| scholarly article | Q13442814 |
| P50 | author | Seymour Benzer | Q1975294 |
| Brian M Zid | Q80178510 | ||
| P2093 | author name string | Pankaj Kapahi | |
| Tony Harper | |||
| Daniel Koslover | |||
| Viveca Sapin | |||
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| P433 | issue | 10 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | Drosophila | Q312154 |
| lifetime | Q22675021 | ||
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| P304 | page(s) | 885-890 | |
| P577 | publication date | 2004-05-01 | |
| P1433 | published in | Current Biology | Q1144851 |
| P1476 | title | Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway | |
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| Q26739045 | Developmental Drift and the Role of Wnt Signaling in Aging |
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| Q27337692 | Fine-Tuning of PI3K/AKT Signalling by the Tumour Suppressor PTEN Is Required for Maintenance of Flight Muscle Function and Mitochondrial Integrity in Ageing Adult Drosophila melanogaster |
| Q37219441 | Folic acid supplementation at lower doses increases oxidative stress resistance and longevity in Caenorhabditis elegans |
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| Q92129927 | Functional Analysis of the Ribosomal uL6 Protein of Saccharomyces cerevisiae |
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| Q43043679 | Intermittent supplementation with rapamycin as a dietary restriction mimetic. |
| Q37645644 | Interrelation between protein synthesis, proteostasis and life span |
| Q47154871 | Intestinal Fork Head Regulates Nutrient Absorption and Promotes Longevity |
| Q36104670 | Intramyocellular fatty-acid metabolism plays a critical role in mediating responses to dietary restriction in Drosophila melanogaster |
| Q92258549 | Is Rapamycin a Dietary Restriction Mimetic? |
| Q47585149 | Jujube (Ziziphus Jujuba Mill.) fruit feeding extends lifespan and increases tolerance to environmental stresses by regulating aging-associated gene expression in Drosophila. |
| Q34461749 | Juvenile hormone and insulin suppress lipolysis between periods of lactation during tsetse fly pregnancy |
| Q59085556 | KLHL22 activates amino-acid-dependent mTORC1 signalling to promote tumorigenesis and ageing |
| Q38926261 | Key proteins and pathways that regulate lifespan |
| Q37314135 | Korean Red Ginseng Tonic Extends Lifespan in D. melanogaster |
| Q36292001 | Koschei the immortal and anti-aging drugs |
| Q37383513 | LKB1 and AMP-activated protein kinase control of mTOR signalling and growth |
| Q33903651 | Late-life rapamycin treatment reverses age-related heart dysfunction. |
| Q51691615 | Learning ability and longevity: a symmetrical evolutionary trade-off in Drosophila. |
| Q21195809 | Leucine supplementation differentially enhances pancreatic cancer growth in lean and overweight mice |
| Q38714725 | Life in the cold: links between mammalian hibernation and longevity |
| Q37215289 | Life-span extension in mice by preweaning food restriction and by methionine restriction in middle age |
| Q35836396 | Lifelong rapamycin administration ameliorates age-dependent cognitive deficits by reducing IL-1β and enhancing NMDA signaling |
| Q36497333 | Lifespan and reproduction in Drosophila: New insights from nutritional geometry. |
| Q29616003 | Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans |
| Q37557211 | Lifespan extension by cranberry supplementation partially requires SOD2 and is life stage independent |
| Q34051379 | Lifespan extension by dietary restriction is not linked to protection against somatic DNA damage in Drosophila melanogaster |
| Q36496159 | Lifespan modification by glucose and methionine in Drosophila melanogaster fed a chemically defined diet |
| Q34642886 | Lifespan modulation in mice and the confounding effects of genetic background. |
| Q27324080 | Lifespan-extending effects of royal jelly and its related substances on the nematode Caenorhabditis elegans |
| Q42588116 | Linking calorie restriction to longevity through sirtuins and autophagy: any role for TOR. |
