PI3K-mTORC1 attenuates stress response by inhibiting cap-independent Hsp70 translation.

scientific article

PI3K-mTORC1 attenuates stress response by inhibiting cap-independent Hsp70 translation. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M110.172882
P932PMC publication ID3057780
P698PubMed publication ID21177857

P50authorCrystal S ConnQ60659244
P2093author name stringJun Sun
Yan Han
Shu-Bing Qian
Vincent Yeung
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mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machineryQ24302549
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Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathwayQ24643816
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mTOR Complex1-S6K1 signaling: at the crossroads of obesity, diabetes and cancerQ36798847
Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translationQ36971030
Re-programming of translation following cell stress allows IRES-mediated translation to predominateQ37029410
New modes of translational control in development, behavior, and diseaseQ37033136
Differential contribution of the m7G-cap to the 5' end-dependent translation initiation of mammalian mRNAs.Q39810210
Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosisQ40002274
Protein quality control: chaperones culling corrupt conformationsQ40400832
Translational control during heat shockQ40614299
Regulation of HSP70 synthesis by messenger RNA degradationQ40640802
The 70 kDa S6 kinase: regulation of a kinase with multiple roles in mitogenic signallingQ40974450
Heat stress regulates the human 70-kDa heat-shock gene through the 3'-untranslated regionQ41550832
Preferential translation of internal ribosome entry site-containing mRNAs during the mitotic cycle in mammalian cellsQ46432262
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The preferential translation of Drosophila hsp70 mRNA requires sequences in the untranslated leader.Q52467701
Rapamycin fed late in life extends lifespan in genetically heterogeneous miceQ24647805
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Internal initiation of translation of eukaryotic mRNA directed by a sequence derived from poliovirus RNAQ27861043
Enhancer of decapping proteins 1 and 2 are important for translation during heat stress in Saccharomyces cerevisiae.Q27936485
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signallingQ28131740
Adapting proteostasis for disease interventionQ28131818
Distinctive properties of the 5'-untranslated region of human hsp70 mRNAQ28189450
Upstream and downstream of mTORQ28277365
Regulation of yeast replicative life span by TOR and Sch9 in response to nutrientsQ28282424
CHIP-mediated stress recovery by sequential ubiquitination of substrates and Hsp70Q28303344
The chaperone function of hsp70 is required for protection against stress-induced apoptosisQ28679271
The mechanism of eukaryotic translation initiation and principles of its regulationQ29547270
An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1Q29614563
Translational control in stress and apoptosisQ29615497
Molecular mechanisms of mTOR-mediated translational controlQ29615529
Growing roles for the mTOR pathwayQ29616212
Genetics: influence of TOR kinase on lifespan in C. elegansQ29616619
The heat-shock proteinsQ29617227
Molecular chaperones and protein quality controlQ29617795
Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulatorsQ29618401
Regulation of Aging and Age-Related Disease by DAF-16 and Heat-Shock FactorQ29619759
Cap-independent polysomal association of natural mRNAs encoding c-myc, BiP, and eIF4G conferred by internal ribosome entry sitesQ31957370
Defining mechanisms that regulate RNA polymerase II transcription in vivoQ33708432
Protein folding in vivo: the importance of molecular chaperonesQ33840775
Selective translation of heat shock mRNA in Drosophila melanogaster depends on sequence information in the leaderQ33931644
Translational control of cell fate: availability of phosphorylation sites on translational repressor 4E-BP1 governs its proapoptotic potencyQ34277370
The function of heat-shock proteins in stress tolerance: degradation and reactivation of damaged proteinsQ34336799
Genome-wide analysis of the biology of stress responses through heat shock transcription factorQ34347448
Dysregulation of the TSC-mTOR pathway in human diseaseQ34380413
Heat shock transcription factors: structure and regulationQ34387283
Translational regulation in cell stress and apoptosis. Roles of the eIF4E binding proteinsQ34524094
Hsp70 chaperone machines.Q34545594
TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activityQ34598209
Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperonesQ35799651
mTOR, translational control and human disease.Q36013966
P433issue8
P407language of work or nameEnglishQ1860
P304page(s)6791-6800
P577publication date2010-12-22
P1433published inJournal of Biological ChemistryQ867727
P1476titlePI3K-mTORC1 attenuates stress response by inhibiting cap-independent Hsp70 translation
P478volume286

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cites work (P2860)
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