High-level HIV-1 viremia suppresses viral antigen-specific CD4(+) T cell proliferation

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High-level HIV-1 viremia suppresses viral antigen-specific CD4(+) T cell proliferation is …
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scholarly articleQ13442814

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P819ADS bibcode2001PNAS...9813878M
P356DOI10.1073/PNAS.251539598
P932PMC publication ID61135
P698PubMed publication ID11717444
P5875ResearchGate publication ID11638822

P2093author name stringHallahan CW
Davey RT Jr
Mican JA
Shupert WL
Connors M
McNeil AC
Iyasere CA
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Resistance to replication of human immunodeficiency virus challenge in SCID-Hu mice engrafted with peripheral blood mononuclear cells of nonprogressors is mediated by CD8(+) T cells and associated with a proliferative response to p24 antigenQ33798154
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Detection of three distinct patterns of T helper cell dysfunction in asymptomatic, human immunodeficiency virus-seropositive patients. Independence of CD4+ cell numbers and clinical stagingQ34581195
Early highly active antiretroviral therapy for acute HIV-1 infection preserves immune function of CD8+ and CD4+ T lymphocytesQ35110576
Progressive loss of CD8+ T cell-mediated control of a gamma-herpesvirus in the absence of CD4+ T cellsQ36367286
CD4+ T cells are required to sustain CD8+ cytotoxic T-cell responses during chronic viral infectionQ36637922
HIV-1 and T cell dynamics after interruption of highly active antiretroviral therapy (HAART) in patients with a history of sustained viral suppressionQ36781531
Cell-Mediated Immunity during Natural Measles InfectionQ37031815
Determination of antigen-specific memory/effector CD4+ T cell frequencies by flow cytometry: evidence for a novel, antigen-specific homeostatic mechanism in HIV-associated immunodeficiencyQ37365738
Lamivudine treatment can restore T cell responsiveness in chronic hepatitis B.Q37384895
The mode and duration of anti-CD28 costimulation determine resistance to infection by macrophage-tropic strains of human immunodeficiency virus type 1 in vitro.Q38956174
Role for HLA class II molecules in HIV-1 suppression and cellular immunity following antiretroviral treatmentQ39906623
Impaired T cell proliferation in acute dengue infectionQ40639461
Immunological abnormalities in human immunodeficiency virus (HIV)-infected asymptomatic homosexual men. HIV affects the immune system before CD4+ T helper cell depletion occursQ41018351
Reversal of the inhibitory effects of HIV-gp120 on CD4+ T cells by stimulation through the CD28 pathwayQ41182146
Absence of recoverable infectious virus and unique immune responses in an asymptomatic HIV+ long-term survivorQ43502245
HIV-1-specific CD4+ T cells are detectable in most individuals with active HIV-1 infection, but decline with prolonged viral suppressionQ43750477
Immunologic responses associated with 12 weeks of combination antiretroviral therapy consisting of zidovudine, lamivudine, and ritonavir: results of AIDS Clinical Trials Group Protocol 315.Q44015315
Functional analysis of T lymphocyte subsets in antiviral host defense.Q44098687
Comparison of activation versus induction of unresponsiveness of virus-specific CD4+ and CD8+ T cells upon acute versus persistent viral infectionQ45000674
Loss of CD4+ T cell proliferative ability but not loss of human immunodeficiency virus type 1 specificity equates with progression to diseaseQ45740979
Maintenance of large numbers of virus-specific CD8+ T cells in HIV-infected progressors and long-term nonprogressorsQ45741753
The relationship between T cell proliferative responses and plasma viremia during treatment of human immunodeficiency virus type 1 infection with combination antiretroviral therapyQ45743180
Strong human immunodeficiency virus (HIV)-specific CD4+ T cell responses in a cohort of chronically infected patients are associated with interruptions in anti-HIV chemotherapyQ45743378
Mechanisms of Immunosuppression in Cytomegalovirus Mononucleosis. II. Virus-Monocyte InteractionsQ45801737
Maximum suppression of HIV replication leads to the restoration of HIV-specific responses in early HIV disease.Q52026668
Lymphocyte-proliferative responses to HIV antigens as a potential measure of immunological reconstitution in HIV diseaseQ58416778
Qualitative analysis of immune function in patients with the acquired immunodeficiency syndrome. Evidence for a selective defect in soluble antigen recognitionQ69383880
Positive effects of combined antiretroviral therapy on CD4+ T cell homeostasis and function in advanced HIV diseaseQ73470103
Normal human CD4+ memory T cells display broad heterogeneity in their activation threshold for cytokine synthesisQ77573851
Lymphoproliferative response to HIV type 1 p24 in long-term survivors of HIV type 1 infection is predictive of persistent AIDS-free infectionQ78121234
P433issue24
P407language of work or nameEnglishQ1860
P304page(s)13878-13883
P577publication date2001-11-01
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleHigh-level HIV-1 viremia suppresses viral antigen-specific CD4(+) T cell proliferation
P478volume98

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