| review article | Q7318358 |
| scholarly article | Q13442814 |
| P50 | author | Mario G Mirisola | Q92028298 |
| P2093 | author name string | Antonio Russo | |
| Giusi Taormina | |||
| Nello Grassi | |||
| Salvatore Vieni | |||
| Federica Ferrante | |||
| P2860 | cites work | Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study | Q21261434 |
| Life span extension by calorie restriction depends on Rim15 and transcription factors downstream of Ras/PKA, Tor, and Sch9 | Q21563331 | ||
| Evolutionary and Biomedical Insights from the Rhesus Macaque Genome | Q22065872 | ||
| Initial sequence of the chimpanzee genome and comparison with the human genome | Q22122468 | ||
| Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics | Q22254097 | ||
| Mutation of the mouse klotho gene leads to a syndrome resembling ageing | Q24328782 | ||
| Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys | Q24568041 | ||
| The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms | Q24597989 | ||
| Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study | Q24598129 | ||
| Extending healthy life span--from yeast to humans | Q24599191 | ||
| mTOR is a key modulator of ageing and age-related disease | Q24610741 | ||
| Genome-wide SNP and haplotype analyses reveal a rich history underlying dog domestication | Q24615541 | ||
| Evolution in health and medicine Sackler colloquium: Genetic variation in human telomerase is associated with telomere length in Ashkenazi centenarians | Q24620612 | ||
| Replicative and chronological aging in Saccharomyces cerevisiae. | Q24633177 | ||
| Mortality and morbidity in laboratory-maintained Rhesus monkeys and effects of long-term dietary restriction | Q44360239 | ||
| The Ras and Sch9 pathways regulate stress resistance and longevity | Q44509502 | ||
| The Ames dwarf gene is required for Pit-1 gene activation. | Q44917596 | ||
| Common polymorphisms in nitric oxide synthase (NOS) genes influence quality of aging and longevity in humans | Q45027559 | ||
| Long-lived growth hormone receptor knockout mice: interaction of reduced insulin-like growth factor i/insulin signaling and caloric restriction | Q45119352 | ||
| Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway | Q46102898 | ||
| Caloric Restriction Study Design Limitations in Rodent and Nonhuman Primate Studies. | Q46295030 | ||
| Diet restriction and ageing in the dog: major observations over two decades. | Q46863628 | ||
| Statistical analysis regarding the effects of height and weight on life span of the domestic dog. | Q47324957 | ||
| Understanding How Dogs Age: Longitudinal Analysis of Markers of Inflammation, Immune Function, and Oxidative Stress | Q47416286 | ||
| Association of the FOXO3A locus with extreme longevity in a southern Italian centenarian study. | Q47880667 | ||
| Genetic associations with human longevity at the APOE and ACE loci | Q48086269 | ||
| Nobel Lecture. Yeast and cancer | Q48359034 | ||
| Stress-associated H3K4 methylation accumulates during postnatal development and aging of rhesus macaque brain | Q48377058 | ||
| Premature ageing in transgenic mice expressing different growth hormone genes | Q48386543 | ||
| Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway | Q24643816 | ||
| Association of FOXO3A variation with human longevity confirmed in German centenarians | Q24646035 | ||
| FOXO3A genotype is strongly associated with human longevity | Q24647408 | ||
| Suppression of aging in mice by the hormone Klotho | Q24650916 | ||
| Caloric restriction delays disease onset and mortality in rhesus monkeys | Q24655994 | ||
| Comparative biology of aging | Q24658144 | ||
| Caenorhabditis elegans DAF-16/FOXO transcription factor and its mammalian homologs associate with age-related disease | Q26781364 | ||
| The early bird catches the worm: new technologies for the Caenorhabditis elegans toolkit | Q27004910 | ||
| Interplay of dFOXO and two ETS-family transcription factors determines lifespan in Drosophila melanogaster | Q27313416 | ||
| Slowed aging during reproductive dormancy is reflected in genome-wide transcriptome changes in Drosophila melanogaster | Q27316798 | ||
| Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families | Q27860677 | ||
| A C. elegans mutant that lives twice as long as wild type | Q27861054 | ||
| Regulation of longevity and stress resistance by Sch9 in yeast | Q27929987 | ||
| Sir2 blocks extreme life-span extension. | Q27931453 | ||
| SCH9, a gene of Saccharomyces cerevisiae that encodes a protein distinct from, but functionally and structurally related to, cAMP-dependent protein kinase catalytic subunits | Q27931473 | ||
| Superoxide dismutase activity is essential for stationary phase survival in Saccharomyces cerevisiae. Mitochondrial production of toxic oxygen species in vivo | Q27932583 | ||
| Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae | Q27933365 | ||
| Saccharomyces cerevisiae Ras/cAMP pathway controls post-diauxic shift element-dependent transcription through the zinc finger protein Gis1. | Q27937593 | ||
| The Saccharomyces cerevisiae zinc finger proteins Msn2p and Msn4p are required for transcriptional induction through the stress response element (STRE) | Q27940320 | ||
| Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans | Q28131824 | ||
| Novel sensing mechanisms and targets for the cAMP-protein kinase A pathway in the yeast Saccharomyces cerevisiae | Q28143822 | ||
| Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein | Q28211215 | ||
| APOE ε4 is associated with higher vitamin D levels in targeted replacement mice and humans | Q28240143 | ||
| Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients | Q28282424 | ||
| The canine genome | Q28285982 | ||
| A simple genetic architecture underlies morphological variation in dogs | Q28290486 | ||
| Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production | Q28511652 | ||
| Ensembl 2016 | Q28603093 | ||
| Genes that regulate both development and longevity in Caenorhabditis elegans | Q28611326 | ||
| daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans | Q28611331 | ||
| daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans | Q28611332 | ||
| Extended longevity in mice lacking the insulin receptor in adipose tissue | Q29614549 | ||
| Ribosomal protein S6 kinase 1 signaling regulates mammalian life span | Q29615975 | ||
| Understanding the odd science of aging | Q29617341 | ||
| A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function | Q29618026 | ||
| Evolutionary medicine: from dwarf model systems to healthy centenarians? | Q35074758 | ||
| Serine- and threonine/valine-dependent activation of PDK and Tor orthologs converge on Sch9 to promote aging | Q35091266 | ||
| Aging-related gene expression in hippocampus proper compared with dentate gyrus is selectively associated with metabolic syndrome variables in rhesus monkeys | Q35161815 | ||
| Age-related cataract in dogs: a biomarker for life span and its relation to body size | Q35201111 | ||
| Connecting serum IGF-1, body size, and age in the domestic dog. | Q35201151 | ||
| Insulin/IGF-I-signaling pathway: an evolutionarily conserved mechanism of longevity from yeast to humans | Q35554316 | ||
| Yeast Golgi apparatus--dynamics and sorting. | Q35639809 | ||
| Telomere maintenance genes SIRT1 and XRCC6 impact age-related decline in telomere length but only SIRT1 is associated with human longevity | Q35737137 | ||
| Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones | Q35799651 | ||
| TP53 codon 72 polymorphism affects accumulation of mtDNA damage in human cells | Q35799814 | ||
| Genetic variation in TERT and TERC and human leukocyte telomere length and longevity: a cross-sectional and longitudinal analysis. | Q35830728 | ||
| Variation in the human TP53 gene affects old age survival and cancer mortality. | Q36054748 | ||
| A mouse model of Werner Syndrome: what can it tell us about aging and cancer? | Q36060175 | ||
| Protein transport from the late Golgi to the vacuole in the yeast Saccharomyces cerevisiae | Q36137664 | ||
| Minireview: role of the growth hormone/insulin-like growth factor system in mammalian aging | Q36141285 | ||
| Use of yeast as a model system to investigate protein conformational diseases | Q36141393 | ||
