scholarly article | Q13442814 |
P50 | author | Lawrence D True | Q114402092 |
P2093 | author name string | Lawrence A Loeb | |
Jason H Bielas | |||
Brian P Rubin | |||
Keith R Loeb | |||
P2860 | cites work | Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis | Q22122362 |
Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability | Q24319995 | ||
A census of human cancer genes | Q24647081 | ||
Inflammation and cancer | Q24649640 | ||
A genetic model for colorectal tumorigenesis | Q27860582 | ||
Worms gang up on bacteria | Q27860588 | ||
p53, the cellular gatekeeper for growth and division | Q27860990 | ||
The consensus coding sequences of human breast and colorectal cancers | Q27861035 | ||
Genetic instabilities in human cancers | Q28131826 | ||
The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer | Q28256988 | ||
Genetic alterations during colorectal-tumor development | Q28281200 | ||
Increased mutation rate at the hprt locus accompanies microsatellite instability in colon cancer | Q28305622 | ||
ras genes | Q29547799 | ||
DNA replication fidelity | Q29616841 | ||
Prevalence of somatic alterations in the colorectal cancer cell genome | Q34016415 | ||
Mutations in APC, Kirsten-ras, and p53--alternative genetic pathways to colorectal cancer. | Q34035601 | ||
A mutator phenotype in cancer. | Q34222899 | ||
Mutational analysis of the tyrosine phosphatome in colorectal cancers | Q34322220 | ||
Multiple mutations and cancer | Q34327554 | ||
Negative clonal selection in tumor evolution | Q34587078 | ||
Radical causes of cancer. | Q35097371 | ||
Comparative genomic hybridization, loss of heterozygosity, and DNA sequence analysis of single cells | Q35129565 | ||
Chromosome aberrations in solid tumors | Q35201471 | ||
In vivo somatic mutations in humans: measurement and analysis | Q37794694 | ||
Differences in the spectrum of spontaneous mutations in the hprt gene between tumor cells of the microsatellite mutator phenotype | Q38358374 | ||
Errors in DNA replication as a basis of malignant changes | Q39870986 | ||
Foundations in cancer research. Chromosomes and cancer: the evolution of an idea. | Q40715297 | ||
Cancer of the microsatellite mutator phenotype. | Q41263775 | ||
Increased p53 mutation load in noncancerous colon tissue from ulcerative colitis: a cancer-prone chronic inflammatory disease | Q41749997 | ||
Stochastic tunnels in evolutionary dynamics | Q42426795 | ||
A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer. | Q50767379 | ||
Quantification of random genomic mutations. | Q54674731 | ||
The fundamental role of epigenetic events in cancer | Q56421597 | ||
ABL mutations in late chronic phase chronic myeloid leukemia patients with up-front cytogenetic resistance to imatinib are associated with a greater likelihood of progression to blast crisis and shorter survival: a study by the GIMEMA Working Party o | Q56999804 | ||
P2507 | corrigendum / erratum | Correction for Bielas et al., Human cancers express a mutator phenotype | Q93637750 |
P433 | issue | 48 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | phenotype | Q104053 |
P304 | page(s) | 18238-42 | |
P577 | publication date | 2006-11-28 | |
P1433 | published in | Proceedings of the National Academy of Sciences of the United States of America | Q1146531 |
P1476 | title | Human cancers express a mutator phenotype | |
P478 | volume | 103 |
Q27679296 | A Nucleotide-Analogue-Induced Gain of Function Corrects the Error-Prone Nature of Human DNA Polymerase iota |
Q33741192 | A branch-migration based fluorescent probe for straightforward, sensitive and specific discrimination of DNA mutations. |
Q27933133 | A genetic screen for increased loss of heterozygosity in Saccharomyces cerevisiae |
Q39549335 | A mechanistic understanding of production instability in CHO cell lines expressing recombinant monoclonal antibodies |
Q26858878 | A periodic table for cancer |
Q39169154 | A population genetics perspective on the determinants of intra-tumor heterogeneity |
