scholarly article | Q13442814 |
review article | Q7318358 |
P6179 | Dimensions Publication ID | 1043625377 |
P356 | DOI | 10.1007/S00335-016-9651-X |
P3181 | OpenCitations bibliographic resource ID | 455585 |
P932 | PMC publication ID | 4935730 |
P698 | PubMed publication ID | 27352213 |
P50 | author | Joanna Poulton | Q63363610 |
Alan Diot | Q82380517 | ||
P2093 | author name string | Karl Morten | |
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SIRT3 interacts with the daf-16 homolog FOXO3a in the mitochondria, as well as increases FOXO3a dependent gene expression | Q36868674 | ||
Parkin overexpression during aging reduces proteotoxicity, alters mitochondrial dynamics, and extends lifespan | Q36884177 | ||
Endurance exercise as a countermeasure for aging | Q36943695 | ||
Alzheimer's brains harbor somatic mtDNA control-region mutations that suppress mitochondrial transcription and replication | Q36986848 | ||
Fission and selective fusion govern mitochondrial segregation and elimination by autophagy | Q24652230 | ||
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A mitochondrial superoxide signal triggers increased longevity in Caenorhabditis elegans | Q27322678 | ||
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Aging: a theory based on free radical and radiation chemistry | Q27860549 | ||
Mitochondria-to-nuclear signaling is regulated by the subcellular localization of the transcription factors Rtg1p and Rtg3p | Q27930525 | ||
A basic helix-loop-helix-leucine zipper transcription complex in yeast functions in a signaling pathway from mitochondria to the nucleus | Q27935203 | ||
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The hallmarks of aging | Q28131641 | ||
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans | Q28131824 | ||
Human mitochondrial DNA deletions associated with mutations in the gene encoding Twinkle, a phage T7 gene 4-like protein localized in mitochondria | Q28204177 | ||
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders | Q28252088 | ||
The sirtuin SIRT6 regulates lifespan in male mice | Q28260687 | ||
SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation | Q28275010 | ||
How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis) | Q28278053 | ||
Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression | Q28297737 | ||
Mitochondria-targeted antioxidant preserves contractile properties and mitochondrial function of skeletal muscle in aged rats | Q28385949 | ||
Age-related decrease in the mitochondrial sirtuin deacetylase Sirt3 expression associated with ROS accumulation in the auditory cortex of the mimetic aging rat model. | Q28567717 | ||
Effects of caloric restriction on mitochondrial function and gene transcripts in rat muscle | Q28574883 | ||
Mitochondrial autophagy involving renal injury and aging is modulated by caloric intake in aged rat kidneys | Q28575545 | ||
Increased expression of Drosophila Sir2 extends life span in a dose-dependent manner | Q28662116 | ||
Calorie restriction increases muscle mitochondrial biogenesis in healthy humans | Q28763406 | ||
Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors | Q29614306 | ||
The role of autophagy in neurodegenerative disease | Q29614834 | ||
ROS function in redox signaling and oxidative stress | Q29615229 | ||
ATP-citrate lyase links cellular metabolism to histone acetylation | Q29615367 | ||
Disruption of fusion results in mitochondrial heterogeneity and dysfunction | Q29616566 | ||
The cell-non-autonomous nature of electron transport chain-mediated longevity | Q29617238 | ||
Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration | Q29618751 | ||
High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease | Q29619113 | ||
Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction | Q29619949 | ||
The senescence-associated secretory phenotype: the dark side of tumor suppression | Q29620106 | ||
A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis | Q29620243 | ||
Progressive loss of SIRT1 with cell cycle withdrawal | Q30441451 | ||
Accelerated aging as evidenced by increased telomere shortening and mitochondrial DNA depletion in patients with type 2 diabetes | Q40025985 | ||
Age-dependent mitochondrial energy dynamics in the mice heart: role of superoxide dismutase-2. | Q40305806 | ||
Loss of mitochondrial membrane potential triggers the retrograde response extending yeast replicative lifespan | Q40673643 | ||