| Mitochondrial oxidant generation and oxidative damage in Ames dwarf and GH transgenic mice | Q36270598 | ||
| Evolutionary conservation of regulated longevity assurance mechanisms | Q36570563 | ||
| Evidence from case-control and longitudinal studies supports associations of genetic variation in APOE, CETP, and IL6 with human longevity | Q36670196 | ||
| From genes to function: the C. elegans genetic toolbox | Q36960940 | ||
| Effect of Ames dwarfism and caloric restriction on spontaneous DNA mutation frequency in different mouse tissues | Q36969402 | ||
| MAP3K7 and GSTZ1 are associated with human longevity: a two-stage case-control study using a multilocus genotyping | Q36993299 | ||
| Sensitivity of primary fibroblasts in culture to atmospheric oxygen does not correlate with species lifespan. | Q37062461 | ||
| Separating cause from effect: how does insulin/IGF signalling control lifespan in worms, flies and mice? | Q37069457 | ||
| Can yeast systems biology contribute to the understanding of human disease? | Q37272910 | ||
| The Mn-superoxide dismutase single nucleotide polymorphism rs4880 and the glutathione peroxidase 1 single nucleotide polymorphism rs1050450 are associated with aging and longevity in the oldest old. | Q37288306 | ||
| Genetic association of FOXO1A and FOXO3A with longevity trait in Han Chinese populations. | Q37465353 | ||
| 4E-BP is a target of the GCN2-ATF4 pathway during Drosophila development and aging | Q37576581 | ||
| DWARF, A NEW MENDELIAN RECESSIVE CHARACTER OF THE HOUSE MOUSE. | Q37578880 | ||
| Age patterns of disease and death in insured Swedish dogs, cats and horses | Q37637307 | ||
| Cachexia and sarcopenia: emerging syndromes of importance in dogs and cats | Q37960096 | ||
| Do sirtuins promote mammalian longevity? A critical review on its relevance to the longevity effect induced by calorie restriction. | Q38105506 | ||
| Approaches to study yeast cell aging and death | Q38155948 | ||
| Stationary-phase regulation of the Saccharomyces cerevisiae SOD2 gene is dependent on additive effects of HAP2/3/4/5- and STRE-binding elements | Q38350078 | ||
| Increased frequency of the 2437T allele of the heat shock protein 70-Hom gene in an aged Irish population. | Q38354742 | ||
| The Companion Dog as a Model for the Longevity Dividend. | Q38383929 | ||
| Longevity: epigenetic and biomolecular aspects | Q38425373 | ||
| Why is the dog an ideal model for aging research? | Q38577932 | ||
| Exploring the power of yeast to model aging and age-related neurodegenerative disorders | Q38996403 | ||
| RAS Proteins and Their Regulators in Human Disease | Q39407402 | ||
| Non-human primates as a model for aging | Q39448698 | ||
| Tor-Sch9 deficiency activates catabolism of the ketone body-like acetic acid to promote trehalose accumulation and longevity | Q39912054 | ||
| Assessing chronological aging in Saccharomyces cerevisiae. | Q40167191 | ||
| Candidate genes associated with ageing and life expectancy in the Jerusalem longitudinal study. | Q40458385 | ||
| Analyses of human-chimpanzee orthologous gene pairs to explore evolutionary hypotheses of aging | Q41956271 | ||
| Acetic acid and acidification accelerate chronological and replicative aging in yeast | Q42410125 | ||
| Chronological aging leads to apoptosis in yeast | Q42774835 | ||
| A genetic pathway conferring life extension and resistance to UV stress in Caenorhabditis elegans. | Q42966749 | ||
| Effects of diet restriction on life span and age-related changes in dogs | Q43980633 | ||
| daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans | Q29618073 | ||
| Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans | Q29619580 | ||
| The endocrine regulation of aging by insulin-like signals | Q29903591 | ||
| Long-lived ames dwarf mice are resistant to chemical stressors | Q30497373 | ||
| Human longevity and variation in GH/IGF-1/insulin signaling, DNA damage signaling and repair and pro/antioxidant pathway genes: cross sectional and longitudinal studies | Q30513719 | ||
| Exploring mechanisms of sex differences in longevity: lifetime ovary exposure and exceptional longevity in dogs | Q33588249 | ||
| Calorie restriction in mammals and simple model organisms. | Q33634614 | ||
| Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster | Q33665807 | ||
| Replication of an association of variation in the FOXO3A gene with human longevity using both case-control and longitudinal data | Q33694756 | ||
| Saccharomyces cerevisiae as a model organism: a comparative study | Q33818079 | ||
| Mutations in signal transduction proteins increase stress resistance and longevity in yeast, nematodes, fruit flies, and mammalian neuronal cells | Q33819434 | ||
| Mechanisms of life span determination in Caenorhabditis elegans | Q33819439 | ||
| Conditional gene expression and RNAi using MEC-8-dependent splicing in C. elegans | Q33820575 | ||
| clk-1, mitochondria, and physiological rates | Q33825382 | ||
| Neuroendocrine inhibition of glucose production and resistance to cancer in dwarf mice | Q33857891 | ||
| Plasma antioxidants and longevity: a study on healthy centenarians. | Q33908994 | ||
| FLP recombinase-mediated induction of Cu/Zn-superoxide dismutase transgene expression can extend the life span of adult Drosophila melanogaster flies | Q33957068 | ||
| The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans | Q33966277 | ||
| Telomerase reverse transcriptase delays aging in cancer-resistant mice | Q34014691 | ||
| Mortality in north american dogs from 1984 to 2004: an investigation into age-, size-, and breed-related causes of death | Q34025888 | ||
| Further support to the uncoupling-to-survive theory: the genetic variation of human UCP genes is associated with longevity | Q34117841 | ||
| Life span of individual yeast cells | Q34246486 | ||
| AMPK modulates tissue and organismal aging in a non-cell-autonomous manner | Q34254596 | ||
| Long lifespan in worms with long telomeric DNA. | Q34318032 | ||
| Association analysis between longevity in the Japanese population and polymorphic variants of genes involved in insulin and insulin-like growth factor 1 signaling pathways | Q34373990 | ||
| Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population. | Q34408943 | ||
| A new rhesus macaque assembly and annotation for next-generation sequencing analyses. | Q34427961 | ||
| Programmed and altruistic ageing | Q34469684 | ||
| Caloric restriction improves health and survival of rhesus monkeys | Q34549441 | ||
| Telomeres and telomerase: the path from maize, Tetrahymena and yeast to human cancer and aging | Q34571596 | ||
| Oxidative stress and life span determination in the nematode Caenorhabditis elegans | Q34614576 | ||
| Aging in the canine and feline brain | Q34625739 | ||
| Role of TOR signaling in aging and related biological processes in Drosophila melanogaster | Q34677806 | ||
| Dysregulated miR-34a-SIRT1-acetyl p65 axis is a potential mediator of immune activation in the colon during chronic simian immunodeficiency virus infection of rhesus macaques | Q34749385 | ||
| Klotho gene variation and expression in 20 inbred mouse strains. | Q50476831 | ||
| Heat-shock protein 70 genes and human longevity: a view from Denmark. | Q50543936 | ||
| TP53*P72 allele influences negatively female life expectancy in a population of central Italy: cross-sectional study and genetic-demographic approach analysis. | Q51298679 | ||
| The Fruit Fly Drosophila melanogaster as a Model for Aging Research. | Q51532283 | ||
| Dietary restriction and aging in rhesus monkeys: the University of Wisconsin study. | Q51552259 | ||
| Oxidative stress and advancing age: results in healthy centenarians. | Q51569021 | ||
| Glucose tolerance and insulin action in healty centenarians. | Q51581456 | ||
| A functional EXO1 promoter variant is associated with prolonged life expectancy in centenarians. | Q51618454 | ||
| Evidence of longer life; a cohort of 39 labrador retrievers. | Q51767112 | ||
| Drosophila as a model for ageing. | Q51793970 | ||
| Modulation of canine immunosenescence by life-long caloric restriction. | Q51983803 | ||
| Specific interactions of growth hormone (GH) with GH-receptors and GH-binding proteins in vivo in genetically GH-deficient Ames dwarf mice. | Q52074193 | ||
| Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster. | Q52543010 | ||
