| scholarly article | Q13442814 |
| P50 | author | Matt Kaeberlein | Q6788872 |
| Stanley Fields | Q7599599 | ||
| P2093 | author name string | Brian K Kennedy | |
| Kathryn T Kirkland | |||
| P2860 | cites work | Transcription-dependent recombination and the role of fork collision in yeast rDNA. | Q35965583 |
| Cloning and characterization of four SIR genes of Saccharomyces cerevisiae | Q36425975 | ||
| Life extension via dietary restriction is independent of the Ins/IGF-1 signalling pathway in Caenorhabditis elegans. | Q48581848 | ||
| An intervention resembling caloric restriction prolongs life span and retards aging in yeast | Q73054284 | ||
| Distinct roles of processes modulated by histone deacetylases Rpd3p, Hda1p, and Sir2p in life extension by caloric restriction in yeast | Q74734232 | ||
| Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase | Q24310456 | ||
| Four genes responsible for a position effect on expression from HML and HMR in Saccharomyces cerevisiae | Q24532215 | ||
| The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms | Q24597989 | ||
| Silent information regulator 2 family of NAD- dependent histone/protein deacetylases generates a unique product, 1-O-acetyl-ADP-ribose | Q24675630 | ||
| Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase | Q27860668 | ||
| Elimination of replication block protein Fob1 extends the life span of yeast mother cells. | Q27929527 | ||
| Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae | Q27931494 | ||
| A new role for a yeast transcriptional silencer gene, SIR2, in regulation of recombination in ribosomal DNA. | Q27932277 | ||
| Sip2, an N-myristoylated beta subunit of Snf1 kinase, regulates aging in Saccharomyces cerevisiae by affecting cellular histone kinase activity, recombination at rDNA loci, and silencing | Q27932945 | ||
| Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae | Q27933365 | ||
| Manipulation of a nuclear NAD+ salvage pathway delays aging without altering steady-state NAD+ levels | Q27933382 | ||
| The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases | Q27934108 | ||
| Rtg2 protein links metabolism and genome stability in yeast longevity | Q27934581 | ||
| Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans | Q28131824 | ||
| Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1 | Q28203762 | ||
| Mammalian SIRT1 represses forkhead transcription factors | Q28246430 | ||
| Mutation in the silencing gene S/R4 can delay aging in S. cerevisiae | Q29397443 | ||
| Modifiers of position effect are shared between telomeric and silent mating-type loci in S. cerevisiae. | Q29465402 | ||
| The genetics of caloric restriction in Caenorhabditis elegans | Q29617240 | ||
| Extrachromosomal rDNA circles--a cause of aging in yeast | Q29618308 | ||
| Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration | Q29618751 | ||
| Transcriptional silencing of Ty1 elements in the RDN1 locus of yeast | Q29618830 | ||
| An unusual form of transcriptional silencing in yeast ribosomal DNA | Q29618831 | ||
| Extending the lifespan of long-lived mice | Q34102936 | ||
| How does calorie restriction work? | Q34175282 | ||
| Life span of individual yeast cells | Q34246486 | ||
| Yeast life-span extension by calorie restriction is independent of NAD fluctuation | Q34275342 | ||
| Calorie restriction extends yeast life span by lowering the level of NADH. | Q34289946 | ||
| High osmolarity extends life span in Saccharomyces cerevisiae by a mechanism related to calorie restriction | Q34303607 | ||
| Interorganelle signaling is a determinant of longevity in Saccharomyces cerevisiae | Q34606789 | ||
| Saccharomyces cerevisiae SSD1-V confers longevity by a Sir2p-independent mechanism | Q34644394 | ||
| The chronological life span of Saccharomyces cerevisiae | Q35185540 | ||
| Using Yeast to Discover the Fountain of Youth | Q35577674 | ||
| P275 | copyright license | Creative Commons Attribution 4.0 International | Q20007257 |
| P6216 | copyright status | copyrighted | Q50423863 |
