of apoptosisQ40505601
Apoptosis-inducing effect of chemotherapeutic agents is potentiated by soy isoflavone genistein, a natural inhibitor of NF-kappaB in BxPC-3 pancreatic cancer cell lineQ40564629
Inhibition of AKT abrogates chemotherapy-induced NF-kappaB survival mechanisms: implications for therapy in pancreatic cancerQ40572213
PSK-mediated NF-kappaB inhibition augments docetaxel-induced apoptosis in human pancreatic cancer cells NOR-P1.Q40657105
Function of nuclear factor kappaB in pancreatic cancer metastasisQ40676051
Chemopreventive effects of tea extracts and various components on human pancreatic and prostate tumor cells in vitroQ40907965
Indole-3-carbinol and tamoxifen cooperate to arrest the cell cycle of MCF-7 human breast cancer cells.Q40964260
Usage of the NF-kappaB inhibitor sulfasalazine as sensitizing agent in combined chemotherapy of pancreatic cancerQ42437041
Resveratrol inhibits proliferation and induces apoptosis in human pancreatic cancer cellsQ44200538
Modulation of the constitutive activated STAT3 transcription factor in pancreatic cancer prevention: effects of indole-3-carbinol (I3C) and genistein.Q44796219
Celecoxib inhibits vascular endothelial growth factor expression in and reduces angiogenesis and metastasis of human pancreatic cancer via suppression of Sp1 transcription factor activityQ44802879
Pilot study of celecoxib and infusional 5-fluorouracil as second-line treatment for advanced pancreatic carcinomaQ44955215
Green tea constituent epigallocatechin-3-gallate selectively inhibits COX-2 without affecting COX-1 expression in human prostate carcinoma cellsQ45083945
Sensitization of taxol-induced apoptosis by curcumin involves down-regulation of nuclear factor-kappaB and the serine/threonine kinase Akt and is independent of tubulin polymerizationQ45182288
Epigallocatechin-3-gallate induces mitochondrial membrane depolarization and caspase-dependent apoptosis in pancreatic cancer cellsQ45261084
Inhibition of integrin-linked kinase by a selective small molecule inhibitor, QLT0254, inhibits the PI3K/PKB/mTOR, Stat3, and FKHR pathways and tumor growth, and enhances gemcitabine-induced apoptosis in human orthotopic primary pancreatic cancer xeQ45285589
Nutritional factors and risk of pancreatic cancer: a population-based case-control study based on direct interview in JapanQ46437656
Inhibition of nuclear factor kappab activity by genistein is mediated via Notch-1 signaling pathway in pancreatic cancer cellsQ46801606
Erlotinib and chemoradiation followed by maintenance erlotinib for locally advanced pancreatic cancer: a phase I studyQ46827306
3,3'-diindolylmethane (DIM) and its derivatives induce apoptosis in pancreatic cancer cells through endoplasmic reticulum stress-dependent upregulation of DR5.Q46839472
Peritumoral injection of adenovirus vector expressing NK4 combined with gemcitabine treatment suppresses growth and metastasis of human pancreatic cancer cells implanted orthotopically in nude mice and prolongs survivalQ46845221
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectpancreatic cancerQ212961
pathogenesisQ372016
preventionQ1717246
P304page(s)326-36
P577publication date2007-11-01
P1433published inToxicology and Applied PharmacologyQ2446974
P1476titlePancreatic cancer: pathogenesis, prevention and treatment
P478volume224

