| scholarly article | Q13442814 |
| review article | Q7318358 |
| P50 | author | Vadim N. Gladyshev | Q44066308 |
| P2093 | author name string | Alexander I Alexandrov | |
| Sergey E Dmitriev | |||
| Aleksandra S Anisimova | |||
| Nadezhda E Makarova | |||
| P2860 | cites work | The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity | Q24293101 |
| Proteomic analysis of cap-dependent translation identifies LARP1 as a key regulator of 5'TOP mRNA translation | Q24337405 | ||
| Extension of chronological life span in yeast by decreased TOR pathway signaling | Q24539948 | ||
| Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice | Q24597354 | ||
| Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity | Q24598427 | ||
| mTOR is a key modulator of ageing and age-related disease | Q24610741 | ||
| Aging as an event of proteostasis collapse | Q24630961 | ||
| Decreased expression of ribosomal proteins in human age-related cataract | Q24634041 | ||
| Aging and the aggregating proteome | Q38062533 | ||
| Less is more: improving proteostasis by translation slow down | Q38152569 | ||
| Transcriptome-wide studies uncover the diversity of modes of mRNA recruitment to eukaryotic ribosomes. | Q38187430 | ||
| The race to decipher the top secrets of TOP mRNAs | Q38252427 | ||
| The role of protein clearance mechanisms in organismal ageing and age-related diseases. | Q38284376 | ||
| TOR Complexes and the Maintenance of Cellular Homeostasis | Q38627464 | ||
| Proteostasis and aging | Q38662553 | ||
| Lifespan-regulating genes in C. elegans | Q38673046 | ||
| Changes of Protein Turnover in Aging Caenorhabditis elegans | Q38692343 | ||
| La-related protein 1 (LARP1) binds the mRNA cap, blocking eIF4F assembly on TOP mRNAs | Q38853441 | ||
| A Ribosomal Perspective on Proteostasis and Aging | Q38865771 | ||
| Translational control by 5'-untranslated regions of eukaryotic mRNAs | Q38867847 | ||
| Upstream Open Reading Frames Differentially Regulate Gene-specific Translation in the Integrated Stress Response | Q38881341 | ||
| Translational tolerance of mitochondrial genes to metabolic energy stress involves TISU and eIF1-eIF4GI cooperation in start codon selection | Q38903731 | ||
| The integrated stress response. | Q38954583 | ||
| Nutrient sensing and TOR signaling in yeast and mammals | Q39092591 | ||
| The molecular basis of mTORC1-regulated translation | Q39137381 | ||
| mTORC1 senses stresses: Coupling stress to proteostasis | Q39179555 | ||
| mTORC1 signaling and the metabolic control of cell growth | Q39243905 | ||
| Alterations of the translation apparatus during aging and stress response. | Q39245772 | ||
| Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway | Q24643816 | ||
| Aging: progressive decline in fitness due to the rising deleteriome adjusted by genetic, environmental, and stochastic processes | Q26750541 | ||
| Regulation of global and specific mRNA translation by the mTOR signaling pathway | Q26771382 | ||
| On the cause of aging and control of lifespan: heterogeneity leads to inevitable damage accumulation, causing aging; control of damage composition and rate of accumulation define lifespan | Q26999289 | ||
| Stress profiling of longevity mutants identifies Afg3 as a mitochondrial determinant of cytoplasmic mRNA translation and aging | Q27936150 | ||
| Age-related changes in the kinetics of human lenses: prevention of the cataract | Q28071361 | ||
| 5' UTR m(6)A Promotes Cap-Independent Translation | Q28114851 | ||
| Dynamic m(6)A mRNA methylation directs translational control of heat shock response | Q28118495 | ||
| La-related Protein 1 (LARP1) Represses Terminal Oligopyrimidine (TOP) mRNA Translation Downstream of mTOR Complex 1 (mTORC1) | Q28118644 | ||
| eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation | Q28118876 | ||
| The hallmarks of aging | Q28131641 | ||
| TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO | Q28266047 | ||
| Sex- and tissue-specific changes in mTOR signaling with age in C57BL/6J mice | Q28271425 | ||
