Limited durability of viral control following treated acute HIV infection

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Limited durability of viral control following treated acute HIV infection is …
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scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PMED.0010036
P932PMC publication ID524377
P698PubMed publication ID15526059
P5875ResearchGate publication ID8194653

P50authorMarylyn AddoQ66714025
Marcus AltfeldQ72531060
Daniel E KaufmannQ87677945
Eric S RosenbergQ89548046
Mathias LichterfeldQ91496240
Elizabeth T KalifeQ114576937
Daryld A StrickQ114576938
Bruce D. WalkerQ23770361
P2093author name stringMary N Johnston
Bradford S Wagner
Paul K Lee
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Stimulation of HIV-specific cellular immunity by structured treatment interruption fails to enhance viral control in chronic HIV infectionQ24536249
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Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapyQ29615992
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Analysis of total human immunodeficiency virus (HIV)-specific CD4(+) and CD8(+) T-cell responses: relationship to viral load in untreated HIV infectionQ33869806
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High-level HIV-1 viremia suppresses viral antigen-specific CD4(+) T cell proliferationQ33950164
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Human immunodeficiency virus type 1 fitness is a determining factor in viral rebound and set point in chronic infectionQ34227596
Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no correlation to viral load.Q34468117
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Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairmentQ34857689
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Cellular immune responses and viral diversity in individuals treated during acute and early HIV-1 infection.Q36369035
HIV-1 viremia prevents the establishment of interleukin 2-producing HIV-specific memory CD4+ T cells endowed with proliferative capacityQ36371562
Diminished Proliferation of Human Immunodeficiency Virus-Specific CD4+T Cells Is Associated with Diminished Interleukin-2 (IL-2) Production and Is Recovered by Exogenous IL-2Q36474240
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Persistent recognition of autologous virus by high-avidity CD8 T cells in chronic, progressive human immunodeficiency virus type 1 infection.Q36943282
Infection with Multiple Human Immunodeficiency Virus Type 1 Variants Is Associated with Faster Disease ProgressionQ37059806
Transient mobilization of human immunodeficiency virus (HIV)-specific CD4 T-helper cells fails to control virus rebounds during intermittent antiretroviral therapy in chronic HIV type 1 infectionQ39601164
Predictors of Plasma Human Immunodeficiency Virus Type 1 RNA Control after Discontinuation of Highly Active Antiretroviral Therapy Initiated at Acute Infection Combined with Structured Treatment Interruptions and Immune‐Based TherapiesQ40548790
A controlled trial of granulocyte macrophage-colony stimulating factor during interruption of HAART.Q40556224
Reduced antiretroviral drug susceptibility among patients with primary HIV infectionQ41692662
Impact of hepatitis G virus co-infection on the course of hepatitis C virus infection before and after liver transplantationQ42991527
Effect of coinfection with GB virus C on survival among patients with HIV infectionQ43034157
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Skewed representation of functionally distinct populations of virus-specific CD4 T cells in HIV-1-infected subjects with progressive disease: changes after antiretroviral therapyQ45721932
Structured treatment interruption in patients with multidrug-resistant human immunodeficiency virusQ45722048
HIV-1 superinfection despite broad CD8+ T-cell responses containing replication of the primary virusQ45729968
Effect of prolonged discontinuation of successful antiretroviral therapy on CD4+ T cell decline in human immunodeficiency virus-infected patients: implications for intermittent therapeutic strategiesQ45731190
Discontinuation of antiretroviral therapy commenced early during the course of human immunodeficiency virus type 1 infection, with or without adjunctive vaccinationQ45731214
Enhancement of human immunodeficiency virus type 1-specific CD4 and CD8 T cell responses in chronically infected persons after temporary treatment interruptionQ45740983
Natural history of human immunodeficiency virus type 1 viremia after seroconversion and proximal to AIDS in a large cohort of homosexual men. Multicenter AIDS Cohort StudyQ45743784
Antiretroviral-drug resistance among patients recently infected with HIV.Q46277555
HIV evolution: CTL escape mutation and reversion after transmissionQ47211742
Humoral immunity to HIV-1: kinetics of antibody responses in chronic infection reflects capacity of immune system to improve viral set pointQ47371942
HIV-1-specific cytotoxicity is preferentially mediated by a subset of CD8(+) T cells producing both interferon-gamma and tumor necrosis factor-alphaQ47835000
Comparison of overlapping peptide sets for detection of antiviral CD8 and CD4 T cell responsesQ48002526
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectacute HIV infectionQ12777087
P304page(s)e36
P577publication date2004-11-01
P1433published inPLOS MEDICINEQ1686921
P1476titleLimited durability of viral control following treated acute HIV infection
P478volume1

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