| Q33591262 | Lipid and Alzheimer's disease genes associated with healthy aging and longevity in healthy oldest-old |
| Q33671589 | Lipidome determinants of maximal lifespan in mammals |
| Q39208079 | Live fast, die soon: cell cycle progression and lifespan in yeast cells |
| Q26770637 | Live strong and prosper: the importance of skeletal muscle strength for healthy ageing |
| Q36243415 | Longevity GWAS Using the Drosophila Genetic Reference Panel |
| Q28083422 | Longevity and skeletal muscle mass: the role of IGF signalling, the sirtuins, dietary restriction and protein intake |
| Q39416630 | Longevity genomics across species. |
| Q33709311 | Longevity pathways and memory aging |
| Q34396541 | Longevity, aging and rapamycin |
| Q92028301 | Longevity: Lesson from Model Organisms |
| Q90700017 | Lysosomes: Signaling Hubs for Metabolic Sensing and Longevity |
| Q27932823 | MSN2 and MSN4 link calorie restriction and TOR to sirtuin-mediated lifespan extension in Saccharomyces cerevisiae. |
| Q33627859 | Macronutrient balance and lifespan |
| Q101217412 | Macronutrient intake and simulated infection threat independently affect life history traits of male decorated crickets |
| Q34402689 | Mammalian models of extended healthy lifespan |
| Q37191067 | Management of multicellular senescence and oxidative stress |
| Q27347278 | Manipulation of behavioral decline in Caenorhabditis elegans with the Rag GTPase raga-1 |
| Q38448975 | Mathematical modelling of metabolic regulation in aging |
| Q92327895 | Mechanisms of Calorie Restriction: A Review of Genes Required for the Life-Extending and Tumor-Inhibiting Effects of Calorie Restriction |
| Q35553753 | Mechanisms of amino acid-mediated lifespan extension in Caenorhabditis elegans |
| Q33665807 | Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster |
| Q36736362 | Mechanistic or mammalian target of rapamycin (mTOR) may determine robustness in young male mice at the cost of accelerated aging |
| Q38238017 | Mechanistic perspectives of calorie restriction on vascular homeostasis |
| Q89720666 | Membrane and synaptic defects leading to neurodegeneration in Adar mutant Drosophila are rescued by increased autophagy |
| Q38040587 | Metabolic regulation, mitochondria and the life-prolonging effect of rapamycin: a mini-review |
| Q36633913 | Metabolic reprogramming in dietary restriction |
| Q36820974 | Metabolic switching and fuel choice during T-cell differentiation and memory development |
| Q37699927 | Metabolism in T cell activation and differentiation |
| Q28083458 | Methionine restriction and life-span control |
| Q35151002 | Methionine restriction extends lifespan of Drosophila melanogaster under conditions of low amino-acid status |
| Q92660744 | Methionyl-tRNA Synthetase Regulates Lifespan in Drosophila |
| Q52796996 | Methuselah regulates longevity via dTOR: a pathway revealed by small-molecule ligands. |
| Q35050458 | Methylation of ribosomal RNA by NSUN5 is a conserved mechanism modulating organismal lifespan. |
| Q36310536 | MicroRNA in Aging: From Discovery to Biology |
| Q36738211 | MicroRNAs Circulate in the Hemolymph of Drosophila and Accumulate Relative to Tissue microRNAs in an Age-Dependent Manner |
| Q36310532 | Mitochondria and organismal longevity. |
| Q28394689 | Mitochondria-ros crosstalk in the control of cell death and aging |
| Q36464286 | Mitochondrial deficiency: a double-edged sword for aging and neurodegeneration |
| Q37686261 | Mitochondrial dysfunction and mitophagy: the beginning and end to diabetic nephropathy? |
| Q37564295 | Mitochondrial dysfunction and oxidative stress in aging and cancer |
| Q28389063 | Mitochondrial dysfunction in cardiac aging |
| Q36953459 | Mitochondrial metabolic reprogramming induced by calorie restriction. |
| Q38536293 | Mitochondrial responsibility in ageing process: innocent, suspect or guilty |
| Q36642733 | Mitochondrial signaling, TOR, and life span |
| Q33676890 | Mitohormesis: Promoting Health and Lifespan by Increased Levels of Reactive Oxygen Species (ROS). |
