Aging, rejuvenation, and epigenetic reprogramming: resetting the aging clock

scientific article

Aging, rejuvenation, and epigenetic reprogramming: resetting the aging clock is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.CELL.2012.01.003
P932PMC publication ID3336960
P698PubMed publication ID22265401
P5875ResearchGate publication ID221766719

P50authorThomas A. RandoQ79331501
P2093author name stringHoward Y Chang
P2860cites workIsolation of a 250 million-year-old halotolerant bacterium from a primary salt crystalQ22122389
Revival and identification of bacterial spores in 25- to 40-million-year-old Dominican amberQ22299397
Premature ageing in mice expressing defective mitochondrial DNA polymeraseQ24294365
SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatinQ24310658
SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life spanQ24315083
Transplantation of Living Nuclei From Blastula Cells into Enucleated Frogs' EggsQ24519327
Sir2 mediates longevity in the fly through a pathway related to calorie restrictionQ24560016
SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during agingQ24595900
Telomere elongation in induced pluripotent stem cells from dyskeratosis congenita patientsQ24595997
The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanismsQ24597989
Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient miceQ24598687
Extending healthy life span--from yeast to humansQ24599191
The ageing systemic milieu negatively regulates neurogenesis and cognitive function.Q24599219
Telomere shortening and loss of self-renewal in dyskeratosis congenita induced pluripotent stem cellsQ24617599
Long noncoding RNA in genome regulation: prospects and mechanismsQ24621946
Histone H3K27ac separates active from poised enhancers and predicts developmental stateQ24628758
Chromatin regulation and genome maintenance by mammalian SIRT6Q24634557
Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathwayQ24643816
Combinatorial patterns of histone acetylations and methylations in the human genomeQ24647290
Rapamycin fed late in life extends lifespan in genetically heterogeneous miceQ24647805
Calorie restriction and the exercise of chromatinQ24652611
Protein homeostasis and aging in neurodegenerationQ37785711
The DNA damage response: Balancing the scale between cancer and ageingQ37824549
The Janus face of DNA methylation in agingQ39914567
Chromatin signature of embryonic pluripotency is established during genome activationQ40694812
The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegansQ41711470
Stem cells: The promises and perils of p53.Q42380567
Change of the hepatic cells in parabiosis between old and young ratsQ44185928
Nuclear reprogramming of somatic cells by in vitro hybridization with ES cells.Q48876988
Epigenetic gambling and epigenetic drift as an antagonistic pleiotropic mechanism of aging.Q51650811
Recreating Pluripotency?Q51902675
Parabiosis in physiological studiesQ73969149
Parabiosis between old and young ratsQ74418620
Increase in activity during calorie restriction requires Sirt1Q81598148
Acquisition and extinction of gene expression programs are separable events in heterokaryon reprogrammingQ83201737
Does damage to DNA and other macromolecules play a role in aging? If so, how?Q37126672
Bmi-1 regulates the Ink4a/Arf locus to control pancreatic beta-cell proliferationQ37175990
Chromatin analysis of occluded genesQ37239866
C. elegans dauer formation and the molecular basis of plasticityQ37245616
Fat metabolism links germline stem cells and longevity in C. elegansQ37383382
The connections between general and reproductive senescence and the evolutionary basis of menopauseQ37782376
Histone demethylase JMJD3 contributes to epigenetic control of INK4a/ARF by oncogenic RASQ24657459
Histone H4 lysine 16 acetylation regulates cellular lifespanQ24657553
Motif module map reveals enforcement of aging by continual NF-kappaB activityQ24680880
Insulin signaling and dietary restriction differentially influence the decline of learning and memory with ageQ27324536
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factorsQ27860937
Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiaeQ27933365
The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencingQ28116655
Generation of germline-competent induced pluripotent stem cellsQ28131699
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegansQ28131824
The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescenceQ28245403
Nuclear reprogramming of somatic cells after fusion with human embryonic stem cellsQ28269087
Sheep cloned by nuclear transfer from a cultured cell lineQ28275874
Genomic instability and aging-like phenotype in the absence of mammalian SIRT6Q28509079
