Gene trap disruption of the mouse heparan sulfate 6-O-endosulfatase gene, Sulf2

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Gene trap disruption of the mouse heparan sulfate 6-O-endosulfatase gene, Sulf2 is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/MCB.01279-06
P932PMC publication ID1800820
P698PubMed publication ID17116694

P50authorZena WerbQ20642782
P2093author name stringSteven D Rosen
David H Lum
Jenille Tan
P2860cites workBayGenomics: a resource of insertional mutations in mouse embryonic stem cellsQ39790431
Death before birth: clues from gene knockouts and mutationsQ40514851
Heparan sulfate 6-o-sulfotransferase is essential for muscle development in zebrafish.Q44463036
Defining brain wiring patterns and mechanisms through gene trapping in mice.Q46112482
Functional analysis of secreted and transmembrane proteins critical to mouse development.Q46905044
A novel protein modification generating an aldehyde group in sulfatases: its role in catalysis and diseaseQ47705926
Expression of a heparan sulfate remodeling enzyme, heparan sulfate 6-O-endosulfatase sulfatase FP2, in the rat nervous systemQ48123270
Differential sulfations and epimerization define heparan sulfate specificity in nervous system developmentQ48202252
Drosophila heparan sulfate 6-O-sulfotransferase (dHS6ST) gene. Structure, expression, and function in the formation of the tracheal systemQ48373088
Cloning and characterization of two extracellular heparin-degrading endosulfatases in mice and humansQ24309373
HSulf-2, an extracellular endoglucosamine-6-sulfatase, selectively mobilizes heparin-bound growth factors and chemokines: effects on VEGF, FGF-1, and SDF-1.Q24541580
Sulf-2, a proangiogenic heparan sulfate endosulfatase, is upregulated in breast cancerQ24550887
Capturing genes encoding membrane and secreted proteins important for mouse developmentQ24563626
Heparan sulfate 6-O-endosulfatases: discrete in vivo activities and functional co-operativityQ24673740
QSulf1 remodels the 6-O sulfation states of cell surface heparan sulfate proteoglycans to promote Wnt signalingQ24675509
How to make a placenta: mechanisms of trophoblast cell differentiation in mice--a reviewQ28245684
Identification of a novel nonlysosomal sulphatase expressed in the floor plate, choroid plexus and cartilageQ28566524
Disruption of gastrulation and heparan sulfate biosynthesis in EXT1-deficient miceQ28586958
Renal agenesis in mice homozygous for a gene trap mutation in the gene encoding heparan sulfate 2-sulfotransferaseQ28589603
Defective heparan sulfate biosynthesis and neonatal lethality in mice lacking N-deacetylase/N-sulfotransferase-1Q28591609
Mice deficient in Ext2 lack heparan sulfate and develop exostosesQ28592253
Heparan sulfate proteoglycans on the cell surface: versatile coordinators of cellular functionsQ28609232
Mice deficient in heparan sulfate 3-O-sulfotransferase-1: Normal hemostasis with unexpected perinatal phenotypesQ29041315
Functions of cell surface heparan sulfate proteoglycansQ29618521
Order out of chaos: assembly of ligand binding sites in heparan sulfateQ29620085
Heparan sulfate: lessons from knockout miceQ30689506
Substrate specificity and domain functions of extracellular heparan sulfate 6-O-endosulfatases, QSulf1 and QSulf2.Q33230305
Diversity and functions of glycosaminoglycan sulfotransferasesQ33878520
Role of heparan sulfate proteoglycans in cell-cell signaling in DrosophilaQ34017795
Regulation of Wnt signaling and embryo patterning by an extracellular sulfataseQ34089065
Loss of HSulf-1 up-regulates heparin-binding growth factor signaling in cancer.Q34189632
Heparan sulfate proteoglycans in invasion and metastasisQ34211764
Genes governing placental development.Q34214367
Domain-specific modification of heparan sulfate by Qsulf1 modulates the binding of the bone morphogenetic protein antagonist NogginQ34279840
hSulf1 Sulfatase promotes apoptosis of hepatocellular cancer cells by decreasing heparin-binding growth factor signaling.Q34286925
Molecular diversity of heparan sulfateQ34310374
The sulfatase gene familyQ34433161
Heparan sulfate proteoglycans and cancer.Q34441253
What cardiovascular defect does my prenatal mouse mutant have, and why?Q35025207
Heparan Sulfate Core Proteins in Cell-Cell SignalingQ35582990
Sulfation pattern in glycosaminoglycan: does it have a code?Q35910297
QSulf1, a heparan sulfate 6-O-endosulfatase, inhibits fibroblast growth factor signaling in mesoderm induction and angiogenesisQ37415156
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectcell biologyQ7141
P304page(s)678-88
P577publication date2007-01-01
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleGene trap disruption of the mouse heparan sulfate 6-O-endosulfatase gene, Sulf2
P478volume27

