Unbalanced Growth, Senescence and Aging.

scientific article

Unbalanced Growth, Senescence and Aging. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/978-3-319-57127-0_8
P932PMC publication ID6345385
P698PubMed publication ID28600787

P50authorBrian K KennedyQ57312179
P2093author name stringMichael Polymenis
P2860cites workLife span extension by calorie restriction depends on Rim15 and transcription factors downstream of Ras/PKA, Tor, and Sch9Q21563331
Cdc2-mediated Schwann cell migration during peripheral nerve regenerationQ24338631
Extension of chronological life span in yeast by decreased TOR pathway signalingQ24539948
Lack of p21 expression links cell cycle control and appendage regeneration in miceQ24600429
Replicative and chronological aging in Saccharomyces cerevisiae.Q24633177
mTOR: from growth signal integration to cancer, diabetes and ageingQ24633662
Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathwayQ24643816
Rapamycin fed late in life extends lifespan in genetically heterogeneous miceQ24647805
Unequal division in Saccharomyces cerevisiae and its implications for the control of cell divisionQ24682072
What is the total number of protein molecules per cell volume? A call to rethink some published valuesQ26782007
Nutritional Control of Growth and Development in YeastQ27003312
Role of asymmetric cell division in lifespan control in Saccharomyces cerevisiaeQ27006778
Enhanced longevity by ibuprofen, conserved in multiple species, occurs in yeast through inhibition of tryptophan importQ27311613
A role for autophagy in the extension of lifespan by dietary restriction in C. elegansQ27314537
Oncogene-induced senescence relayed by an interleukin-dependent inflammatory networkQ27863386
The translational landscape of mTOR signalling steers cancer initiation and metastasisQ36873513
A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging.Q36888608
Adenylyl cyclase type 5 in cardiac disease, metabolism, and aging.Q37054928
Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice.Q37201250
Activin signaling targeted by insulin/dFOXO regulates aging and muscle proteostasis in DrosophilaQ37289065
Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4.Q37359194
Attenuation of age-related metabolic dysfunction in mice with a targeted disruption of the Cbeta subunit of protein kinase A.Q37413129
Protein kinase A and TORC1 activate genes for ribosomal biogenesis by inactivating repressors encoded by Dot6 and its homolog Tod6.Q37415934
Coming full circle: cyclin-dependent kinases as anti-cancer drug targetsQ37655465
Translate to divide: control of the cell cycle by protein synthesisQ37698109
Protein kinase A signaling as an anti-aging targetQ37699498
Stressing the cell cycle in senescence and agingQ38126692
Start and the restriction pointQ38126722
BubR1 kinase: protection against aneuploidy and premature agingQ38474180
Forging a signature of in vivo senescenceQ38536371
Sizing up to divide: mitotic cell-size control in fission yeastQ38632801
The Biosynthetic Basis of Cell Size Control.Q38634750
A Ribosomal Perspective on Proteostasis and AgingQ38865771
The ins(ide) and outs(ide) of asymmetric stem cell divisionQ38869306
TOR modulates GCN4-dependent expression of genes turned on by nitrogen limitationQ39503240
Permanent cell cycle exit in G2 phase after DNA damage in normal human fibroblasts.Q39804772
Genetic control of cell division in yeast cultured at different growth ratesQ40813100
Control of cell division in the yeast Saccharomyces cerevisiae cultured at different growth ratesQ40866579
Effects of temperature and nutritional conditions on the mitotic cell cycle of Saccharomyces cerevisiaeQ40911319
G1 cyclin-dependent kinases are sufficient to initiate DNA synthesis in quiescent human fibroblastsQ41056387
Autophagy is required for extension of yeast chronological life span by rapamycinQ41679914
A genomic analysis of chronological longevity factors in budding yeastQ42153109
Dietary restriction and mitochondrial function link replicative and chronological aging in Saccharomyces cerevisiaeQ42180763
pH neutralization protects against reduction in replicative lifespan following chronological aging in yeastQ42325506
Chronological and replicative lifespan in yeast: do they meet in the middle?Q42410130
Continuous protein synthesis is required to maintain the probability of entry into S phaseQ42831274
Global Promoter Targeting of a Conserved Lysine Deacetylase for Transcriptional Shutoff during Quiescence EntryQ43110840
Statistical reconciliation of the elemental and molecular biomass composition of Saccharomyces cerevisiaeQ43759345
Gene expression analysis of mTOR pathway: association with human longevityQ43885264
