An RGS-containing sorting nexin controls Drosophila lifespan

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An RGS-containing sorting nexin controls Drosophila lifespan is …
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scholarly articleQ13442814

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P819ADS bibcode2008PLoSO...3.2152S
P356DOI10.1371/JOURNAL.PONE.0002152
P932PMC publication ID2359856
P698PubMed publication ID18478054
P5875ResearchGate publication ID5373608

P2093author name stringJohn M Peters
Drew Stenesen
Jonathan M Graff
Jae Myoung Suh
Angela Cade
Akiko Inoue
P2860cites workIdentification of a family of sorting nexin molecules and characterization of their association with receptorsQ22008017
RGS-PX1, a GAP for GalphaS and sorting nexin in vesicular traffickingQ24291954
Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gammaQ24294948
Endosomal localization and function of sorting nexin 1Q24531264
Sir2 mediates longevity in the fly through a pathway related to calorie restrictionQ24560016
A role for sorting nexin 2 in epidermal growth factor receptor down-regulation: evidence for distinct functions of sorting nexin 1 and 2 in protein traffickingQ24561415
Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathwayQ24643816
Adipose is a conserved dosage-sensitive antiobesity geneQ24654087
The Drosophila forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signalingQ24794823
Resveratrol improves health and survival of mice on a high-calorie dietQ27860950
Targeted gene expression as a means of altering cell fates and generating dominant phenotypesQ27861039
Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate proteinQ28211215
Sorting out the cellular functions of sorting nexinsQ28216490
Aging is no longer an unsolved problem in biologyQ28248790
Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alphaQ28274682
Enhanced degradation of EGF receptors by a sorting nexin, SNX1Q28279650
C elegans: a model for exploring the genetics of fat storageQ28611310
daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegansQ28611331
Extension of murine life span by overexpression of catalase targeted to mitochondriaQ29614546
Extended longevity in mice lacking the insulin receptor in adipose tissueQ29614549
Leptin and the regulation of body weight in mammalsQ29615976
The plasticity of aging: insights from long-lived mutantsQ29616584
Genetic Transformation of Drosophila with Transposable Element VectorsQ29618208
Mammalian RGS proteins: multifunctional regulators of cellular signalling.Q30354302
The variability between individuals as a measure of senescence: a study of the number of eggs laid and the percentage of hatched eggs in the case of Drosophila melanogasterQ52431841
A discrete transcriptional silencer in the bam gene determines asymmetric division of the Drosophila germline stem cell.Q52603134
A green fluorescent protein enhancer trap screen in Drosophila photoreceptor cellsQ57662295
Insulin signaling in the adipocyteQ60155837
Systematic gene targeting on the X chromosome of Drosophila melanogasterQ80852810
No influence of Indy on lifespan in Drosophila after correction for genetic and cytoplasmic background effectsQ33287882
Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligandsQ33863373
A P element containing suppressor of hairy-wing binding regions has novel properties for mutagenesis in Drosophila melanogaster.Q33966050
Molecular regulation of adipogenesisQ34059685
Lipid storage and mobilization in insects: current status and future directionsQ34096422
The role of fat depletion in the biological benefits of caloric restrictionQ34174776
Fat metabolism in insectsQ34262846
JNK Signaling Confers Tolerance to Oxidative Stress and Extends Lifespan in DrosophilaQ34274911
Genetics of aging in the fruit fly, Drosophila melanogasterQ34276670
Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat bodyQ34324394
Extended life-span and stress resistance in the Drosophila mutant methuselahQ34477849
Life extension in the dwarf mouseQ34552549
The BDGP gene disruption project: single transposon insertions associated with 40% of Drosophila genesQ34645019
How regulators of G protein signaling achieve selective regulationQ35652043
Sorting nexins--unifying trends and new perspectivesQ36000866
Calorie restriction, SIRT1 and metabolism: understanding longevityQ36071224
Toward a unified theory of caloric restriction and longevity regulationQ36127231
Etiology of insulin resistanceQ36431215
Calorie restriction mimetics: an emerging research fieldQ36454381
Wolbachia, normally a symbiont of Drosophila, can be virulent, causing degeneration and early deathQ36595326
Sirtuins: the 'magnificent seven', function, metabolism and longevityQ36911415
16S rRNA phylogenetic analysis of the bacterial endosymbionts associated with cytoplasmic incompatibility in insectsQ36916808
Variable fitness effects of Wolbachia infection in Drosophila melanogasterQ38449329
Quantitative analysis of mating behavior in aging male drosophila melanogasterQ39672507
Rapid iterative negative geotaxis (RING): a new method for assessing age-related locomotor decline in DrosophilaQ39718172
Hedgehog signaling plays a conserved role in inhibiting fat formationQ42806335
Molecular links between aging and adipose tissueQ43527162
Extra sequences found at P element excision sites in Drosophila melanogasterQ43960260
Selection on stress resistance increases longevity in Drosophila melanogasterQ46145128
Life extension through neurofibromin mitochondrial regulation and antioxidant therapy for neurofibromatosis-1 in Drosophila melanogasterQ46449699
Systematic generation of high-resolution deletion coverage of the Drosophila melanogaster genomeQ46518014
Extended life-span conferred by cotransporter gene mutations in Drosophila.Q47070414
Specialized hepatocyte-like cells regulate Drosophila lipid metabolism.Q47070881
Long-lived Drosophila with overexpressed dFOXO in adult fat bodyQ47070959
Regulation of Drosophila life span by olfaction and food-derived odorsQ47813082
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectDrosophilaQ312154
lifetimeQ22675021
Snazarus Dmel_CG1514Q29814470
P304page(s)e2152
P577publication date2008-05-14
P1433published inPLOS OneQ564954
P1476titleAn RGS-containing sorting nexin controls Drosophila lifespan
P478volume3

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cites work (P2860)
Q34322163Adenosine nucleotide biosynthesis and AMPK regulate adult life span and mediate the longevity benefit of caloric restriction in flies.
Q47942997Discovery and Roles of ER-Endolysosomal Contact Sites in Disease
Q98463838Diverse species-specific phenotypic consequences of loss of function sorting nexin 14 mutations
Q37968311Insights into the PX (phox-homology) domain and SNX (sorting nexin) protein families: structures, functions and roles in disease
Q26739484Inter-organelle ER-endolysosomal contact sites in metabolism and disease across evolution
Q64979829Organelle remodeling at membrane contact sites.
Q52690998SNX14 mutations affect endoplasmic reticulum associated neutral lipid metabolism in autosomal recessive spinocerebellar ataxia 20.
Q24302345Structural basis for different phosphoinositide specificities of the PX domains of sorting nexins regulating G-protein signaling
Q37177979The developmental origins of adipose tissue

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