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cites work (P2860)
Q52656069A non-conserved miRNA regulates lysosomal function and impacts on a human lysosomal storage disorder
Q39829323A novel SULF1 splice variant inhibits Wnt signalling but enhances angiogenesis by opposing SULF1 activity
Q24322725Characterization of the human sulfatase Sulf1 and its high affinity heparin/heparan sulfate interaction domain
Q42389690Differential involvement of the extracellular 6-O-endosulfatases Sulf1 and Sulf2 in brain development and neuronal and behavioural plasticity
Q24328759Direct detection of HSulf-1 and HSulf-2 activities on extracellular heparan sulfate and their inhibition by PI-88
Q82087914Dynamic expression patterns of 6‐O endosulfatases during zebrafish development suggest a subfunctionalisation event for sulf2
Q37042791Endosulfatases SULF1 and SULF2 limit Chlamydia muridarum infection
Q82061689Enhanced osteogenic activity of bone morphogenetic protein-2 by 2-O-desulfated heparin
Q50918830Epithelial Deletion of Sulf2 Exacerbates Bleomycin-Induced Lung Injury, Inflammation, and Mortality
Q24654744Expression of novel extracellular sulfatases Sulf-1 and Sulf-2 in normal and osteoarthritic articular cartilage
Q84303192Expression patterns of sulfatase genes in the developing mouse embryo
Q33282863Extracellular sulfatases, elements of the Wnt signaling pathway, positively regulate growth and tumorigenicity of human pancreatic cancer cells
Q24337783Functional consequences of the subdomain organization of the sulfs
Q33828849Glycomics analysis of mammalian heparan sulfates modified by the human extracellular sulfatase HSulf2.
Q92132671HS and Inflammation: A Potential Playground for the Sulfs?
Q99555914Heparan Sulfate Proteoglycans Biosynthesis and Post Synthesis Mechanisms Combine Few Enzymes and Few Core Proteins to Generate Extensive Structural and Functional Diversity
Q35059448Heparan sulfate proteoglycans
Q36510967Heparan sulfate proteoglycans and their binding proteins in embryo implantation and placentation
Q35780214Heparan sulfate sulfatase SULF2 regulates PDGFRα signaling and growth in human and mouse malignant glioma
Q37352004Heparin-degrading sulfatases in hepatocellular carcinoma: roles in pathogenesis and therapy targets
Q26995332Human genetic disorders and knockout mice deficient in glycosaminoglycan
Q37784305Mice Deficient in Heparan Sulfate 6-O-Sulfotransferase-1
Q37976598Models for Studies of Proteoglycans in Kidney Pathophysiology
Q37560675Multifunctionality of extracellular and cell surface heparan sulfate proteoglycans
Q36154405New negative feedback regulators of Egfr signaling in Drosophila.
Q34251345Organ-specific sulfation patterns of heparan sulfate generated by extracellular sulfatases Sulf1 and Sulf2 in mice
Q38181492Post-Synthetic Regulation of HS Structure: The Yin and Yang of the Sulfs in Cancer
Q36919927Proteoglycan desulfation determines the efficiency of chondrocyte autophagy and the extent of FGF signaling during endochondral ossification
Q36816444Proteoglycans and their roles in brain cancer
Q28512642Redundant function of the heparan sulfate 6-O-endosulfatases Sulf1 and Sulf2 during skeletal development
Q55545192RegenDbase: a comparative database of noncoding RNA regulation of tissue regeneration circuits across multiple taxa.
Q36562888Role of heparan sulfatases in ovarian and breast cancer.
Q26852401Role of sulphate in development
Q35763789SULF 1 gene polymorphism, rs6990375 is in significant association with fetus failure in IVF technique.
Q21144445Secreted sulfatases Sulf1 and Sulf2 have overlapping yet essential roles in mouse neonatal survival
Q33401779Substrate specificity of 6-O-endosulfatase (Sulf-2) and its implications in synthesizing anticoagulant heparan sulfate
Q24321612Sulf loss influences N-, 2-O-, and 6-O-sulfation of multiple heparan sulfate proteoglycans and modulates fibroblast growth factor signaling
Q39783590Sulf-2, a heparan sulfate endosulfatase, promotes human lung carcinogenesis
Q37772524Sulf-2: an extracellular modulator of cell signaling and a cancer target candidate
Q50667639Sulf1 influences the Shh morphogen gradient during the dorsal ventral patterning of the neural tube in Xenopus tropicalis
Q35659513Sulfatase 1 and sulfatase 2 in hepatocellular carcinoma: associated signaling pathways, tumor phenotypes, and survival.
Q28592245Sulfatase 1 is an inhibitor of ductal morphogenesis with sexually dimorphic expression in the urogenital sinus
Q37855050Sulfate in fetal development
Q34699189Sulfs are regulators of growth factor signaling for satellite cell differentiation and muscle regeneration.
Q51967151Systemic inactivation of Hs6st1 in mice is associated with late postnatal mortality without major defects in organogenesis
Q38290246The "in and out" of glucosamine 6-O-sulfation: the 6th sense of heparan sulfate.
Q26771338The Extracellular Matrix in Bronchopulmonary Dysplasia: Target and Source
Q27310845The SULFs, Extracellular Sulfatases for Heparan Sulfate, Promote the Migration of Corneal Epithelial Cells during Wound Repair
Q35055646The Transcriptional Repressor ZNF503/Zeppo2 Promotes Mammary Epithelial Cell Proliferation and Enhances Cell Invasion
Q37601077The association of arylendosulfatase 1 (SULF1) gene polymorphism with recurrent miscarriage
Q38949781The function of heparan sulfate during branching morphogenesis
Q36572550Transcriptional analysis of human cranial compartments with different embryonic origins
Q35942715Transcriptional regulation of the assT-dsbL-dsbI gene cluster in Salmonella enterica serovar Typhi IMSS-1 depends on LeuO, H-NS, and specific growth conditions.
Q33684163Use of a phage display antibody to measure the enzymatic activity of the Sulfs
Q28506573WT1-dependent sulfatase expression maintains the normal glomerular filtration barrier
Q28586976Zeppo1 is a novel metastasis promoter that represses E-cadherin expression and regulates p120-catenin isoform expression and localization

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