Mitochondrial DNA alterations as a source of human disorders | Q40878686 | ||
The daily rhythms of mitochondrial gene expression and oxidative stress regulation are altered by aging in the mouse liver | Q41172588 | ||
Aging-dependent functional alterations of mitochondrial DNA (mtDNA) from human fibroblasts transferred into mtDNA-less cells | Q41186102 | ||
Simultaneous impairment of mitochondrial fission and fusion reduces mitophagy and shortens replicative lifespan | Q41560727 | ||
LON is the master protease that protects against protein aggregation in human mitochondria through direct degradation of misfolded proteins | Q41811406 | ||
A novel quantitative assay of mitophagy: Combining high content fluorescence microscopy and mitochondrial DNA load to quantify mitophagy and identify novel pharmacological tools against pathogenic heteroplasmic mtDNA. | Q41917170 | ||
A mitochondrially targeted compound delays aging in yeast through a mechanism linking mitochondrial membrane lipid metabolism to mitochondrial redox biology | Q41959039 | ||
Autophagy maintains stemness by preventing senescence | Q42487109 | ||
Complex IV-deficient Surf1(-/-) mice initiate mitochondrial stress responses | Q42545198 | ||
Intrinsic cooperation between p16INK4a and p21Waf1/Cip1 in the onset of cellular senescence and tumor suppression in vivo | Q42825660 | ||
Effect of calorie restriction on the metabolic history of chronologically aging yeast | Q43744672 | ||
Increasing organismal healthspan by enhancing mitochondrial protein quality control. | Q45960044 | ||
Mitochondrial DNA polymerase gamma deficiency and mtDNA depletion in a child with Alpers' syndrome. | Q45989418 | ||
Mitochondrial dysfunction leads to reduced chronological lifespan and increased apoptosis in yeast | Q46212558 | ||
Ydc1p ceramidase triggers organelle fragmentation, apoptosis and accelerated ageing in yeast | Q46578356 | ||
Sirt3 inhibits hepatocellular carcinoma cell growth through reducing Mdm2-mediated p53 degradation. | Q46668139 | ||
Mitochondrial dysfunction as a cause of ageing | Q46787387 | ||
A mitochondrial DNA deletion in normally aging and in Alzheimer brain tissue. | Q48275140 | ||
The mitochondrial genotype can influence nuclear gene expression in yeast | Q48350472 | ||
Sirtuin-independent effects of nicotinamide on lifespan extension from calorie restriction in yeast. | Q48422925 | ||
Iron-Starvation-Induced Mitophagy Mediates Lifespan Extension upon Mitochondrial Stress in C. elegans. | Q49128288 | ||
Defective mitophagy in XPA via PARP-1 hyperactivation and NAD(+)/SIRT1 reduction. | Q35165995 | ||
The anti-ageing effects of caloric restriction may involve stimulation of macroautophagy and lysosomal degradation, and can be intensified pharmacologically | Q35187790 | ||
The role of mitochondrial DNA rearrangements in aging and human diseases | Q35207232 | ||
Mitochondrial and nuclear accumulation of the transcription factor ATFS-1 promotes OXPHOS recovery during the UPR(mt). | Q35269008 | ||
Association of mitochondrial DNA damage with aging and coronary atherosclerotic heart disease | Q35340937 | ||
Stem cells. Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness | Q35509884 | ||
Global variability in gene expression and alternative splicing is modulated by mitochondrial content | Q35561948 | ||
L-Lactate Protects Skin Fibroblasts against Aging-Associated Mitochondrial Dysfunction via Mitohormesis | Q35773497 | ||
Programmed cell death in aging | Q35779447 | ||
To unite or divide: mitochondrial dynamics in the murine outer retina that preceded age related photoreceptor loss | Q35783316 | ||
Effects of lithium on age-related decline in mitochondrial turnover and function in Caenorhabditis elegans. | Q50464262 | ||
Light-dark condition regulates sirtuin mRNA levels in the retina. | Q51016231 | ||
Coenzyme Q Protects Against Age-Related Alveolar Bone Loss Associated to n-6 Polyunsaturated Fatty Acid Rich-Diets by Modulating Mitochondrial Mechanisms. | Q51608997 | ||
Aging- and oxygen-induced modifications in brain biochemistry and behavior. | Q53313669 | ||
Mistargeted mitochondrial proteins activate a proteostatic response in the cytosol. | Q53394237 | ||
Epigenome-wide association study in the European Prospective Investigation into Cancer and Nutrition (EPIC-Turin) identifies novel genetic loci associated with smoking | Q57054077 | ||
