Enhancement of mitomycin C-induced cytotoxicity by curcumin results from down-regulation of MKK1/2-ERK1/2-mediated thymidine phosphorylase expression

scientific article published on 4 November 2011

Enhancement of mitomycin C-induced cytotoxicity by curcumin results from down-regulation of MKK1/2-ERK1/2-mediated thymidine phosphorylase expression is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1111/J.1742-7843.2011.00806.X
P698PubMed publication ID21973306
P5875ResearchGate publication ID51698313

P2093author name stringHuang-Jen Chen
Min-Shao Tsai
Shao-Hsing Weng
Ya-Hsun Kuo
Yu-Fan Chiu
Yun-Wei Lin
P2860cites workA review of cancer chemopreventive agentsQ28189096
Cancer statistics, 2006Q29615133
Repair of DNA interstrand cross-linksQ34343361
Heterogeneous nuclear ribonucleoprotein H1/H2-dependent unsplicing of thymidine phosphorylase results in anticancer drug resistanceQ34536974
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Repair of DNA interstrand crosslinks: molecular mechanisms and clinical relevance.Q34571928
Curcumin and cancer: an "old-age" disease with an "age-old" solutionQ34776812
The dual role of thymidine phosphorylase in cancer development and chemotherapyQ34980526
Chemoresistance in non-small cell lung cancerQ36048311
Thymidine phosphorylase (platelet-derived endothelial-cell growth factor) in cancer biology and treatmentQ36057816
Mitomycin C and Vinorelbine for second-line chemotherapy in NSCLC--a phase II trialQ36610248
Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteinsQ37163664
Thymidine phosphorylase expression in normal, hyperplastic and neoplastic prostates: correlation with tumour associated macrophages, infiltrating lymphocytes, and angiogenesisQ38283244
The Sp1 transcription factor contributes to the tumor necrosis factor-induced expression of the angiogenic factor thymidine phosphorylase in human colon carcinoma cellsQ38360146
Curcumin reduced the side effects of mitomycin C by inhibiting GRP58-mediated DNA cross-linking in MCF-7 breast cancer xenograftsQ39809002
Thymidine phosphorylase mRNA stability and protein levels are increased through ERK-mediated cytoplasmic accumulation of hnRNP K in nasopharyngeal carcinoma cells.Q39866965
Curcumin sensitizes lung cancer cells to cisplatin-induced apoptosis through superoxide anion-mediated Bcl-2 degradationQ39873493
Curcumin augments gemcitabine cytotoxic effect on pancreatic adenocarcinoma cell lines.Q40078110
Synergistic inhibitory effects of curcumin and 5-fluorouracil on the growth of the human colon cancer cell line HT-29.Q40341471
Curcumin suppresses the paclitaxel-induced nuclear factor-kappaB pathway in breast cancer cells and inhibits lung metastasis of human breast cancer in nude miceQ40358890
Interferons upregulate thymidine phosphorylase expression via JAK-STAT-dependent transcriptional activation and mRNA stabilization in human glioblastoma cellsQ40413196
Antitumor effects of curcumin, alone or in combination with cisplatin or doxorubicin, on human hepatic cancer cells. Analysis of their possible relationship to changes in NF-kB activation levels and in IAP gene expressionQ40418488
Curcumin enhances Vinorelbine mediated apoptosis in NSCLC cells by the mitochondrial pathwayQ40424818
Curcumin induces apoptosis in human melanoma cells through a Fas receptor/caspase-8 pathway independent of p53.Q43804591
Molecular mechanisms of curcumin-induced cytotoxicity: induction of apoptosis through generation of reactive oxygen species, down-regulation of Bcl-XL and IAP, the release of cytochrome c and inhibition of Akt.Q44478685
Sensitization of taxol-induced apoptosis by curcumin involves down-regulation of nuclear factor-kappaB and the serine/threonine kinase Akt and is independent of tubulin polymerizationQ45182288
Involvement of Rad51 in cytotoxicity induced by epidermal growth factor receptor inhibitor (gefitinib, IressaR) and chemotherapeutic agents in human lung cancer cells.Q46547397
Upregulation of thymidine phosphorylase in rectal cancer tissues by mitomycin C.Q46850345
A phase III trial of docetaxel/carboplatin versus mitomycin C/ifosfamide/cisplatin (MIC) or mitomycin C/vinblastine/cisplatin (MVP) in patients with advanced non-small-cell lung cancer: a randomised multicentre trial of the British Thoracic OncologyQ57569726
P433issue3
P921main subjectcytotoxicityQ246181
curcuminQ312266
P304page(s)298-306
P577publication date2011-11-04
P1433published inBasic and Clinical Pharmacology and ToxicologyQ15724438
P1476titleEnhancement of mitomycin C-induced cytotoxicity by curcumin results from down-regulation of MKK1/2-ERK1/2-mediated thymidine phosphorylase expression
P478volume110

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cites work (P2860)
Q38212780Curcumin and lung cancer--a review
Q38782479Curcumin downregulates p38 MAPK-dependent X-ray repair cross-complement group 1 (XRCC1) expression to enhance cisplatin-induced cytotoxicity in human lung cancer cells
Q44774245Histology as a potential clinical predictor of outcome in advanced non-small-cell lung cancer treated with vinorelbine and mitomycin combination chemotherapy
Q38987177Inosine strongly enhances proliferation of human C32 melanoma cells through PLC-PKC-MEK1/2-ERK1/2 and PI3K pathways
Q39202165Metformin induces cytotoxicity by down-regulating thymidine phosphorylase and excision repair cross-complementation 1 expression in non-small cell lung cancer cells.

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