| scholarly article | Q13442814 |
| P50 | author | James F. Gusella | Q1602688 |
| P2093 | author name string | Hiroki Takano | |
| P2860 | cites work | The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs | Q22001450 |
| Structure of the nuclear transport complex karyopherin-beta2-Ran x GppNHp | Q22009923 | ||
| Structure of importin-beta bound to the IBB domain of importin-alpha | Q27618407 | ||
| Structural view of the Ran-Importin beta interaction at 2.3 A resolution | Q27618579 | ||
| Fitting a mixture model by expectation maximization to discover motifs in biopolymers | Q27860556 | ||
| A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. | Q27860836 | ||
| Targeted gene expression as a means of altering cell fates and generating dominant phenotypes | Q27861039 | ||
| Flamingo, a seven-pass transmembrane cadherin, regulates planar cell polarity under the control of Frizzled | Q28144517 | ||
| Topological characteristics of helical repeat proteins | Q28199033 | ||
| Combining evidence using p-values: application to sequence homology searches | Q28265811 | ||
| Wild-type and mutant huntingtins function in vesicle trafficking in the secretory and endocytic pathways | Q28277799 | ||
| Huntingtin: an iron-regulated protein essential for normal nuclear and perinuclear organelles | Q28589989 | ||
| Huntingtin is required for neurogenesis and is not impaired by the Huntington's disease CAG expansion | Q28594526 | ||
| Inactivation of Hdh in the brain and testis results in progressive neurodegeneration and sterility in mice | Q28594828 | ||
| Comparison of ARM and HEAT protein repeats | Q29616046 | ||
| NF-kappaB to the rescue: RELs, apoptosis and cellular transformation | Q33650519 | ||
| Protein function in the post-genomic era. | Q33906809 | ||
| Localizing proteins in the cell from their phylogenetic profiles. | Q33921865 | ||
| Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis. | Q33948101 | ||
| NF-kappaB transcription factors: critical regulators of hematopoiesis and neuronal survival | Q34013841 | ||
| Wild-type huntingtin reduces the cellular toxicity of mutant huntingtin in vivo | Q34044164 | ||
| Huntington disease: new insights on the role of huntingtin cleavage | Q34112455 | ||
| Loss of normal huntingtin function: new developments in Huntington's disease research | Q34142361 | ||
| Molecular genetics: unmasking polyglutamine triggers in neurodegenerative disease | Q34185510 | ||
| Nuclear import of the Drosophila Rel protein Dorsal is regulated by phosphorylation | Q35190695 | ||
| members only encodes a Drosophila nucleoporin required for rel protein import and immune response activation. | Q35200220 | ||
| Regulated nuclear import of the Drosophila rel protein dorsal: structure-function analysis | Q36557521 | ||
| Huntington's disease. Pathogenesis and management | Q39460676 | ||
| Proteases acting on mutant huntingtin generate cleaved products that differentially build up cytoplasmic and nuclear inclusions | Q40709427 | ||
| Analysis of function and regulation of proteins that mediate signal transduction by use of lipid-modified plasma membrane-targeting sequences | Q40846839 | ||
| Wild-type huntingtin protects from apoptosis upstream of caspase-3. | Q40880907 | ||
| A functional interaction between dorsal and components of the Smt3 conjugation machinery | Q40901992 | ||
| Huntingtin is required for normal hematopoiesis | Q40902755 | ||
| Mutant huntingtin forms in vivo complexes with distinct context-dependent conformations of the polyglutamine segment | Q40922131 | ||
| The dorsoventral signal transduction pathway and the Rel-like transcription factors in Drosophila | Q41595432 | ||
| Early phenotypes that presage late-onset neurodegenerative disease allow testing of modifiers in Hdh CAG knock-in mice | Q43931334 | ||
| Calcium-dependent cleavage of endogenous wild-type huntingtin in primary cortical neurons | Q44117680 | ||
| Huntingtin: a single bait hooks many species | Q45296265 | ||
| A putative Drosophila homolog of the Huntington's disease gene | Q45298821 | ||
| HEAT repeats in the Huntington's disease protein | Q45307276 | ||
| Regulated nuclear import of Rel proteins in the Drosophila immune response | Q47072818 | ||