| Q33678212 | Moderate lifelong overexpression of tuberous sclerosis complex 1 (TSC1) improves health and survival in mice |
| Q97644577 | Modulated Expression of the Protein Kinase GSK3 in Motor and Dopaminergic Neurons Increases Female Lifespan in Drosophila melanogaster |
| Q46309715 | Molecular Mechanisms Determining Lifespan in Short- and Long-Lived Species |
| Q42542033 | Molecular basis of ageing |
| Q35740772 | Molecular damage in cancer: an argument for mTOR-driven aging |
| Q33535892 | Molecular evolution and functional characterization of Drosophila insulin-like peptides |
| Q24633947 | Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments |
| Q36202303 | Molecular mechanisms of aging and immune system regulation in Drosophila |
| Q59789765 | Molecular mechanisms regulating lifespan and environmental stress responses |
| Q83278064 | Monitoring the role of autophagy in C. elegans aging |
| Q39985250 | Multiple Metazoan Life-span Interventions Exhibit a Sex-specific Strehler-Mildvan Inverse Relationship Between Initial Mortality Rate and Age-dependent Mortality Rate Acceleration. |
| Q101403046 | Musashi expression in intestinal stem cells attenuates radiation-induced decline in intestinal permeability and survival in Drosophila |
| Q28072348 | NADPH oxidases: key modulators in aging and age-related cardiovascular diseases? |
| Q35764401 | NCI's provocative questions on cancer: some answers to ignite discussion |
| Q35806773 | NF-κB in Aging and Disease |
| Q38140624 | Natural compounds with anti-ageing activity |
| Q33421579 | Natural genetic variation in transcriptome reflects network structure inferred with major effect mutations: insulin/TOR and associated phenotypes in Drosophila melanogaster |
| Q34013667 | Natural polymorphism in BUL2 links cellular amino acid availability with chronological aging and telomere maintenance in yeast. |
| Q24595310 | Naturally secreted amyloid-beta increases mammalian target of rapamycin (mTOR) activity via a PRAS40-mediated mechanism |
| Q33811819 | Neuronal expression of a single-subunit yeast NADH-ubiquinone oxidoreductase (Ndi1) extends Drosophila lifespan |
| Q34587578 | Neuropathology in Drosophila membrane excitability mutants |
| Q35188224 | New comparative genomics approach reveals a conserved health span signature across species |
| Q91833159 | Next Generation Strategies for Geroprotection via mTORC1 Inhibition |
| Q33287882 | No influence of Indy on lifespan in Drosophila after correction for genetic and cytoplasmic background effects |
| Q36243410 | Nordihydroguaiaretic Acid Extends the Lifespan of Drosophila and Mice, Increases Mortality-Related Tumors and Hemorrhagic Diathesis, and Alters Energy Homeostasis in Mice. |
| Q38659532 | Novel strategies for anti-aging drug discovery |
| Q37712052 | Nutrient signaling in protein homeostasis: an increase in quantity at the expense of quality |
| Q64070827 | Nutrigenomics as a tool to study the impact of diet on aging and age-related diseases: the approach |
| Q34045524 | Nutrigenomics in honey bees: digital gene expression analysis of pollen's nutritive effects on healthy and varroa-parasitized bees |
| Q36466453 | Nutrigenomics: integrating genomic approaches into nutrition research |
| Q35080563 | Nutrigerontology: why we need a new scientific discipline to develop diets and guidelines to reduce the risk of aging-related diseases |
| Q37970820 | Nutritional stress in eukaryotic cells: oxidative species and regulation of survival in time of scarceness |
| Q24288717 | OASIS: online application for the survival analysis of lifespan assays performed in aging research |
| Q89315183 | Obesity and Aging in the Drosophila Model |
| Q92513050 | On the Fly: Recent Progress on Autophagy and Aging in Drosophila |
| Q35740777 | One size may not fit all: anti-aging therapies and sarcopenia |
| Q35103827 | Optimization of dietary restriction protocols in Drosophila |
| Q98154098 | Ovariectomy uncouples lifespan from metabolic health and reveals a sex-hormone-dependent role of hepatic mTORC2 in aging |