Ink4a/Arf expression is a biomarker of agingQ28570483
Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factorsQ28589872
daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegansQ28611331
The Polycomb complex PRC2 and its mark in lifeQ29547358
The genetics of ageingQ29547430
Dissecting direct reprogramming through integrative genomic analysisQ29614211
A unique chromatin signature uncovers early developmental enhancers in humansQ29614327
Methylation of lysine 4 on histone H3: intricacy of writing and reading a single epigenetic markQ29614516
Control of the embryonic stem cell stateQ29614793
Rejuvenation of aged progenitor cells by exposure to a young systemic environmentQ29615250
Understanding the odd science of agingQ29617341
Extrachromosomal rDNA circles--a cause of aging in yeastQ29618308
Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosisQ29619965
Accumulation of mitochondrial DNA deletion mutations in aged muscle fibers: evidence for a causal role in muscle fiber lossQ33280200
mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cellsQ33609242
Genome-wide views of chromatin structureQ33611702
Widespread and tissue specific age-related DNA methylation changes in mice.Q33736551
Protein homeostasis and aging: The importance of exquisite quality controlQ33925901
Molecular coupling of Xist regulation and pluripotency.Q34013837
Epigenetic reprogramming in plant and animal developmentQ34024503
Nuclear cloning and epigenetic reprogramming of the genomeQ34086441
Telomere rejuvenation during nuclear reprogrammingQ34100113
Epigenetic modifications in pluripotent and differentiated cellsQ34143430
The aging stress responseQ34144973
Molecular signals of epigenetic statesQ34146698
TGF-β and insulin signaling regulate reproductive aging via oocyte and germline quality maintenanceQ34204996
Induced pluripotency: history, mechanisms, and applicationsQ34206028
Adult frogs derived from the nuclei of single somatic cellsQ34252349
The essence of senescenceQ34288983
Stem cell ageing and non-random chromosome segregation.Q34402704
Stem cells from the Mammalian blastocystQ34442507
Suppression of Polycomb group proteins by JNK signalling induces transdetermination in Drosophila imaginal discsQ34466613
Noncoding RNA landmarks of pluripotency and reprogrammingQ34523201
Increased cell-to-cell variation in gene expression in ageing mouse heartQ34540791
Pluripotency and cellular reprogramming: facts, hypotheses, unresolved issuesQ34545153
Timescales of genetic and epigenetic inheritanceQ34576261
Theoretical analysis of epigenetic cell memory by nucleosome modification.Q34629739
DNMT1 maintains progenitor function in self-renewing somatic tissueQ34632106
Absence of effects of Sir2 overexpression on lifespan in C. elegans and DrosophilaQ34632518
How stem cells age and why this makes us grow old.Q34667132
The pluripotency factor Oct4 interacts with Ctcf and also controls X-chromosome pairing and countingQ34675046
Sirtuins in aging and diseaseQ34770789
Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegansQ34784199
Imbalance between pSmad3 and Notch induces CDK inhibitors in old muscle stem cells.Q34786450
Germination, genetics, and growth of an ancient date seed.Q34786697
Manifestations and mechanisms of stem cell aging.Q34825281
DNA methyltransferase 1 is essential for and uniquely regulates hematopoietic stem and progenitor cellsQ35005985
Using heterokaryons to understand pluripotency and reprogrammingQ35088507
DNA damage and ageing: new-age ideas for an age-old problemQ35153827
Emerging models and paradigms for stem cell ageingQ35671770
Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegansQ36010849
Aging and genome maintenanceQ36357846
Stem cells, ageing and the quest for immortality.Q36523915
Biological aging is no longer an unsolved problemQ36802089
The role of nuclear architecture in genomic instability and ageingQ36911164
Human embryonic stem cells: mechanisms to escape replicative senescence?Q37008502
Chromatin structure and the regulation of gene expression: the lessons of PEV in DrosophilaQ37087566
Systematic identification of cis-silenced genes by trans complementationQ37092437
P433issue1-2
P407language of work or nameEnglishQ1860
P921main subjectepigenetic rejuvenationQ107569137
P304page(s)46-57
P577publication date2012-01-01
P1433published inCellQ655814
P1476titleAging, rejuvenation, and epigenetic reprogramming: resetting the aging clock
P478volume148

Reverse relations

cites work (P2860)
Q33714246A Fine-Tune Role of Mir-125a-5p on Foxn1 During Age-Associated Changes in the Thymus
Q26781342A Tale from TGF-β Superfamily for Thymus Ontogeny and Function
Q33719048A paternal environmental legacy: evidence for epigenetic inheritance through the male germ line.
