To kill or be killed: how HIV exhausts the immune system

scientific article published on 01 August 2005

To kill or be killed: how HIV exhausts the immune system is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/SJ.CDD.4401616
P698PubMed publication ID15832178

P2093author name stringGougeon ML
P2860cites workHuman immunodeficiency virus type 1 Nef and p56lck protein-tyrosine kinase interact with a common element in CD4 cytoplasmic tailQ24310700
Vpr R77Q is associated with long-term nonprogressive HIV infection and impaired induction of apoptosisQ24675034
CD95's deadly mission in the immune systemQ28142072
Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cellsQ28215003
Rapid and irreversible CD4+ T-cell depletion induced by the highly pathogenic simian/human immunodeficiency virus SHIV(DH12R) is systemic and synchronousQ28366094
Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytesQ29616210
Human immunodeficiency virus type 1 vpr induces apoptosis through caspase activationQ33801078
Structured intermittent treatment for HIV disease: Necessary concession or premature compromise?Q33896112
The dynamics of CD4+ T-cell depletion in HIV diseaseQ33942992
High-level HIV-1 viremia suppresses viral antigen-specific CD4(+) T cell proliferationQ33950164
HIV preferentially infects HIV-specific CD4+ T cellsQ33958893
Differential effects of interleukin-7 and interleukin-15 on NK cell anti-human immunodeficiency virus activityQ34150316
Apoptosis as a mechanism of cell death in cultured T lymphoblasts acutely infected with HIV-1Q34188750
Cellular immune responses to HIV.Q34223069
Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV- and SIV-infected lymph nodesQ34297394
Cytopathic killing of peripheral blood CD4(+) T lymphocytes by human immunodeficiency virus type 1 appears necrotic rather than apoptotic and does not require env.Q34338445
In vivo dynamics of T cell activation, proliferation, and death in HIV-1 infection: why are CD4+ but not CD8+ T cells depleted?Q34387944
Cardiomyocytes undergo apoptosis in human immunodeficiency virus cardiomyopathy through mitochondrion- and death receptor-controlled pathwaysQ34393925
Influence of mitochondrial control of apoptosis on the pathogenesis, complications and treatment of HIV infectionQ34648909
HIV-1 envelope induces activation of caspase-3 and cleavage of focal adhesion kinase in primary human CD4(+) T cellsQ35009887
Monocytes treated with human immunodeficiency virus Tat kill uninfected CD4(+) cells by a tumor necrosis factor-related apoptosis-induced ligand-mediated mechanism.Q35020357
Impact of HIV-1 infection and highly active antiretroviral therapy on the kinetics of CD4+ and CD8+ T cell turnover in HIV-infected patientsQ35575683
Kinetics of CD4+ T cell repopulation of lymphoid tissues after treatment of HIV-1 infectionQ35797256
CXCR4 and CD4 mediate a rapid CD95-independent cell death in CD4(+) T cellsQ36526710
Long-term kinetics of T cell production in HIV-infected subjects treated with highly active antiretroviral therapyQ36974912
Induction of "tissue" transglutaminase in HIV pathogenesis: evidence for high rate of apoptosis of CD4+ T lymphocytes and accessory cells in lymphoid tissuesQ37309112
Apoptosis mediated by HIV protease is preceded by cleavage of Bcl-2Q37356313
Interleukin-7-treated naive T cells can be productively infected by T-cell-adapted and primary isolates of human immunodeficiency virus 1.Q39488466
Human immunodeficiency virus type 1 Tat induces apoptosis and increases sensitivity to apoptotic signals by up-regulating FLICE/caspase-8.Q39551717
Dynamics of CCR5 expression by CD4(+) T cells in lymphoid tissues during simian immunodeficiency virus infectionQ39597678
Plasmacytoid dendritic cells are highly susceptible to human immunodeficiency virus type 1 infection and release infectious virusQ39603628
The expression of Fas Ligand by macrophages and its upregulation by human immunodeficiency virus infection.Q39805021
Characterization of Nef-CXCR4 interactions important for apoptosis inductionQ40161550
Potential deleterious effect of anti-viral cytotoxic lymphocyte through the CD95 (FAS/APO-1)-mediated pathway during chronic HIV infectionQ41106437
Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120.Q41335848
Induction of apoptosis in uninfected lymphocytes by HIV-1 Tat proteinQ41349382
AIDS virus-specific cytotoxic T lymphocytes in lung disordersQ41447927
AIDS retrovirus induced cytopathology: giant cell formation and involvement of CD4 antigenQ41830365
Lack of control of T cell apoptosis under HAART. Influence of therapy regimen in vivo and in vitroQ42162688
Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation.Q42830166
Apoptosis enhancement by the HIV-1 Nef protein.Q42833248
A syndrome of peripheral lipodystrophy, hyperlipidaemia and insulin resistance in patients receiving HIV protease inhibitorsQ43613003
Evidence for increased T cell turnover and decreased thymic output in HIV infectionQ43803719
Gene expression profiling of host response in models of acute HIV infectionQ43867121
Role of the HTLV-III/LAV envelope in syncytium formation and cytopathicityQ43894349
Association between altered expression of adipogenic factor SREBP1 in lipoatrophic adipose tissue from HIV-1-infected patients and abnormal adipocyte differentiation and insulin resistanceQ43950417
HIV-1 Tat-mediated apoptosis in human brain microvascular endothelial cellsQ44320785
HIV-infected Langerhans cells preferentially transmit virus to proliferating autologous CD4+ memory T cells located within Langerhans cell-T cell clustersQ45694453
IL-7 Stimulates T Cell Renewal Without Increasing Viral Replication in Simian Immunodeficiency Virus-Infected MacaquesQ45710909
Elevated interleukin-7 levels not sufficient to maintain T-cell homeostasis during simian immunodeficiency virus–induced disease progressionQ45710935
Activation, survival and apoptosis of CD45RO+ and CD45RO- T cells of human immunodeficiency virus-infected individuals: effects of interleukin-15 and comparison with interleukin-2.Q45747794
Effects of IL-7 on early human thymocyte progenitor cells in vitro and in SCID-hu Thy/Liv miceQ46757494
HIV-specific CD8+ T cells exhibit markedly reduced levels of Bcl-2 and Bcl-xL.Q47914791
The cytopathic effect of HIV is associated with apoptosis.Q50799294
Increased thymic mass and circulating naive CD4 T cells in HIV-1-infected adults treated with growth hormone.Q52012861
HIV-1 Tat protein concomitantly down-regulates apical caspase-10 and up-regulates c-FLIP in lymphoid T cells: a potential molecular mechanism to escape TRAIL cytotoxicity.Q53878239
HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes.Q54148550
Apoptosis of CD8+ T cells is mediated by macrophages through interaction of HIV gp120 with chemokine receptor CXCR4.Q55067967
Quantitation of HIV-1-Specific Cytotoxic T Lymphocytes and Plasma Load of Viral RNAQ56930699
Immune control of HIV-1 after early treatment of acute infectionQ56961920
IL-15 enhances survival and function of HIV-specific CD8+ T cellsQ58479905
Changes in thymic function with age and during the treatment of HIV infectionQ59066353
Programmed death of T cells in HIV-1 infectionQ67518695
Apoptosis in AIDSQ72218940
Transdifferentiation comes of ageQ73173510
Chemokine receptors and HIV entryQ74012124
Stromal cell-derived factor 1/CXCR4 signaling is critical for early human T-cell developmentQ77461355
Increased sensitivity of T lymphocytes to tumor necrosis factor receptor 1 (TNFR1)- and TNFR2-mediated apoptosis in HIV infection: relation to expression of Bcl-2 and active caspase-8 and caspase-3Q77678310
HIV-gp120 induced cell death in hematopoietic progenitor CD34+ cellsQ79332327
Contagious apoptosis facilitated by the HIV-1 envelope: fusion-induced cell-to-cell transmission of a lethal signalQ80884226
The selective increase in caspase-3 expression in effector but not memory T cells allows susceptibility to apoptosisQ80884484
P304page(s)845-854
P577publication date2005-08-01
P1433published inCell Death & DifferentiationQ2943974
P1476titleTo kill or be killed: how HIV exhausts the immune system
P478volume12 Suppl 1

Reverse relations

cites work (P2860)
Q34455550Apoptosis in virus infection dynamics models
Q36512585Apoptosis resistance in HIV-1 persistently-infected cells is independent of active viral replication and involves modulation of the apoptotic mitochondrial pathway
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Q28743559Exposure to apoptotic activated CD4+ T cells induces maturation and APOBEC3G-mediated inhibition of HIV-1 infection in dendritic cells
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Q34301788Perturbations of cell cycle control in T cells contribute to the different outcomes of simian immunodeficiency virus infection in rhesus macaques and sooty mangabeys
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Q32183747The Role of Caveolin 1 in HIV Infection and Pathogenesis
Q38280290The effect of HIV infection on the host response to bacterial sepsis
Q36685165The presence of HIV-1 Tat protein second exon delays fas protein-mediated apoptosis in CD4+ T lymphocytes: a potential mechanism for persistent viral production

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