Germinal center founder cells display propensity for apoptosis before onset of somatic mutation

scientific article published on February 1997

Germinal center founder cells display propensity for apoptosis before onset of somatic mutation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1084/JEM.185.3.563
P932PMC publication ID2196025
P698PubMed publication ID9053456
P5875ResearchGate publication ID277402476

P50authorJacques BanchereauQ55097670
P2093author name stringS Lebecque
Y J Liu
C Arpin
O de Bouteiller
P2860cites workImmunoglobulin D (IgD)-deficient mice reveal an auxiliary receptor function for IgD in antigen-mediated recruitment of B cellsQ24680746
Biology of germinal centers in lymphoid tissueQ28247064
Germinal centersQ29616234
Analysis of somatic mutation in five B cell subsets of human tonsilQ34328629
In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. I. The architecture and dynamics of responding cell populationsQ34885732
Expansion, selection and mutation of antigen-specific B cells in germinal centersQ35320490
Human B lymphocytes: phenotype, proliferation, and differentiationQ35533659
Phenotypic expression of B-lymphocytes. 2. Immunoglobulin expression of germinal center cellsQ35858084
The molecular and cellular basis of affinity maturation in the antibody responseQ35862643
Expression of IgD by murine lymphocytes. Loss of surface IgD indicates maturation of memory B cellsQ36340200
Memory B cells at successive stages of differentiation. Affinity maturation and the role of IgD receptorsQ36343552
Antigen-driven B cell differentiation in vivoQ36361955
In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. III. The kinetics of V region mutation and selection in germinal center B cellsQ36362440
Germinal centres in T-cell-dependent antibody responsesQ36774105
Antigen-driven selection of virgin and memory B cellsQ38595897
Role of IgD and T delta cells in the regulation of the humoral immune responseQ39545224
Functional anatomy of germinal centersQ40186432
How B and T cells talk to each otherQ40714365
Developmental switches in the immune systemQ40807421
Tracing B cell development in human germinal centres by molecular analysis of single cells picked from histological sectionsQ40874465
Among naive precursor cell subpopulations only progenitors of memory B cells originate germinal centersQ41092267
Intraclonal generation of antibody mutants in germinal centresQ41172275
Within germinal centers, isotype switching of immunoglobulin genes occurs after the onset of somatic mutationQ41224472
Human germinal center B cells express the apoptosis-inducing genes Fas, c-myc, P53, and Bax but not the survival gene bcl-2Q42759511
Variable region gene analysis of B cell subsets derived from a 4-year-old child: somatically mutated memory B cells accumulate in the peripheral blood already at young age.Q42942605
Germinal centers develop oligoclonallyQ43487651
Sites of specific B cell activation in primary and secondary responses to T cell-dependent and T cell-independent antigensQ43603650
Accumulation of somatic mutants in the B cell compartment after primary immunization with a T cell-dependent antigenQ48187772
Maturation of the immune response in germinal centersQ48194763
Memory B cells from human tonsils colonize mucosal epithelium and directly present antigen to T cells by rapid up-regulation of B7-1 and B7-2.Q52054113
Comparison of IgD+ and IgD- thoracic duct B lymphocytes as germinal center precursor cells in the rat.Q52082625
Memory B cells in T cell-dependent antibody responses colonize the splenic marginal zones.Q52125189
The molecular biology of immunoglobulin D.Q52211747
The relationship between surface immunoglobulin isotype and the immune function of murine B lymphocytes. V. High affinity secondary antibody responses are transferred by both IgD-positive and IgD-negative memory B cells.Q52224614
Mechanism of antigen-driven selection in germinal centresQ59072211
The germinal center precursor cell is surface mu and delta positiveQ67254793
T cells with receptors for IgDQ69872496
Polyclonal activation of the murine immune system by an antibody to IgD V. Effect on germinal centersQ70223301
A role for immunoglobulin D: interference with tolerance inductionQ70526999
B lymphocyte activation: entry into cell cycle is accompanied by decreased expression of IgD but not IgMQ70983795
The phenotype and fate of the antibody-forming cells of the splenic fociQ71047935
Normal human IgD+IgM- germinal center B cells can express up to 80 mutations in the variable region of their IgD transcriptsQ71169448
CD40-activated surface IgD-positive lymphocytes constitute the long term IL-4-dependent proliferating B cell poolQ71601488
The differences in survival and phenotype between centroblasts and centrocytesQ71687171
IgD expression on B cells is more efficient than IgM but both receptors are functionally equivalent in up-regulation CD80/CD86 co-stimulatory moleculesQ71702772
Maturity of precursor cells for germinal centersQ72118425
Subpopulations of B lymphocytes in germinal centers, II. A germinal center B cell subpopulation expresses sIgD and CD23Q93517950
P433issue3
P407language of work or nameEnglishQ1860
P304page(s)563-571
P577publication date1997-02-01
P1433published inJournal of Experimental MedicineQ3186912
P1476titleGerminal center founder cells display propensity for apoptosis before onset of somatic mutation
P478volume185