Q94521923A β-galactosidase kiss of death for senescent cells
Q90640124Age-Associated DNA Methylation Patterns Are Shared Between the Hippocampus and Peripheral Blood Cells
Q37195037Age-associated epigenetic drift: implications, and a case of epigenetic thrift?
Q46320656Age-related epigenetic drift and phenotypic plasticity loss: implications in prevention of age-related human diseases
Q90469129Age-related trends in lipid levels: a large-scale cross-sectional study of the general Chinese population
Q35096716Age-specific functional epigenetic changes in p21 and p16 in injury-activated satellite cells
Q38886086Ageing and ocular surface immunity.
Q55025189Aging Hallmarks: The Benefits of Physical Exercise.
Q36518127Aging and reprogramming: a two-way street
Q21183983Aging of blood can be tracked by DNA methylation changes at just three CpG sites
Q38259859Aging with ING: a comparative study of different forms of stress induced premature senescence
Q38018293An aging program at the systems level?
Q48098265An epigenetic clock controls aging
Q52691452Analysis of long non-coding RNA (lncRNA) expression in hepatitis B patients.
Q41475139Axonal Degeneration during Aging and Its Functional Role in Neurodegenerative Disorders
Q38642565Back and forth in time: Directing age in iPSC-derived lineages.
Q41422353Biogenesis of Pro-senescent Microparticles by Endothelial Colony Forming Cells from Premature Neonates is driven by SIRT1-Dependent Epigenetic Regulation of MKK6.
Q41468737Blockade of PD-1 or p38 MAP kinase signaling enhances senescent human CD8(+) T-cell proliferation by distinct pathways
Q35153456Blue journal conference. Aging and susceptibility to lung disease
Q48911542Caenorhabditis elegans: an old genetic model can learn new epigenetic tricks.
Q36638131Causes, consequences, and reversal of immune system aging
Q35947877Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation
Q26767454Cellular Senescence as the Causal Nexus of Aging
Q98939376Cellular quality control during gametogenesis
Q34496408Cellular reprogramming for understanding and treating human disease
Q55346896Chromatin changes trigger laminin genes dysregulation in aging kidneys.
Q33918478Chromatin modifications as determinants of muscle stem cell quiescence and chronological aging.
Q92257276Clonal Hematopoiesis in Aging
Q36861673Concise review: hematopoietic stem cell aging, life span, and transplantation
Q56001204DNA methylation-based biomarkers and the epigenetic clock theory of ageing
Q43098018Direct Lineage Reprogramming Reveals Disease-Specific Phenotypes of Motor Neurons from Human ALS Patients
Q38411818Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects.
Q49552882Dynamic and Diverse Changes in the Functional Properties of Vascular Smooth Muscle Cells in Pulmonary Hypertension.
Q36912509Early events in lymphopoiesis: an update
Q50187342Elixir of Life: Thwarting Aging With Regenerative Reprogramming.
Q37611719Emerging Molecular Pathways Governing Dietary Regulation of Neural Stem Cells during Aging.