| P433 | issue | 9 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | calorie restriction | Q1332886 |
| lifetime | Q22675021 | ||
| P304 | page(s) | E296 | |
| P577 | publication date | 2004-09-01 | |
| P1433 | published in | PLOS Biology | Q1771695 |
| P1476 | title | Sir2-independent life span extension by calorie restriction in yeast | |
| P478 | volume | 2 |
| Q36888608 | A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging. |
| Q37071022 | A budding yeast's perspective on aging: the shape I'm in. |
| Q42153109 | A genomic analysis of chronological longevity factors in budding yeast |
| Q81026414 | A mid-life crisis for aging theory |
| Q37352346 | A molecular mechanism of chronological aging in yeast. |
| Q34625412 | A natural polymorphism in rDNA replication origins links origin activation with calorie restriction and lifespan |
| Q34559032 | A reduction in age-enhanced gluconeogenesis extends lifespan |
| Q33331800 | Age- and calorie-independent life span extension from dietary restriction by bacterial deprivation in Caenorhabditis elegans |
| Q42034620 | Ammonium is a key determinant on the dietary restriction of yeast chronological aging in culture medium |
| Q41834228 | An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans |
| Q51802490 | An age-dependent feedback control model of calcium dynamics in yeast cells. |
| Q41970961 | An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeast |
| Q36385747 | Are sirtuins viable targets for improving healthspan and lifespan? |
| Q37413129 | Attenuation of age-related metabolic dysfunction in mice with a targeted disruption of the Cbeta subunit of protein kinase A. |
| Q59085743 | Benchmarks for ageing studies |
| Q26777407 | Biochemical Genetic Pathways that Modulate Aging in Multiple Species |
| Q38183940 | Budding yeast as a model organism to study the effects of age. |
| Q41862528 | Buffering the pH of the culture medium does not extend yeast replicative lifespan |
| Q37245616 | C. elegans dauer formation and the molecular basis of plasticity |
| Q38947696 | CAN1 Arginine Permease Deficiency Extends Yeast Replicative Lifespan via Translational Activation of Stress Response Genes. |
| Q37507727 | Caloric Restriction to Moderate Senescence: Mechanisms and Clinical Utility |
| Q37588274 | Caloric restriction, SIRT1 and longevity |
| Q37362543 | Calorie restriction and sirtuins revisited |
| Q24652611 | Calorie restriction and the exercise of chromatin |
| Q36807218 | Calorie restriction as an intervention in ageing. |
| Q34060511 | Calorie restriction does not elicit a robust extension of replicative lifespan in Saccharomyces cerevisiae |
| Q30430955 | Calorie restriction effects on silencing and recombination at the yeast rDNA. |
| Q30437337 | Calorie restriction reduces rDNA recombination independently of rDNA silencing |
| Q36071224 | Calorie restriction, SIRT1 and metabolism: understanding longevity |
| Q35551405 | Calorie restriction-mediated replicative lifespan extension in yeast is non-cell autonomous |
| Q36767838 | Calorie restriction: is AMPK a key sensor and effector? |
| Q34776579 | Calorie restriction: what recent results suggest for the future of ageing research |
| Q37412454 | Candida albicans, a distinctive fungal model for cellular aging study |
| Q35898648 | Cardiac aging: from molecular mechanisms to significance in human health and disease |
| Q84327496 | Cell biology: High-tech yeast ageing |
| Q90173258 | Cell organelles and yeast longevity: an intertwined regulation |
| Q34621058 | Cell size and growth rate are major determinants of replicative lifespan |
| Q33610791 | Characterization of physiological defects in adult SIRT6-/- mice |
| Q24634557 | Chromatin regulation and genome maintenance by mammalian SIRT6 |
| Q36876218 | Chronological aging-induced apoptosis in yeast |
| Q24322745 | Deacetylation of FOXO3 by SIRT1 or SIRT2 leads to Skp2-mediated FOXO3 ubiquitination and degradation |
