Nicotine-induced survival signaling in lung cancer cells is dependent on their p53 status while its down-regulation by curcumin is independent

scientific article published on 20 August 2010

Nicotine-induced survival signaling in lung cancer cells is dependent on their p53 status while its down-regulation by curcumin is independent is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1018476165
P356DOI10.1186/1476-4598-9-220
P932PMC publication ID2936340
P698PubMed publication ID20727180
P5875ResearchGate publication ID45797654

P2093author name stringVineshkumar T Puliyappadamba
Vino T Cheriyan
Arun Kumar T Thulasidasan
Ruby John Anto
Ranji Varghese
Balachandran S Vinod
Priya R Prabhu
Smitha V Bava
Shalini Venugopal
Arathy Bevin
P2860cites workL-929 cells harboring ectopically expressed RelA resist curcumin-induced apoptosisQ22253415
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A functional role for nicotine in Bcl2 phosphorylation and suppression of apoptosisQ24317110
Activation of Akt/protein kinase B overcomes a G(2)/m cell cycle checkpoint induced by DNA damageQ24537734
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Curcumin (diferuloylmethane) induces apoptosis through activation of caspase-8, BID cleavage and cytochrome c release: its suppression by ectopic expression of Bcl-2 and Bcl-xlQ28213620
Tobacco carcinogen-induced cellular transformation increases activation of the phosphatidylinositol 3'-kinase/Akt pathway in vitro and in vivoQ28240836
Tobacco components stimulate Akt-dependent proliferation and NFkappaB-dependent survival in lung cancer cellsQ28241697
MAP kinase-dependent, NF-kappaB-independent regulation of inhibitor of apoptosis protein genes by TNF-alphaQ28276227
NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activationQ29618715
Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound.Q31041084
Characterization of metabolites of the chemopreventive agent curcumin in human and rat hepatocytes and in the rat in vivo, and evaluation of their ability to inhibit phorbol ester-induced prostaglandin E2 productionQ32061424
NF-kappaB controls cell growth and differentiation through transcriptional regulation of cyclin D1.Q33959017
Angiogenic activity of nicotinic acetylcholine receptors: implications in tobacco-related vascular diseasesQ34015071
Long-term effects of inhaled nicotineQ34062469
NMDA antagonist inhibits the extracellular signal-regulated kinase pathway and suppresses cancer growthQ34098628
P53-mediated induction of Cox-2 counteracts p53- or genotoxic stress-induced apoptosisQ34207195
p53 induces NF-kappaB activation by an IkappaB kinase-independent mechanism involving phosphorylation of p65 by ribosomal S6 kinase 1.Q34312166
Effects of aging on acute toxicity of nicotine in ratsQ34326434
Curcumin: the story so far.Q34559908
Nicotine inhibits apoptosis induced by chemotherapeutic drugs by up-regulating XIAP and survivinQ34597500
Clonogenic assay of cells in vitro.Q34615431
Nicotine induces cell proliferation by beta-arrestin-mediated activation of Src and Rb-Raf-1 pathwaysQ34803242
Nicotine induces cell proliferation, invasion and epithelial-mesenchymal transition in a variety of human cancer cell linesQ34849133
p53, apoptosis and axon-guidance moleculesQ36092830
Constitutive activation of NF-kappaB during progression of breast cancer to hormone-independent growthQ36569036
Sustained activation of Ras/Raf/mitogen-activated protein kinase cascade by the tumor suppressor p53.Q37222088
NF-kappaB and AP-1 connection: mechanism of NF-kappaB-dependent regulation of AP-1 activity.Q37349742
p53-Dependent and -independent responses to cisplatin in mouse testicular teratocarcinoma cellsQ37385633
Akt is a downstream target of NF-kappa B.Q38288465
Mutant human tumor suppressor p53 modulates the activation of mitogen-activated protein kinase and nuclear factor-kappaB, but not c-Jun N-terminal kinase and activated protein-1.Q38319170