Q35674189Epigenetic Aging Signatures Are Coherently Modified in Cancer
Q64071921Epigenetic Analysis in Human Neurons: Considerations for Disease Modeling in PD
Q92042145Epigenetic changes during aging and their reprogramming potential
Q34514496Epigenetic clock analyses of cellular senescence and ageing
Q38814870Epigenetic drift, epigenetic clocks and cancer risk.
Q38216619Epigenetic resolution of the 'curse of complexity' in adaptive evolution of complex traits
Q33616185Epigenetics of aging and aging-related disease.
Q50422460Epigenome comparisons reveal linkage between gene expression and postnatal remodeling of chromatin domain topology.
Q38838046Evaluating cell reprogramming, differentiation and conversion technologies in neuroscience
Q50541796Experimental manipulation of telomere length: does it reveal a corner-stone role for telomerase in the natural variability of individual fitness?
Q88755179Extracellular vesicles extracted from young donor serum attenuate inflammaging via partially rejuvenating aged T-cell immunotolerance
Q59090300Facing up to the global challenges of ageing
Q46314960Fleeting factors, turning back time.
Q37001419Functional annotation of noncoding variants and prioritization of cancer-associated lncRNAs in lung cancer
Q60951267GRK5 - A Functional Bridge Between Cardiovascular and Neurodegenerative Disorders
Q98289675Ganoderic Acid D Protects Human Amniotic Mesenchymal Stem Cells against Oxidative Stress-Induced Senescence through the PERK/NRF2 Signaling Pathway
Q94465937Genetic predispositions of Parkinson's disease revealed in patient-derived brain cells
Q26853420Genetic regulation of thymocyte progenitor aging
Q34511671Genetic variants near MLST8 and DHX57 affect the epigenetic age of the cerebellum
Q26828858Genomic imprinting in mammals
Q38622592Germline and Pluripotent Stem Cells
Q38914376Global reorganization of the nuclear landscape in senescent cells
Q26740026Hallmarks of progeroid syndromes: lessons from mice and reprogrammed cells
Q33811539Heterochronic parabiosis: historical perspective and methodological considerations for studies of aging and longevity
Q58765738Horizons in the evolution of aging
Q47813385How regularities of mortality statistics explain why we age despite having potentially ageless somatic stem cells
Q55005606Implications of Cellular Aging in Cardiac Reprogramming.
Q48201443In Vivo Transient and Partial Cell Reprogramming to Pluripotency as a Therapeutic Tool for Neurodegenerative Diseases
Q51823732Influence of anaerobic and aerobic exercise on age-related pathways in skeletal muscle.
Q39106739Interaction between epigenetic and metabolism in aging stem cells
Q38738844Interindividual epigenetic variability: Sound or noise?
Q90422160Investigating the role of Sirtuins in cell reprogramming
Q34547502In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming
Q36692844Lifespan of neurons is uncoupled from organismal lifespan
Q37514776Long non-coding RNA H19 enhances cell proliferation and anchorage-independent growth of cervical cancer cell lines
Q37553716Long non-coding RNA LOC283070 mediates the transition of LNCaP cells into androgen-independent cells possibly via CAMK1D
Q64898040Long-term every-other-day administration of DMAMCL has little effect on aging and age-associated physiological decline in mice.
Q55002845MeCP2-mediated epigenetic regulation in senescent endothelial progenitor cells.
Q37366137Mechanistic links between aging and lung fibrosis
Q39085780Metabolism and Skeletal Muscle Homeostasis in Lung Disease.
Q39334309MicroRNA-191 triggers keratinocytes senescence by SATB1 and CDK6 downregulation
Q64272061Mitochondria: multifaceted regulators of aging
Q33563545Mitochondrial protein Fus1/Tusc2 in premature aging and age-related pathologies: critical roles of calcium and energy homeostasis
Q39363647Mitotic Dysfunction Associated with Aging Hallmarks
Q28076026Modeling ALS with motor neurons derived from human induced pluripotent stem cells
Q38574034Molecular biomarkers for chronological age in animal ecology
Q27021113Molecular mechanism of extrinsic factors affecting anti-aging of stem cells
Q41358122Molecular mechanisms involved in the aging of the T-cell immune response.
