| scholarly article | Q13442814 |
| P356 | DOI | 10.1016/S0065-2776(05)87007-5 |
| P698 | PubMed publication ID | 16102576 |
| P50 | author | Patrick Revy | Q44556029 |
| Jean-Pierre de Villartay | Q29840762 | ||
| P2093 | author name string | Dietke Buck | |
| Françoise le Deist | |||
| P2860 | cites work | Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2) | Q24290325 |
| The interaction of DNA mismatch repair proteins with human exonuclease I | Q24291370 | ||
| Crystal structure of an Xrcc4-DNA ligase IV complex | Q24291890 | ||
| Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination | Q24294409 | ||
| MDC1 is a mediator of the mammalian DNA damage checkpoint | Q24296229 | ||
| Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1 | Q24307678 | ||
| NBS1 localizes to gamma-H2AX foci through interaction with the FHA/BRCT domain | Q24316234 | ||
| Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome | Q24316811 | ||
| The hMre11/hRad50 Protein Complex and Nijmegen Breakage Syndrome: Linkage of Double-Strand Break Repair to the Cellular DNA Damage Response | Q24316950 | ||
| Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells | Q24320116 | ||
| Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV | Q24323238 | ||
| Metallo-beta-lactamase fold within nucleic acids processing enzymes: the beta-CASP family | Q24538351 | ||
| The cellular response to DNA double-strand breaks: defining the sensors and mediators | Q63383934 | ||
| Double-strand signal sequence breaks in V(D)J recombination are blunt, 5'-phosphorylated, RAG-dependent, and cell cycle regulated | Q64389767 | ||
| V(D)J recombination: broken DNA molecules with covalently sealed (hairpin) coding ends in scid mouse thymocytes | Q67521111 | ||
| On the nature of a defect in cells from individuals with ataxia-telangiectasia | Q70065595 | ||
| Genomic Organization of the ATM gene | Q71139418 | ||
| The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome | Q72068543 | ||
| V(D)J recombination and ataxia-telangiectasia: a review | Q72468470 | ||
| Radiosensitivity in ataxia-telangiectasia: anomalies in radiation-induced cell cycle delay | Q72670297 | ||
| Ig gene somatic hypermutation in mice defective for DNA polymerase delta proofreading | Q73188841 | ||
| Mortality rates among carriers of ataxia-telangiectasia mutant alleles | Q73208768 | ||
| The influence of transcriptional orientation on endogenous switch region function | Q73224719 | ||
| V(D)J Recombination in Ku86-Deficient Mice: Distinct Effects on Coding, Signal, and Hybrid Joint Formation | Q73574910 | ||
| Outcome of hematopoietic stem cell transplantation in hyper-IgM syndrome caused by CD40 deficiency | Q73803094 | ||
| Mutations at the ataxia-telangiectasia locus and clinical phenotypes of A-T patients | Q73806937 | ||
| ATAXIA-TELANGIECTASIA. ITS ASSOCIATION WITH A DEFECTIVE THYMUS, IMMUNOLOGICAL-DEFICIENCY DISEASE, AND MALIGNANCY | Q76773624 | ||
| VDJ recombination: a transposase goes to work | Q77198189 | ||
| A Targeted DNA-PKcs-Null Mutation Reveals DNA-PK-Independent Functions for KU in V(D)J Recombination | Q77398644 | ||
| Cutting edge: DNA polymerases mu and lambda are dispensable for Ig gene hypermutation | Q77892518 | ||
| Cell-cycle-dependent and ATM-independent expression of human Chk1 kinase | Q77954362 | ||
| IgH class switch recombination to IgG1 in DNA-PKcs-deficient B cells | Q77995587 | ||
| Alternative end joining during switch recombination in patients with ataxia-telangiectasia | Q78022313 | ||
| The Gene for Severe Combined Immunodeficiency Disease in Athabascan-Speaking Native Americans Is Located on Chromosome 10p | Q24538682 | ||
| A DNA Damage-Regulated BRCT-Containing Protein, TopBP1, Is Required for Cell Survival | Q24540067 | ||
| TRRAP-dependent and TRRAP-independent transcriptional activation by Myc family oncoproteins | Q24540114 | ||
