Sensitization of taxol-induced apoptosis by curcumin involves down-regulation of nuclear factor-kappaB and the serine/threonine kinase Akt and is independent of tubulin polymerization

scientific article published on 7 December 2004

Sensitization of taxol-induced apoptosis by curcumin involves down-regulation of nuclear factor-kappaB and the serine/threonine kinase Akt and is independent of tubulin polymerization is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M410647200
P698PubMed publication ID15590651

P2093author name stringAsha Nair
Devarajan Karunagaran
Ruby John Anto
Smitha V Bava
Vineshkumar T Puliappadamba
Ayswaria Deepti
P2860cites workL-929 cells harboring ectopically expressed RelA resist curcumin-induced apoptosisQ22253415
NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinaseQ28144326
Curcumin (diferuloylmethane) induces apoptosis through activation of caspase-8, BID cleavage and cytochrome c release: its suppression by ectopic expression of Bcl-2 and Bcl-xlQ28213620
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4-Hydroxy-3-methoxybenzoic acid methyl ester: a curcumin derivative targets Akt/NF kappa B cell survival signaling pathway: potential for prostate cancer managementQ34771742
Mechanism of action of taxolQ35255662
Reversal of Taxol resistance in hepatoma by cyclosporin A: involvement of the PI-3 kinase-AKT 1 pathwayQ36648809
Suppression of c-Jun/AP-1 activation by an inhibitor of tumor promotion in mouse fibroblast cellsQ37532626
Taxol selectively blocks microtubule dependent NF-kappaB activation by phorbol ester via inhibition of IkappaBalpha phosphorylation and degradationQ38328865
Activation of NF-kappaB by antineoplastic agents. Role of protein kinase C.Q38345137
Constitutive nuclear factor-kappaB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cellsQ39795545
Bcl-2 and Bcl-xL are important for the induction of paclitaxel resistance in human hepatocellular carcinoma cellsQ40587649
Dose-intense taxol: high response rate in patients with platinum-resistant recurrent ovarian cancerQ40705982
Inhibition of phosphorylation of BAD and Raf-1 by Akt sensitizes human ovarian cancer cells to paclitaxelQ40721866
Taxol induced Bcl-2 protein phosphorylation in human hepatocellular carcinoma QGY-7703 cell lineQ40806290
Her-2/neu overexpression induces NF-kappaB via a PI3-kinase/Akt pathway involving calpain-mediated degradation of IkappaB-alpha that can be inhibited by the tumor suppressor PTEN.Q40811083
Microtubule-interfering agents stimulate the transcription of cyclooxygenase-2. Evidence for involvement of ERK1/2 AND p38 mitogen-activated protein kinase pathwaysQ40880153
Potential anticancer activity of turmeric (Curcuma longa).Q42229848
Inhibition of NF-κB Sensitizes A431 Cells to Epidermal Growth Factor-induced Apoptosis, whereas Its Activation by Ectopic Expression of RelA Confers ResistanceQ42440321
Inhibitory effects of curcumin on protein kinase C activity induced by 12-O-tetradecanoyl-phorbol-13-acetate in NIH 3T3 cellsQ42809796
Paclitaxel-resistant human ovarian cancer cells have mutant beta-tubulins that exhibit impaired paclitaxel-driven polymerizationQ42815194
Transcriptional upregulation and activation of p55Cdc via p34(cdc2) in Taxol-induced apoptosisQ42827738
Curcumin disrupts mitotic spindle structure and induces micronucleation in MCF-7 breast cancer cellsQ44026767
Cigarette smoke condensate activates nuclear transcription factor-kappaB through phosphorylation and degradation of IkappaB(alpha): correlation with induction of cyclooxygenase-2.Q44110063
Beta-catenin-mediated transactivation and cell-cell adhesion pathways are important in curcumin (diferuylmethane)-induced growth arrest and apoptosis in colon cancer cellsQ44239025
Human colon cancer cells differ in their sensitivity to curcumin-induced apoptosis and heat shock protects them by inhibiting the release of apoptosis-inducing factor and caspasesQ44359934
Inhibition of cell survival signal protein kinase B/Akt by curcumin in human prostate cancer cellsQ44395138
Molecular mechanisms of curcumin-induced cytotoxicity: induction of apoptosis through generation of reactive oxygen species, down-regulation of Bcl-XL and IAP, the release of cytochrome c and inhibition of Akt.Q44478685
Ectopic expression of Hsp70 confers resistance and silencing its expression sensitizes human colon cancer cells to curcumin-induced apoptosisQ44646931
Potentiation of paclitaxel cytotoxicity in lung and esophageal cancer cells by pharmacologic inhibition of the phosphoinositide 3-kinase/protein kinase B (Akt)-mediated signaling pathwayQ44755444
First line therapy with paclitaxel (Taxol) and pegylated liposomal doxorubicin (Caelyx) in patients with metastatic breast cancer: a multicentre phase II studyQ44921053
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectapoptotic processQ14599311
curcuminQ312266
P304page(s)6301-6308
P577publication date2004-12-07
P1433published inJournal of Biological ChemistryQ867727
P1476titleSensitization of taxol-induced apoptosis by curcumin involves down-regulation of nuclear factor-kappaB and the serine/threonine kinase Akt and is independent of tubulin polymerization
P478volume280

Reverse relations

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