| The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span | Q28272121 | ||
| Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients | Q28282424 | ||
| Rapalogs and mTOR inhibitors as anti-aging therapeutics | Q28286510 | ||
| The eEF2 kinase confers resistance to nutrient deprivation by blocking translation elongation | Q28291406 | ||
| Hierarchies of ATP-consuming processes: direct compared with indirect measurements, and comparative aspects | Q28361818 | ||
| Rat peptide methionine sulphoxide reductase: cloning of the cDNA, and down-regulation of gene expression and enzyme activity during aging | Q28363267 | ||
| Mutations in Nonessential eIF3k and eIF3l Genes Confer Lifespan Extension and Enhanced Resistance to ER Stress in Caenorhabditis elegans | Q28554423 | ||
| The cerebellum ages slowly according to the epigenetic clock | Q28648405 | ||
| Superior proteome stability in the longest lived animal | Q28656280 | ||
| Cytoplasmic m6A reader YTHDF3 promotes mRNA translation | Q29465772 | ||
| An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1 | Q29614563 | ||
| Ribosomal protein S6 kinase 1 signaling regulates mammalian life span | Q29615975 | ||
| Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans | Q29616003 | ||
| Protein modification and maintenance systems as biomarkers of ageing. | Q30316667 | ||
| Protein oxidation in aging and the removal of oxidized proteins. | Q30426117 | ||
| Lifespan regulation by evolutionarily conserved genes essential for viability | Q33281293 | ||
| Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster | Q33665807 | ||
| Oxygen sufficiency controls TOP mRNA translation via the TSC-Rheb-mTOR pathway in a 4E-BP-independent manner. | Q33668452 | ||
| A cytoprotective perspective on longevity regulation | Q33754491 | ||
| From rapalogs to anti-aging formula | Q33829205 | ||
| Regulation of selenoproteins and methionine sulfoxide reductases A and B1 by age, calorie restriction, and dietary selenium in mice. | Q33830115 | ||
| The translational landscape of mTOR signalling steers cancer initiation and metastasis | Q36873513 | ||
| A cell epigenotype specific model for the correction of brain cellular heterogeneity bias and its application to age, brain region and major depression | Q36891918 | ||
| Hot topics in aging research: protein translation, 2009. | Q36905860 | ||
| Transcriptome analysis of human ageing in male skin shows mid-life period of variability and central role of NF-κB. | Q36941352 | ||
| The DEAD-box helicase DDX3 substitutes for the cap-binding protein eIF4E to promote compartmentalized translation initiation of the HIV-1 genomic RNA | Q36963199 | ||
| Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation | Q36971030 | ||
| Effect of age on in vivo rates of mitochondrial protein synthesis in human skeletal muscle | Q37094241 | ||
| Protein stability and resistance to oxidative stress are determinants of longevity in the longest-living rodent, the naked mole-rat. | Q37117504 | ||
| Detoxification reactions: relevance to aging | Q37164094 | ||
| mTORC1 phosphorylation sites encode their sensitivity to starvation and rapamycin | Q37166913 | ||
| Analysis of cancer genomes reveals basic features of human aging and its role in cancer development | Q37188263 | ||
| Identification of long-lived proteins reveals exceptional stability of essential cellular structures | Q37210826 | ||
| Distinct spectra of somatic mutations accumulated with age in mouse heart and small intestine | Q37226538 | ||
| Longevity determined by developmental arrest genes in Caenorhabditis elegans | Q37351702 | ||
| Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4. | Q37359194 | ||
| A site-specific deletion in mitochondrial DNA of Podospora is under the control of nuclear genes | Q37491983 | ||
| The shock of aging: molecular chaperones and the heat shock response in longevity and aging--a mini-review | Q37527534 | ||
| The control of translational accuracy is a determinant of healthy ageing in yeast. | Q37637130 | ||