Q39496794 | A quantitative analysis of genomic instability in lymphoid and plasma cell neoplasms based on the PIG-A gene. |
Q35041017 | A random mutation capture assay to detect genomic point mutations in mouse tissue |
Q37799102 | Aberrant expression of alternative DNA polymerases: A source of mutator phenotype as well as replicative stress in cancer |
Q48986975 | Abrupt transitions to tumor extinction: a phenotypic quasispecies model |
Q34186488 | Active site mutations in mammalian DNA polymerase delta alter accuracy and replication fork progression |
Q40230898 | Adaptive tuning of mutation rates allows fast response to lethal stress in Escherichia coli |
Q33611809 | Administration of cyclophosphamide changes the immune profile of tumor-bearing mice |
Q28756544 | Advances in chemical carcinogenesis: a historical review and prospective |
Q34494738 | Age-related somatic mutations in the cancer genome |
Q36369411 | An analogy between the evolution of drug resistance in bacterial communities and malignant tissues |
Q33507538 | Analysis of cancer mutation signatures in blood by a novel ultra-sensitive assay: monitoring of therapy or recurrence in non-metastatic breast cancer |
Q35281575 | Androgen receptor gene polymorphisms and alterations in prostate cancer: of humanized mice and men. |
Q27024636 | Antimutator variants of DNA polymerases |
Q41865883 | Beyond microarrays |
Q34692190 | Biomarkers in the age of omics: time for a systems biology approach |
Q38337296 | Biotinylated probe isolation of targeted gene region improves detection of T790M epidermal growth factor receptor mutation via peptide nucleic acid-enriched real-time PCR. |
Q43185856 | BitPhylogeny: a probabilistic framework for reconstructing intra-tumor phylogenies |
Q26827700 | Breaking bad: The mutagenic effect of DNA repair |
Q35840622 | Bringing Down Cancer Aircraft: Searching for Essential Hypomutated Proteins in Skin Melanoma |
Q36163366 | C/EBPα expression is downregulated in human nonmelanoma skin cancers and inactivation of C/EBPα confers susceptibility to UVB-induced skin squamous cell carcinomas |
Q34023291 | CFL1 expression levels as a prognostic and drug resistance marker in nonsmall cell lung cancer |
Q35036964 | COLD-PCR: improving the sensitivity of molecular diagnostics assays |
Q51094931 | Can a minimal replicating construct be identified as the embodiment of cancer? |
Q43258142 | Cancer Prevention and Treatment by Wholistic Nutrition |
Q38249438 | Cancer genomics: one cell at a time |
Q37209758 | Cancer, stem cells, and oncolytic viruses |
Q27860907 | Cancer-related inflammation |
Q22242922 | Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability |
Q33583898 | Chromium reduces the in vitro activity and fidelity of DNA replication mediated by the human cell DNA synthesome |
Q27025915 | Chronic Pancreatitis and Pancreatic Cancer |
Q34041603 | Clonal evolution in breast cancer revealed by single nucleus genome sequencing. |
Q33302051 | Clonal mutations in primary human glial tumors: evidence in support of the mutator hypothesis |
Q36981107 | Colorectal cancers in patients with the (9A/6A) polymorphism of TGFBR1 exhibit lesser inter-(simple sequence repeat) PCR genomic instability and present clinically at greater age. |
Q39392958 | Combination of a modified block PCR and endonuclease IV-based signal amplification system for ultra-sensitive detection of low-abundance point mutations |
Q41147905 | Comparing nodal versus bony metastatic spread using tumour phylogenies. |
Q39022359 | Curing tumor-bearing mice by shifting a Th2 to a Th1 anti-tumor response |
Q37386020 | DNA polymerase epsilon and delta proofreading suppress discrete mutator and cancer phenotypes in mice |
Q37084895 | DNA polymerases and cancer. |
Q34795963 | DNA polymerases and human disease |
Q28295863 | DNA replication fidelity and cancer |
Q84273227 | Decoding the genome beyond sequencing: the new phase of genomic research |
Q34299414 | Decreased mitochondrial DNA mutagenesis in human colorectal cancer |
