| scholarly article | Q13442814 |
| P50 | author | Stephen W. Fesik | Q86531385 |
| P2093 | author name string | Yu Shen | |
| Mark G Anderson | |||
| Xiaoyu Lin | |||
| Xiaoan Ruan | |||
| Paul E Kroeger | |||
| Jeffrey A McDowell | |||
| P2860 | cites work | A large-scale RNAi screen in human cells identifies new components of the p53 pathway | Q24319883 |
| MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms | Q24680714 | ||
| Prediction of mammalian microRNA targets | Q27860498 | ||
| Targeting HIF-1 for cancer therapy | Q27860504 | ||
| Asymmetry in the assembly of the RNAi enzyme complex | Q27860763 | ||
| Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets | Q27860792 | ||
| Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells | Q27860926 | ||
| Functional siRNAs and miRNAs Exhibit Strand Bias | Q27861038 | ||
| Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs | Q27861053 | ||
| Involvement of microRNA in AU-rich element-mediated mRNA instability | Q28118466 | ||
| Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB | Q28201706 | ||
| Specificity of microRNA target selection in translational repression | Q28776123 | ||
| Hypoxia--a key regulatory factor in tumour growth | Q29547318 | ||
| Expression profiling reveals off-target gene regulation by RNAi | Q29615965 | ||
| Micro RNAs are complementary to 3' UTR sequence motifs that mediate negative post-transcriptional regulation | Q29618303 | ||
| Activation of the interferon system by short-interfering RNAs | Q29620341 | ||
| Small RNAs with imperfect match to endogenous mRNA repress translation. Implications for off-target activity of small inhibitory RNA in mammalian cells | Q30311189 | ||
| siRNA-mediated gene silencing: a global genome view | Q30500906 | ||
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| Nonspecific, concentration-dependent stimulation and repression of mammalian gene expression by small interfering RNAs (siRNAs). | Q34365459 | ||
| Short interfering RNAs can induce unexpected and divergent changes in the levels of untargeted proteins in mammalian cells | Q36603910 | ||
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| Identification of Modulators of TRAIL-Induced Apoptosis via RNAi-Based Phenotypic Screening | Q47585614 | ||
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| P433 | issue | 14 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | gene silencing | Q1431332 |
| P304 | page(s) | 4527-35 | |
| P577 | publication date | 2005-01-01 | |
| P1433 | published in | Nucleic Acids Research | Q135122 |
| P1476 | title | siRNA-mediated off-target gene silencing triggered by a 7 nt complementation | |
| P478 | volume | 33 |
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| Q39706132 | A screen of chemical modifications identifies position-specific modification by UNA to most potently reduce siRNA off-target effects |
| Q42148413 | A simple method for analyzing actives in random RNAi screens: introducing the "H Score" for hit nomination & gene prioritization |
| Q27339381 | Abasic pivot substitution harnesses target specificity of RNA interference |
| Q46804486 | Actin stress fiber pre-extension in human aortic endothelial cells |
| Q37195758 | Activity of TAR in inducible inhibition of HIV replication by foamy virus vector expressing siRNAs under the control of HIV LTR. |
| Q38301030 | Adipocyte differentiation induced using nonspecific siRNA controls in cultured human mesenchymal stem cells. |
| Q37037641 | Advances in microRNAs: implications for gene therapists |
| Q38351487 | Advances, nuances, and potential pitfalls when exploiting the therapeutic potential of RNA interference. |
| Q34103346 | An off-target nucleostemin RNAi inhibits growth in human glioblastoma-derived cancer stem cells |
| Q38227931 | An update on RNA interference-mediated gene silencing in cancer therapy |
| Q37753212 | Antiviral strategies to control calicivirus infections |
| Q53436494 | Asymmetric RNA duplexes mediate RNA interference in mammalian cells. |
| Q35762812 | Carbon nanotubes part II: a remarkable carrier for drug and gene delivery |
| Q37798545 | Cationic nanosystems for the delivery of small interfering ribonucleic acid therapeutics: a focus on toxicogenomics |
| Q49408746 | Chemical Modification of the siRNA Seed Region Suppresses Off-Target Effects by Steric Hindrance to Base-Pairing with Targets |
| Q33286936 | Chemogenomics approaches to novel target discovery |