| Q37454610 | Deleting the 14-3-3 protein Bmh1 extends life span in Saccharomyces cerevisiae by increasing stress response |
| Q34573125 | Design and synthesis of compounds that extend yeast replicative lifespan |
| Q26774911 | Dietary Restriction and Nutrient Balance in Aging |
| Q36897755 | Dietary deprivation extends lifespan in Caenorhabditis elegans |
| Q39050922 | Dietary restriction and lifespan: Lessons from invertebrate models |
| Q42180763 | Dietary restriction and mitochondrial function link replicative and chronological aging in Saccharomyces cerevisiae |
| Q34990260 | Dietary restriction extends lifespan in wild-derived populations of Drosophila melanogaster |
| Q21296850 | Dietary, metabolic, and potentially environmental modulation of the lysine acetylation machinery |
| Q49804274 | Differences in Sirtuin Regulation in Response to Calorie Restriction in Cryptococcus neoformans. |
| Q37187457 | Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans |
| Q38105506 | Do sirtuins promote mammalian longevity? A critical review on its relevance to the longevity effect induced by calorie restriction. |
| Q44965473 | Does eating less make you live longer and better? An update on calorie restriction |
| Q34023025 | Elevated proteasome capacity extends replicative lifespan in Saccharomyces cerevisiae |
| Q38370208 | End-of-life cell cycle arrest contributes to stochasticity of yeast replicative aging |
| Q46432254 | Enforcement of a lifespan-sustaining distribution of Sir2 between telomeres, mating-type loci, and rDNA repeats by Rif1. |
| Q36531421 | Epigenetic regulation of ageing: linking environmental inputs to genomic stability |
| Q34037400 | Epigenetics in Saccharomyces cerevisiae |
| Q35869772 | Functional analyses of human DNA repair proteins important for aging and genomic stability using yeast genetics |
| Q33889036 | Gene regulatory changes in yeast during life extension by nutrient limitation |
| Q53660194 | Genetic instability in aging yeast: a metastable hyperrecombinational state. |
| Q33344701 | Genetic links between diet and lifespan: shared mechanisms from yeast to humans |
| Q64932051 | Genetic screen identifies adaptive aneuploidy as a key mediator of ER stress resistance in yeast. |
| Q28469314 | Genetics of aging in Caenorhabditis elegans |
| Q36310528 | Genome-Wide RNAi Longevity Screens in Caenorhabditis elegans |
| Q36149209 | Global heterochromatin loss: a unifying theory of aging? |
| Q38038608 | Growth culture conditions and nutrient signaling modulating yeast chronological longevity |
| Q35910113 | High-throughput analysis of yeast replicative aging using a microfluidic system |
| Q64102216 | Histone Modifications as an Intersection Between Diet and Longevity |
| Q21563472 | Increased life span due to calorie restriction in respiratory-deficient yeast |
| Q36747003 | Increased respiration in the sch9Delta mutant is required for increasing chronological life span but not replicative life span |
| Q34978376 | Inferring the effective TOR-dependent network: a computational study in yeast |
| Q53346541 | Insulin/IGF-I and related signaling pathways regulate aging in nondividing cells: from yeast to the mammalian brain. |
| Q38884503 | K-Ras promotes the non-small lung cancer cells survival by cooperating with sirtuin 1 and p27 under ROS stimulation |
| Q37283423 | Less is more: Nutrient limitation induces cross-talk of nutrient sensing pathways with NAD(+) homeostasis and contributes to longevity |
| Q24606290 | Lessons on longevity from budding yeast |
| Q21563331 | Life span extension by calorie restriction depends on Rim15 and transcription factors downstream of Ras/PKA, Tor, and Sch9 |
| Q98613805 | Life span extension by glucose restriction is abrogated by methionine supplementation: Cross-talk between glucose and methionine and implication of methionine as a key regulator of life span |
| Q38673046 | Lifespan-regulating genes in C. elegans |
| Q38196808 | Linking Peroxiredoxin and Vacuolar-ATPase Functions in Calorie Restriction-Mediated Life Span Extension. |
