Gcn4p and novel upstream activating sequences regulate targets of the unfolded protein response

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Gcn4p and novel upstream activating sequences regulate targets of the unfolded protein response is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PBIO.0020246
P932PMC publication ID509306
P698PubMed publication ID15314660
P5875ResearchGate publication ID8396136

P2093author name stringHao Li
Peter Walter
Christopher K Patil
P2860cites workMammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stressQ22010800
Finding Functional Features in Saccharomyces Genomes by Phylogenetic FootprintingQ22065823
Sequencing and comparison of yeast species to identify genes and regulatory elementsQ22122502
ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPsQ24290776
Endoplasmic reticulum stress-induced formation of transcription factor complex ERSF including NF-Y (CBF) and activating transcription factors 6alpha and 6beta that activates the mammalian unfolded protein responseQ24548363
Mammalian eukaryotic initiation factor 2 alpha kinases functionally substitute for GCN2 protein kinase in the GCN4 translational control mechanism of yeastQ24562926
Comparison of the consensus sequence flanking translational start sites in Drosophila and vertebratesQ24629553
IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein responseQ24672592
IRE1-independent gain control of the unfolded protein responseQ24798921
Transcriptional regulatory networks in Saccharomyces cerevisiaeQ27860846
Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiaeQ27861085
A transmembrane protein with a cdc2+/CDC28-related kinase activity is required for signaling from the ER to the nucleusQ27930818
A regulatory link between ER-associated protein degradation and the unfolded-protein responseQ27931238
Signalling from endoplasmic reticulum to nucleus: transcription factor with a basic-leucine zipper motif is required for the unfolded protein-response pathwayQ27932953
The transmembrane kinase Ire1p is a site-specific endonuclease that initiates mRNA splicing in the unfolded protein responseQ27933479
Gene-specific translational control of the yeast GCN4 gene by phosphorylation of eukaryotic initiation factor 2.Q27934963
A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein responseQ27938493
Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinaseQ27938837
tRNA ligase is required for regulated mRNA splicing in the unfolded protein responseQ27940124
Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradationQ28131669
Perk is essential for translational regulation and cell survival during the unfolded protein responseQ28140062
IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNAQ28214814
Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinaseQ28296183
The proteasome regulates the UV-induced activation of the AP-1-like transcription factor Gcn4Q28346040
Regulated translation initiation controls stress-induced gene expression in mammalian cellsQ28506388
Characterization of mouse Ire1 alpha: cloning, mRNA localization in the brain and functional analysis in a neural cell lineQ28586245
Regulatory element detection using a probabilistic segmentation model.Q52074413
Genetic evidence for functional specificity of the yeast GCN2 kinaseQ57243225
The role of DNA replication in the repression of the yeast mating-type silent lociQ57270210
The bZIP domains of Fos and Jun mediate a physical association with the TATA box-binding proteinQ58796390
Heme regulates transcription of the CYC1 gene of S. cerevisiae via an upstream activation siteQ67284397
Genetic and biochemical evidence for yeast GCN2 protein kinase polymerizationQ72499579
Degradation of proteins from the ER of S. cerevisiae requires an intact unfolded protein response pathwayQ73958524
Two distinct stress signaling pathways converge upon the CHOP promoter during the mammalian unfolded protein responseQ74359929
Palindrome with spacer of one nucleotide is characteristic of the cis-acting unfolded protein response element in Saccharomyces cerevisiaeQ74450519
Monitoring the Gcn4 protein-mediated response in the yeast Saccharomyces cerevisiaeQ74531608
Cloning of mammalian Ire1 reveals diversity in the ER stress responsesQ28587224
Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiaeQ29546523
An integrated stress response regulates amino acid metabolism and resistance to oxidative stressQ29547441
Transcriptional profiling shows that Gcn4p is a master regulator of gene expression during amino acid starvation in yeastQ29614487
Identifying DNA and protein patterns with statistically significant alignments of multiple sequencesQ29615307
Clustering gene expression patternsQ33882299
A 22 bp cis-acting element is necessary and sufficient for the induction of the yeast KAR2 (BiP) gene by unfolded proteinsQ33938056
Chemical inhibition of the Pho85 cyclin-dependent kinase reveals a role in the environmental stress responseQ33947897
Glucose limitation induces GCN4 translation by activation of Gcn2 protein kinaseQ33962759
IRE1 and efferent signaling from the endoplasmic reticulum.Q34062577
Block of HAC1 mRNA translation by long-range base pairing is released by cytoplasmic splicing upon induction of the unfolded protein responseQ34094604
Intracellular signaling from the endoplasmic reticulum to the nucleus: the unfolded protein response in yeast and mammalsQ34245400
A role for Hsp90 in retinoid receptor signal transductionQ34454414
Translational control by TOR and TAP42 through dephosphorylation of eIF2alpha kinase GCN2.Q35964633
Fos and Jun repress transcription activation by NF-IL6 through association at the basic zipper regionQ36643268
Building a dictionary for genomes: identification of presumptive regulatory sites by statistical analysisQ37408450
GCN4 binds with high affinity to DNA sequences containing a single consensus half-siteQ38311899
Endoplasmic reticulum stress-induced mRNA splicing permits synthesis of transcription factor Hac1p/Ern4p that activates the unfolded protein responseQ38614162
Endoproteolysis of the ER stress transducer ATF6 in the presence of functionally inactive presenilinsQ40787709
Translational regulation of yeast GCN4. A window on factors that control initiator-trna binding to the ribosomeQ41575247
The promoter region of the yeast KAR2 (BiP) gene contains a regulatory domain that responds to the presence of unfolded proteins in the endoplasmic reticulumQ42083502
Monomeric and dimeric bZIP transcription factor GCN4 bind at the same rate to their target DNA siteQ44733820
Activation of ATF6 and an ATF6 DNA binding site by the endoplasmic reticulum stress response.Q45345766
Translational attenuation mediated by an mRNA intronQ46210134
Ligand-independent dimerization activates the stress response kinases IRE1 and PERK in the lumen of the endoplasmic reticulum.Q50336389
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue8
P407language of work or nameEnglishQ1860
P304page(s)E246
P577publication date2004-08-01
P1433published inPLOS BiologyQ1771695
P1476titleGcn4p and novel upstream activating sequences regulate targets of the unfolded protein response
P478volume2

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cites work (P2860)
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