Q38572102 | Deoxyribonucleotide metabolism, mutagenesis and cancer |
Q34221722 | Dissecting DNA repair in adult high grade gliomas for patient stratification in the post-genomic era. |
Q92854514 | Dissecting Molecular Features of Gliomas: Genetic Loci and Validated Biomarkers |
Q28741663 | Distinct patterns of somatic alterations in a lymphoblastoid and a tumor genome derived from the same individual |
Q26851006 | Do mutator mutations fuel tumorigenesis? |
Q27938305 | Dpb2p, a noncatalytic subunit of DNA polymerase epsilon, contributes to the fidelity of DNA replication in Saccharomyces cerevisiae |
Q53282043 | Dynamic rewiring of the androgen receptor protein interaction network correlates with prostate cancer clinical outcomes. |
Q28472842 | Epigenetic regulation of the mammalian cell |
Q33534685 | Evidence of genetic instability in tumors and normal nearby tissues |
Q42067716 | Evolutionary dynamics of chronic myeloid leukemia |
Q39648589 | Evolutionary dynamics of two related malignant plasma cell lines |
Q39078887 | Experimental design to evaluate directed adaptive mutation in Mammalian cells. |
Q37620662 | Expression of base excision repair key factors and miR17 in familial and sporadic breast cancer |
Q46593630 | Fen1 mutations result in autoimmunity, chronic inflammation and cancers |
Q24653877 | Field defects in progression to gastrointestinal tract cancers |
Q36904971 | First steps in experimental cancer evolution. |
Q34184661 | Frequent heterogeneous missense mutations of GGAP2 in prostate cancer: implications for tumor biology, clonality and mutation analysis |
Q37764795 | Generation, function, and prognostic utility of somatic mitochondrial DNA mutations in cancer |
Q37453787 | Genetic and epigenetic alterations as biomarkers for cancer detection, diagnosis and prognosis |
Q38103747 | Genetic and non-genetic instability in tumor progression: link between the fitness landscape and the epigenetic landscape of cancer cells |
Q47927353 | Genetic changes of MLH1 and MSH2 genes could explain constant findings on microsatellite instability in intracranial meningioma |
Q83791245 | Genetic heterogeneity and cancer drug resistance |
Q21563505 | Genetic progression and the waiting time to cancer |
Q37422915 | Genome based cell population heterogeneity promotes tumorigenicity: the evolutionary mechanism of cancer |
Q28553238 | Genome-Wide Estimation of the Spontaneous Mutation Rate of Human Adenovirus 5 by High-Fidelity Deep Sequencing |
Q28536837 | Genome-wide mutation avalanches induced in diploid yeast cells by a base analog or an APOBEC deaminase |
Q37514904 | Genomic instability and carcinogenesis: an update. |
Q48484152 | Genomic instability and p53 alterations in patients with malignant glioma. |
Q40097485 | Genomic instability induced by mutant succinate dehydrogenase subunit D (SDHD) is mediated by O2(-•) and H2O2. |
Q36499435 | High incidence of leukemia in large animals after stem cell gene therapy with a HOXB4-expressing retroviral vector |
Q33554201 | Human cancers express mutator phenotypes: origin, consequences and targeting |
Q37890253 | Hydrophobic bile acids, genomic instability, Darwinian selection, and colon carcinogenesis |
Q42145055 | Immune rejection of mouse tumors expressing mutated self. |
Q24615812 | Implications of genetic heterogeneity in cancer |
Q34166653 | Infection, immunoregulation, and cancer. |
Q36802553 | Integrated one- and two-photon imaging platform reveals clonal expansion as a major driver of mutation load |
Q90429110 | Investigation of solid tumor progression with account of proliferation/migration dichotomy via Darwinian mathematical model |
Q37826096 | Invited review: decoding the microRNA response to hypoxia. |
Q33627916 | Ionizing radiation and aging: rejuvenating an old idea |
Q31027665 | Key Characteristics of Carcinogens as a Basis for Organizing Data on Mechanisms of Carcinogenesis |
Q35669158 | Lethal Mutagenesis: Targeting the Mutator Phenotype in Cancer |