| Q39573387 | Links between nucleolar activity, rDNA stability, aneuploidy and chronological aging in the yeast Saccharomyces cerevisiae |
| Q37515461 | Loss of Nat4 and its associated histone H4 N-terminal acetylation mediates calorie restriction-induced longevity |
| Q27932823 | MSN2 and MSN4 link calorie restriction and TOR to sirtuin-mediated lifespan extension in Saccharomyces cerevisiae. |
| Q29614496 | Mammalian sirtuins: biological insights and disease relevance |
| Q33474758 | Measuring replicative life span in the budding yeast |
| Q90043584 | Metabolic Reprogramming and Signaling to Chromatin Modifications in Tumorigenesis |
| Q38303686 | Metabolic effects of resveratrol: addressing the controversies. |
| Q38813623 | Microfluidic Platforms for Yeast-Based Aging Studies |
| Q38789160 | Microfluidic technologies for yeast replicative lifespan studies |
| Q28396663 | Mitochondrial function in hypoxic ischemic injury and influence of aging |
| Q38536293 | Mitochondrial responsibility in ageing process: innocent, suspect or guilty |
| Q34367770 | Mitochondrial-nuclear epistasis: implications for human aging and longevity |
| Q33676890 | Mitohormesis: Promoting Health and Lifespan by Increased Levels of Reactive Oxygen Species (ROS). |
| Q26746323 | Mitophagy plays a central role in mitochondrial ageing |
| Q37611733 | Modulation of Replicative Lifespan in Cryptococcus neoformans: Implications for Virulence |
| Q41876018 | Molecular mechanisms underlying genotype-dependent responses to dietary restriction. |
| Q27671007 | NMR Structure of Hsp12, a Protein Induced by and Required for Dietary Restriction-Induced Lifespan Extension in Yeast |
| Q36536935 | Nampt/PBEF/Visfatin: a regulator of mammalian health and longevity? |
| Q97651150 | Natural Products as Modulators of Sirtuins |
| Q37718609 | Neural mechanisms of ageing and cognitive decline |
| Q39855416 | Nitrogen and carbon source balance determines longevity, independently of fermentative or respiratory metabolism in the yeast Saccharomyces cerevisiae |
| Q92257313 | Nucleolar and Ribosomal DNA Structure under Stress: Yeast Lessons for Aging and Cancer |
| Q46128800 | Nutritional Control of Chronological Aging and Heterochromatin in Saccharomyces cerevisiae |
| Q36835832 | Overexpression of Sir2 in the adult fat body is sufficient to extend lifespan of male and female Drosophila |
| Q38044329 | Peroxiredoxins, gerontogenes linking aging to genome instability and cancer. |
| Q91775571 | Phenotypic and Genotypic Consequences of CRISPR/Cas9 Editing of the Replication Origins in the rDNA of Saccharomyces cerevisiae |
| Q37785711 | Protein homeostasis and aging in neurodegeneration |
| Q35589945 | Protocols and programs for high-throughput growth and aging phenotyping in yeast |
| Q36761262 | Public and private mechanisms of life extension in Caenorhabditis elegans |
| Q42092305 | Quantitative evidence for early life fitness defects from 32 longevity-associated alleles in yeast |
| Q21145229 | Recent developments in yeast aging |
| Q50115780 | Recent insights into the cellular and molecular determinants of aging. |
| Q29617573 | Recent progress in the biology and physiology of sirtuins |
| Q34622726 | Regulation of NAD+ metabolism, signaling and compartmentalization in the yeast Saccharomyces cerevisiae |
| Q37745178 | Regulation of SIRT1 in cellular functions: role of polyphenols |
| Q33915356 | Regulation of yeast sirtuins by NAD(+) metabolism and calorie restriction |
| Q37212205 | Replicative aging in yeast: the means to the end |
| Q24608197 | Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases |
| Q36291200 | Resveratrol as a calorie restriction mimetic: therapeutic implications |
| Q36897454 | Resveratrol in prevention and treatment of common clinical conditions of aging |
| Q42150966 | Resveratrol inhibits insulin responses in a SirT1-independent pathway |
| Q37706770 | Resveratrol, sirtuins, and the promise of a DR mimetic |