Telomerase does not counteract telomere shortening but protects mitochondrial function under oxidative stress | Q60284577 | ||
Neurodegenerative diseases: new concepts of pathogenesis and their therapeutic implications | Q37014754 | ||
Thymidine kinase and mtDNA depletion in human cardiomyopathy: epigenetic and translational evidence for energy starvation | Q37054681 | ||
A novel role for mitochondria in regulating epigenetic modification in the nucleus | Q37091272 | ||
What causes mitochondrial DNA deletions in human cells? | Q37096545 | ||
A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues | Q37147048 | ||
Sirt3 regulates metabolic flexibility of skeletal muscle through reversible enzymatic deacetylation | Q37193340 | ||
Germline mitochondrial DNA mutations aggravate ageing and can impair brain development | Q37288018 | ||
Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice | Q37328511 | ||
Muscle mitohormesis promotes longevity via systemic repression of insulin signaling | Q37377087 | ||
A methylome-wide study of aging using massively parallel sequencing of the methyl-CpG-enriched genomic fraction from blood in over 700 subjects | Q37572145 | ||
Actin dynamics affect mitochondrial quality control and aging in budding yeast | Q37599011 | ||
Antiaging properties of a grape-derived antioxidant are regulated by mitochondrial balance of fusion and fission leading to mitophagy triggered by a signaling network of Sirt1-Sirt3-Foxo3-PINK1-PARKIN. | Q37616776 | ||
Regulation of MnSOD enzymatic activity by Sirt3 connects the mitochondrial acetylome signaling networks to aging and carcinogenesis | Q37617643 | ||
Markers of human skeletal muscle mitochondrial biogenesis and quality control: effects of age and aerobic exercise training | Q37670850 | ||
Activation of the mitochondrial unfolded protein response does not predict longevity in Caenorhabditis elegans | Q37699083 | ||
Mitochondrial dynamics in yeast cell death and aging | Q37936567 | ||
Myocardial substrate metabolism in heart disease | Q37971767 | ||
Mitochondrial quality control: a matter of life and death for neurons | Q37987023 | ||
Tightrope act: autophagy in stem cell renewal, differentiation, proliferation, and aging. | Q38016322 | ||
Fusion and fission: interlinked processes critical for mitochondrial health | Q38039146 | ||
The roles of senescence and telomere shortening in cardiovascular disease | Q38088106 | ||
Evaluating and responding to mitochondrial dysfunction: the mitochondrial unfolded-protein response and beyond | Q38089315 | ||
Oxidative stress response elicited by mitochondrial dysfunction: implication in the pathophysiology of aging | Q38121750 | ||
Loss-of-SIRT1 function during vascular ageing: hyperphosphorylation mediated by cyclin-dependent kinase 5. | Q38130762 | ||
Mitochondria: Are they causal players in cellular senescence? | Q38509689 | ||
The epigenetics of aging and neurodegeneration. | Q38527233 | ||
Mitochondria and the non-genetic origins of cell-to-cell variability: More is different. | Q38667428 | ||
Stem cells and healthy aging | Q38702921 | ||
Mutant SOD1G93A triggers mitochondrial fragmentation in spinal cord motor neurons: neuroprotection by SIRT3 and PGC-1α. | Q38844786 | ||
Coenzyme Q-dependent mitochondrial respiratory chain activity in granulosa cells is reduced with aging. | Q38998682 | ||
Aberrant expression of SIRT3 is conversely correlated with the progression and prognosis of human gastric cancer | Q39052574 | ||
Mitochondrial DNA haplotypes define gene expression patterns in pluripotent and differentiating embryonic stem cells. | Q39212570 | ||
Global DNA methylation levels are modulated by mitochondrial DNA variants | Q39396837 | ||
Random intracellular drift explains the clonal expansion of mitochondrial DNA mutations with age. | Q39413342 | ||
Mitochondria, maternal inheritance, and asymmetric fitness: why males die younger | Q39492752 | ||
The SIRT1 activator SRT1720 extends lifespan and improves health of mice fed a standard diet | Q33566310 | ||
The accumulation of misfolded proteins in the mitochondrial matrix is sensed by PINK1 to induce PARK2/Parkin-mediated mitophagy of polarized mitochondria | Q33638683 | ||
MitoTimer probe reveals the impact of autophagy, fusion, and motility on subcellular distribution of young and old mitochondrial protein and on relative mitochondrial protein age | Q33638695 | ||