| Nonhomologous end joining and V(D)J recombination require an additional factor | Q24554076 | ||
| The essential cofactor TRRAP recruits the histone acetyltransferase hGCN5 to c-Myc | Q24554343 | ||
| Partial T and B lymphocyte immunodeficiency and predisposition to lymphoma in patients with hypomorphic mutations in Artemis | Q24554368 | ||
| Functional and biochemical dissection of the structure-specific nuclease ARTEMIS | Q24564574 | ||
| The metallo-beta-lactamase/beta-CASP domain of Artemis constitutes the catalytic core for V(D)J recombination | Q24647735 | ||
| Genetic variants of NHEJ DNA ligase IV can affect the risk of developing multiple myeloma, a tumour characterised by aberrant class switch recombination | Q24672591 | ||
| Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance | Q24672646 | ||
| Human activation-induced cytidine deaminase causes transcription-dependent, strand-biased C to U deaminations | Q24678876 | ||
| Megabase chromatin domains involved in DNA double-strand breaks in vivo | Q24680284 | ||
| Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase | Q24683335 | ||
| Phosphorylation of Artemis following irradiation-induced DNA damage | Q27919664 | ||
| Evidence that polyadenylation factor CPSF-73 is the mRNA 3' processing endonuclease. | Q27932064 | ||
| The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder | Q28115238 | ||
| DNA Double-stranded Breaks Induce Histone H2AX Phosphorylation on Serine 139 | Q28131715 | ||
| Response to RAG-mediated VDJ cleavage by NBS1 and gamma-H2AX | Q28139663 | ||
| Mutations in activation-induced cytidine deaminase in patients with hyper IgM syndrome | Q28139861 | ||
| Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway | Q28141324 | ||
| A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage | Q28144576 | ||
| ATM phosphorylates histone H2AX in response to DNA double-strand breaks | Q28188651 | ||
| Transcription enhances AID-mediated cytidine deamination by exposing single-stranded DNA on the nontemplate strand | Q28190690 | ||
| Transcription-targeted DNA deamination by the AID antibody diversification enzyme | Q28190732 | ||
| DNA polymerase eta is an A-T mutator in somatic hypermutation of immunoglobulin variable genes | Q28190856 | ||
| Accumulation of Checkpoint Protein 53BP1 at DNA Breaks Involves Its Binding to Phosphorylated Histone H2AX | Q28191330 | ||
| Analysis of the V(D)J recombination efficiency at lymphoid chromosomal translocation breakpoints | Q28199398 | ||
| Histone H2AX Is Phosphorylated in an ATR-dependent Manner in Response to Replicational Stress | Q28201846 | ||
| The role of polymerase eta in somatic hypermutation determined by analysis of mutations in a patient with xeroderma pigmentosum variant | Q28203111 | ||
| NFBD1, like 53BP1, is an early and redundant transducer mediating Chk2 phosphorylation in response to DNA damage | Q28205262 | ||
| NFBD1/MDC1 regulates ionizing radiation-induced focus formation by DNA checkpoint signaling and repair factors | Q28205931 | ||
| DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation | Q28206029 | ||
| Targeted disruption of NBS1 reveals its roles in mouse development and DNA repair | Q28206244 | ||
| Histone H2A variants H2AX and H2AZ | Q28207014 | ||
| DNA double-strand breaks: prior to but not sufficient in targeting hypermutation | Q42944715 | ||
| Constitutive expression of AID leads to tumorigenesis | Q42944928 | ||
| Role of ATM in oxidative stress-mediated c-Jun phosphorylation in response to ionizing radiation and CdCl2. | Q43559235 | ||
| Bone marrow transplantation for T-B- severe combined immunodeficiency disease in Athabascan-speaking native Americans | Q43613019 | ||
| Mismatch repair co-opted by hypermutation. | Q43917262 | ||
| Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice | Q44194766 | ||
| Critical roles of activation-induced cytidine deaminase in the homeostasis of gut flora | Q44218058 | ||
| Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes. | Q44378806 | ||
| Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation | Q44486460 | ||
| The block in immunoglobulin class switch recombination caused by activation-induced cytidine deaminase deficiency occurs prior to the generation of DNA double strand breaks in switch mu region | Q44555997 | ||
| Gene-targeted mice lacking the Ung uracil-DNA glycosylase develop B-cell lymphomas | Q44559497 | ||
| Human uracil-DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination | Q44575368 | ||
| Reduced switching in SCID B cells is associated with altered somatic mutation of recombined S regions | Q44684968 | ||
| Transcription-coupled events associating with immunoglobulin switch region chromatin | Q44699066 | ||
| Staggered AID-dependent DNA double strand breaks are the predominant DNA lesions targeted to S mu in Ig class switch recombination | Q44811129 | ||
| Distinct functional domains of Nbs1 modulate the timing and magnitude of ATM activation after low doses of ionizing radiation | Q44817175 | ||
| PMS2-deficiency diminishes hypermutation of a lambda1 transgene in young but not older mice | Q44874917 | ||
| AID is required for c-myc/IgH chromosome translocations in vivo | Q45021537 | ||
| Induction of RNA-stabilized DMA conformers by transcription of an immunoglobulin switch region | Q45110397 | ||
| Severe combined immunodeficiency: a retrospective single-center study of clinical presentation and outcome in 117 patients | Q45167817 | ||
| Requirement for an Interaction of XRCC4 with DNA Ligase IV for Wild-type V(D)J Recombination and DNA Double-strand Break Repairin Vivo | Q46031860 | ||
| Nuclear localization of Cdc25 is regulated by DNA damage and a 14-3-3 protein | Q46098415 | ||
| DNA ligase IV binds to XRCC4 via a motif located between rather than within its BRCT domains | Q46835609 | ||
| Delineation of the role of the Mre11 complex in class switch recombination | Q47237271 | ||
| DNA transposition by the RAG1 and RAG2 proteins: a possible source of oncogenic translocations | Q47750695 | ||
| RAG proteins shepherd double-strand breaks to a specific pathway, suppressing error-prone repair, but RAG nicking initiates homologous recombination | Q47765927 | ||
| BRCA1 protein products ... Functional motifs... | Q48062839 | ||
| mRNA sequences define an unusually restricted IgG response to 2-phenyloxazolone and its early diversification | Q48397569 | ||
| Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps | Q49167454 | ||
| Decreased immunoglobulin class switching in nijmegen breakage syndrome due to the DNA repair defect | Q49167867 | ||
| Healing the wounds inflicted by sleeping beauty transposition by double-strand break repair in mammalian somatic cells | Q51829783 | ||
| Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice | Q52542455 | ||
| Unrepaired DNA breaks in p53-deficient cells lead to oncogenic gene amplification subsequent to translocations | Q53965557 | ||
| CD40 Ligand Gene Defects Responsible for X-Linked Hyper-IgM Syndrome | Q55670500 | ||
| A new gene involved in DNA double-strand break repair and V(D)J recombination is located on human chromosome 10p | Q57131989 | ||
| DNA Double-Strand Breaks in Immunoglobulin Genes Undergoing Somatic Hypermutation | Q57198273 | ||
| Decreased Frequency of Somatic Hypermutation and Impaired Affinity Maturation but Intact Germinal Center Formation in Mice Expressing Antisense RNA to DNA Polymerase | Q58424602 | ||
| Somatic hypermutation does not require Rad54 and Rad54B-mediated homologous recombination | Q58451213 | ||
| CD40 ligand mutations in X-linked immunodeficiency with hyper-IgM | Q58478788 | ||
| The scid mutation in mice causes a general defect in DNA repair | Q59073681 | ||
| Defective expression of T-cell CD40 ligand causes X-linked immunodeficiency with hyper-IgM | Q59086599 | ||