| Q47382536 | Combined shRNA over CRISPR/cas9 as a methodology to detect off-target effects and a potential compensatory mechanism |
| Q34527135 | Combined small interfering RNA therapy and in vivo magnetic resonance imaging in islet transplantation |
| Q35641220 | Comparison of siRNA-induced off-target RNA and protein effects |
| Q38511964 | Connecting genotypes, phenotypes and fitness: harnessing the power of CRISPR/Cas9 genome editing |
| Q38934556 | Control of the localization and function of a miRNA silencing component TNRC6A by Argonaute protein |
| Q50138597 | DISE: A Seed-Dependent RNAi Off-Target Effect That Kills Cancer Cells. |
| Q33605316 | Design and evaluation of genome-wide libraries for RNA interference screens |
| Q37111734 | Design of siRNA Therapeutics from the Molecular Scale |
| Q33505682 | Designer siRNAs to overcome the challenges from the RNAi pathway. |
| Q38775735 | Development of Novel Small Hairpin RNAs That do not Require Processing by Dicer or AGO2. |
| Q36174842 | Development of Therapeutic-Grade Small Interfering RNAs by Chemical Engineering |
| Q45861940 | Development of antithrombotic miniribozymes that target peripheral tryptophan hydroxylase |
| Q36073816 | Development of lead hammerhead ribozyme candidates against human rod opsin mRNA for retinal degeneration therapy |
| Q34113601 | E-cadherin is transcriptionally activated via suppression of ZEB1 transcriptional repressor by small RNA-mediated gene silencing |
| Q37575234 | Efficient genome editing of differentiated renal epithelial cells |
| Q39810017 | Efficient knockdown of human prnp mRNA expression levels using hybrid hammerhead ribozymes |
| Q42638565 | Endoribonuclease-prepared short interfering RNAs induce effective and specific inhibition of human immunodeficiency virus type 1 replication |
| Q39527299 | Enhanced specificity of HPV16 E6E7 siRNA by RNA-DNA chimera modification |
| Q39595690 | Enhancers of adeno-associated virus AAV2 transduction via high throughput siRNA screening |
| Q33255054 | Enzymatically prepared RNAi libraries |
| Q36783160 | Epigenetics and microRNAs |
| Q42151459 | Essential notes regarding the design of functional siRNAs for efficient mammalian RNAi |
| Q42777701 | Evaluation and control of miRNA-like off-target repression for RNA interference |
| Q33257000 | Evidence of off-target effects associated with long dsRNAs in Drosophila melanogaster cell-based assays |
| Q43157457 | Experimental validation of the importance of seed complement frequency to siRNA specificity |
| Q37665372 | Exploring chemical modifications for siRNA therapeutics: a structural and functional outlook |
| Q27010574 | Fighting against kidney diseases with small interfering RNA: opportunities and challenges |
| Q36768065 | Function and localization of microRNAs in mammalian cells |
| Q40014125 | Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect. |
| Q33277841 | Genome-wide resources of endoribonuclease-prepared short interfering RNAs for specific loss-of-function studies |
| Q34057815 | Genome-wide small interfering RNA screens reveal VAMP3 as a novel host factor required for Uukuniemi virus late penetration |
| Q58744834 | Growth-restricting effects of siRNA transfections: a largely deterministic combination of off-target binding and hybridization-independent competition |
| Q37038732 | Guidelines for the optimal design of miRNA-based shRNAs. |
| Q33633510 | High throughput genome-wide survey of small RNAs from the parasitic protists Giardia intestinalis and Trichomonas vaginalis |
| Q47589530 | High-Content Screening Approaches That Minimize Confounding Factors in RNAi, CRISPR, and Small Molecule Screening |
| Q36118845 | High-Throughput Screening of Tyrosine Kinase Inhibitor Resistant Genes in CML. |
| Q34111180 | High-throughput screening for genes that prevent excess DNA replication in human cells and for molecules that inhibit them |
| Q47675158 | Identification of DISE-inducing shRNAs by monitoring cellular responses. |
| Q37118767 | Identification of an inter-transcription factor regulatory network in human hepatoma cells by Matrix RNAi |
| Q41505671 | Identification of siRNA generating hot spots in multiple viral suppressors to generate broad-spectrum antiviral resistance in plants |
| Q39636192 | Improved specificity of gene silencing by siRNAs containing unlocked nucleobase analogs |
| Q50234594 | In Vivo RNAi Efficacy of Palmitic Acid-Conjugated Dicer-Substrate siRNA in a Subcutaneous Tumor Mouse Model. |