Rapamycin-induced translational derepression of GCN4 mRNA involves a novel mechanism for activation of the eIF2 alpha kinase GCN2.Q44391314
Suppression of B cell activation by cyclosporin A, FK506 and rapamycinQ44832153
Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult DrosophilaQ46506998
A cyclin-dependent kinase inhibitor, Dacapo, is necessary for timely exit from the cell cycle during Drosophila embryogenesisQ47070342
Dacapo, a cyclin-dependent kinase inhibitor, stops cell proliferation during Drosophila development.Q47070780
BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in miceQ47315084
Biodemographic trajectories of age-specific reproliferation from stationary phase in the yeast Saccharomyces cerevisiae seem multiphasicQ47337730
New mutations in the yeast Saccharomyces cerevisiae affecting completion of "start".Q47731365
Preadaptation to efficient respiratory maintenance is essential both for maximal longevity and the retention of replicative potential in chronologically ageing yeast.Q51177133
Longevity pathways converge on autophagy genes to regulate life span in Caenorhabditis elegansQ52687989
Asymmetric segregation: the shape of things to come?Q53266735
Artificial tethering to nuclear pores promotes partitioning of extrachromosomal DNA during yeast asymmetric cell division.Q53277016
Nuclear geometry and rapid mitosis ensure asymmetric episome segregation in yeast.Q53278838
Segregation of yeast nuclear poresQ53310916
Cardiomyocyte proliferation and protection against post-myocardial infarction heart failure by cyclin D1 and Skp2 ubiquitin ligaseQ53468657
Aging-associated vascular phenotype in mutant mice with low levels of BubR1.Q53573577
Regulated arrest of cell proliferation mediated by yeast prt1 mutationsQ68188397
Regulation of G1 cyclin-dependent kinases in liver regenerationQ77475972
Relationship between the replicative age and cell volume in Saccharomyces cerevisiaeQ79360458
Type 5 adenylyl cyclase disruption increases longevity and protects against stressQ80700459
Hypertrophy hypothesis as an alternative explanation of the phenomenon of replicative aging of yeastQ82555447
The budding yeast rRNA and ribosome biosynthesis (RRB) regulon contains over 200 genesQ82862931
A mechanism for asymmetric segregation of age during yeast buddingQ27929801
Regulation of longevity and stress resistance by Sch9 in yeastQ27929987
A Nutrient-Responsive Pathway that Determines M Phase Timing through Control of B-Cyclin mRNA StabilityQ27930046
Making ribosomesQ27930690
CDC33 encodes mRNA cap-binding protein eIF-4E of Saccharomyces cerevisiaeQ27930856
A survey of essential gene function in the yeast cell division cycleQ27933676
Ribosome synthesis in Saccharomyces cerevisiaeQ27935371
The list of cytoplasmic ribosomal proteins of Saccharomyces cerevisiaeQ27936301
A dynamic transcriptional network communicates growth potential to ribosome synthesis and critical cell sizeQ27936478
GCD2, a translational repressor of the GCN4 gene, has a general function in the initiation of protein synthesis in Saccharomyces cerevisiaeQ27939500
Systematic identification of pathways that couple cell growth and division in yeastQ27939933
Superresolution imaging of ribosomes and RNA polymerase in live Escherichia coli cellsQ27976501
Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespanQ28005547
Transcriptional and epigenetic regulation of autophagy in agingQ28083637
Cell biology. On being the right (cell) sizeQ28086941
Senescence from G2 arrest, revisitedQ28088672
The economics of ribosome biosynthesis in yeastQ28131645
THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINSQ28202269
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disordersQ28252088
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and AgingQ28276378
Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in YeastQ28277565
Regulation of yeast replicative life span by TOR and Sch9 in response to nutrientsQ28282424
Characterization of the yeast transcriptomeQ28302110
Cell Size Control in YeastQ28730014
Overexpression of Atg5 in mice activates autophagy and extends lifespanQ29038178
Inhibitors of mammalian G1 cyclin-dependent kinasesQ29547907
Translational regulation of GCN4 and the general amino acid control of yeastQ29615275
Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressorQ29615559
Genetics: influence of TOR kinase on lifespan in C. elegansQ29616619
Extrachromosomal rDNA circles--a cause of aging in yeastQ29618308
G1 events and regulation of cell proliferationQ29618317
Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respirationQ29618751
Coordination of growth with cell division in the yeast Saccharomyces cerevisiaeQ29619674
Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5' capQ29620550
Disruption of protein kinase A in mice enhances healthy aging.Q33470238