Reverse relations

cites work (P2860)
Q37790673Advances in pancreatic cancer detection
Q38717006Anticancer Activity of Punica granatum (Pomegranate): A Review.
Q34447152Application of chitosan-based nanocarriers in tumor-targeted drug delivery.
Q44623273Assessment of soluble angiogenic markers in pancreatic cancer.
Q38089821Biomarkers in the diagnosis and early detection of pancreatic cancer
Q44221301Bmi-1 promotes the chemoresistance, invasion and tumorigenesis of pancreatic cancer cells
Q49907239CQ sensitizes human pancreatic cancer cells to gemcitabine through the lysosomal apoptotic pathway via reactive oxygen species
Q58652240Cancer Therapy Based on Nanomaterials and Nanocarrier Systems
Q36642898Chemoprevention of pancreatic cancer using solid-lipid nanoparticulate delivery of a novel aspirin, curcumin and sulforaphane drug combination regimen
Q84966111Clinical significance of ephrin (eph)-A1, -A2, -a4, -a5 and -a7 receptors in pancreatic ductal adenocarcinoma
Q29248618Current applications and future prospects of nanomaterials in tumor therapy
Q59228035Dextrin and poly(lactide)-based biocompatible and biodegradable nanogel for cancer targeted delivery of doxorubicin hydrochloride
Q34658072Diet and supplements and their impact on colorectal cancer
Q46360353Effect of soybean oil on atherogenic metabolic risks associated with estrogen deficiency in ovariectomized rats: dietary soybean oil modulate atherogenic risks in overiectomized rats
Q30477815Experimental ablation of the pancreas with high intensity focused ultrasound (HIFU) in a porcine model.
Q31066570Gene expression profile analysis of pancreatic cancer based on microarray data
Q35145009Genomic analysis of drug resistant pancreatic cancer cell line by combining long non-coding RNA and mRNA expression profling
Q38196813Histamine and histamine receptor regulation of gastrointestinal cancers
Q37084377Hyperglycemia Promotes the Epithelial-Mesenchymal Transition of Pancreatic Cancer via Hydrogen Peroxide
Q36062094Identification of disease-associated pathways in pancreatic cancer by integrating genome-wide association study and gene expression data
Q38450835Identification of genes and pathways associated with pancreatic ductal adenocarcinoma by bioinformatics analyses
Q57127188Identification of key microRNAs and their targets in exosomes of pancreatic cancer using bioinformatics analysis
Q47155278Identification of potential prognostic ceRNA module biomarkers in patients with pancreatic adenocarcinoma
Q33891498In vitro antiproliferative activity of partially purified Trigona laeviceps propolis from Thailand on human cancer cell lines
Q89081796In vitro antiproliferative and apoptosis-inducing activities of crude ethyle alcohole extract of Quercus brantii L. acorn and subsequent fractions
Q43184695Investigation of Astragalus honey and propolis extract's cytotoxic effect on two human cancer cell lines and their oncogen and proapoptotic gene expression profiles
Q38289532Lessons from Nature: Sources and Strategies for Developing AMPK Activators for Cancer Chemotherapeutics
Q34496697Ligand stimulation of ErbB4 and a constitutively-active ErbB4 mutant result in different biological responses in human pancreatic tumor cell lines.
Q36326344MUC16-mediated activation of mTOR and c-Myc reprograms pancreatic cancer metabolism.
Q24630097MicroRNAs in NF-kappaB signaling
Q37492447Novel dual cyclooxygenase and lipoxygenase inhibitors targeting hyaluronan-CD44v6 pathway and inducing cytotoxicity in colon cancer cells
Q24564267Novel therapeutic targets for pancreatic cancer
Q33599115Optimized construction of MUC1-VNTRn DNA vaccine and its anti-pancreatic cancer efficacy
Q53502200Overexpressions of DLL4 and CD105 are Associated with Poor Prognosis of Patients with Pancreatic Ductal Adenocarcinoma.
Q40489308Overexpressions of miR-212 are associated with poor prognosis of patients with pancreatic ductal adenocarcinoma.
Q38994024PRIMA-1, a mutant p53 reactivator, induces apoptosis and enhances chemotherapeutic cytotoxicity in pancreatic cancer cell lines
Q34027390PROFESS: a PROtein function, evolution, structure and sequence database
Q33857806Resveratrol inhibits the epithelial-mesenchymal transition of pancreatic cancer cells via suppression of the PI-3K/Akt/NF-κB pathway
Q34979334Structure-activity studies on therapeutic potential of Thymoquinone analogs in pancreatic cancer
Q93015111Study of anticancer, antimicrobial, immunomodulatory, and silver nanoparticles production by Sidr honey from three different sources
Q36004784Synergistic effect of garcinol and curcumin on antiproliferative and apoptotic activity in pancreatic cancer cells
Q34332428Synthetic triterpenoids prolong survival in a transgenic mouse model of pancreatic cancer.
Q37730861Targeting Notch signaling in pancreatic cancer
Q39779735Trigona laeviceps propolis from Thailand: antimicrobial, antiproliferative and cytotoxic activities
Q33375215Triphala inhibits both in vitro and in vivo xenograft growth of pancreatic tumor cells by inducing apoptosis
Q38477847Uncovering the pathogenesis and identifying novel targets of pancreatic cancer using bioinformatics approach

Search more.