Q36355653 | Leukemic blasts with the paroxysmal nocturnal hemoglobinuria phenotype in children with acute lymphoblastic leukemia |
Q34153811 | Ligand-independent toll-like receptor signals generated by ectopic overexpression of MyD88 generate local and systemic antitumor immunity |
Q28306694 | MicroRNA regulation of DNA repair gene expression in hypoxic stress |
Q55043447 | Mitochondrial point mutations do not limit the natural lifespan of mice. |
Q35106771 | Multiscale computational models in physical systems biology of intracellular trafficking |
Q58731111 | Mutant allele quantification reveals a genetic basis for TP53 mutation-driven castration resistance in prostate cancer cells |
Q35869358 | Mutation as a stress response and the regulation of evolvability |
Q36031579 | Mutational heterogeneity in human cancers: origin and consequences. |
Q21261249 | Mutational profiling of kinases in glioblastoma |
Q33466042 | Mutator mutations enhance tumorigenic efficiency across fitness landscapes |
Q39134775 | Mutator phenotype in cancer: origin and consequences |
Q34055320 | Mutator suppression and escape from replication error-induced extinction in yeast |
Q64079982 | NUT midline carcinoma of the head and neck: current perspectives |
Q41671780 | Natural mismatch repair mutations mediate phenotypic diversity and drug resistance in Cryptococcus deuterogattii |
Q47559164 | Noise-induced bistability in the fate of cancer phenotypic quasispecies: a bit-strings approach |
Q30009589 | Nuclear T-STAR protein expression correlates with HER2 status, hormone receptor negativity and prolonged recurrence free survival in primary breast cancer and decreased cancer cell growth in vitro |
Q37477518 | PCR-free method detects high frequency of genomic instability in prostate cancer. |
Q37808385 | PI3Kinase signaling in glioblastoma |
Q83224650 | Perturbation of base excision repair sensitizes breast cancer cells to APOBEC3 deaminase-mediated mutations |
Q28741797 | Peto's Paradox: evolution's prescription for cancer prevention |
Q52837128 | Phylogenetic Quantification of Intratumor Heterogeneity. |
Q41842603 | Phylogenetic analysis of developmental and postnatal mouse cell lineages. |
Q53212651 | Point mutation instability (PIN) mutator phenotype as model for true back mutations seen in hereditary tyrosinemia type 1 - a hypothesis. |
Q30481763 | Predicting cancer involvement of genes from heterogeneous data |
Q37357108 | Profiling human androgen receptor mutations reveals treatment effects in a mouse model of prostate cancer |
Q36766892 | Programmed genetic instability: a tumor-permissive mechanism for maintaining the evolvability of higher species through methylation-dependent mutation of DNA repair genes in the male germ line |
Q34418244 | Protective actions of vitamin D in UVB induced skin cancer |
Q34443888 | Protective role of vitamin D signaling in skin cancer formation |
Q34542337 | Proteomic-coupled-network analysis of T877A-androgen receptor interactomes can predict clinical prostate cancer outcomes between White (non-Hispanic) and African-American groups |
Q34030011 | Quasispecies as a matter of fact: viruses and beyond. |
Q35722008 | Random mutations, selected mutations: A PIN opens the door to new genetic landscapes |
Q24645423 | Rational design of human DNA ligase inhibitors that target cellular DNA replication and repair |
Q34420649 | Repair of naturally occurring mismatches can induce mutations in flanking DNA. |
Q26822957 | Repair of oxidative DNA damage and cancer: recent progress in DNA base excision repair |
Q37628288 | Risks at the DNA Replication Fork: Effects upon Carcinogenesis and Tumor Heterogeneity |
Q33614018 | Role of double-stranded DNA translocase activity of human HLTF in replication of damaged DNA |
Q33482815 | Role of mutation in Pseudomonas aeruginosa biofilm development. |
Q34904694 | S-nitrosylation from GSNOR deficiency impairs DNA repair and promotes hepatocarcinogenesis |
Q37680742 | Selection and mutation in the "new" genetics: an emerging hypothesis. |