Q51765832Molecular profiling of aged neural progenitors identifies Dbx2 as a candidate regulator of age-associated neurogenic decline.
Q35262077Muscle dysfunction in patients with lung diseases: a growing epidemic
Q27025990NF-kB in premature aging
Q38848975NF-κB activation impairs somatic cell reprogramming in ageing
Q42220488NF-κB inhibition delays DNA damage-induced senescence and aging in mice
Q36964401NF-κB pathway activators as potential ageing biomarkers: targets for new therapeutic strategies.
Q37040356Negative reciprocal regulation between Sirt1 and Per2 modulates the circadian clock and aging
Q38213553New insights into skin stem cell aging and cancer.
Q37409450Nfatc1 orchestrates aging in hair follicle stem cells
Q39270104Nuclear lamina defects cause ATM-dependent NF-κB activation and link accelerated aging to a systemic inflammatory response
Q97527575Optimized method for extraction of exosomes from human primary muscle cells
Q64900318Perspective: Why Exercise Is Good and Its Lack Bad for Everything.
Q28533351Phenethylisothiocyanate alters site- and promoter-specific histone tail modifications in cancer cells
Q90952568Pluripotent Stem Cells to Model Degenerative Retinal Diseases: The RPE Perspective
Q39256627Pluripotent stem cells escape from senescence-associated DNA methylation changes
Q33915908Prolonged fasting reduces IGF-1/PKA to promote hematopoietic-stem-cell-based regeneration and reverse immunosuppression.
Q37402142Promoting longevity by maintaining metabolic and proliferative homeostasis
Q90634541Quantitative iTRAQ-based proteomic analysis of differentially expressed proteins in aging in human and monkey
Q34737490Regenerative capacity of old muscle stem cells declines without significant accumulation of DNA damage
Q34023658Regulation of the mRNA half-life in breast cancer
Q92493414Rehmannia glutinosa exhibits anti-aging effect through maintaining the quiescence and decreasing the senescence of hematopoietic stem cells
Q38981139Rejuvenating Strategies for Stem Cell-Based Therapies in Aging
Q60044565Rejuvenation by cell reprogramming: a new horizon in gerontology
Q38763576Renal Aging: Causes and Consequences
Q35684586Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells
Q44955740Reversal of aging and lifespan elongation. Current biomedical key publications and the implications for geriatrics
Q38761159Roles for long non-coding RNAs in physiology and disease.
Q35782076SIRT1 affects DNA methylation of polycomb group protein target genes, a hotspot of the epigenetic shift observed in ageing
Q35093088SIRT1-mediated epigenetic downregulation of plasminogen activator inhibitor-1 prevents vascular endothelial replicative senescence
Q33802446SOX17 Regulates Conversion of Human Fibroblasts Into Endothelial Cells and Erythroblasts by Dedifferentiation Into CD34+ Progenitor Cells
Q93067806Sarcopenia: Aging-Related Loss of Muscle Mass and Function
Q26777962Satellite cells in human skeletal muscle plasticity
Q92599529Screening for genes that accelerate the epigenetic aging clock in humans reveals a role for the H3K36 methyltransferase NSD1
Q97883660Searching for the Mechanisms of Mammalian Cellular Aging Through Underlying Gene Regulatory Networks
Q83230352Self-sperm induce resistance to the detrimental effects of sexual encounters with males in hermaphroditic nematodes
Q37150507Sirtuins, tissue maintenance, and tumorigenesis
Q41848436Solar-simulated ultraviolet radiation induces histone 3 methylation changes in the gene promoters of matrix metalloproteinases 1 and 3 in primary human dermal fibroblasts
Q36118417Stem cell aging in adult progeria.
