Genomic instability induced by mutant succinate dehydrogenase subunit D (SDHD) is mediated by O2(-•) and H2O2.

scientific article published on 19 October 2011

Genomic instability induced by mutant succinate dehydrogenase subunit D (SDHD) is mediated by O2(-•) and H2O2. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.FREERADBIOMED.2011.10.435
P932PMC publication ID3249516
P698PubMed publication ID22041456
P5875ResearchGate publication ID51758826

P50authorDouglas R SpitzQ57069683
Mitchell C ColemanQ57168123
Frederick E. DomannQ37378727
P2093author name stringKjerstin M Owens
Disha Dayal
Nūkhet Aykin-Burns
P2860cites workA mutation in succinate dehydrogenase cytochrome b causes oxidative stress and ageing in nematodesQ47068796
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Ubiquinone-binding Site Mutations in the Saccharomyces cerevisiae Succinate Dehydrogenase Generate Superoxide and Lead to the Accumulation of SuccinateQ57658444
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Human cancers express a mutator phenotypeQ24673022
Architecture of succinate dehydrogenase and reactive oxygen species generationQ27640410
Distinct clinical features of paraganglioma syndromes associated with SDHB and SDHD gene mutationsQ28278673
Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylaseQ28302589
The R22X mutation of the SDHD gene in hereditary paraganglioma abolishes the enzymatic activity of complex II in the mitochondrial respiratory chain and activates the hypoxia pathwayQ28361936
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Inborn errors of complex II--unusual human mitochondrial diseasesQ34501870
Hypersensitivity to oxygen and shortened lifespan in a Drosophila mitochondrial complex II mutantQ35103877
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Mutation of succinate dehydrogenase subunit C results in increased O2.-, oxidative stress, and genomic instabilityQ40248526
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Oxygen free radicals and human diseaseQ40466296
A mutation in the SDHC gene of complex II increases oxidative stress, resulting in apoptosis and tumorigenesis.Q40467225
Reactive oxygen species, chromosome mutation, and cancer: possible role of clastogenic factors in carcinogenesisQ40810580
Mutation rate at the hprt locus in human cancer cell lines with specific mismatch repair-gene defectsQ41140973
A Chinese Hamster Mutant Cell Line with a Defect in the Integral Membrane Protein CII-3 of Complex II of the Mitochondrial Electron Transport ChainQ41272763
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Reduced expression and loss of heterozygosity of the SDHD gene in colorectal and gastric cancer.Q44527718
SDHD mutations in head and neck paragangliomas result in destabilization of complex II in the mitochondrial respiratory chain with loss of enzymatic activity and abnormal mitochondrial morphology.Q44640882
An assay for superoxide dismutase activity in mammalian tissue homogenatesQ45026389
Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutationsQ46575022
P433issue1
P304page(s)160-166
P577publication date2011-10-19
P1433published inFree Radical Biology and MedicineQ5500023
P1476titleGenomic instability induced by mutant succinate dehydrogenase subunit D (SDHD) is mediated by O2(-•) and H2O2
P478volume52

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cites work (P2860)
Q93048619Clinical implications of the oncometabolite succinate in SDHx-mutation carriers
Q33590969Current views on cell metabolism in SDHx-related pheochromocytoma and paraganglioma
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Q34245699Genetic and epigenetic changes in chromosomally stable and unstable progeny of irradiated cells
Q37606472Health risks of space exploration: targeted and nontargeted oxidative injury by high-charge and high-energy particles
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Q46398509Lessons learned from an unstable genomic landscape
Q28390732Low-dose radiation-induced enhancement of thymic lymphomagenesis in Lck-Bax mice is dependent on LET and gender
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