| Q41853149 | Increased siRNA duplex stability correlates with reduced off-target and elevated on-target effects |
| Q38362040 | Inducible RNAi system and its application in novel therapeutics |
| Q34561070 | Insights into cellular factors that regulate HIV-1 replication in human cells |
| Q36836598 | Interfering with disease: a progress report on siRNA-based therapeutics |
| Q26749041 | Is the Efficiency of RNA Silencing Evolutionarily Regulated? |
| Q36509069 | Knockdown of TNFR1 by the sense strand of an ICAM-1 siRNA: dissection of an off-target effect |
| Q37855818 | Leveraging therapeutic potential of multi-targeted siRNA inhibitors |
| Q42637848 | Many si/shRNAs can kill cancer cells by targeting multiple survival genes through an off-target mechanism |
| Q39895165 | MicroRNA-like off-target transcript regulation by siRNAs is species specific. |
| Q33572896 | Minimal-length short hairpin RNAs: the relationship of structure and RNAi activity |
| Q42544704 | Minimizing off-target effects by using diced siRNAs for RNA interference |
| Q35140265 | Mitochondrial malic enzyme 3 is important for insulin secretion in pancreatic β-cells |
| Q38585780 | Modified siRNA structure with a single nucleotide bulge overcomes conventional siRNA-mediated off-target silencing. |
| Q93358749 | Modulating the expression of long non-coding RNAs for functional studies |
| Q36692835 | Molecular therapy in the microRNA era. |
| Q35829326 | Multiplexing siRNAs to compress RNAi-based screen size in human cells. |
| Q40031356 | New highly potent and specific E6 and E7 siRNAs for treatment of HPV16 positive cervical cancer |
| Q39587509 | New signaling pathways from cancer progression modulators to mRNA expression of matrix metalloproteinases in breast cancer cells |
| Q36007007 | Non-Target Effects of Green Fluorescent Protein (GFP)-Derived Double-Stranded RNA (dsRNA-GFP) Used in Honey Bee RNA Interference (RNAi) Assays. |
| Q38079180 | Non-coding RNAs in crop genetic modification: considerations and predictable environmental risk assessments (ERA). |
| Q37024768 | Nonviral delivery of synthetic siRNAs in vivo |
| Q39797171 | Off-target and a portion of target-specific siRNA mediated mRNA degradation is Ago2 'Slicer' independent and can be mediated by Ago1. |
| Q34703017 | Off-target effects by siRNA can induce toxic phenotype |
| Q28914776 | Off-target effects dominate a large-scale RNAi screen for modulators of the TGF-β pathway and reveal microRNA regulation of TGFBR2 |
| Q36575382 | On the art of identifying effective and specific siRNAs |
| Q37777745 | Oncolytic-adenovirus-expressed RNA interference for cancer therapy |
| Q41948527 | Optimal choice of functional and off-target effect-reduced siRNAs for RNAi therapeutics |
| Q57675694 | Patented therapeutic RNAi strategies for neurodegenerative diseases of the CNS |
| Q37873825 | Personalized cancer approach: using RNA interference technology |
| Q38180388 | Plant miRNAome and antiviral resistance: a retrospective view and prospective challenges |
| Q41627339 | Position-specific chemical modification of siRNAs reduces "off-target" transcript silencing |
| Q40233605 | Prevalence of off-target effects in Drosophila RNA interference screens |
| Q46238743 | Profiling the Mismatch Tolerance of Argonaute 2 through Deep Sequencing of Sliced Polymorphic Viral RNAs. |
| Q37419313 | Progress in the therapeutic applications of siRNAs against HIV-1. |
| Q28297652 | Progress towards in vivo use of siRNAs |
| Q37716734 | RNA Interference-Induced Innate Immunity, Off-Target Effect, or Immune Adjuvant? |
| Q40151467 | RNA interference against hepatitis B virus with endoribonuclease-prepared siRNA despite of the target sequence variations |
| Q37481329 | RNA interference as an anticancer therapy: a patent perspective |
| Q34729434 | RNA interference for improving the outcome of islet transplantation. |
| Q34995323 | RNA interference screening for the discovery of oncology targets |
| Q42272671 | RNA interference with special reference to combating viruses of crustacea |
| Q37102336 | RNA interference: an emerging generation of biologicals |
| Q35786068 | RNAe: an effective method for targeted protein translation enhancement by artificial non-coding RNA with SINEB2 repeat. |
| Q34735628 | RNAi induces innate immunity through multiple cellular signaling pathways |
| Q42544696 | RNAi off-targeting: Light at the end of the tunnel |
| Q36654918 | RNAi therapeutics: a potential new class of pharmaceutical drugs |