Q37420606 | Sequence context-specific mutagenesis and base excision repair |
Q35890860 | Silencing of the TGF-β1 gene increases the immunogenicity of cells from human ovarian carcinoma |
Q27000745 | Somatic mutations in aging, cancer and neurodegeneration |
Q46463787 | Stochasticity and determinism in cancer creation and progression |
Q47655848 | Stress-induced cellular adaptive strategies: ancient evolutionarily conserved programs as new anticancer therapeutic targets. |
Q51052567 | Stress-induced mutagenesis and complex adaptation. |
Q27024626 | Systems cancer medicine: towards realization of predictive, preventive, personalized and participatory (P4) medicine |
Q38958030 | Targeting BRCA1-BER deficient breast cancer by ATM or DNA-PKcs blockade either alone or in combination with cisplatin for personalized therapy |
Q92067118 | Targeting the DNA Damage Response for the Treatment of High Risk Neuroblastoma |
Q39346123 | Targeting the tumor microenvironment as a potential therapeutic approach in colorectal cancer: Rational and progress. |
Q26830817 | The FHIT gene product: tumor suppressor and genome "caretaker" |
Q33815796 | The Mutator Phenotype in Cancer: Molecular Mechanisms and Targeting Strategies |
Q51810724 | The Use of PARP Inhibitors in Cancer Therapy: Use as Adjuvant with Chemotherapy or Radiotherapy, Use as a Single Agent in Susceptible Patients, and Techniques Used to Identify Susceptible Patients. |
Q37923163 | The aneuploidy paradox: costs and benefits of an incorrect karyotype |
Q36535553 | The conserved Wobble uridine tRNA thiolase Ctu1-Ctu2 is required to maintain genome integrity |
Q98613081 | The evolution of metapopulation dynamics and the number of stem cells in intestinal crypts and other tissue structures in multicellular bodies |
Q36834008 | The expression of embryonic liver development genes in hepatitis C induced cirrhosis and hepatocellular carcinoma |
Q41890682 | The first five years of single-cell cancer genomics and beyond |
Q26781693 | The influence of subclonal resistance mutations on targeted cancer therapy |
Q28751110 | The mutational spectrum of non-CpG DNA varies with CpG content |
Q92154411 | The plasmid-borne quinolone resistance protein QnrB, a novel DnaA-binding protein, increases the bacterial mutation rate by triggering DNA replication stress |
Q34045721 | The protective role of symmetric stem cell division on the accumulation of heritable damage |
Q51820596 | The scientific drunk and the lamppost: massive sequencing efforts in cancer discovery and treatment. |
Q93023467 | Therapeutic potential of ReACp53 targeting mutant p53 protein in CRPC |
Q38111449 | Therapeutic targeting of EGFR-activated metabolic pathways in glioblastoma |
Q82459173 | Towards a unifying theory of late stochastic effects of ionizing radiation |
Q38811931 | Towards precision prevention: Technologies for identifying healthy individuals with high risk of disease |
Q33998432 | Tracing the tumor lineage |
Q37396357 | Treatment-dependent androgen receptor mutations in prostate cancer exploit multiple mechanisms to evade therapy |
Q56876356 | Tumor Regression and Cure Depends on Sustained Th1 Responses |
Q34813119 | Tumor hypoxia and genetic alterations in sporadic cancers |
Q28646966 | Tumour evolution inferred by single-cell sequencing |
Q24649847 | Two-round coamplification at lower denaturation temperature-PCR (COLD-PCR)-based sanger sequencing identifies a novel spectrum of low-level mutations in lung adenocarcinoma |
Q38102639 | Update on pediatric cancer predisposition syndromes |
Q35498335 | Variable epitope library carrying heavily mutated survivin-derived CTL epitope variants as a new class of efficient vaccine immunogen tested in a mouse model of breast cancer |
Q42441596 | Vitamin D receptor, UVR, and skin cancer: a potential protective mechanism |
Q38047250 | Why imatinib remains an exception of cancer research |
Q37444742 | Y-family DNA polymerases in mammalian cells |
Search more.