Yeast as a tool to identify anti-aging compounds.

scientific article published in September 2018

Yeast as a tool to identify anti-aging compounds. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1093/FEMSYR/FOY020
P932PMC publication ID6001894
P698PubMed publication ID29905792

P50authorSebastian HoferQ56784490
Andreas ZimmermannQ60609278
P2093author name stringDidac Carmona-Gutierrez
Frank Madeo
Katharina Kainz
Tobias Pendl
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Chemical genetic screen identifies lithocholic acid as an anti-aging compound that extends yeast chronological life span in a TOR-independent manner, by modulating housekeeping longevity assurance processesQ24616983
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Rapamycin fed late in life extends lifespan in genetically heterogeneous miceQ24647805
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Growth factors, nutrient signaling, and cardiovascular agingQ26852243
The search for antiaging interventions: from elixirs to fasting regimensQ26863497
Aging and cell death in the other yeasts, Schizosaccharomyces pombe and Candida albicansQ26866874
Spermidine Suppresses Age-Associated Memory Impairment by Preventing Adverse Increase of Presynaptic Active Zone Size and ReleaseQ27340068
Resveratrol improves health and survival of mice on a high-calorie dietQ27860950
Regulation of longevity and stress resistance by Sch9 in yeastQ27929987
The cell death protease Kex1p is essential for hypochlorite-induced apoptosis in yeast.Q27937978
A caspase-related protease regulates apoptosis in yeastQ27938405
Role of gamma-glutamyltranspeptidase in detoxification of xenobiotics in the yeasts Hansenula polymorpha and Saccharomyces cerevisiae.Q27938544
The pleitropic drug ABC transporters from Saccharomyces cerevisiae.Q27938933
A new dominant peroxiredoxin allele identified by whole-genome re-sequencing of random mutagenized yeast causes oxidant-resistance and premature agingQ27939527
Essential role for autophagy in life span extensionQ28085050
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Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespanQ28203572
Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screeningQ28210511
A human tRNA synthetase is a potent PARP1-activating effector target for resveratrolQ28254419
Endonuclease G mediates α-synuclein cytotoxicity during Parkinson's diseaseQ28300290
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Identification of a small molecule inhibitor of Sir2pQ28344005
Genome-wide consequences of deleting any single geneQ28383348
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Ink4a/Arf expression is a biomarker of agingQ28570483
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Induction of autophagy by spermidine promotes longevityQ29614498
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Ribosomal protein S6 kinase 1 signaling regulates mammalian life spanQ29615975
Genome-wide analysis of functional sirtuin chromatin targets in yeastQ30412508
A microarray-based genetic screen for yeast chronological aging factorsQ30436367
The genetic architecture in Saccharomyces cerevisiae that contributes to variation in drug response to the antifungals benomyl and ketoconazole.Q53313492
Ribosomal proteins Rpl10 and Rps6 are potent regulators of yeast replicative life span.Q53582417
p16INK4A is a robust in vivo biomarker of cellular aging in human skin.Q53605130
Chemical genetic screen in fission yeast reveals roles for vacuolar acidification, mitochondrial fission, and cellular GMP levels in lifespan extension.Q54442297
The therapeutic potential of resveratrol: a review of clinical trials.Q55151370
Ceramide triggers metacaspase-independent mitochondrial cell death in yeastQ58350041
Yeast as an honorary mammalQ74071835
Yeast as a model system for anticancer drug discoveryQ80146770
Type 5 adenylyl cyclase disruption increases longevity and protects against stressQ80700459
Aminoguanidine delays the replicative senescence of human diploid fibroblasts.Q46859641
Defects in N-glycosylation induce apoptosis in yeastQ46899354
A yeast-based cytotoxicity and genotoxicity assay for environmental monitoring using novel portable instrumentationQ47249706
A Novel Sterol-Signaling Pathway Governs Azole Antifungal Drug Resistance and Hypoxic Gene Repression in Saccharomyces cerevisiae.Q47274009
Guidelines and recommendations on yeast cell death nomenclature.Q47550728
Cell differentiation within a yeast colony: metabolic and regulatory parallels with a tumor-affected organism.Q47804989
Glycation inhibitors extend yeast chronological lifespan by reducing advanced glycation end products and by back regulation of proteins involved in mitochondrial respirationQ47987670
Spermidine in health and disease.Q48163525
The integrated stress response in budding yeast lifespan extension.Q49278406
Methods to Assess Autophagy and Chronological Aging in Yeast.Q50207016
Effect of Low-Dose Rapamycin on Senescence Markers and Physical Functioning in Older Adults with Coronary Artery Disease: Results of a Pilot Study.Q51305911
Transcriptional remodeling in response to transfer upon carbon-limited or metformin-supplemented media in S. cerevisiae and its effect on chronological life span.Q51619207