| CD40 ligand expression deficiency in a female carrier of the X-linked hyper-IgM syndrome as a result of X chromosome lyonization | Q59548349 | ||
| Induction by anti-CD40 antibody or soluble CD40 ligand and cytokines of IgG, IgA and IgE production by B cells from patients with X-linked hyper IgM syndrome | Q59548368 | ||
| Influence of severe combined immunodeficiency phenotype on the outcome of HLA non-identical, T-cell–depleted bone marrow transplantationA retrospective European survey from the European Group for Bone Marrow Transplantation and the European Society | Q61714678 | ||
| Lack of detectable defect in DNA double-strand break repair and DNA-dependent protein kinase activity in radiosensitive human severe combined immunodeficiency fibroblasts | Q61714693 | ||
| DNA repair: The Nijmegen breakage syndrome protein | Q63362925 | ||
| Increased radiosensitivity of granulocyte macrophage colony-forming units and skin fibroblasts in human autosomal recessive severe combined immunodeficiency | Q33894252 | ||
| Effect of HIV integrase inhibitors on the RAG1/2 recombinase | Q33896796 | ||
| Partners and pathwaysrepairing a double-strand break. | Q33927291 | ||
| Artemis, a novel DNA double-strand break repair/V(D)J recombination protein, is mutated in human severe combined immune deficiency. | Q33945446 | ||
| Cellular and biochemical impact of a mutation in DNA ligase IV conferring clinical radiosensitivity | Q33946410 | ||
| Mutations ofCD40gene cause an autosomal recessive form of immunodeficiency with hyper IgM | Q33947934 | ||
| Variable deletion and duplication at recombination junction ends: Implication for staggered double-strand cleavage in class-switch recombination | Q33950143 | ||
| p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts | Q33986335 | ||
| DNA mismatch repair and genetic instability | Q34090778 | ||
| DNA ligase IV mutations identified in patients exhibiting developmental delay and immunodeficiency | Q34108148 | ||
| A murine model of Nijmegen breakage syndrome | Q34124812 | ||
| A founder mutation in Artemis, an SNM1-like protein, causes SCID in Athabascan-speaking Native Americans | Q34132594 | ||
| 53BP1, a mediator of the DNA damage checkpoint | Q34153067 | ||
| Radiosensitive SCID patients with Artemis gene mutations show a complete B-cell differentiation arrest at the pre-B-cell receptor checkpoint in bone marrow. | Q34156865 | ||
| Novel Artemis gene mutations of radiosensitive severe combined immunodeficiency in Japanese families | Q34178243 | ||
| DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme? | Q34180691 | ||
| Chk1 mediates S and G2 arrests through Cdc25A degradation in response to DNA-damaging agents | Q34188494 | ||
| R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells | Q34188845 | ||
| Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex | Q34311086 | ||
| Expansion of the zinc metallo-hydrolase family of the beta-lactamase fold | Q34341856 | ||
| Analysis of DNA ligase IV mutations found in LIG4 syndrome patients: the impact of two linked polymorphisms | Q34343834 | ||
| DNA double strand break repair and chromosomal translocation: lessons from animal models | Q34405417 | ||
| Mutations in the DNA ligase I gene of an individual with immunodeficiencies and cellular hypersensitivity to DNA-damaging agents | Q34409945 | ||
| Structure and function of mammalian DNA ligases | Q34463842 | ||
| A recombinase diversified: new functions of the RAG proteins | Q34547234 | ||
| A unified view of the DNA-damage checkpoint | Q34560932 | ||
| Does artemis end the hunt for the hairpin-opening activity in V(D)J recombination? | Q34602625 | ||
| The mechanism and regulation of chromosomal V(D)J recombination | Q34619795 | ||
| CD40-CD40L independent Ig gene hypermutation suggests a second B cell diversification pathway in humans | Q34651496 | ||
