| scholarly article | Q13442814 |
| review article | Q7318358 |
| P356 | DOI | 10.1042/BST0390460 |
| P698 | PubMed publication ID | 21428920 |
| P50 | author | Linda Partridge | Q6551889 |
| Ivana Bjedov | Q54933582 | ||
| P2860 | cites work | Extending healthy life span--from yeast to humans | Q24599191 |
| Targeting mTOR: prospects for mTOR complex 2 inhibitors in cancer therapy | Q24632296 | ||
| Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway | Q24643816 | ||
| A role for autophagy in the extension of lifespan by dietary restriction in C. elegans | Q27314537 | ||
| TOR signaling in growth and metabolism | Q27860757 | ||
| Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2 | Q28511429 | ||
| Cell stress and aging: new emphasis on multiplex resistance mechanisms | Q28755165 | ||
| The genetics of ageing | Q29547430 | ||
| Autophagy genes are essential for dauer development and life-span extension in C. elegans | Q29614180 | ||
| Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity | Q29614241 | ||
| Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress | Q29614493 | ||
| Activation of a metabolic gene regulatory network downstream of mTOR complex 1 | Q29615179 | ||
| Molecular mechanisms of mTOR-mediated translational control | Q29615529 | ||
| Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis | Q29615683 | ||
| Ribosomal protein S6 kinase 1 signaling regulates mammalian life span | Q29615975 | ||
| Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans | Q29616003 | ||
| Genetic links between diet and lifespan: shared mechanisms from yeast to humans | Q33344701 | ||
| mTOR regulation and therapeutic rejuvenation of aging hematopoietic stem cells | Q33609242 | ||
| Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster | Q33665807 | ||
| TOR-dependent control of autophagy: biting the hand that feeds | Q33787702 | ||
| With TOR, less is more: a key role for the conserved nutrient-sensing TOR pathway in aging | Q33912952 | ||
| Can autophagy promote longevity? | Q34135551 | ||
| TOR and ageing: a complex pathway for a complex process. | Q34402682 | ||
| 4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila | Q35006474 | ||
| Broad spectrum detoxification: the major longevity assurance process regulated by insulin/IGF-1 signaling? | Q36017390 | ||
| Mitochondrial signaling, TOR, and life span | Q36642733 | ||
| Aging and survival: the genetics of life span extension by dietary restriction. | Q37121798 | ||
| Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4. | Q37359194 | ||
| A new player in the orchestra of cell growth: SREBP activity is regulated by mTORC1 and contributes to the regulation of cell and organ size | Q37368338 | ||
| Translational responses to growth factors and stress | Q37368342 | ||
| Fat metabolism links germline stem cells and longevity in C. elegans | Q37383382 | ||
| mTOR and the control of whole body metabolism | Q37406462 | ||
| The multiple facets of mTOR in immunity. | Q37441725 | ||
| TOR complex 2: a signaling pathway of its own. | Q37624179 | ||
| TOR on the brain. | Q37789848 | ||
| Stressin' Sestrins take an aging fight | Q37794096 | ||
| Functions and regulation of the 70kDa ribosomal S6 kinases. | Q37798912 | ||
| Regulation of mammalian autophagy in physiology and pathophysiology. | Q37801517 | ||
| Growth stimulation leads to cellular senescence when the cell cycle is blocked | Q39925937 | ||
| The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans | Q41711470 | ||
| Immunology: A metabolic switch to memory. | Q45942810 | ||
| Immune regulation by rapamycin: moving beyond T cells | Q46041821 | ||
| The pharmacology of mTOR inhibition | Q46041824 | ||
| RAG GTPases in nutrient-mediated TOR signaling pathway | Q46095500 | ||
| Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila | Q46506998 | ||
| Inflamm-ageing and lifelong antigenic load as major determinants of ageing rate and longevity. | Q51993068 | ||
| Translational control of the innate immune response through IRF-7 | Q57203299 | ||
| P433 | issue | 2 | |
| P304 | page(s) | 460-465 | |
| P577 | publication date | 2011-04-01 | |
| P1433 | published in | Biochemical Society Transactions | Q864226 |
| P1476 | title | A longer and healthier life with TOR down-regulation: genetics and drugs | |
| P478 | volume | 39 |
| Q33754491 | A cytoprotective perspective on longevity regulation |
| Q37424472 | A holidic medium for Drosophila melanogaster |
| Q33878933 | A nonapoptotic role for CASP2/caspase 2: modulation of autophagy |
| Q37721518 | Advancing age is associated with gene expression changes resembling mTOR inhibition: evidence from two human populations |
| Q92074835 | Agephagy - Adapting Autophagy for Health During Aging |
| Q34341924 | Aging and energetics' 'Top 40' future research opportunities 2010-2013. |
| Q27014722 | Aging signaling pathways and circadian clock-dependent metabolic derangements |
| Q36557465 | All-trans retinoic acid and rapamycin normalize Hutchinson Gilford progeria fibroblast phenotype. |
| Q37300631 | Association of the K153R polymorphism in the myostatin gene and extreme longevity |
| Q34373575 | Autophagy and ageing: implications for age-related neurodegenerative diseases. |
| Q55405496 | Autophagy in Age-Associated Neurodegeneration. |
| Q36071788 | Caveolin-1 and accelerated host aging in the breast tumor microenvironment: chemoprevention with rapamycin, an mTOR inhibitor and anti-aging drug |
| Q35947377 | Cell cycle arrest is not yet senescence, which is not just cell cycle arrest: terminology for TOR-driven aging |
