The Coordinated Action of Calcineurin and Cathepsin D Protects Against α-Synuclein Toxicity.

scientific article published on 30 June 2017

The Coordinated Action of Calcineurin and Cathepsin D Protects Against α-Synuclein Toxicity. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3389/FNMOL.2017.00207
P932PMC publication ID5491553
P698PubMed publication ID28713240

P50authorAndreas AufschnaiterQ40999037
Tobias EisenbergQ56418521
Sabrina BüttnerQ59661707
Verena KohlerQ87983331
Walter KellerQ38325496
P2093author name stringDidac Carmona-Gutierrez
Lukas Habernig
Jutta Diessl
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Endosome to Golgi retrieval of the vacuolar protein sorting receptor, Vps10p, requires the function of the VPS29, VPS30, and VPS35 gene productsQ27939459
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The role of the ubiquitin-proteasomal pathway in Parkinson's disease and other neurodegenerative disordersQ28205399
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Critical role of calpain-mediated cleavage of calcineurin in excitotoxic neurodegeneration.Q33195171
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Optimization of formaldehyde cross-linking for protein interaction analysis of non-tagged integrin beta1Q33961172
The calcineurin signaling network evolves via conserved kinase-phosphatase modules that transcend substrate identityQ34021964
Lysosomes and α-synuclein form a dangerous duet leading to neuronal cell death.Q34043163
Calcineurin determines toxic versus beneficial responses to α-synucleinQ34120215
Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicityQ39914071
Control of macroautophagy by calcium, calmodulin-dependent kinase kinase-beta, and Bcl-2.Q40179972
An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeastQ41970961
Homotypic vacuole fusion in yeast requires organelle acidification and not the V-ATPase membrane domain.Q42105526
Nilotinib reverses loss of dopamine neurons and improves motor behavior via autophagic degradation of -synuclein in Parkinson's disease modelsQ42711308
The Rab GTPase Ypt7 is linked to retromer-mediated receptor recycling and fusion at the yeast late endosomeQ42825741
Yeast cells provide insight into alpha-synuclein biology and pathobiologyQ42988614
Ca 2+ -dependent autophagy is enhanced by the pharmacological agent PK11195.Q43079159
Mitochondrial degradation in acetic acid-induced yeast apoptosis: the role of Pep4 and the ADP/ATP carrierQ43117448
Forebrain-specific calcineurin knockout selectively impairs bidirectional synaptic plasticity and working/episodic-like memoryQ43815520
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Functional mitochondria are required for alpha-synuclein toxicity in aging yeast.Q46810246
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pH-dependent processing of yeast procarboxypeptidase Y by proteinase A in vivo and in vitroQ61447128
Cytosolic acidification stimulates a calcium influx that activates Na(+)-H+ exchange in LLC-PK1Q68258899
Oxidative stress-induced phosphorylation, degradation and aggregation of alpha-synuclein are linked to upregulated CK2 and cathepsin DQ80831427
Mitochondrial dysfunction in Parkinson's diseaseQ88170868
The molecular machinery for lysosome biogenesisQ34194555
Yeast reveal a "druggable" Rsp5/Nedd4 network that ameliorates α-synuclein toxicity in neurons.Q34380191
Identification of genes affecting vacuole membrane fragmentation in Saccharomyces cerevisiaeQ34577025
In vivo demonstration that alpha-synuclein oligomers are toxicQ34652122
α-Synuclein impairs macroautophagy: implications for Parkinson's disease.Q35005567
The propeptide of yeast cathepsin D inhibits programmed necrosis.Q35064998
Lifespan extension by methionine restriction requires autophagy-dependent vacuolar acidificationQ35160736
Calcineurin signaling in Saccharomyces cerevisiae: how yeast go crazy in response to stressQ35586574
Vacuole acidification is required for trans-SNARE pairing, LMA1 release, and homotypic fusionQ35642673
Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodiesQ35764504
Vacuolar H+-ATPase (V-ATPase) Promotes Vacuolar Membrane Permeabilization and Nonapoptotic Death in Stressed YeastQ36003655
Mannose 6-Phosphate Receptor Is Reduced in -Synuclein Overexpressing Models of Parkinsons DiseaseQ36100354
The Ca2+/Mn2+ ion-pump PMR1 links elevation of cytosolic Ca(2+) levels to α-synuclein toxicity in Parkinson's disease modelsQ36603128
Vacuolar and plasma membrane proton pumps collaborate to achieve cytosolic pH homeostasis in yeastQ36761876
TFEB-mediated autophagy rescues midbrain dopamine neurons from α-synuclein toxicityQ36835587
Bleach gel: A simple agarose gel for analyzing RNA qualityQ36975439
Acetate-induced apoptosis in colorectal carcinoma cells involves lysosomal membrane permeabilization and cathepsin D releaseQ37073584
Cathepsin D expression level affects alpha-synuclein processing, aggregation, and toxicity in vivo.Q37102231
The yeast lysosome-like vacuole: endpoint and crossroadsQ37266848
A sorting nexin-1 homologue, Vps5p, forms a complex with Vps17p and is required for recycling the vacuolar protein-sorting receptorQ37386983
Blockade of protein phosphatase 2B activity in the amygdala increases anxiety- and depression-like behaviors in miceQ37455947
The Role of Autophagy in Parkinson's DiseaseQ37999796
Lysosome-dependent pathways as a unifying theme in Parkinson's disease.Q38038561
Dysfunction of the autophagy/lysosomal degradation pathway is a shared feature of the genetic synucleinopathiesQ38107478
Lysosomal Dysfunction and α-Synuclein Aggregation in Parkinson's Disease: Diagnostic Links.Q38753762
Cathepsin D protects colorectal cancer cells from acetate-induced apoptosis through autophagy-independent degradation of damaged mitochondriaQ38862588
Corynoxine, a natural autophagy enhancer, promotes the clearance of alpha-synuclein via Akt/mTOR pathwayQ39024437
Calcium: Alpha-Synuclein Interactions in Alpha-SynucleinopathiesQ39075636
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AMPK-independent induction of autophagy by cytosolic Ca2+ increase.Q39746175
The inositol 1,4,5-trisphosphate receptor regulates autophagy through its interaction with Beclin 1.Q39867616
P921main subjectSynucleinQ24767155
P304page(s)207
P577publication date2017-06-30
P1433published inFrontiers in Molecular NeuroscienceQ27721913
P1476titleThe Coordinated Action of Calcineurin and Cathepsin D Protects Against α-Synuclein Toxicity
P478volume10

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cites work (P2860)
Q58565095A Cinderella story: how the vacuolar proteases Pep4 and Prb1 do more than cleaning up the cell's mass degradation processes
Q92824710Acetyl-CoA carboxylase 1-dependent lipogenesis promotes autophagy downstream of AMPK
Q91975980Cytotoxic and Antitumor Activity of Lactaptin in Combination with Autophagy Inducers and Inhibitors
Q99202584Membrane-tethering of cytochrome c accelerates regulated cell death in yeast
Q91795634Stable and destabilized GFP reporters to monitor calcineurin activity in Saccharomyces cerevisiae
Q47112563Taking out the garbage: cathepsin D and calcineurin in neurodegeneration.
Q55442883The Enzymatic Core of the Parkinson’s Disease-Associated Protein LRRK2 Impairs Mitochondrial Biogenesis in Aging Yeast.
Q55262989Yeast as a tool to identify anti-aging compounds.

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