| Q29038178 | Overexpression of Atg5 in mice activates autophagy and extends lifespan |
| Q36973677 | Overexpression of glucose-6-phosphate dehydrogenase extends the life span of Drosophila melanogaster |
| Q35987295 | Oxidative stress and aberrant signaling in aging and cognitive decline |
| Q34675631 | PI3K-mTORC1 attenuates stress response by inhibiting cap-independent Hsp70 translation. |
| Q36470021 | Peripheral Circadian Clocks Mediate Dietary Restriction-Dependent Changes in Lifespan and Fat Metabolism in Drosophila. |
| Q90307490 | Peripheral Circulating Exosomal miRNAs Potentially Contribute to the Regulation of Molecular Signaling Networks in Aging |
| Q34449372 | Pharmacologic Means of Extending Lifespan. |
| Q36972415 | Pharmacological Strategies to Retard Cardiovascular Aging |
| Q41438914 | Phenotypes, antioxidant responses, and gene expression changes accompanying a sugar-only diet in Bactrocera dorsalis (Hendel) (Diptera: Tephritidae). |
| Q92394724 | Plausible Links Between Metabolic Networks, Stem Cells, and Longevity |
| Q90403574 | Pleiotropic Effects of mTOR and Autophagy During Development and Aging |
| Q50420614 | Prediction and characterization of human ageing-related proteins by using machine learning. |
| Q36392161 | Pro-autophagic polyphenols reduce the acetylation of cytoplasmic proteins |
| Q38573503 | Progeria, rapamycin and normal aging: recent breakthrough |
| Q35064974 | Promoting autophagic clearance: viable therapeutic targets in Alzheimer's disease |
| Q49907039 | Protein Turnover in Aging and Longevity. |
| Q34496326 | Protein biogenesis machinery is a driver of replicative aging in yeast |
| Q37785711 | Protein homeostasis and aging in neurodegeneration |
| Q60949288 | Protein synthesis and quality control in aging |
| Q92665809 | Proteomics profiling and pathway analysis of hippocampal aging in rhesus monkeys |
| Q28084341 | Quality control systems in cardiac aging |
| Q42116517 | REPTOR and REPTOR-BP Regulate Organismal Metabolism and Transcription Downstream of TORC1. |
| Q34047337 | RNAi screening implicates a SKN-1-dependent transcriptional response in stress resistance and longevity deriving from translation inhibition. |
| Q34986923 | RNAi screens to identify components of gene networks that modulate aging in Caenorhabditis elegans |
| Q36460802 | RPD3 histone deacetylase and nutrition have distinct but interacting effects on Drosophila longevity |
| Q28286510 | Rapalogs and mTOR inhibitors as anti-aging therapeutics |
| Q26866151 | Rapalogs in cancer prevention: anti-aging or anticancer? |
| Q58761442 | Rapamycin Treatment Ameliorates Age-Related Accumulation of Toxic Metabolic Intermediates in Brains of the Ts65Dn Mouse Model of Down Syndrome and Aging |
| Q41818673 | Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss. |
| Q34633680 | Rapamycin ameliorates nephropathy despite elevating hyperglycemia in a polygenic mouse model of type 2 diabetes, NONcNZO10/LtJ. |
| Q35468262 | Rapamycin and ageing: when, for how long, and how much? |
| Q33947048 | Rapamycin and interleukin-1β impair brain-derived neurotrophic factor-dependent neuron survival by modulating autophagy |
| Q37228766 | Rapamycin extends life- and health span because it slows aging |
| Q36455201 | Rapamycin extends lifespan and delays tumorigenesis in heterozygous p53+/- mice |
| Q33816255 | Rapamycin extends maximal lifespan in cancer-prone mice |
| Q30541884 | Rapamycin extends murine lifespan but has limited effects on aging |
| Q24647805 | Rapamycin fed late in life extends lifespan in genetically heterogeneous mice |
| Q90510568 | Rapamycin for longevity: opinion article |
| Q36021893 | Rapamycin increases oxidative stress response gene expression in adult stem cells |
| Q34609231 | Rapamycin increases rDNA stability by enhancing association of Sir2 with rDNA in Saccharomyces cerevisiae |
| Q41970207 | Rapamycin partially mimics the anticancer effects of calorie restriction in a murine model of pancreatic cancer |
| Q37950771 | Rapamycin passes the torch: a new generation of mTOR inhibitors |
