| scholarly article | Q13442814 |
| P356 | DOI | 10.1038/NBT.1512 |
| P2888 | exact match | https://scigraph.springernature.com/pub.10.1038/nbt.1512 |
| P698 | PubMed publication ID | 19029911 |
| P5875 | ResearchGate publication ID | 23493810 |
| P2093 | author name string | Chiang J Li | |
| Harry A Rogoff | |||
| Xiangao Sun | |||
| P2860 | cites work | The contributions of dsRNA structure to Dicer specificity and efficiency | Q24537392 |
| Therapeutic application of RNAi: is mRNA targeting finally ready for prime time? | Q24669624 | ||
| siRNA-mediated off-target gene silencing triggered by a 7 nt complementation | Q24812419 | ||
| Argonaute2 is the catalytic engine of mammalian RNAi | Q27860545 | ||
| Asymmetry in the assembly of the RNAi enzyme complex | Q27860763 | ||
| Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans | Q27860867 | ||
| Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells | Q27860926 | ||
| Functional siRNAs and miRNAs Exhibit Strand Bias | Q27861038 | ||
| Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes | Q28115751 | ||
| Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate | Q28365532 | ||
| RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals | Q29547713 | ||
| Expression profiling reveals off-target gene regulation by RNAi | Q29615965 | ||
| Activation of the interferon system by short-interfering RNAs | Q29620341 | ||
| Chemical modification: the key to clinical application of RNA interference? | Q33308712 | ||
| Off-target effects of siRNA specific for GFP | Q33346459 | ||
| Short hairpin RNA-expressing bacteria elicit RNA interference in mammals | Q34525784 | ||
| Sticky overhangs enhance siRNA-mediated gene silencing | Q36092509 | ||
| Strand-specific 5'-O-methylation of siRNA duplexes controls guide strand selection and targeting specificity | Q36400708 | ||
| Knockdown of TNFR1 by the sense strand of an ICAM-1 siRNA: dissection of an off-target effect | Q36509069 | ||
| Short interfering RNAs can induce unexpected and divergent changes in the levels of untargeted proteins in mammalian cells | Q36603910 | ||
| Interfering with disease: a progress report on siRNA-based therapeutics | Q36836598 | ||
| Utilizing RNA interference to enhance cancer drug discovery | Q36864047 | ||
| Effect of asymmetric terminal structures of short RNA duplexes on the RNA interference activity and strand selection | Q36935389 | ||
| Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect. | Q40014125 | ||
| Argonaute2 cleaves the anti-guide strand of siRNA during RISC activation | Q40354595 | ||
| Potent RNAi by short RNA triggers. | Q41940226 | ||
| Synthetic dsRNA Dicer substrates enhance RNAi potency and efficacy. | Q51562160 | ||
| Synthetic shRNAs as potent RNAi triggers. | Q51562164 | ||
| Enhancement of RNAi activity by improved siRNA duplexes. | Q54732681 | ||
| P433 | issue | 12 | |
| P921 | main subject | RNA interference | Q201993 |
| P304 | page(s) | 1379-1382 | |
| P577 | publication date | 2008-11-23 | |
| P1433 | published in | Nature Biotechnology | Q1893837 |
| P1476 | title | Asymmetric RNA duplexes mediate RNA interference in mammalian cells. | |
| P478 | volume | 26 |
| Q37068331 | 5' Unlocked Nucleic Acid Modification Improves siRNA Targeting |
| Q34187525 | An evaluation of oligonucleotide-based therapeutic strategies for polyQ diseases |
| Q39040772 | An intracellular buildup reaction of active siRNA species from short RNA fragments |
| Q35988727 | Asymmetric siRNA: new strategy to improve specificity and reduce off-target gene expression |
| Q45884815 | Asymmetry in siRNA design |
| Q38511172 | Bioregulation |
| Q37655882 | Chemical modification of siRNA. |
| Q38121824 | Chemistry and formulations for siRNA therapeutics |
| Q49882664 | Circular siRNAs for Reducing Off-Target Effects and Enhancing Long-Term Gene Silencing in Cells and Mice. |
| Q38383297 | Clinical translation of RNAi-based treatments for respiratory diseases |
| Q38221915 | Complexity in the therapeutic delivery of RNAi medicines: an analytical challenge. |
| Q92755701 | Current Aspects of siRNA Bioconjugate for In Vitro and In Vivo Delivery |
