Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4.

scientific article published on April 2008

Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.CELL.2008.02.037
P932PMC publication ID2749658
P698PubMed publication ID18423200
P5875ResearchGate publication ID5429898

P50authorMatt KaeberleinQ6788872
Brian K KennedyQ57312179
P2093author name stringDiana N Pak
Di Hu
Stanley Fields
Lindsay A Fox
Mitsuhiro Tsuchiya
Emily O Kerr
Jonathan A Oakes
Kristan K Steffen
Nick Dang
Vivian L MacKay
Elijah D Johnston
Bie N Tchao
P2860cites workSir2-independent life span extension by calorie restriction in yeastQ21146406
Normal assembly of 60 S ribosomal subunits is required for the signaling in response to a secretory defect in Saccharomyces cerevisiaeQ77763852
Comment on "HST2 mediates SIR2-independent life-span extension by calorie restriction"Q83896183
C. elegans SGK-1 is the critical component in the Akt/PKB kinase complex to control stress response and life spanQ24324828
Extension of chronological life span in yeast by decreased TOR pathway signalingQ24539948
Diazaborine treatment of yeast cells inhibits maturation of the 60S ribosomal subunitQ24563995
The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanismsQ24597989
Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathwayQ24643816
Gcn4p and novel upstream activating sequences regulate targets of the unfolded protein responseQ24799136
Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysisQ27860815
Genes determining yeast replicative life span in a long-lived genetic backgroundQ27929505
Elimination of replication block protein Fob1 extends the life span of yeast mother cells.Q27929527
The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factorsQ27929794
Regulation of longevity and stress resistance by Sch9 in yeastQ27929987
Nuclear recycling of the pre-60S ribosomal subunit-associated factor Arx1 depends on Rei1 in Saccharomyces cerevisiaeQ27930836
Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiaeQ27933365
TOR regulates ribosomal protein gene expression via PKA and the Forkhead transcription factor FHL1.Q27933425
Sch9 is a major target of TORC1 in Saccharomyces cerevisiaeQ27934968
Composition and functional characterization of yeast 66S ribosome assembly intermediates.Q27936383
A dynamic transcriptional network communicates growth potential to ribosome synthesis and critical cell sizeQ27936478
Chronological aging-independent replicative life span regulation by Msn2/Msn4 and Sod2 in Saccharomyces cerevisiaeQ27936862
Regulation of ribosome biogenesis by the rapamycin-sensitive TOR-signaling pathway in Saccharomyces cerevisiaeQ27937080
A functional network involved in the recycling of nucleocytoplasmic pre-60S factorsQ27939018
GCD2, a translational repressor of the GCN4 gene, has a general function in the initiation of protein synthesis in Saccharomyces cerevisiaeQ27939500
Mks1 in concert with TOR signaling negatively regulates RTG target gene expression in S. cerevisiaeQ27939752
A ribosomal protein is required for translational regulation of GCN4 mRNA. Evidence for involvement of the ribosome in eIF2 recyclingQ27939864
Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeastQ27939948
Regulation of fungal gene expression via short open reading frames in the mRNA 5'untranslated regionQ28190745
Overview of caloric restriction and ageingQ28249686
The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life spanQ28272121
Regulation of yeast replicative life span by TOR and Sch9 in response to nutrientsQ28282424
Autophagy genes are essential for dauer development and life-span extension in C. elegansQ29614180
Transcriptional profiling shows that Gcn4p is a master regulator of gene expression during amino acid starvation in yeastQ29614487
Translational regulation of GCN4 and the general amino acid control of yeastQ29615275
Lifespan extension by conditions that inhibit translation in Caenorhabditis elegansQ29616003
Genetics: influence of TOR kinase on lifespan in C. elegansQ29616619
Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respirationQ29618751
Lifespan regulation by evolutionarily conserved genes essential for viabilityQ33281293
A systematic RNAi screen for longevity genes in C. elegansQ33891931
Glucose limitation induces GCN4 translation by activation of Gcn2 protein kinaseQ33962759
Life span of individual yeast cellsQ34246486
Inhibition of mRNA translation extends lifespan in Caenorhabditis elegansQ34608059
The chronological life span of Saccharomyces cerevisiaeQ35185540
Ribosomal protein L33 is required for ribosome biogenesis, subunit joining, and repression of GCN4 translationQ35950325
Translational control by TOR and TAP42 through dephosphorylation of eIF2alpha kinase GCN2.Q35964633
Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress responseQ36322641
TOR signaling and S6 kinase 1: Yeast catches up.Q36873638
Saccharomyces cerevisiae coordinates accumulation of yeast ribosomal proteins by modulating mRNA splicing, translational initiation, and protein turnoverQ36891055
Protein translation, 2007.Q36973850
Longevity determined by developmental arrest genes in Caenorhabditis elegansQ37351702
Global expression profiling of yeast treated with an inhibitor of amino acid biosynthesis, sulfometuron methylQ38307932
Autoregulation in the biosynthesis of ribosomesQ38359024
TOR modulates GCN4-dependent expression of genes turned on by nitrogen limitationQ39503240
Functional specificity among ribosomal proteins regulates gene expressionQ39666047
Mechanism of action of diazaborines.Q40854626
Influences of aging and dietary restriction on serum thymosin alpha 1 levels in miceQ43624058
Rapamycin-induced translational derepression of GCN4 mRNA involves a novel mechanism for activation of the eIF2 alpha kinase GCN2.Q44391314
A role for SIR-2.1 regulation of ER stress response genes in determining C. elegans life spanQ46780211
eIF4E function in somatic cells modulates ageing in Caenorhabditis elegansQ47069066
Gene expression analyzed by high-resolution state array analysis and quantitative proteomics: response of yeast to mating pheromoneQ47215581
Identification and characterization of upstream open reading frames (uORF) in the 5' untranslated regions (UTR) of genes in Saccharomyces cerevisiaeQ48130143
daf-16 protects the nematode Caenorhabditis elegans during food deprivation.Q48445936
Ribosomal proteins Rpl10 and Rps6 are potent regulators of yeast replicative life span.Q53582417
Ribosomal protein synthesis is not regulated at the translational level in Saccharomyces cerevisiae: balanced accumulation of ribosomal proteins L16 and rp59 is mediated by turnover of excess proteinQ70211070
An intervention resembling caloric restriction prolongs life span and retards aging in yeastQ73054284
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectlifetimeQ22675021
P304page(s)292-302
P577publication date2008-04-01
P1433published inCellQ655814
P1476titleYeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4
P478volume133

Reverse relations

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