| Q24648173 | Rapamycin rescues TDP-43 mislocalization and the associated low molecular mass neurofilament instability |
| Q33885171 | Rapamycin rescues the poor developmental capacity of aged porcine oocytes |
| Q34275079 | Rapamycin slows aging in mice |
| Q37298898 | Rapamycin suppresses brain aging in senescence-accelerated OXYS rats |
| Q37538274 | Rapamycin treatment benefits glucose metabolism in mouse models of type 2 diabetes |
| Q24597354 | Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice |
| Q39524807 | Rapamycin-induced hypophosphatemia and insulin resistance are associated with mTORC2 activation and Klotho expression |
| Q24598427 | Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity |
| Q28304066 | Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction |
| Q34461300 | Rapamycin-mediated mTORC2 inhibition is determined by the relative expression of FK506-binding proteins |
| Q21145229 | Recent developments in yeast aging |
| Q50115780 | Recent insights into the cellular and molecular determinants of aging. |
| Q36926098 | Recent progress in genetics of aging, senescence and longevity: focusing on cancer-related genes |
| Q36865167 | Receptor tyrosine kinases in Drosophila development |
| Q24633031 | Reduced TOR signaling extends chronological life span via increased respiration and upregulation of mitochondrial gene expression |
| Q37121889 | Reduced insulin/insulin-like growth factor signaling decreases translation in Drosophila and mice |
| Q37388987 | Reduced insulin/insulin-like growth factor-1 signaling and dietary restriction inhibit translation but preserve muscle mass in Caenorhabditis elegans |
| Q36157810 | Reducing Ribosomal Protein S6 Kinase 1 Expression Improves Spatial Memory and Synaptic Plasticity in a Mouse Model of Alzheimer's Disease |
| Q33769106 | Reduction of protein translation and activation of autophagy protect against PINK1 pathogenesis in Drosophila melanogaster |
| Q91786756 | Regulation of Age-related Decline by Transcription Factors and Their Crosstalk with the Epigenome |
| Q33829934 | Regulation of Drosophila Lifespan by bellwether Promoter Alleles |
| Q47598084 | Regulation of reproduction and longevity by nutrient-sensing pathways. |
| Q35032890 | Regulation of yeast chronological life span by TORC1 via adaptive mitochondrial ROS signaling |
| Q36260537 | Rejuvenating immunity: "anti-aging drug today" eight years later |
| Q37212205 | Replicative aging in yeast: the means to the end |
| Q27860950 | Resveratrol improves health and survival of mice on a high-calorie diet |
| Q48052882 | Reversible developmental stasis in response to nutrient availability in the Xenopus laevis central nervous system |
| Q54110987 | Reversing age-associated arterial dysfunction: insight from preclinical models. |
| Q34677806 | Role of TOR signaling in aging and related biological processes in Drosophila melanogaster |
| Q47945019 | Role of dFOXO in lifespan extension by dietary restriction in Drosophila melanogaster: not required, but its activity modulates the response |
| Q27692402 | Role of the hypothalamus in mediating protective effects of dietary restriction during aging |
| Q38914374 | Roles of mTOR complexes in the kidney: implications for renal disease and transplantation. |
| Q37914096 | Running on empty: does mitochondrial DNA mutation limit replicative lifespan in yeast?: Mutations that increase the division rate of cells lacking mitochondrial DNA also extend replicative lifespan in Saccharomyces cerevisiae |
| Q21142655 | SIRT1 negatively regulates the mammalian target of rapamycin |
| Q24653962 | SIRT6 in DNA repair, metabolism and ageing |
| Q92375206 | Selenium Deficiency Is Associated with Pro-longevity Mechanisms |
| Q38082328 | Senescence and aging: the critical roles of p53. |
| Q30429190 | Sensory perception and aging in model systems: from the outside in. |
| Q38077486 | Sestrins: novel antioxidant and AMPK-modulating functions regulated by exercise? |
| Q40425440 | Sex-specific Tradeoffs With Growth and Fitness Following Life-span Extension by Rapamycin in an Outcrossing Nematode, Caenorhabditis remanei |