Mechanisms of cyclin-dependent kinase regulation: structures of Cdks, their cyclin activators, and Cip and INK4 inhibitorsQ33604662
mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cellsQ33609242
Ribosomal protein L33 is required for ribosome biogenesis, subunit joining, and repression of GCN4 translationQ35950325
Translational control by TOR and TAP42 through dephosphorylation of eIF2alpha kinase GCN2.Q35964633
Systematic analysis of asymmetric partitioning of yeast proteome between mother and daughter cells reveals "aging factors" and mechanism of lifespan asymmetryQ36103120
Replicatively senescent cells are arrested in G1 and G2 phasesQ36132413
Geroconversion: irreversible step to cellular senescenceQ36186369
Direct observation of mammalian cell growth and size regulationQ36207904
Resonant microchannel volume and mass measurements show that suspended cells swell during mitosis.Q36310568
MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translationQ36405926
Growth and cell division during nitrogen starvation of the yeast Saccharomyces cerevisiaeQ36415518
The mystery of intracellular developmental programmes and timersQ36628579
Answering the ultimate question "what is the proximal cause of aging?"Q36736351
Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogasterQ33665807
Defining cellular senescence in IMR-90 cells: a flow cytometric analysisQ33679727
Visual account of protein investment in cellular functionsQ33767436
Gene duplication and the evolution of ribosomal protein gene regulation in yeastQ33778051
Mutations in signal transduction proteins increase stress resistance and longevity in yeast, nematodes, fruit flies, and mammalian neuronal cellsQ33819434
Using buoyant mass to measure the growth of single cellsQ33820496
Cyclin-dependent kinasesQ33900533
Synthesis of labile, serum-dependent protein in early G 1 controls animal cell growthQ33973989
Four faces of cellular senescenceQ34025754
The Achilles' heel of senescent cells: from transcriptome to senolytic drugs.Q34043405
Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in miceQ34045591
Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factorsQ34045737
Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice.Q34046144
Reserve carbohydrate metabolism in Saccharomyces cerevisiae: responses to nutrient limitationQ34153582
Kinetic evidence for a critical rate of protein synthesis in the Saccharomyces cerevisiae yeast cell cycleQ34172544
Aging, Cellular Senescence, and CancerQ34199776
AMPK modulates tissue and organismal aging in a non-cell-autonomous mannerQ34254596
Control of the yeast cell cycle by protein synthesis.Q34268394
Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan.Q34317812
How cells coordinate growth and divisionQ34374885
mTOR inhibition improves immune function in the elderlyQ34455680
The history and future of targeting cyclin-dependent kinases in cancer therapyQ34460347
The restriction point of the cell cycleQ34528876
SOD2 functions downstream of Sch9 to extend longevity in yeastQ34616845
A natural polymorphism in rDNA replication origins links origin activation with calorie restriction and lifespanQ34625412
Control of cell division in Saccharomyces cerevisiae by methionyl-tRNAQ35002489
ATF4 activity: a common feature shared by many kinds of slow-aging miceQ35080596
Elevated ATF4 function in fibroblasts and liver of slow-aging mutant miceQ35152873
Mitochondrial quality control during inheritance is associated with lifespan and mother-daughter age asymmetry in budding yeastQ35214172
Passage through stationary phase advances replicative aging in Saccharomyces cerevisiaeQ35596176
Target of rapamycin (TOR) in nutrient signaling and growth controlQ35620394
From egg to gastrula: how the cell cycle is remodeled during the Drosophila mid-blastula transitionQ35794854
Sir2p-dependent protein segregation gives rise to a superior reactive oxygen species management in the progeny of Saccharomyces cerevisiaeQ35865008
Cell cycle arrest is not yet senescence, which is not just cell cycle arrest: terminology for TOR-driven agingQ35947377
P407language of work or nameEnglishQ1860
P304page(s)189-208
P577publication date2017-01-01
P13046publication type of scholarly workreview articleQ7318358
P1433published inAdvances in Experimental Medicine and BiologyQ4686385
P1476titleUnbalanced Growth, Senescence and Aging
P478volume1002

Reverse relations

cites work (P2860)
Q90746119Evidence for immortality and autonomy in animal cancer models is often not provided, which causes confusion on key issues of cancer biology
Q92668029Mechanisms underlying T cell ageing
Q90431532Rapamycin, proliferation and geroconversion to senescence

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