| V(D)J recombination: RAG proteins, repair factors, and regulation | Q34667417 | ||
| In vivo transposition mediated by V(D)J recombinase in human T lymphocytes | Q34794778 | ||
| De novo protein synthesis is required for the activation-induced cytidine deaminase function in class-switch recombination | Q34807643 | ||
| Impact of DNA ligase IV on the fidelity of end joining in human cells | Q34966793 | ||
| Sensing of intermediates in V(D)J recombination by ATM. | Q35005088 | ||
| Nijmegen breakage syndrome gene, NBS1, and molecular links to factors for genome stability | Q35026390 | ||
| Ku80 is required for addition of N nucleotides to V(D)J recombination junctions by terminal deoxynucleotidyl transferase | Q35079436 | ||
| DNA double strand breaks (DSB) and non-homologous end joining (NHEJ) pathways in human leukemia | Q35105914 | ||
| Hyper-IgM syndrome type 4 with a B lymphocyte-intrinsic selective deficiency in Ig class-switch recombination | Q35108519 | ||
| Genetic heterogeneity for a Nijmegen breakage‐like syndrome | Q35110142 | ||
| Critical role for Atm in suppressing V(D)J recombination-driven thymic lymphoma | Q35197081 | ||
| Restraining the V(D)J recombinase | Q35219034 | ||
| Human and animal models of V(D)J recombination deficiency | Q35538187 | ||
| The V(D)J recombination activating gene, RAG-1. | Q35633860 | ||
| Human models of inherited immunoglobulin class switch recombination and somatic hypermutation defects (hyper-IgM syndromes). | Q35671715 | ||
| Recombinase-activating gene (RAG) 2-mediated V(D)J recombination is not essential for tumorigenesis in Atm-deficient mice | Q35795447 | ||
| AID: how does it aid antibody diversity? | Q35800376 | ||
| The DNA-dependent protein kinase: the director at the end. | Q35830413 | ||
| The DNA double-strand break response in the nervous system | Q35848537 | ||
| Ataxia-telangiectasia, an evolving phenotype | Q35848556 | ||
| Ataxia-telangiectasia-like disorder (ATLD)-its clinical presentation and molecular basis | Q35848561 | ||
| In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. II. A common clonal origin for periarteriolar lymphoid sheath-associated foci and germinal centers | Q36231790 | ||
| The translesion DNA polymerase zeta plays a major role in Ig and bcl-6 somatic hypermutation. | Q36248087 | ||
| Requirement of the MRN complex for ATM activation by DNA damage | Q36267304 | ||
| AID mediates hypermutation by deaminating single stranded DNA. | Q36370366 | ||
| H2AX is required for recombination between immunoglobulin switch regions but not for intra-switch region recombination or somatic hypermutation | Q36370913 | ||
| DNA-dependent protein kinase activity is not required for immunoglobulin class switching | Q36371923 | ||
| Evidence for replicative repair of DNA double-strand breaks leading to oncogenic translocation and gene amplification | Q36376595 | ||
| DNA polymerase eta is involved in hypermutation occurring during immunoglobulin class switch recombination. | Q36399002 | ||
| Absence of DNA polymerase eta reveals targeting of C mutations on the nontranscribed strand in immunoglobulin switch regions | Q36399387 | ||
| Somatic hypermutation is limited by CRM1-dependent nuclear export of activation-induced deaminase | Q36399510 | ||
| Ku70 is required for late B cell development and immunoglobulin heavy chain class switching | Q36401127 | ||
| A role for Msh6 but not Msh3 in somatic hypermutation and class switch recombination | Q36403922 | ||
| A human severe combined immunodeficiency (SCID) condition with increased sensitivity to ionizing radiations and impaired V(D)J rearrangements defines a new DNA recombination/repair deficiency | Q36404053 | ||
| scid cells are deficient in Ku and replication protein A phosphorylation by the DNA-dependent protein kinase | Q36555430 | ||
| Artemis and p53 cooperate to suppress oncogenic N-myc amplification in progenitor B cells. | Q36602126 | ||