| Female fitness in Drosophila melanogaster: an interaction between the effect of nutrition and of encounter rate with males. | Q52549571 | ||
| Cellular metabolism and oxidative stress as a possible determinant for longevity in small breed and large breed dogs. | Q52563692 | ||
| Low body temperature in long-lived Ames dwarf mice at rest and during stress. | Q52895233 | ||
| Insulin/IGF-I and related signaling pathways regulate aging in nondividing cells: from yeast to the mammalian brain. | Q53346541 | ||
| The Hagyard, Davidson and McGee practice, a cornerstone in the development of Kentucky's racehorse-breeding industry. | Q53597107 | ||
| Reduced insulin/IGF-1 signalling and human longevity. | Q53863930 | ||
| Glutaredoxin Deletion Shortens Chronological Life Span in Saccharomyces cerevisiae via ROS-Mediated Ras/PKA Activation. | Q54978464 | ||
| Dwarf mice and the ageing process. | Q55066759 | ||
| Editorial: Cell Stress, Metabolic Reprogramming, and Cancer. | Q55497799 | ||
| Polymorphic variants of insulin-like growth factor I (IGF-I) receptor and phosphoinositide 3-kinase genes affect IGF-I plasma levels and human longevity: cues for an evolutionarily conserved mechanism of life span control | Q57003670 | ||
| Metabolic Phenotype Modulation by Caloric Restriction in a Lifelong Dog Study | Q58045481 | ||
| The allele (A)(-110) in the promoter region of the HSP70-1 gene is unfavorable to longevity in women | Q60807631 | ||
| Two variants located in the upstream enhancer region of human UCP1 gene affect gene expression and are correlated with human longevity | Q61758403 | ||
| A universal transcriptomic signature of age reveals the temporal scaling of Caenorhabditis elegans aging trajectories. | Q63874606 | ||
| Age-dependent changes and biomarkers of aging in Caenorhabditis elegans | Q64261514 | ||
| Increasing Saccharomyces cerevisiae stress resistance, through the overactivation of the heat shock response resulting from defects in the Hsp90 chaperone, does not extend replicative life span but can be associated with slower chronological ageing o | Q64454226 | ||
| Hyperprolactinemia Suppresses Copulatory Behavior in Male Rats and Mice | Q66939283 | ||
| Insulin-like growth factor I levels in proportionate dogs, chondrodystrophic dogs and in giant dogs | Q68428110 | ||
| Apolipoprotein E and B polymorphisms--longevity factors assessed in nonagenarians | Q72356424 | ||
| Mutagenic alteration of the distal switch II region of RAS blocks CDC25-dependent signaling functions | Q72466107 | ||
| Estimation of apolipoprotein E genotype-specific relative mortality risks from the distribution of genotypes in centenarians and middle-aged men: apolipoprotein E gene is a "frailty gene," not a "longevity gene" | Q73030113 | ||
| Skeletal effects of aging and menopausal status in female rhesus macaques | Q73194316 | ||
| Antioxidative mechanisms and plasma growth hormone levels: potential relationship in the aging process | Q73433206 | ||
| Catalase expression in delayed and premature aging mouse models | Q73682311 | ||
| Genotyping the Prop-1 mutation in Ames dwarf mice | Q74513987 | ||
| The Snell dwarf mutation Pit1(dw) can increase life span in mice | Q77218978 | ||
| Does growth hormone prevent or accelerate aging? | Q78022540 | ||
| Muscle mass loss in Rhesus monkeys: age of onset | Q81901430 | ||
| A common polymorphism in the UCP3 promoter influences hand grip strength in elderly people | Q83451235 | ||
| P275 | copyright license | Creative Commons Attribution 4.0 International | Q20007257 |
| P6216 | copyright status | copyrighted | Q50423863 |
| P433 | issue | 7 | |
| P921 | main subject | model organism | Q213907 |
| P577 | publication date | 2019-07-09 | |
| P1433 | published in | Genes | Q5532699 |
| P1476 | title | Longevity: Lesson from Model Organisms | |
| P478 | volume | 10 |
| Q102141588 | Longevity strategies in response to light in the reef coral Stylophora pistillata |
| Q92444736 | Signaling Network of Forkhead Family of Transcription Factors (FOXO) in Dietary Restriction |
| Q92344741 | Untangling the Genetics of Human Longevity-A Challenging Quest |
Search more.