Mitogen-activated protein kinase pathway was significantly activated in human bronchial epithelial cells by nicotine.Q38518426
Transcriptional cross talk between NF-kappaB and p53.Q39445554
Rapid activation of Stat3 and ERK1/2 by nicotine modulates cell proliferation in human bladder cancer cells.Q39986725
Independent activation of Akt and NF-kappaB pathways and their role in resistance to TNF-alpha mediated cytotoxicity in gliomasQ40082150
c-Myc-induced chemosensitization is mediated by suppression of cyclin D1 expression and nuclear factor-kappa B activity in pancreatic cancer cellsQ40138478
Up-regulation of NFkappaB-responsive gene expression by DeltaNp73alpha in p53 null cells.Q40326159
Nicotine induces cyclooxygenase-2 and vascular endothelial growth factor receptor-2 in association with tumor-associated invasion and angiogenesis in gastric cancerQ40346011
Long-term exposure to nicotine, via ras pathway, induces cyclin D1 to stimulate G1 cell cycle transitionQ40485886
Nocodazole-induced p53-dependent c-Jun N-terminal kinase activation reduces apoptosis in human colon carcinoma HCT116 cellsQ40705173
Transcription of cyclooxygenase-2 is enhanced in transformed mammary epithelial cells.Q41165420
Inhibition of NF-κB Sensitizes A431 Cells to Epidermal Growth Factor-induced Apoptosis, whereas Its Activation by Ectopic Expression of RelA Confers ResistanceQ42440321
High frequency of somatically acquired p53 mutations in small-cell lung cancer cell lines and tumorsQ42598884
Nicotine stimulates angiogenesis and promotes tumor growth and atherosclerosisQ43658826
Cigarette smoke condensate activates nuclear transcription factor-kappaB through phosphorylation and degradation of IkappaB(alpha): correlation with induction of cyclooxygenase-2.Q44110063
Reciprocal inhibition of p53 and nuclear factor-kappaB transcriptional activities determines cell survival or death in neurons.Q44588640
Oxidative stress and cigarette smoke alter chromatin remodeling but differentially regulate NF-kappaB activation and proinflammatory cytokine release in alveolar epithelial cellsQ45084821
Sensitization of taxol-induced apoptosis by curcumin involves down-regulation of nuclear factor-kappaB and the serine/threonine kinase Akt and is independent of tubulin polymerizationQ45182288
Nicotinic receptors mediate tumorigenic action of tobacco-derived nitrosamines on immortalized oral epithelial cellsQ46082844
Nicotinic receptor-induced apoptotic cell death of hippocampal progenitor cells.Q46614299
The nicotinic receptor antagonists abolish pathobiologic effects of tobacco-derived nitrosamines on BEP2D cellsQ46732324
A JNK1/AP-1-dependent, COX-2 induction is implicated in 12-O-tetradecanoylphorbol-13-acetate-induced cell transformation through regulating cell cycle progressionQ46782178
MAPK/AP-1 signal pathway in tobacco smoke-induced cell proliferation and squamous metaplasia in the lungs of ratsQ46885411
Nicotine prevents the apoptosis induced by menadione in human lung cancer cells.Q52021344
NFkappaB-independent signaling to the cyclin D1 gene by Rac.Q53560247
Role of NF-κB in p53-mediated programmed cell deathQ57248006
Smokers of low-yield cigarettes do not consume less nicotineQ71773884
p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damageQ72297293
Nicotine-induced gene expression of proenkephalin in bovine chromaffin cellsQ72639673
Protective actions of 5'-n-alkylated curcumins on living cells suffering from oxidative stressQ77654446
The inhibitors of apoptosis (IAPs) and their emerging role in cancerQ77900361
P921main subjectlung cancerQ47912
curcuminQ312266
P304page(s)220
P577publication date2010-08-20
P1433published inMolecular CancerQ15724585
P1476titleNicotine-induced survival signaling in lung cancer cells is dependent on their p53 status while its down-regulation by curcumin is independent
P478volume9

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