| Identification of a nonsense mutation in the carboxyl-terminal region of DNA-dependent protein kinase catalytic subunit in the scid mouse | Q36820879 | ||
| The SCID mouse mutant: definition, characterization, and potential uses | Q37357870 | ||
| AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification | Q28208979 | ||
| Normal V(D)J recombination in cells from patients with Nijmegen breakage syndrome | Q28209736 | ||
| MDC1 is required for the intra-S-phase DNA damage checkpoint | Q28212500 | ||
| MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways | Q28212514 | ||
| NFBD1, a novel nuclear protein with signature motifs of FHA and BRCT, and an internal 41-amino acid repeat sequence, is an early participant in DNA damage response | Q28217141 | ||
| Cancer-susceptibility genes. Gatekeepers and caretakers | Q28236512 | ||
| Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints | Q28266170 | ||
| The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination | Q28272412 | ||
| Assembly of a 12/23 Paired Signal Complex: A Critical Control Point in V(D)J Recombination | Q28275539 | ||
| A new chromosomal instability disorder: the Nijmegen breakage syndrome | Q28281429 | ||
| RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination | Q28289238 | ||
| DNA-dependent kinase (p350) as a candidate gene for the murine SCID defect | Q28307262 | ||
| AID is required to initiate Nbs1/γ-H2AX focus formation and mutations at sites of class switching | Q28366125 | ||
| Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV | Q28504490 | ||
| Increased Hypermutation at G and C Nucleotides in Immunoglobulin Variable Genes from Mice Deficient in the MSH2 Mismatch Repair Protein | Q28505917 | ||
| Targeted disruption of the catalytic subunit of the DNA-PK gene in mice confers severe combined immunodeficiency and radiosensitivity | Q28506163 | ||
| Hot Spot Focusing of Somatic Hypermutation in MSH2-Deficient Mice Suggests Two Stages of Mutational Targeting | Q28506440 | ||
| Hypermutation of immunoglobulin genes in memory B cells of DNA repair-deficient mice | Q28507519 | ||
| Rad51 expression and localization in B cells carrying out class switch recombination | Q28508346 | ||
| Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells | Q28509339 | ||
| Somatic hypermutation in MutS homologue (MSH)3-, MSH6-, and MSH3/MSH6-deficient mice reveals a role for the MSH2-MSH6 heterodimer in modulating the base substitution pattern | Q28510640 | ||
| Defective DNA repair and increased genomic instability in Artemis-deficient murine cells | Q28513655 | ||
| Altered somatic hypermutation and reduced class-switch recombination in exonuclease 1-mutant mice | Q28513971 | ||
| Severe attenuation of the B cell immune response in Msh2-deficient mice | Q28585021 | ||
| Reduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymes | Q28585862 | ||
| Msh2 ATPase activity is essential for somatic hypermutation at a-T basepairs and for efficient class switch recombination | Q28586272 | ||
| 129-derived strains of mice are deficient in DNA polymerase iota and have normal immunoglobulin hypermutation | Q28587504 | ||
| Genomic instability in mice lacking histone H2AX | Q28589826 | ||
| Examination of Msh6- and Msh3-deficient mice in class switching reveals overlapping and distinct roles of MutS homologues in antibody diversification | Q28589828 | ||
| RAG-1-deficient mice have no mature B and T lymphocytes | Q28592133 | ||
| Leaky Scid phenotype associated with defective V(D)J coding end processing in Artemis-deficient mice | Q28592390 | ||
| Mice reconstituted with DNA polymerase beta-deficient fetal liver cells are able to mount a T cell-dependent immune response and mutate their Ig genes normally | Q28592782 | ||
| RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement | Q28594711 | ||