| Homology-based method for identification of protein repeats using statistical significance estimates. | Q52079602 | ||
| Expression and nuclear translocation of the rel/NF-kappa B-related morphogen dorsal during the immune response of Drosophila. | Q52542588 | ||
| A role for the Drosophila Toll/Cactus pathway in larval hematopoiesis. | Q52562914 | ||
| Cactus-independent regulation of Dorsal nuclear import by the ventral signal. | Q52576177 | ||
| Nuclear import factors importin α and importin β undergo mutually induced conformational changes upon association | Q57973315 | ||
| P433 | issue | 1 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 15 | |
| P577 | publication date | 2002-10-14 | |
| P1433 | published in | BMC Neuroscience | Q15766477 |
| P1476 | title | The predominantly HEAT-like motif structure of huntingtin and its association and coincident nuclear entry with dorsal, an NF-kB/Rel/dorsal family transcription factor | |
| P478 | volume | 3 |
| Q47787775 | A comprehensive in silico analysis of huntingtin and its interactome |
| Q34828144 | A huntingtin peptide inhibits polyQ-huntingtin associated defects |
| Q37653685 | Adaptation to Blue Light in Marine Synechococcus Requires MpeU, an Enzyme with Similarity to Phycoerythrobilin Lyase Isomerases |
| Q33563614 | Age-associated chromatin relaxation is enhanced in Huntington's disease mice |
| Q97570181 | Axonal transport and neurodegenerative disease: vesicle-motor complex formation and their regulation |
| Q34984579 | Categorizer: a tool to categorize genes into user-defined biological groups based on semantic similarity |
| Q64259754 | Cellular Specificity of NF-κB Function in the Nervous System |
| Q35371378 | Characterization of the activities of the CpeY, CpeZ, and CpeS bilin lyases in phycoerythrin biosynthesis in Fremyella diplosiphon strain UTEX 481. |
| Q24619721 | Congenital hydrocephalus associated with abnormal subcommissural organ in mice lacking huntingtin in Wnt1 cell lineages |
| Q45292589 | Decreased BDNF levels are a major contributor to the embryonic phenotype of huntingtin knockdown zebrafish. |
| Q27341119 | Deficiency of huntingtin has pleiotropic effects in the social amoeba Dictyostelium discoideum |
| Q28510315 | Deletion of the triplet repeat encoding polyglutamine within the mouse Huntington's disease gene results in subtle behavioral/motor phenotypes in vivo and elevated levels of ATP with cellular senescence in vitro |
| Q34675885 | Dominant effects of the Huntington's disease HTT CAG repeat length are captured in gene-expression data sets by a continuous analysis mathematical modeling strategy |
| Q36767264 | Drug targeting of dysregulated transcription in Huntington's disease |
| Q45289091 | Expanded-polyglutamine huntingtin protein suppresses the secretion and production of a chemokine (CCL5/RANTES) by astrocytes |
| Q89612213 | Exploring the role of high-mobility group box 1 (HMGB1) protein in the pathogenesis of Huntington's disease |
| Q40295769 | Expression and characterization of full-length human huntingtin, an elongated HEAT repeat protein |
| Q34029504 | Genome wide gene expression regulation by HIP1 Protein Interactor, HIPPI: prediction and validation |
| Q45298206 | HD CAG repeat implicates a dominant property of huntingtin in mitochondrial energy metabolism |
| Q35056067 | HD CAG-correlated gene expression changes support a simple dominant gain of function |
| Q30353778 | Huntingtin Is Required for Neural But Not Cardiac/Pancreatic Progenitor Differentiation of Mouse Embryonic Stem Cells In vitro. |
| Q30164317 | Huntingtin bodies sequester vesicle-associated proteins by a polyproline-dependent interaction. |
| Q33594204 | Huntingtin facilitates polycomb repressive complex 2. |
| Q33263046 | Huntingtin gene evolution in Chordata and its peculiar features in the ascidian Ciona genus |
| Q36981055 | Huntingtin modulates transcription, occupies gene promoters in vivo, and binds directly to DNA in a polyglutamine-dependent manner |
| Q39106346 | Huntingtin polyQ Mutation Impairs the 17β-Estradiol/Neuroglobin Pathway Devoted to Neuron Survival. |
| Q36098669 | Huntingtin proteolysis releases non-polyQ fragments that cause toxicity through dynamin 1 dysregulation. |
| Q36839701 | Huntingtin's spherical solenoid structure enables polyglutamine tract-dependent modulation of its structure and function |