| Q21091205 | Short-term calorie restriction in male mice feminizes gene expression and alters key regulators of conserved aging regulatory pathways |
| Q92444736 | Signaling Network of Forkhead Family of Transcription Factors (FOXO) in Dietary Restriction |
| Q37006339 | Signaling mechanisms involved in the response to genotoxic stress and regulating lifespan |
| Q38358191 | Signalling through RHEB-1 mediates intermittent fasting-induced longevity in C. elegans |
| Q35921741 | Silencing of genes in cultured Drosophila neurons by RNA interference |
| Q24560016 | Sir2 mediates longevity in the fly through a pathway related to calorie restriction |
| Q33986353 | Sirt1 overexpression in neurons promotes neurite outgrowth and cell survival through inhibition of the mTOR signaling. |
| Q37061424 | Sirt1 protects the heart from aging and stress. |
| Q26799889 | Sirtuin 1 and aging theory for chronic obstructive pulmonary disease |
| Q37337943 | Sod2 knockdown in the musculature has whole-organism consequences in Drosophila. |
| Q33917682 | Starvation and oxidative stress resistance in Drosophila are mediated through the eIF4E-binding protein, d4E-BP. |
| Q46840429 | Steroid hormone signalling links reproduction to lifespan in dietary-restricted Caenorhabditis elegans |
| Q36623669 | Stress and mTORture signaling |
| Q37780207 | Stress-responsive sestrins link p53 with redox regulation and mammalian target of rapamycin signaling |
| Q37794096 | Stressin' Sestrins take an aging fight |
| Q33438473 | Strong dietary restrictions protect Drosophila against anoxia/reoxygenation injuries |
| Q33791037 | Studying aging in Drosophila |
| Q28571864 | Suppression of replicative senescence by rapamycin in rodent embryonic cells |
| Q36593112 | Systems biology of AGC kinases in fungi |
| Q37789848 | TOR on the brain. |
| Q35882186 | TOR pathway: linking nutrient sensing to life span |
| Q33379093 | TOR regulates cell death induced by telomere dysfunction in budding yeast |
| Q42775625 | TOR signaling couples oxygen sensing to lifespan in C. elegans |
| Q34148062 | TOR signaling never gets old: aging, longevity and TORC1 activity. |
| Q45863420 | TOR-mediated regulation of metabolism in aging |
| Q35620394 | Target of rapamycin (TOR) in nutrient signaling and growth control |
| Q46323859 | Target of rapamycin signaling orchestrates growth-defense trade-offs in plants. |
| Q33801201 | Target of rapamycin signalling mediates the lifespan-extending effects of dietary restriction by essential amino acid alteration |
| Q38815881 | Targeting mTOR to reduce Alzheimer-related cognitive decline: from current hits to future therapies |
| Q37610497 | Targeting tissue-specific metabolic signaling pathways in aging: the promise and limitations |
| Q48044199 | The Aging Mitochondria. |
| Q36694934 | The Biology of Aging: Citizen Scientists and Their Pets as a Bridge Between Research on Model Organisms and Human Subjects |
| Q64089623 | The Effect of Inulin on Lifespan, Related Gene Expression and Gut Microbiota in /TM3 Mutant : A Preliminary Study |
| Q54943366 | The Good, the Bad, and the Ugly of ROS: New Insights on Aging and Aging-Related Diseases from Eukaryotic and Prokaryotic Model Organisms. |
| Q36149798 | The Insulin-Like Proteins dILPs-2/5 Determine Diapause Inducibility in Drosophila |
| Q99709066 | The Lipidome Fingerprint of Longevity |
| Q28276378 | The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging |
| Q36209976 | The Natural Variation in Lifespans of Single Yeast Cells Is Related to Variation in Cell Size, Ribosomal Protein, and Division Time. |
| Q35103174 | The Regulation of Aging and Longevity: A New and Complex Role of p53. |
| Q38932691 | The Senescence-Associated Secretory Phenotype: Critical Effector in Skin Cancer and Aging |
| Q24568353 | The TOR pathway comes of age |
| Q28246133 | The TSC complex is required for the benefits of dietary protein restriction on stress resistance in vivo |