| scid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair | Q37404182 | ||
| A link between double-strand break-related repair and V(D)J recombination: the scid mutation | Q37508055 | ||
| De novo protein synthesis is required for activation-induced cytidine deaminase-dependent DNA cleavage in immunoglobulin class switch recombination | Q37512400 | ||
| Speculations on ataxia-telangiectasia: defective regulation of the immunoglobulin gene superfamily | Q38729487 | ||
| V(D)J-mediated translocations in lymphoid neoplasms: a functional assessment of genomic instability by cryptic sites. | Q39017691 | ||
| Structure of Nonhairpin Coding-End DNA Breaks in Cells Undergoing V(D)J Recombination | Q39631050 | ||
| DNA-PK is activated by nucleosomes and phosphorylates H2AX within the nucleosomes in an acetylation-dependent manner | Q40315391 | ||
| Uracil DNA glycosylase activity is dispensable for immunoglobulin class switch | Q40522938 | ||
| Activation-induced cytosine deaminase (AID) is actively exported out of the nucleus but retained by the induction of DNA breaks | Q40566152 | ||
| A non-B-DNA structure at the Bcl-2 major breakpoint region is cleaved by the RAG complex | Q40582495 | ||
| The DNA crosslink-induced S-phase checkpoint depends on ATR-CHK1 and ATR-NBS1-FANCD2 pathways | Q40584861 | ||
| Ablation of XRCC2/3 transforms immunoglobulin V gene conversion into somatic hypermutation | Q40782991 | ||
| Cell-cycle-regulated DNA double-stranded breaks in somatic hypermutation of immunoglobulin genes | Q40840741 | ||
| Transposition mediated by RAG1 and RAG2 and its implications for the evolution of the immune system | Q41011364 | ||
| Ku70: a candidate tumor suppressor gene for murine T cell lymphoma | Q41017020 | ||
| RAG mutations in human B cell-negative SCID. | Q41159572 | ||
| An instance of clinical radiation morbidity and cellular radiosensitivity, not associated with ataxia-telangiectasia | Q41186496 | ||
| Within germinal centers, isotype switching of immunoglobulin genes occurs after the onset of somatic mutation | Q41224472 | ||
| Human blood IgM "memory" B cells are circulating splenic marginal zone B cells harboring a prediversified immunoglobulin repertoire | Q41505077 | ||
| V(D)J recombination in mammalian cell mutants defective in DNA double-strand break repair | Q41549015 | ||
| Impairment of V(D)J recombination in double-strand break repair mutants | Q41560292 | ||
| Oral and genital ulceration: a unique presentation of immunodeficiency in Athabascan-speaking American Indian children with severe combined immunodeficiency | Q41686285 | ||
| Ataxia-telangiectasia: phenotype/genotype studies of ATM protein expression, mutations, and radiosensitivity | Q41744212 | ||
| AID-dependent generation of resected double-strand DNA breaks and recruitment of Rad52/Rad51 in somatic hypermutation | Q41771550 | ||
| Ku80 is required for immunoglobulin isotype switching | Q41821763 | ||
| Positional cloning of the gene for Nijmegen breakage syndrome | Q41926361 | ||
| Human immunoglobulin (Ig)M+IgD+ peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells | Q42108183 | ||
| Germinal center founder cells display propensity for apoptosis before onset of somatic mutation | Q42114332 | ||
| Deficiency in Msh2 affects the efficiency and local sequence specificity of immunoglobulin class-switch recombination: parallels with somatic hypermutation. | Q42676262 | ||
| AID mutant analyses indicate requirement for class-switch-specific cofactors | Q42798287 | ||
| DNA-PKcs: a T-cell tumour suppressor encoded at the mouse scid locus | Q42833970 | ||
| Somatic hypermutation in the absence of DNA-dependent protein kinase catalytic subunit (DNA-PK(cs)) or recombination-activating gene (RAG)1 activity | Q42944177 | ||
| The activation-induced deaminase functions in a postcleavage step of the somatic hypermutation process | Q42944711 | ||
