Genetic variants of NHEJ DNA ligase IV can affect the risk of developing multiple myeloma, a tumour characterised by aberrant class switch recombination

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Genetic variants of NHEJ DNA ligase IV can affect the risk of developing multiple myeloma, a tumour characterised by aberrant class switch recombination is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1136/JMG.39.12.900
P932PMC publication ID1757220
P698PubMed publication ID12471202
P5875ResearchGate publication ID277484175

P50authorMark O'DriscollQ55149611
Gareth J. MorganQ61996585
P2093author name stringA Jack
P A Jeggo
S Rollinson
P L Roddam
P2860cites workFollicular lymphoma with a novel t(14;18) breakpoint involving the immunoglobulin heavy chain switch mu region indicates an origin from germinal center B cellsQ42667161
Somatic hypermutation in the absence of DNA-dependent protein kinase catalytic subunit (DNA-PK(cs)) or recombination-activating gene (RAG)1 activityQ42944177
Requirement for an interaction of XRCC4 with DNA ligase IV for wild-type V(D)J recombination and DNA double-strand break repair in vivo.Q46031860
DNA ligase IV binds to XRCC4 via a motif located between rather than within its BRCT domainsQ46835609
V(D)J recombinase-mediated transposition of the BCL2 gene to the IGH locus in follicular lymphomaQ47834210
Poor metabolizers at the cytochrome P450 2D6 and 2C19 loci are at increased risk of developing adult acute leukaemia.Q52863563
V(D)J Recombination in Mature B Cells: A Mechanism for Altering Antibody ResponsesQ56687402
New guardians of the genomeQ59000055
DNA ligase IV is essential for V(D)J recombination and DNA double-strand break repair in human precursor lymphocytesQ22007974
DNA binding of Xrcc4 protein is associated with V(D)J recombination but not with stimulation of DNA ligase IV activityQ24534080
Crystal structure of the Xrcc4 DNA repair protein and implications for end joiningQ24597643
The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocationsQ24685574
Interactions of the DNA ligase IV-XRCC4 complex with DNA ends and the DNA-dependent protein kinaseQ28138342
DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformationQ28141630
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Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and developmentQ28143170
Chromosomal stability and the DNA double-stranded break connectionQ28205315
Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IVQ28504490
Targeted disruption of the catalytic subunit of the DNA-PK gene in mice confers severe combined immunodeficiency and radiosensitivityQ28506163
Genetic interactions between ATM and the nonhomologous end-joining factors in genomic stability and developmentQ28512255
How to make ends meet in V(D)J recombinationQ32067274
Somatic hypermutation of immunoglobulin and non-immunoglobulin genesQ33770250
Regulated genomic instability and neoplasia in the lymphoid lineageQ33789653
Absence of DNA ligase IV protein in XR-1 cells: evidence for stabilization by XRCC4.Q33853314
Identification of a defect in DNA ligase IV in a radiosensitive leukaemia patientQ33867168
Switch junction sequences in PMS2-deficient mice reveal a microhomology-mediated mechanism of Ig class switch recombination.Q33952028
Immunodeficiency associated with DNA repair defectsQ33962066
DNA ligase IV mutations identified in patients exhibiting developmental delay and immunodeficiencyQ34108148
Linking class-switch recombination with somatic hypermutationQ34297090
Mechanisms of chromosomal translocations in B cell lymphomasQ34405423
Molecular mechanisms of DNA double strand break repairQ34484541
Ku70 is required for late B cell development and immunoglobulin heavy chain class switchingQ36401127
Molecular and biochemical characterization of xrs mutants defective in Ku80.Q40021061
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectmultiple myelomaQ467635
P304page(s)900-905
P577publication date2002-12-01
P1433published inJournal of Medical GeneticsQ14640281
P1476titleGenetic variants of NHEJ DNA ligase IV can affect the risk of developing multiple myeloma, a tumour characterised by aberrant class switch recombination
P478volume39

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cites work (P2860)
Q34347694A human iPSC model of Ligase IV deficiency reveals an important role for NHEJ-mediated-DSB repair in the survival and genomic stability of induced pluripotent stem cells and emerging haematopoietic progenitors.
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Q34343834Analysis of DNA ligase IV mutations found in LIG4 syndrome patients: the impact of two linked polymorphisms
Q33807557Assessing Candidate Gene nsSNPs for Phenotypic Differences in Double-Strand Break Repair Using Radiation-Induced gammaH2A.X Foci
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Q37135926DNA double strand break repair via non-homologous end-joining
Q37068167DNA repair gene polymorphisms and risk of pancreatic cancer
Q37505517DNA repair pathways in human multiple myeloma: role in oncogenesis and potential targets for treatment
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Q36790428Double-strand break damage and associated DNA repair genes predispose smokers to gene methylation
Q47747812Genetic intersection of male infertility and cancer
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Q21145035Genetic variation in an individual human exome
Q37924891Genetic variations in multiple myeloma I: effect on risk of multiple myeloma
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Q38163845Inherited genetic susceptibility to multiple myeloma
Q37778044Ligase IV Syndrome
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