| Synthesis, modification and turnover of proteins during aging. | Q37795722 | ||
| Profiling of m6A RNA modifications identified an age-associated regulation of AGO2 mRNA stability. | Q51759962 | ||
| Decline in synthesis of elongation factor one (EF-1) precedes the decreased synthesis of total protein in aging Drosophila melanogaster. | Q52520245 | ||
| Changes in the expression of genes involved in protein synthesis during Drosophila aging. | Q52549989 | ||
| Dissociation between functional senescence and oxidative stress resistance in Drosophila. | Q52602917 | ||
| Mitogen-activated protein kinase (MAPK) pathway activation: effects of age and acute exercise on human skeletal muscle. | Q53942492 | ||
| p70 Ribosomal protein S6 kinase (Rps6kb1): an update. | Q54332389 | ||
| Effects of single amino acid deficiency on mRNA translation are markedly different for methionine versus leucine. | Q55209127 | ||
| Ssd1 and Gcn2 suppress global translation efficiency in replicatively aged yeast while their activation extends lifespan | Q56529591 | ||
| Copy Number of Human Ribosomal Genes With Aging: Unchanged Mean, but Narrowed Range and Decreased Variance in Elderly Group | Q58797371 | ||
| Translation attenuation by minocycline enhances longevity and proteostasis in old post-stress-responsive organisms | Q59329148 | ||
| Widespread Accumulation of Ribosome-Associated Isolated 3' UTRs in Neuronal Cell Populations of the Aging Brain | Q64004913 | ||
| HuD Is a Neural Translation Enhancer Acting on mTORC1-Responsive Genes and Counteracted by the Y3 Small Non-coding RNA | Q64443077 | ||
| The effect of aging on protein synthesis in the yeast Saccharomyces cerevisiae | Q67560295 | ||
| Decreased accuracy of protein synthesis in extracts from aging human diploid fibroblasts | Q69610957 | ||
| Does the capacity of ribosomes to control translation fidelity change with age? | Q70770298 | ||
| Codon recognition fidelity of ribosomes at the first and second positions does not decrease during aging | Q71047246 | ||
| Fidelity of protein synthesis does not decline during aging of cultured human fibroblasts | Q71401680 | ||
| Missense translation errors in Saccharomyces cerevisiae | Q77228606 | ||
| On why decreasing protein synthesis can increase lifespan | Q80200362 | ||
| Stable isotope-labelling analysis of the impact of inhibition of the mammalian target of rapamycin on protein synthesis | Q83687490 | ||
| DDX3 Activates CBC-eIF3-Mediated Translation of uORF-Containing Oncogenic mRNAs to Promote Metastasis in HNSCC | Q89157697 | ||
| Phosphorylation and Signal Transduction Pathways in Translational Control | Q89355474 | ||
| Translational Control through Differential Ribosome Pausing during Amino Acid Limitation in Mammalian Cells | Q90365771 | ||
| Reappraisal to the study of 4E-BP1 as an mTOR substrate - A normative critique. | Q39253130 | ||
| Proteasomal and Autophagic Degradation Systems | Q39275553 | ||
| Protein modification and replicative senescence of WI-38 human embryonic fibroblasts. | Q39747783 | ||
| Protein elongation rates in tissues of growing and adult sheep | Q40088197 | ||
| The effects of enhanced expression of elongation factor EF-1 alpha on lifespan in Drosophila melanogaster. IV. A summary of three experiments | Q40723796 | ||
| Synthesis, modifications, and turnover of proteins during aging | Q41032582 | ||
| LARP1 functions as a molecular switch for mTORC1-mediated translation of an essential class of mRNAs. | Q41042567 | ||
| Aging in Rats Differentially Affects Markers of Transcriptional and Translational Capacity in Soleus and Plantaris Muscle | Q41061730 | ||
| Age-related dysfunctions of the autophagy lysosomal pathway in hippocampal pyramidal neurons under proteasome stress. | Q41148325 | ||
| Nucleolar expansion and elevated protein translation in premature aging | Q41565087 | ||
| Translation fidelity coevolves with longevity | Q41628879 | ||
| A Cap for Every Occasion: Alternative eIF4F Complexes | Q41658238 | ||