| Altered spectra of hypermutation in antibodies from mice deficient for the DNA mismatch repair protein PMS2 | Q28910215 | ||
| Mammalian G1- and S-phase checkpoints in response to DNA damage | Q29013238 | ||
| Severe combined immunodeficiencies (SCID) | Q29042256 | ||
| 53BP1 is required for class switch recombination | Q29465541 | ||
| 53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination. | Q29465548 | ||
| Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme | Q29547201 | ||
| ATM and related protein kinases: safeguarding genome integrity | Q29547735 | ||
| Somatic generation of antibody diversity | Q29616439 | ||
| From BRCA1 to RAP1: a widespread BRCT module closely associated with DNA repair | Q29619880 | ||
| Replication protein A interacts with AID to promote deamination of somatic hypermutation targets | Q31099047 | ||
| DNA damage: Chk1 and Cdc25, more than meets the eye. | Q31858938 | ||
| Chk1 Kinase Negatively Regulates Mitotic Function of Cdc25A Phosphatase through 14-3-3 Binding | Q33292076 | ||
| Clinical, immunologic and genetic analysis of 29 patients with autosomal recessive hyper-IgM syndrome due to Activation-Induced Cytidine Deaminase deficiency | Q33359560 | ||
| Metallo-beta-lactamase: structure and mechanism | Q33745008 | ||
| Cellular origin of human B-cell lymphomas. | Q33772424 | ||
| Absence of DNA ligase IV protein in XR-1 cells: evidence for stabilization by XRCC4. | Q33853314 | ||
| Identification of a defect in DNA ligase IV in a radiosensitive leukaemia patient | Q33867168 | ||
| P304 | page(s) | 237-295 | |
| P577 | publication date | 2005-01-01 | |
| P13046 | publication type of scholarly work | review article | Q7318358 |
| P1433 | published in | Advances in Immunology | Q15752932 |
| P1476 | title | The repair of DNA damages/modifications during the maturation of the immune system: lessons from human primary immunodeficiency disorders and animal models | |
| P478 | volume | 87 |
| Q39947968 | A biochemically defined system for coding joint formation in V(D)J recombination |
| Q36382754 | ATM-dependent DNA damage surveillance in T-cell development and leukemogenesis: the DSB connection |
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| Q33438469 | CD27(-) B-cells produce class switched and somatically hyper-mutated antibodies during chronic HIV-1 infection |
| Q34506736 | Cernunnos interacts with the XRCC4 x DNA-ligase IV complex and is homologous to the yeast nonhomologous end-joining factor Nej1. |
| Q24302120 | Cernunnos, a novel nonhomologous end-joining factor, is mutated in human immunodeficiency with microcephaly |
| Q41596688 | Cryo-EM structure of human DNA-PK holoenzyme |
| Q36986713 | DNA repair and the immune system: From V(D)J recombination to aging lymphocytes. |
| Q37471650 | DNA repair mechanisms and Toxoplasma gondii infection |
| Q37974984 | DNA repair: the link between primary immunodeficiency and cancer |
| Q37304668 | Dealing with dangerous accidents: DNA double-strand breaks take centre stage. Symposium on Genome Instability and DNA Repair |
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| Q36542548 | RAG2 and XLF/Cernunnos interplay reveals a novel role for the RAG complex in DNA repair |
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| Q41919979 | Severe combined immunodeficiency and microcephaly in siblings with hypomorphic mutations in DNA ligase IV. |
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| Q37526483 | The MRE11 complex: starting from the ends. |
| Q34061457 | The human LINE-1 retrotransposon creates DNA double-strand breaks. |
| Q37027193 | V(D)J and immunoglobulin class switch recombinations: a paradigm to study the regulation of DNA end-joining. |
| Q41918614 | XLF/Cernunnos: An important but puzzling participant in the nonhomologous end joining DNA repair pathway. |
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