| Q47945019 | Role of dFOXO in lifespan extension by dietary restriction in Drosophila melanogaster: not required, but its activity modulates the response |
| Q30582056 | Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide |
| Q36488997 | SIRT1 acts as a nutrient-sensitive growth suppressor and its loss is associated with increased AMPK and telomerase activity |
| Q37533104 | SIRT1 but not its increased expression is essential for lifespan extension in caloric-restricted mice. |
| Q39348163 | SIRT1 negatively regulates the activities, functions, and protein levels of hMOF and TIP60 |
| Q21142655 | SIRT1 negatively regulates the mammalian target of rapamycin |
| Q36903847 | SIRT1: recent lessons from mouse models. |
| Q48192684 | Sesamin extends lifespan through pathways related to dietary restriction in Caenorhabditis elegans |
| Q33386853 | Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity |
| Q92444736 | Signaling Network of Forkhead Family of Transcription Factors (FOXO) in Dietary Restriction |
| Q33224429 | Sir-dependent downregulation of various aging processes |
| Q35549231 | Sir2 deletion prevents lifespan extension in 32 long-lived mutants |
| Q36101389 | Sir2 phosphorylation through cAMP-PKA and CK2 signaling inhibits the lifespan extension activity of Sir2 in yeast |
| Q40900716 | Sir2 plays a key role in cell fate determination upon SAPK activation. |
| Q42914852 | SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons |
| Q47745453 | Sirt1's complex roles in neuroprotection |
| Q26828607 | Sirtuin 1 and sirtuin 3: physiological modulators of metabolism |
| Q38849140 | Sirtuin 7 is decreased in pulmonary fibrosis and regulates the fibrotic phenotype of lung fibroblasts |
| Q36281133 | Sirtuin biology and relevance to diabetes treatment |
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| Q36379286 | Sirtuin regulation in aging and injury |
| Q64272038 | Sirtuin signaling in cellular senescence and aging |
| Q35068878 | Sirtuin-1 regulation of mammalian metabolism |
| Q48422925 | Sirtuin-independent effects of nicotinamide on lifespan extension from calorie restriction in yeast. |
| Q37548942 | Sirtuins and p53. |
| Q35923139 | Sirtuins and their relevance to the kidney. |
| Q34699239 | Sirtuins as novel players in the pathogenesis of diabetes mellitus |
| Q36682665 | Sirtuins as potential targets for metabolic syndrome |
| Q34770789 | Sirtuins in aging and disease |
| Q38930264 | Sirtuins, a promising target in slowing down the ageing process. |
| Q28314993 | Slowing ageing by design: the rise of NAD(+) and sirtuin-activating compounds |
| Q36209390 | Sorbitol treatment extends lifespan and induces the osmotic stress response in Caenorhabditis elegans |
| Q35609538 | Strategies for reducing or preventing the generation of oxidative stress |
| Q27936150 | Stress profiling of longevity mutants identifies Afg3 as a mitochondrial determinant of cytoplasmic mRNA translation and aging |
| Q36103120 | Systematic analysis of asymmetric partitioning of yeast proteome between mother and daughter cells reveals "aging factors" and mechanism of lifespan asymmetry |
| Q35907645 | Systemic regulation of mammalian ageing and longevity by brain sirtuins |
| Q90127454 | TEMPORARY REMOVAL: The antifungal plant defensin HsAFP1 induces autophagy, vacuolar dysfunction and cell cycle impairment in yeast |
| Q33474860 | Telomere recombination accelerates cellular aging in Saccharomyces cerevisiae |
| Q27311649 | The MDT-15 subunit of mediator interacts with dietary restriction to modulate longevity and fluoranthene toxicity in Caenorhabditis elegans |
| Q34824438 | The SAGA histone deubiquitinase module controls yeast replicative lifespan via Sir2 interaction. |
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| Q27931892 | The malate-aspartate NADH shuttle components are novel metabolic longevity regulators required for calorie restriction-mediated life span extension in yeast. |
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