Q38702921Stem cells and healthy aging
Q33616166Stem cells as vehicles for youthful regeneration of aged tissues.
Q48377058Stress-associated H3K4 methylation accumulates during postnatal development and aging of rhesus macaque brain
Q36756829Suppression of EZH2 Prevents the Shift of Osteoporotic MSC Fate to Adipocyte and Enhances Bone Formation During Osteoporosis
Q55426070TGF-β signaling alters H4K20me3 status via miR-29 and contributes to cellular senescence and cardiac aging.
Q93047344Ten Years of BrainAGE as a Neuroimaging Biomarker of Brain Aging: What Insights Have We Gained?
Q37029584The Aging Epigenome
Q47105441The Potential of iPSCs for the Treatment of Premature Aging Disorders
Q89532840The ageing epigenome and its rejuvenation
Q38098875The ageing haematopoietic stem cell compartment
Q39089125The aging hematopoietic stem cell niche: Phenotypic and functional changes and mechanisms that contribute to hematopoietic aging
Q34386434The aging signature: a hallmark of induced pluripotent stem cells?
Q30819335The anti-aging effects of LW-AFC via correcting immune dysfunctions in senescence accelerated mouse resistant 1 (SAMR1) strain
Q38180970The biochemistry and cell biology of aging: metabolic regulation through mitochondrial signaling.
Q28648405The cerebellum ages slowly according to the epigenetic clock
Q47806831The chromatin accessibility signature of human immune aging stems from CD8+ T cells.
Q38239897The decalog of long non-coding RNA involvement in cancer diagnosis and monitoring.
Q94103502The effect of age on stem cell function and utility for therapy
Q34864525The expanding epigenetic landscape of non-model organisms
Q28131641The hallmarks of aging
Q39157599The mystery of puberty initiation: genetics and epigenetics of idiopathic central precocious puberty (ICPP).
Q34379834The nexus of chromatin regulation and intermediary metabolism.
Q43937697The place of genetics in ageing research.
Q38967406The role of hydrogen sulfide in aging and age-related pathologies
Q57034268The rs2147578 C > G polymorphism in the Inc-LAMC2-1:1 gene is associated with increased neuroblastoma risk in the Henan children
Q34371037The scientific quest for lasting youth: prospects for curing aging
Q35578950Three-dimensional human facial morphologies as robust aging markers
Q34385068Topical hypochlorite ameliorates NF-κB-mediated skin diseases in mice
Q89018656Transient non-integrative expression of nuclear reprogramming factors promotes multifaceted amelioration of aging in human cells
Q48590196Treadmill exercise alters histone acetyltransferases and histone deacetylases activities in frontal cortices from wistar rats.
Q90854384Turning back time with emerging rejuvenation strategies
Q36956854Two Conserved Histone Demethylases Regulate Mitochondrial Stress-Induced Longevity
Q47191098UNC-120/SRF independently controls muscle aging and lifespan in Caenorhabditis elegans.
Q51768235Ultraviolet A irradiation induces senescence in human dermal fibroblasts by down-regulating DNMT1 via ZEB1.
Q90721478Uncovering Natural Longevity Alleles from Intercrossed Pools of Aging Fission Yeast Cells
Q42790918Uncovering the mechanisms of Caenorhabditis elegans ageing from global quantification of the underlying landscape
Q34031710Uncovering the role of genomic "dark matter" in human disease
Q38163265Using zebrafish models to explore genetic and epigenetic impacts on evolutionary developmental origins of aging
Q89752915When function follows form: Nuclear compartment structure and the epigenetic landscape of the aging neuron
Q91750070Young bone marrow Sca-1 cells protect aged retina from ischaemia-reperfusion injury through activation of FGF2
Q64262792Young plasma ameliorates aging-related acute brain injury after intracerebral hemorrhage

Search more.