| The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans | Q41711470 | ||
| 4E-BP functions as a metabolic brake used under stress conditions but not during normal growth | Q41825413 | ||
| THE FREQUENCY OF ERRORS IN PROTEIN BIOSYNTHESIS | Q41826526 | ||
| Rapid cytoplasmic turnover of yeast ribosomes in response to rapamycin inhibition of TOR. | Q41893438 | ||
| Mitochondrial-targeted catalase is good for the old mouse proteome, but not for the young: 'reverse' antagonistic pleiotropy? | Q42154295 | ||
| The mitochondrial ribosomal protein of the large subunit, Afo1p, determines cellular longevity through mitochondrial back-signaling via TOR1. | Q42206698 | ||
| Cap-proximal nucleotides via differential eIF4E binding and alternative promoter usage mediate translational response to energy stress | Q42321544 | ||
| Translation initiation mediated by nuclear cap-binding protein complex. | Q42348650 | ||
| FOXO/4E-BP signaling in Drosophila muscles regulates organism-wide proteostasis during aging | Q42705331 | ||
| The accuracy of protein synthesis in reticulocyte and HeLa cell lysates | Q43578389 | ||
| Erythromycin slows aging of Saccharomyces cerevisiae | Q43843496 | ||
| In vitro activity of human translation initiation factor eIF4B is not affected by phosphomimetic amino acid substitutions S422D and S422E. | Q44260806 | ||
| Selective recruitment of proteins to 5' cap complexes during the growth cycle in Arabidopsis. | Q45408602 | ||
| Inhibition of a eukaryotic initiation factor (eIF2Bdelta/F11A3.2) during adulthood extends lifespan in Caenorhabditis elegans | Q46410604 | ||
| eIF4E function in somatic cells modulates ageing in Caenorhabditis elegans | Q47069066 | ||
| La-related protein 1 (LARP1) repression of TOP mRNA translation is mediated through its cap-binding domain and controlled by an adjacent regulatory region. | Q47290550 | ||
| m6A Facilitates eIF4F-Independent mRNA Translation | Q47436391 | ||
| Increased longevity of EF-1 alpha high-fidelity mutants in Podospora anserina. | Q48085816 | ||
| Translational activation of the non-AUG-initiated c-myc 1 protein at high cell densities due to methionine deprivation | Q48166624 | ||
| mRNA 3'-UTR shortening is a molecular signature of mTORC1 activation | Q48173809 | ||
| daf-16 protects the nematode Caenorhabditis elegans during food deprivation. | Q48445936 | ||
| Translation fidelity in the aging mammal: studies with an accurate in vitro system on aged rats. | Q48526294 | ||
| Aging and Oxidative Stress Decrease Pineal Elongation Factor 2: In Vivo Protective Effect of Melatonin in Young Rats Treated With Cumene Hydroperoxide. | Q48681928 | ||
| The integrated stress response in budding yeast lifespan extension. | Q49278406 | ||
| Protein Turnover in Aging and Longevity. | Q49907039 | ||
| Time-resolved analysis of amino acid stress identifies eIF2 phosphorylation as necessary to inhibit mTORC1 activity in liver. | Q49960374 | ||
| 3' UTR lengthening as a novel mechanism in regulating cellular senescence. | Q50027116 | ||
| Cross-species comparison of proteome turnover kinetics. | Q50102206 | ||
| Translation control of mRNAs encoding mammalian translation initiation factors. | Q50134469 | ||
| DNA methylation age is elevated in breast tissue of healthy women | Q33843836 | ||
| A systematic RNAi screen for longevity genes in C. elegans | Q33891931 | ||
| Methionine oxidation and aging | Q33984659 | ||
| Mutational fingerprints of aging | Q34012361 | ||
| Life span extension via eIF4G inhibition is mediated by posttranscriptional remodeling of stress response gene expression in C. elegans | Q34197008 | ||
| Identification of long-lived proteins retained in cells undergoing repeated asymmetric divisions | Q34314582 | ||
| The nascent polypeptide-associated complex is a key regulator of proteostasis | Q34340544 | ||
| Naked mole-rat has increased translational fidelity compared with the mouse, as well as a unique 28S ribosomal RNA cleavage | Q34374464 | ||
| Rapid accumulation of genome rearrangements in liver but not in brain of old mice | Q34449310 | ||