| Q35926921 | The absence of a mitochondrial genome in rho0 yeast cells extends lifespan independently of retrograde regulation |
| Q38098875 | The ageing haematopoietic stem cell compartment |
| Q34144973 | The aging stress response |
| Q36473396 | The amino acid sensitive TOR pathway from yeast to mammals. |
| Q38180970 | The biochemistry and cell biology of aging: metabolic regulation through mitochondrial signaling. |
| Q37196064 | The cell biology of autophagy in metazoans: a developing story |
| Q29617238 | The cell-non-autonomous nature of electron transport chain-mediated longevity |
| Q27318396 | The circadian clock coordinates ribosome biogenesis |
| Q36911187 | The common biology of cancer and ageing |
| Q36433751 | The coordination of nuclear and mitochondrial communication during aging and calorie restriction |
| Q36057638 | The effects of age and dietary restriction on the tissue-specific metabolome of Drosophila. |
| Q51111641 | The endosymbiont Wolbachia increases insulin/IGF-like signalling in Drosophila |
| Q34318188 | The evolution of the TOR pathway and its role in cancer |
| Q34477454 | The general control nonderepressible-2 kinase mediates stress response and longevity induced by target of rapamycin inactivation in Caenorhabditis elegans |
| Q29547430 | The genetics of ageing |
| Q34966717 | The implication of Sir2 in replicative aging and senescence in Saccharomyces cerevisiae |
| Q47835984 | The inhibitory effect in Fraxinellone on oxidative stress-induced senescence correlates with AMP-activated protein kinase-dependent autophagy restoration. |
| Q36006533 | The intersection between aging and cardiovascular disease |
| Q36209151 | The lifespan extension effects of resveratrol are conserved in the honey bee and may be driven by a mechanism related to caloric restriction |
| Q90009351 | The mTOR pathway is necessary for survival of mice with short telomeres |
| Q33914286 | The mammalian target of rapamycin at the crossroad between cognitive aging and Alzheimer's disease |
| Q38662555 | The metabolic regulation of aging |
| Q42206698 | The mitochondrial ribosomal protein of the large subunit, Afo1p, determines cellular longevity through mitochondrial back-signaling via TOR1. |
| Q33743134 | The new biology of ageing |
| Q38559901 | The opposing actions of target of rapamycin and AMP-activated protein kinase in cell growth control |
| Q95936711 | The quest to slow ageing through drug discovery |
| Q37371440 | The regulation of aging: does autophagy underlie longevity? |
| Q35379199 | The role of TORC1 in muscle development in Drosophila |
| Q37846569 | The role of autophagy in genetic pathways influencing ageing |
| Q28256247 | The role of mTOR signaling in Alzheimer disease |
| Q36638140 | The role of mitochondria in aging |
| Q38199772 | The role of mitochondria in mTOR-regulated longevity |
| Q26770848 | The role of the ribosome in the regulation of longevity and lifespan extension |
| Q26863497 | The search for antiaging interventions: from elixirs to fasting regimens |
| Q37619650 | The underlying mechanism of proinflammatory NF-κB activation by the mTORC2/Akt/IKKα pathway during skin aging. |
| Q37236107 | Therapeutic targeting of autophagy in disease: biology and pharmacology |
| Q38208069 | Therapeutic targeting of the mTOR-signalling pathway in cancer: benefits and limitations |
| Q34076176 | Tissue-specific insulin signaling in the regulation of metabolism and aging |
| Q38807732 | Tissue-specific transcription of the neuronal gene Lim3 affects Drosophila melanogaster lifespan and locomotion |
| Q36465061 | Tor1 regulates protein solubility in Saccharomyces cerevisiae |
| Q42123184 | Tor1/Sch9-regulated carbon source substitution is as effective as calorie restriction in life span extension |
| Q37101633 | Toward a control theory analysis of aging |
| Q35222558 | Transcript and protein expression decoupling reveals RNA binding proteins and miRNAs as potential modulators of human aging. |
| Q36957104 | Transcriptional feedback in the insulin signalling pathway modulates ageing in both Caenorhabditis elegans and Drosophila melanogaster |