| Q36738386 | Design and analysis of effects of triplet repeat oligonucleotides in cell models for myotonic dystrophy |
| Q37111734 | Design of siRNA Therapeutics from the Molecular Scale |
| Q36174842 | Development of Therapeutic-Grade Small Interfering RNAs by Chemical Engineering |
| Q39200306 | Dicer-independent processing of short hairpin RNAs |
| Q34171685 | Effect of siRNA with an asymmetric RNA/dTdT overhang on RNA interference activity |
| Q41159509 | Effective inhibition of HIV-1 production by short hairpin RNAs and small interfering RNAs targeting a highly conserved site in HIV-1 Gag RNA is optimized by evaluating alternative length formats |
| Q44396769 | Highly potent and stable capped siRNAs with picomolar activity for RNA interference |
| Q30279300 | Hypoxia promotes colon cancer dissemination through up-regulation of cell migration-inducing protein (CEMIP) |
| Q34103204 | Improved siRNA/shRNA functionality by mismatched duplex |
| Q39636192 | Improved specificity of gene silencing by siRNAs containing unlocked nucleobase analogs |
| Q43417198 | Improvement of RNAi activity and strand selectivity of RISC formation by modified siRNA involving intercalators near 5' termini |
| Q42836546 | Inhibition of mutant huntingtin expression by RNA duplex targeting expanded CAG repeats |
| Q38585780 | Modified siRNA structure with a single nucleotide bulge overcomes conventional siRNA-mediated off-target silencing. |
| Q42110364 | Molecular Properties, Functional Mechanisms, and Applications of Sliced siRNA. |
| Q36963243 | Molecular basis for improved gene silencing by Dicer substrate interfering RNA compared with other siRNA variants |
| Q37678180 | Novel RNA-based strategies for therapeutic gene silencing |
| Q33791247 | Oligonucleotide-based strategies to combat polyglutamine diseases |
| Q30235525 | Overcoming cellular barriers for RNA therapeutics |
| Q28255877 | Progress toward in vivo use of siRNAs-II |
| Q45871459 | RNA interference for glioblastoma therapy: Innovation ladder from the bench to clinical trials |
| Q38019046 | RNA interference trigger variants: getting the most out of RNA for RNA interference-based therapeutics |
| Q33730699 | RNAi-mediated CCR5 silencing by LFA-1-targeted nanoparticles prevents HIV infection in BLT mice |
| Q38788187 | Recent advances in RNAi-based strategies for therapy and prevention of HIV-1/AIDS. |
| Q35536672 | Repurposing the antipsychotic trifluoperazine as an antimetastasis agent |
| Q37461352 | Selection and optimization of asymmetric siRNA targeting the human c-MET gene |
| Q37134134 | Short non-coding RNA biology and neurodegenerative disorders: novel disease targets and therapeutics |
| Q36347546 | Short-interference RNAs: becoming medicines |
| Q39658259 | Silencing USP22 by asymmetric structure of interfering RNA inhibits proliferation and induces cell cycle arrest in bladder cancer cells |
| Q29039090 | Silencing disease genes in the laboratory and the clinic |
| Q36341509 | Silencing of Parkinson's disease-associated genes with artificial mirtron mimics of miR-1224. |
| Q35930516 | Single base mismatches in the mRNA target site allow specific seed region-mediated off-target binding of siRNA targeting human coagulation factor 7. |
| Q42125976 | Single-stranded microRNA mimics |
| Q47144806 | Site-Specific Modification Using the 2'-Methoxyethyl Group Improves the Specificity and Activity of siRNAs |
| Q37900313 | Structural diversity repertoire of gene silencing small interfering RNAs. |
| Q42816699 | Synthesis and characterization of small circular double-stranded RNAs |
| Q38382964 | The application of RNAi-based treatments for inflammatory bowel disease |
| Q28395166 | The pursuit of oncotargets through understanding defective cell regulation |
| Q39800539 | The sense strand pre-cleaved RNA duplex mediates an efficient RNA interference with less off-target and immune response effects |
| Q35836004 | Vigilance and validation: Keys to success in RNAi screening |
| Q26769738 | siRNA and RNAi optimization |
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