| The biology of proteostasis in aging and disease | Q34467650 | ||
| Widespread Proteome Remodeling and Aggregation in Aging C. elegans | Q34475749 | ||
| Protein biogenesis machinery is a driver of replicative aging in yeast | Q34496326 | ||
| Mechanisms of In Vivo Ribosome Maintenance Change in Response to Nutrient Signals | Q34546939 | ||
| Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans | Q34608059 | ||
| Ageing and the regulation of protein synthesis: a balancing act? | Q34762413 | ||
| 4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila | Q35006474 | ||
| Methylation of ribosomal RNA by NSUN5 is a conserved mechanism modulating organismal lifespan. | Q35050458 | ||
| ATF4 activity: a common feature shared by many kinds of slow-aging mice | Q35080596 | ||
| Lifespan extension conferred by endoplasmic reticulum secretory pathway deficiency requires induction of the unfolded protein response. | Q35082235 | ||
| Elevated ATF4 function in fibroblasts and liver of slow-aging mutant mice | Q35152873 | ||
| Loss of hepatic chaperone-mediated autophagy accelerates proteostasis failure in aging | Q35192146 | ||
| Protein synthesis elongation factor EF-1 alpha expression and longevity in Drosophila melanogaster | Q35220853 | ||
| Translational coregulation of 5'TOP mRNAs by TIA-1 and TIAR. | Q35393305 | ||
| Aging and molecular chaperones | Q35569048 | ||
| An editing-defective aminoacyl-tRNA synthetase is mutagenic in aging bacteria via the SOS response | Q35629407 | ||
| A unifying model for mTORC1-mediated regulation of mRNA translation. | Q35945036 | ||
| Translational control by TOR and TAP42 through dephosphorylation of eIF2alpha kinase GCN2. | Q35964633 | ||
| Systematic analysis of asymmetric partitioning of yeast proteome between mother and daughter cells reveals "aging factors" and mechanism of lifespan asymmetry | Q36103120 | ||
| The Natural Variation in Lifespans of Single Yeast Cells Is Related to Variation in Cell Size, Ribosomal Protein, and Division Time. | Q36209976 | ||
| Unfolded protein response is activated in aged retinas | Q36372969 | ||
| Age modifies respiratory complex I and protein homeostasis in a muscle type-specific manner | Q36475207 | ||
| Quantitative evidence for conserved longevity pathways between divergent eukaryotic species | Q36517946 | ||
| Integrated Transcriptome and Proteome Analyses Reveal Organ-Specific Proteome Deterioration in Old Rats | Q36713874 | ||
| RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation | Q36745240 | ||
| P275 | copyright license | Creative Commons Attribution 3.0 Unported | Q14947546 |
| P6216 | copyright status | copyrighted | Q50423863 |
| P433 | issue | 12 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | protein biosynthesis | Q211935 |
| P304 | page(s) | 4269-4288 | |
| P577 | publication date | 2018-12-18 | |
| P1433 | published in | Aging | Q2845875 |
| P1476 | title | Protein synthesis and quality control in aging | |
| P478 | volume | 10 |
| Q99557396 | Age-dependent decline in stress response capacity revealed by proteins dynamics analysis |
| Q92881918 | Aging and Caloric Restriction Modulate the DNA Methylation Profile of the Ribosomal RNA Locus in Human and Rat Liver |
| Q92922603 | Cellular Aging Characteristics and Their Association with Age-Related Disorders |
| Q100737078 | Cytoskeletal disorganization underlies PABPN1-mediated myogenic disability |
| Q101051196 | Dynamic changes in the brain protein interaction network correlates with progression of Aβ42 pathology in Drosophila |
| Q100526363 | H3K4me2 regulates the recovery of protein biosynthesis and homeostasis following DNA damage |
| Q99616693 | Translation elongation factor 2 depletion by siRNA in mouse liver leads to mTOR-independent translational upregulation of ribosomal protein genes |
| Q92542931 | mTORC1-Rps15 Axis Contributes to the Mechanisms Underlying Global Translation Reduction During Senescence of Mouse Embryonic Fibroblasts |
Search more.