| Q28732892 | Transcriptional profiling of human familial longevity indicates a role for ASF1A and IL7R |
| Q34254910 | Transcriptional response to dietary restriction in Drosophila melanogaster. |
| Q34257999 | Transcriptome analysis of a long-lived natural Drosophila variant: a prominent role of stress- and reproduction-genes in lifespan extension |
| Q59329148 | Translation attenuation by minocycline enhances longevity and proteostasis in old post-stress-responsive organisms |
| Q41628879 | Translation fidelity coevolves with longevity |
| Q92147739 | Translational Regulation of Non-autonomous Mitochondrial Stress Response Promotes Longevity |
| Q35579583 | Translational regulation in nutrigenomics |
| Q41939101 | Ubiquitin ligases join the field of dietary restriction in C.elegans |
| Q39363654 | Unbalanced Growth, Senescence and Aging. |
| Q33588700 | Validation of anti-aging drugs by treating age-related diseases |
| Q38660086 | Vascular mTOR-dependent mechanisms linking the control of aging to Alzheimer's disease. |
| Q37413524 | Water- and nutrient-dependent effects of dietary restriction on Drosophila lifespan. |
| Q64890764 | Weighing In on mTOR Complex 2 Signaling: The Expanding Role in Cell Metabolism. |
| Q36025835 | Weight Loss Upregulates the Small GTPase DIRAS3 in Human White Adipose Progenitor Cells, Which Negatively Regulates Adipogenesis and Activates Autophagy via Akt-mTOR Inhibition |
| Q35552767 | Why is aging conserved and what can we do about it? |
| Q33912952 | With TOR, less is more: a key role for the conserved nutrient-sensing TOR pathway in aging |
| Q37936551 | Yeast chronological lifespan and proteotoxic stress: is autophagy good or bad? |
| Q37359194 | Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4. |
| Q34051632 | Yeast replicative aging: a paradigm for defining conserved longevity interventions |
| Q39430569 | Yeast-like chronological senescence in mammalian cells: phenomenon, mechanism and pharmacological suppression |
| Q91770398 | circRNAs expressed in human peripheral blood are associated with human aging phenotypes, cellular senescence and mouse lifespan |
| Q30493481 | d4eBP acts downstream of both dTOR and dFoxo to modulate cardiac functional aging in Drosophila |
| Q37394753 | dSir2 and Dmp53 interact to mediate aspects of CR-dependent lifespan extension in D. melanogaster |
| Q34020669 | drr-2 encodes an eIF4H that acts downstream of TOR in diet-restriction-induced longevity of C. elegans |
| Q37385781 | mTOR Inhibition: From Aging to Autism and Beyond. |
| Q33962054 | mTOR Signaling from Cellular Senescence to Organismal Aging |
| Q38747508 | mTOR Signaling in Growth, Metabolism, and Disease. |
| Q49486147 | mTOR as Regulator of Lifespan, Aging, and Cellular Senescence: A Mini-Review. |
| Q91973686 | mTOR as a central regulator of lifespan and aging |
| Q92643974 | mTOR at the nexus of nutrition, growth, ageing and disease |
| Q38565769 | mTOR in Brain Physiology and Pathologies |
| Q24610741 | mTOR is a key modulator of ageing and age-related disease |
| Q33609242 | mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells |
| Q24634174 | mTOR signaling in growth control and disease |
| Q37873702 | mTOR signaling in protein homeostasis: less is more? |
| Q37693034 | mTOR's role in ageing: protein synthesis or autophagy? |
| Q61807513 | mTOR: A Cellular Regulator Interface in Health and Disease |
| Q28087019 | mTOR: a potential therapeutic target in osteoarthritis? |
| Q24633662 | mTOR: from growth signal integration to cancer, diabetes and ageing |
| Q58795101 | mTORC Inhibitors as Broad-Spectrum Therapeutics for Age-Related Diseases |
| Q58553598 | mTORC1 Overactivation as a Key Aging Factor in the Progression to Type 2 Diabetes Mellitus |
| Q92287729 | mTORC1 and mTORC2 Differentially Regulate Cell Fate Programs to Coordinate Osteoblastic Differentiation in Mesenchymal Stromal Cells |
| Q34094616 | mTORC1 links protein quality and quantity control by sensing chaperone availability |
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