| Q56602105 | Huntingtin: Alive and Well and Working in Middle Management |
| Q28182055 | Huntingtin: alive and well and working in middle management |
| Q39035495 | Huntington's Disease: Mechanisms of Pathogenesis and Therapeutic Strategies |
| Q79121423 | Huntington's disease |
| Q37889820 | Huntington's disease, calcium, and mitochondria |
| Q33193898 | Huntington's disease: a synaptopathy? |
| Q57178431 | Huntington's disease: the coming of age |
| Q35126285 | Identification of binding sites in Huntingtin for the Huntingtin Interacting Proteins HIP14 and HIP14L |
| Q24813199 | Inactivation of the Huntington's disease gene (Hdh) impairs anterior streak formation and early patterning of the mouse embryo |
| Q39426587 | Inhibiting the nucleation of amyloid structure in a huntingtin fragment by targeting α-helix-rich oligomeric intermediates |
| Q30353134 | Is Huntingtin Dispensable in the Adult Brain? |
| Q24311369 | KIAA0649, a 1A6/DRIM-interacting protein with the oncogenic potential |
| Q34699467 | Longitudinal behavioral, cross-sectional transcriptional and histopathological characterization of a knock-in mouse model of Huntington's disease with 140 CAG repeats |
| Q39626047 | Modulation of mutant huntingtin N-terminal cleavage and its effect on aggregation and cell death. |
| Q37776087 | Molecular Mechanisms and Potential Therapeutical Targets in Huntington's Disease |
| Q30837903 | Motivational, proteostatic and transcriptional deficits precede synapse loss, gliosis and neurodegeneration in the B6.HttQ111/+ model of Huntington's disease |
| Q36686156 | Multiple pathways contribute to the pathogenesis of Huntington disease |
| Q37308357 | Mutant huntingtin and mitochondrial dysfunction |
| Q36709527 | NF-kappa B as a therapeutic target in neurodegenerative diseases |
| Q38025541 | NF-κB signaling pathways: role in nervous system physiology and pathology |
| Q28281904 | Normal huntingtin function: an alternative approach to Huntington's disease |
| Q55207041 | Novel DNA Aptamers that Bind to Mutant Huntingtin and Modify Its Activity. |
| Q24624357 | Nuclear transport, oxidative stress, and neurodegeneration |
| Q44931209 | Nuclear-targeting of mutant huntingtin fragments produces Huntington's disease-like phenotypes in transgenic mice |
| Q42654161 | Optimization of trans-Splicing for Huntington's Disease RNA Therapy |
| Q38374920 | Post-Translational Modifications (PTMs), Identified on Endogenous Huntingtin, Cluster within Proteolytic Domains between HEAT Repeats |
| Q34009621 | Regulation of miR-146a by RelA/NFkB and p53 in STHdh(Q111)/Hdh(Q111) cells, a cell model of Huntington's disease |
| Q28544898 | Scalable production in human cells and biochemical characterization of full-length normal and mutant huntingtin |
| Q24681194 | Stimulation of NeuroD activity by huntingtin and huntingtin-associated proteins HAP1 and MLK2 |
| Q30153482 | Structural and biochemical characterization of the bilin lyase CpcS from Thermosynechococcus elongatus |
| Q55099888 | The COOH-terminal domain of huntingtin interacts with RhoGEF kalirin and modulates cell survival. |
| Q28571426 | The Huntington's disease mutation impairs Huntingtin's role in the transport of NF-κB from the synapse to the nucleus. |
| Q37969749 | The biological function of the Huntingtin protein and its relevance to Huntington's Disease pathology |
| Q50551501 | The composition of the polyglutamine-containing proteins influences their co-aggregation properties. |
| Q52162415 | The cryo-electron microscopy structure of huntingtin |
| Q28203006 | The hunt for huntingtin function: interaction partners tell many different stories |
| Q28087539 | The promise and perils of HDAC inhibitors in neurodegeneration |
| Q34411338 | Therapeutic approaches to preventing cell death in Huntington disease |
| Q35113363 | Transcriptional abnormalities in Huntington disease |
| Q28469280 | Unbiased gene expression analysis implicates the huntingtin polyglutamine tract in extra-mitochondrial energy metabolism |
| Q24316303 | pARIS-htt: an optimised expression platform to study huntingtin reveals functional domains required for vesicular trafficking |
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