Age-dependent accumulation of advanced glycation end-products in adult Drosophila melanogaster.Q52563298
New rapid screening method for anti-aging compounds using budding yeast and identification of beauveriolide I as a potent active compound.Q53157400
Autophagy extends lifespan via vacuolar acidificationQ37705715
Simple is good: yeast models of neurodegeneration.Q37767749
Cytochrome P450 enzymes in the fungal kingdomQ37771488
Mitochondria, reactive oxygen species, and chronological aging: a message from yeastQ37925178
Chronological aging in Saccharomyces cerevisiaeQ37957577
Chaperone networks in protein disaggregation and prion propagationQ38009622
Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variationQ38075335
Aging and differentiation in yeast populations: elders with different properties and functionsQ38151967
Lipids and cell death in yeastQ38151973
Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decadeQ38616109
Studying the replicative life span of yeast cellsQ38729455
The budding yeast Saccharomyces cerevisiae as a model organism: possible implications for gerontological studies.Q38749590
Caloric Restriction Mimetics Enhance Anticancer ImmunosurveillanceQ38758370
Intracellular pH Modulates Autophagy and Mitophagy.Q38792770
The Substrate Specificity of SirtuinsQ38810867
The frequency of yeast [PSI+] prion formation is increased during chronological ageingQ38823866
Yeast proteinopathy models: a robust tool for deciphering the basis of neurodegeneration.Q39208066
Live fast, die soon: cell cycle progression and lifespan in yeast cellsQ39208079
From the baker to the bedside: yeast models of Parkinson's disease.Q39208122
Autophagy: machinery and regulationQ39208155
Signaling pathways and posttranslational modifications of tau in Alzheimer's disease: the humanization of yeast cellsQ39208164
Exacerbating and reversing lysosomal storage diseases: from yeast to humansQ40038745
The Coordinated Action of Calcineurin and Cathepsin D Protects Against α-Synuclein Toxicity.Q40998960
Cellular responses of Saccharomyces cerevisiae at near-zero growth rates: transcriptome analysis of anaerobic retentostat cultures.Q41138196
Yeast as a model system to screen purine derivatives against human CDK1 and CDK2 kinasesQ41648702
Autophagy is a critical regulator of memory CD8(+) T cell formationQ41668622
Autophagy is required for extension of yeast chronological life span by rapamycinQ41679914
Rapamycin ameliorates age-dependent obesity associated with increased mTOR signaling in hypothalamic POMC neuronsQ41774391
Expression of a human cytochrome p450 in yeast permits analysis of pathways for response to and repair of aflatoxin-induced DNA damageQ41834934
Somatic growth, aging, and longevityQ41907365
A yeast mutant showing diagnostic markers of early and late apoptosisQ42065466
Inhibition of Aβ42 oligomerization in yeast by a PICALM ortholog and certain FDA approved drugsQ42119629
A yeast-based model of alpha-synucleinopathy identifies compounds with therapeutic potentialQ42167795
Recovery from rapamycin: drug-insensitive activity of yeast target of rapamycin complex 1 (TORC1) supports residual proliferation that dilutes rapamycin among progeny cells.Q42212596
Yeast screening platform identifies FDA-approved drugs that reduce Aβ oligomerizationQ42316646
Anti-inflammatory and antioxidant effects of resveratrol in healthy smokers a randomized, double-blind, placebo-controlled, cross-over trialQ42713454
Chronological aging leads to apoptosis in yeastQ42774835
Oxygen stress: a regulator of apoptosis in yeastQ42797452
Identification of ACA-28, a 1'-acetoxychavicol acetate analogue compound, as a novel modulator of ERK MAPK signaling, which preferentially kills human melanoma cells.Q42800772
Evolution. Systematic humanization of yeast genes reveals conserved functions and genetic modularityQ43079790
Elevation of endogenous sphingolipid long-chain base phosphates kills Saccharomyces cerevisiae cellsQ43857471
Regulation of longevity and stress resistance: a molecular strategy conserved from yeast to humans?Q44095372
Restoring polyamines protects from age-induced memory impairment in an autophagy-dependent mannerQ44800085
A common highly conserved cadmium detoxification mechanism from bacteria to humans: heavy metal tolerance conferred by the ATP-binding cassette (ABC) transporter SpHMT1 requires glutathione but not metal-chelating phytochelatin peptidesQ46215291
A genome-wide screen for FTY720-sensitive mutants reveals genes required for ROS homeostasisQ46242463
A method for high-throughput quantitative analysis of yeast chronological life spanQ46722596
High-throughput screening for growth inhibitors using a yeast model of familial paragangliomaQ30457876
Insights into TOR function and rapamycin response: chemical genomic profiling by using a high-density cell array method.Q30852003
High-throughput screening for fatty acid uptake inhibitors in humanized yeast identifies atypical antipsychotic drugs that cause dyslipidemiasQ33302249
Detection of compounds that rescue Rab1-synuclein toxicityQ33326182
An integrated platform of genomic assays reveals small-molecule bioactivitiesQ33351287
Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson's disease modelsQ33521022
Recombinant yeast screen for new inhibitors of human acetyl-CoA carboxylase 2 identifies potential drugs to treat obesityQ33571309
Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neuronsQ33616462
A simple microfluidic platform to study age-dependent protein abundance and localization changes in Saccharomyces cerevisiaeQ33658227
Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogasterQ33665807
Effects of resveratrol on cerebral blood flow variables and cognitive performance in humans: a double-blind, placebo-controlled, crossover investigation.Q34107721
Candida Albicans: a molecular revolution built on lessons from budding yeastQ34161985
An overview on glutathione in versus non-conventional yeastsQ34191410
The role of glutathione-S-transferase in anti-cancer drug resistanceQ34272162
Metformin improves healthspan and lifespan in miceQ34360789
Growth signaling promotes chronological aging in budding yeast by inducing superoxide anions that inhibit quiescenceQ34361242
Yeast reveal a "druggable" Rsp5/Nedd4 network that ameliorates α-synuclein toxicity in neurons.Q34380191
Cardioprotection and lifespan extension by the natural polyamine spermidine.Q34544613
Advanced glycation end products: sparking the development of diabetic vascular injuryQ34555042
Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteomeQ34600785
SOD2 functions downstream of Sch9 to extend longevity in yeastQ34616845
Resveratrol prevents high fat/sucrose diet-induced central arterial wall inflammation and stiffening in nonhuman primates.Q34624641
Target identification and mechanism of action in chemical biology and drug discoveryQ34626974
Yeast as a biosensor of detoxification: a tool for identifying new compounds that revert multidrug resistance.Q34686134
Separation of mother and daughter cellsQ34694887
Quantification of genetically controlled cell death in budding yeastQ34754970
Screen for small molecules increasing the mitochondrial membrane potentialQ34836339
Spermidine induces autophagy by inhibiting the acetyltransferase EP300.Q35079516
Phosphatidylethanolamine positively regulates autophagy and longevityQ35079520
Protein folding and quality control in the endoplasmic reticulum: Recent lessons from yeast and mammalian cell systemsQ35160159
Chemogenomic profiling: identifying the functional interactions of small molecules in yeastQ35554300
Target of rapamycin (TOR) in nutrient signaling and growth controlQ35620394
Yeast as a system for modeling mitochondrial disease mechanisms and discovering therapiesQ35687142
Different 8-hydroxyquinolines protect models of TDP-43 protein, α-synuclein, and polyglutamine proteotoxicity through distinct mechanismsQ35763165
A High-Throughput Genetic Complementation Assay in Yeast Cells Identified Selective Inhibitors of Sphingosine Kinase 1 Not Found Using a Cell-Free Enzyme AssayQ35794951
H3K36 methylation promotes longevity by enhancing transcriptional fidelityQ35879041
Identification of a small molecule yeast TORC1 inhibitor with a multiplex screen based on flow cytometryQ35903219
High-throughput analysis of yeast replicative aging using a microfluidic systemQ35910113
Using Yeast Transposon-Insertion Libraries for Phenotypic Screening and Protein LocalizationQ36037048
Continuous beer fermentation using immobilized yeast cell bioreactor systems.Q36149046
The Ca2+/Mn2+ ion-pump PMR1 links elevation of cytosolic Ca(2+) levels to α-synuclein toxicity in Parkinson's disease modelsQ36603128
The role of mitochondria in agingQ36638140
Measurement of lifespan in Drosophila melanogasterQ36639173
Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humansQ36658296
Metformin: an old but still the best treatment for type 2 diabetesQ36715464
Resveratrol for primary prevention of atherosclerosis: clinical trial evidence for improved gene expression in vascular endothelium.Q36823957
Development of the FUN-1 family of fluorescent probes for vacuole labeling and viability testing of yeastsQ36869468
A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging.Q36888608
Pathways change in expression during replicative aging in Saccharomyces cerevisiaeQ36924456
Epigenetic silencing mediates mitochondria stress-induced longevityQ36960145
Combining chemical genomics screens in yeast to reveal spectrum of effects of chemical inhibition of sphingolipid biosynthesisQ37076826
Drug-induced apoptosis in yeastQ37077860
Replicative aging in yeast: the means to the endQ37212205
Passage of molecules through yeast cell walls: a brief essay-reviewQ37249507
Resveratrol improves adipose insulin signaling and reduces the inflammatory response in adipose tissue of rhesus monkeys on high-fat, high-sugar diet.Q37320110
Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4.Q37359194
Targeting mTOR with rapamycin: one dose does not fit allQ37409171
Fission yeast and other yeasts as emergent models to unravel cellular aging in eukaryotes.Q37624333
Apoptosis in yeast: triggers, pathways, subroutinesQ37675909
Rapamycin: one drug, many effectsQ37679469
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue6
P921main subjecteukaryoteQ19088
yeastQ45422
biomedical investigative techniqueQ66648976
small molecule librariesQ50573438
P577publication date2018-09-01
P1433published inFEMS Yeast ResearchQ15751211
P1476titleYeast as a tool to identify anti-aging compounds.
P478volume18

Reverse relations

cites work (P2860)
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