Caloric restriction prevents age-associated accrual of oxidative damage to mouse skeletal muscle mitochondria | Q33735271 | ||
The matrix peptide exporter HAF-1 signals a mitochondrial UPR by activating the transcription factor ZC376.7 in C. elegans | Q33757350 | ||
Metformin promotes lifespan through mitohormesis via the peroxiredoxin PRDX-2 | Q33790225 | ||
The age-related accumulation of a mitochondrial DNA control region mutation in muscle, but not brain, detected by a sensitive PNA-directed PCR clamping based method | Q33826111 | ||
Mitochondrial ROS production correlates with, but does not directly regulate lifespan in Drosophila | Q33894012 | ||
Transmission from centenarians to their offspring of mtDNA heteroplasmy revealed by ultra-deep sequencing | Q33910477 | ||
Mitochondrial ultrastructure and markers of dynamics in hepatocytes from aged, calorie restricted mice fed with different dietary fats | Q33925058 | ||
Caloric restriction decreases mitochondrial free radical generation at complex I and lowers oxidative damage to mitochondrial DNA in the rat heart | Q33953235 | ||
Sublethal mitochondrial stress with an attendant stoichiometric augmentation of reactive oxygen species may precipitate many of the beneficial alterations in cellular physiology produced by caloric restriction, intermittent fasting, exercise and die | Q33990893 | ||
A mitochondrial specific stress response in mammalian cells | Q34090940 | ||
The frequency of heteroplasmy in the HVII region of mtDNA differs across tissue types and increases with age. | Q34145586 | ||
Sirt3 protects cortical neurons against oxidative stress via regulating mitochondrial Ca2+ and mitochondrial biogenesis | Q34158665 | ||
Clonal expansion of early to mid-life mitochondrial DNA point mutations drives mitochondrial dysfunction during human ageing. | Q34213867 | ||
AMPK modulates tissue and organismal aging in a non-cell-autonomous manner | Q34254596 | ||
Calorie restriction extends yeast life span by lowering the level of NADH. | Q34289946 | ||
Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction in the mouse | Q34323890 | ||
SirT3 regulates the mitochondrial unfolded protein response | Q34390829 | ||
Genetic and environmental exposures constrain epigenetic drift over the human life course | Q34439314 | ||
NRMT1 knockout mice exhibit phenotypes associated with impaired DNA repair and premature aging | Q34470316 | ||
Association of telomere length and mitochondrial DNA copy number in a community sample of healthy adults | Q34470450 | ||
CNS SIRT3 expression is altered by reactive oxygen species and in Alzheimer's disease | Q34471903 | ||
Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans | Q34472739 | ||
Mitochondrial quality control and age-associated arterial stiffening | Q34613192 | ||
Neutral mitochondrial heteroplasmy and the influence of aging | Q34718136 | ||
SIRT3 opposes reprogramming of cancer cell metabolism through HIF1α destabilization | Q34729713 | ||
Differential expression of sirtuin family members in the developing, adult, and aged rat brain. | Q34730013 | ||
Mito-protective autophagy is impaired in erythroid cells of aged mtDNA-mutator mice | Q34802375 | ||
Human aging and somatic point mutations in mtDNA: A comparative study of generational differences (grandparents and grandchildren). | Q34896871 | ||
Dysregulation of mitochondrial quality control processes contribute to sarcopenia in a mouse model of premature aging | Q34919832 | ||
The effect of pro-inflammatory conditioning and/or high glucose on telomere shortening of aging fibroblasts | Q35004804 | ||
Mathematical modeling of the role of mitochondrial fusion and fission in mitochondrial DNA maintenance | Q35022679 | ||
P275 | copyright license | Creative Commons Attribution 4.0 International | Q20007257 |
P6216 | copyright status | copyrighted | Q50423863 |
P433 | issue | 7-8 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | cell | Q7868 |
regulation of gene expression | Q411391 | ||
autophagy of mitochondrion | Q1806192 | ||
genetic epigenesis | Q64443099 | ||
physiological phenomenon | Q66615932 | ||
P1104 | number of pages | 15 | |
P304 | page(s) | 381-395 | |
P577 | publication date | 2016-06-28 | |
2016-08-01 | |||
P1433 | published in | Mammalian Genome | Q1348949 |
P1476 | title | Mitophagy plays a central role in mitochondrial ageing | |
P478 | volume | 27 |
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