| Q64114497 | Cellular parabiosis and the latency of age-related diseases |
| Q36926148 | Common drugs and treatments for cancer and age-related diseases: revitalizing answers to NCI's provocative questions |
| Q35819175 | Diet-induced changes in brain structure and behavior in old gerbils |
| Q38177394 | Dietary restriction and the pursuit of effective mimetics. |
| Q28544630 | Drug synergy drives conserved pathways to increase fission yeast lifespan |
| Q36414149 | Dual mTORC1/C2 inhibitors suppress cellular geroconversion (a senescence program). |
| Q35950832 | Epidemiological, genetic and epigenetic aspects of the research on healthy ageing and longevity. |
| Q35991231 | Evidence that hematopoietic stem cell function is preserved during aging in long-lived S6K1 mutant mice |
| Q34336644 | Extension of Saccharomyces paradoxus chronological lifespan by retrotransposons in certain media conditions is associated with changes in reactive oxygen species |
| Q37322075 | Frameworks for Proof-of-Concept Clinical Trials of Interventions That Target Fundamental Aging Processes |
| Q36283905 | Geroprotectors as a novel therapeutic strategy for COPD, an accelerating aging disease |
| Q38112382 | Growth or longevity: the TOR's decision on lifespan regulation |
| Q35645142 | Hormesis does not make sense except in the light of TOR-driven aging |
| Q36288653 | How to save Medicare: the anti-aging remedy |
| Q30533934 | Hyper-mitogenic drive coexists with mitotic incompetence in senescent cells |
| Q41899062 | Insights from yeast into whether the inhibition of heat shock transcription factor (Hsf1) by rapamycin can prevent the Hsf1 activation that results from treatment with an Hsp90 inhibitor |
| Q34252732 | Ketone bodies as signaling metabolites. |
| Q37581235 | Lifespan extension and delay of age-related functional decline caused by Rhodiola rosea depends on dietary macronutrient balance |
| Q34642886 | Lifespan modulation in mice and the confounding effects of genetic background. |
| Q29036305 | Lithium suppresses Aβ pathology by inhibiting translation in an adult Drosophila model of Alzheimer's disease |
| Q44159799 | Loss of the Birt-Hogg-Dubé gene product folliculin induces longevity in a hypoxia-inducible factor-dependent manner |
| Q33637828 | Meat and Nicotinamide: A Causal Role in Human Evolution, History, and Demographics |
| Q38174328 | Mitochondria in ageing: there is metabolism beyond the ROS. |
| Q33665207 | Molecular Pathways: Increased Susceptibility to Infection Is a Complication of mTOR Inhibitor Use in Cancer Therapy |
| Q35764401 | NCI's provocative questions on cancer: some answers to ignite discussion |
| Q27011395 | Oxidative damage, ageing, and life-history evolution: where now? |
| Q26830832 | Proteostasis and longevity: when does aging really begin? |
| Q26866151 | Rapalogs in cancer prevention: anti-aging or anticancer? |
| Q64241474 | Rapamycin as a potential treatment for succinate dehydrogenase deficiency |
| Q37228766 | Rapamycin extends life- and health span because it slows aging |
| Q88261423 | Rapamycin reduces Drosophila longevity under low nutrition |
| Q38812960 | Rapamycin reduces fibroblast proliferation without causing quiescence and induces STAT5A/B-mediated cytokine production |
| Q37388987 | Reduced insulin/insulin-like growth factor-1 signaling and dietary restriction inhibit translation but preserve muscle mass in Caenorhabditis elegans |
| Q37022133 | Reducing signs of aging and increasing lifespan by drug synergy. |
| Q37170675 | Reducing sphingolipid synthesis orchestrates global changes to extend yeast lifespan |
| Q36260537 | Rejuvenating immunity: "anti-aging drug today" eight years later |
| Q36586516 | Resveratrol potentiates rapamycin to prevent hyperinsulinemia and obesity in male mice on high fat diet |
| Q37586487 | Sphingolipids and lifespan regulation |
| Q35621941 | TOR in the immune system |
| Q36242812 | Target of rapamycin activation predicts lifespan in fruit flies. |
| Q28390367 | Teaching the basics of autophagy and mitophagy to redox biologists--mechanisms and experimental approaches |
| Q90239357 | The GATA Transcription Factor Gaf1 Represses tRNAs, Inhibits Growth, and Extends Chronological Lifespan Downstream of Fission Yeast TORC1 |
| Q26771316 | The Progress of Mitophagy and Related Pathogenic Mechanisms of the Neurodegenerative Diseases and Tumor |
| Q26750137 | The Role of Autophagy, Mitophagy and Lysosomal Functions in Modulating Bioenergetics and Survival in the Context of Redox and Proteotoxic Damage: Implications for Neurodegenerative Diseases |
| Q38714678 | The TOR Signaling Pathway in Spatial and Temporal Control of Cell Size and Growth |
| Q90854196 | The lysosome as a cellular centre for signalling, metabolism and quality control |
| Q38028872 | The mTOR signaling pathway in the brain: focus on epilepsy and epileptogenesis |
| Q26863497 | The search for antiaging interventions: from elixirs to fasting regimens |
| Q34305775 | Tissue-specific responses of IGF-1/insulin and mTOR signaling in calorie restricted rats. |
| Q34515933 | Using answer set programming to integrate RNA expression with signalling pathway information to infer how mutations affect ageing |
| Q35080619 | Weekly administration of rapamycin improves survival and biomarkers in obese male mice on high-fat diet |
| Q37856364 | mTOR Signalling in Health and Disease |
| Q37093673 | mTOR plays a critical role in p53-induced oxidative kidney cell injury in HIVAN. |
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