Circular siRNAs for Reducing Off-Target Effects and Enhancing Long-Term Gene Silencing in Cells and Mice.

scientific article published on 19 December 2017

Circular siRNAs for Reducing Off-Target Effects and Enhancing Long-Term Gene Silencing in Cells and Mice. is …
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scholarly articleQ13442814

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P356DOI10.1016/J.OMTN.2017.12.007
P932PMC publication ID5768153
P698PubMed publication ID29499936

P50authorChangmai ChenQ85401964
P2093author name stringYuan Wang
Ivan J Dmochowski
Liangliang Zhang
Jiali Yang
Lijia Yu
Duanwei Liang
Xinjing Tang
Gubu Amu
P2860cites workOff-target effects related to the phosphorothioate modification of nucleic acids.Q39693685
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Turning the 10-23 DNAzyme on and off with lightQ42287457
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Dumbbell-shaped nanocircular RNAs for RNA interferenceQ42820652
Highly potent and stable capped siRNAs with picomolar activity for RNA interferenceQ44396769
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Modification of the siRNA passenger strand by 5-nitroindole dramatically reduces its off-target effectsQ84782712
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Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cellsQ27860926
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A universal plasmid library encoding all permutations of small interfering RNA.Q31146643
Asymmetric shorter-duplex siRNA structures trigger efficient gene silencing with reduced nonspecific effectsQ33713446
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Strand-specific 5'-O-methylation of siRNA duplexes controls guide strand selection and targeting specificityQ36400708
Manipulation of gene expression in zebrafish using caged circular morpholino oligomers.Q36422235
Knockdown of TNFR1 by the sense strand of an ICAM-1 siRNA: dissection of an off-target effectQ36509069
Caged circular antisense oligonucleotides for photomodulation of RNA digestion and gene expression in cellsQ36668733
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Dynamic Release of Bending Stress in Short dsDNA by Formation of a Kink and ForksQ38277383
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Effect of the guide strand 3'-end structure on the gene-silencing potency of asymmetric siRNA.Q38998025
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Improved specificity of gene silencing by siRNAs containing unlocked nucleobase analogsQ39636192
P921main subjectgene silencingQ1431332
P304page(s)237-244
P577publication date2017-12-19
P1433published inMolecular Therapy. Nucleic acidsQ27724110
P1476titleCircular siRNAs for Reducing Off-Target Effects and Enhancing Long-Term Gene Silencing in Cells and Mice
P478volume10

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