| Q34621268 | RNAi therapeutics: principles, prospects and challenges |
| Q37871417 | RNAi: a potential new class of therapeutic for human genetic disease |
| Q39747448 | Rational design of micro-RNA-like bifunctional siRNAs targeting HIV and the HIV coreceptor CCR5. |
| Q37665303 | Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application |
| Q40096614 | Reduced seed region-based off-target activity with lentivirus-mediated RNAi |
| Q42219751 | Requirement for protein synthesis at developing synapses |
| Q57871120 | Reticulon 3 Binds the 2C Protein of Enterovirus 71 and Is Required for Viral Replication |
| Q34999910 | SeedSeq: off-target transcriptome database |
| Q39784931 | Selection of hyperfunctional siRNAs with improved potency and specificity |
| Q41841425 | Silencing of amyloid precursor protein expression using a new engineered delta ribozyme |
| Q45383409 | Silencing potential of viral derived RNAi constructs in Tomato leaf curl virus-AC4 gene suppression in tomato. |
| Q37366057 | Simultaneous knockdown of the expression of two genes using multiple shRNAs and subsequent knock-in of their expression |
| Q35930516 | Single base mismatches in the mRNA target site allow specific seed region-mediated off-target binding of siRNA targeting human coagulation factor 7. |
| Q38498393 | Smooth muscle cell arachidonic acid release, migration, and proliferation are markedly attenuated in mice null for calcium-independent phospholipase A2beta |
| Q42071110 | Stability of miRNA 5'terminal and seed regions is correlated with experimentally observed miRNA-mediated silencing efficacy |
| Q36400708 | Strand-specific 5'-O-methylation of siRNA duplexes controls guide strand selection and targeting specificity |
| Q37130349 | Structure-Guided Control of siRNA Off-Target Effects |
| Q37950261 | Subcellular fate and off-target effects of siRNA, shRNA, and miRNA. |
| Q36897394 | The versatility of oligonucleotides as potential therapeutics |
| Q24669624 | Therapeutic application of RNAi: is mRNA targeting finally ready for prime time? |
| Q36386418 | Therapeutic silence of pleiotrophin by targeted delivery of siRNA and its effect on the inhibition of tumor growth and metastasis |
| Q42120040 | Thermodynamic Control of Small RNA-Mediated Gene Silencing |
| Q41887103 | Thermodynamic stability and Watson-Crick base pairing in the seed duplex are major determinants of the efficiency of the siRNA-based off-target effect. |
| Q37606516 | Toward a durable anti-HIV gene therapy based on RNA interference |
| Q40158066 | Toxicogenomics of drug delivery systems: Exploiting delivery system-induced changes in target gene expression to enhance siRNA activity |
| Q84713069 | Transgenic RNAi applications in the mouse |
| Q55399094 | Translating SOD1 Gene Silencing toward the Clinic: A Highly Efficacious, Off-Target-free, and Biomarker-Supported Strategy for fALS. |
| Q37226224 | Unexpected off-targeting effects of anti-huntingtin ribozymes and siRNA in vivo. |
| Q37856768 | Unlocked nucleic acid--an RNA modification with broad potential. |
| Q37967034 | Using non-coding small RNAs to develop therapies for Huntington's disease |
| Q36536623 | Variation is function: Are single cell differences functionally important?: Testing the hypothesis that single cell variation is required for aggregate function |
| Q35836004 | Vigilance and validation: Keys to success in RNAi screening |
| Q39902786 | West Nile virus genome amplification requires the functional activities of the proteasome |
| Q41626666 | Widespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity |
| Q92734224 | miRNAs as Influencers of Cell-Cell Communication in Tumor Microenvironment |
| Q36341483 | microRNAs associated with the different human Argonaute proteins |
| Q21563456 | p53 activation by knockdown technologies |
| Q30931909 | siDirect 2.0: updated software for designing functional siRNA with reduced seed-dependent off-target effect |
| Q26786876 | siRNA Versus miRNA as Therapeutics for Gene Silencing |
| Q34474388 | siRNA has greatly elevated mismatch tolerance at 3'-UTR sites |
| Q28742959 | siRNA off-target effects can be reduced at concentrations that match their individual potency |
| Q35992666 | siRNA off-target effects in genome-wide screens identify signaling pathway members |
| Q38074462 | siRNA therapeutics in the treatment of diseases. |
| Q38229425 | siRNA: novel therapeutics from functional genomics |
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