Not so crystal clear: the structure of the human telomere G-quadruplex in solution differs from that present in a crystal

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Not so crystal clear: the structure of the human telomere G-quadruplex in solution differs from that present in a crystal is …
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scholarly articleQ13442814

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P356DOI10.1093/NAR/GKI782
P3181OpenCitations bibliographic resource ID912336
P932PMC publication ID1187823
P698PubMed publication ID16106044
P5875ResearchGate publication ID7654760

P50authorJonathan B. ChairesQ41509784
P2093author name stringJing Li
Lei Wang
John O Trent
John J Correia
P2860cites workNormal human chromosomes have long G-rich telomeric overhangs at one endQ22065787
Crystal structure of parallel quadruplexes from human telomeric DNAQ22122125
Extension of life-span by introduction of telomerase into normal human cellsQ24336088
Highly prevalent putative quadruplex sequence motifs in human DNAQ24529050
Prevalence of quadruplexes in the human genomeQ24529051
Direct evidence for a G-quadruplex in a promoter region and its targeting with a small molecule to repress c-MYC transcriptionQ24535577
Covalent ligation studies on the human telomere quadruplexQ24810245
The high-resolution crystal structure of a parallel-stranded guanine tetraplexQ27730831
Refined solution structure of the dimeric quadruplex formed from the Oxytricha telomeric oligonucleotide d(GGGGTTTTGGGG)Q27730882
Crystal structure of four-stranded Oxytricha telomeric DNAQ43751324
2-Aminopurine electronic structure and fluorescence properties in DNA.Q44196633
Fluorescence properties of 2-aminopurine in human telomeric DNA.Q44923122
Strand orientation in the DNA quadruplex formed from the Oxytricha telomere repeat oligonucleotide d(G4T4G4) in solution.Q45998149
Analysis of heterologous interacting systems by sedimentation velocity: curve fitting algorithms for estimation of sedimentation coefficients, equilibrium and kinetic constantsQ47884569
Effect of ions on the polymorphism, effective charge, and stability of human telomeric DNA. Photon correlation spectroscopy and circular dichroism studies.Q51937353
An Ambiguous Structure of a DNA 15-mer Thrombin ComplexQ60163781
Structure and stability of human telomeric sequenceQ72136114
Excitation energy transfer in DNA: duplex melting and transfer from normal bases to 2-aminopurineQ72551869
Porphyrins can catalyze the interconversion of DNA quadruplex structural typesQ73334907
Determinants of DNA quadruplex structural type: sequence and potassium bindingQ77293595
The Bloom's syndrome helicase unwinds G4 DNAQ77387768
Hydration from hydrodynamics. General considerations and applications of bead modelling to globular proteinsQ77530436
G-quadruplex DNA: a target for drug designQ77658670
Accelerated assembly of G-quadruplex structures by a small moleculeQ77828149
Solution structure of the human telomeric repeat d[AG3(T2AG3)3] G-tetraplexQ27730906
The structure of alpha-thrombin inhibited by a 15-mer single-stranded DNA aptamerQ27730933
The Saccharomyces cerevisiae Sgs1 helicase efficiently unwinds G-G paired DNAsQ27930229
The influence of macromolecular crowding and macromolecular confinement on biochemical reactions in physiological mediaQ28209077
DNA tetraplex formation in the control region of c-mycQ28262361
Two-repeat human telomeric d(TAGGGTTAGGGT) sequence forms interconverting parallel and antiparallel G-quadruplexes in solution: distinct topologies, thermodynamic properties, and folding/unfolding kineticsQ28603454
Size-distribution analysis of proteins by analytical ultracentrifugation: strategies and application to model systemsQ29616418
Calculation of hydrodynamic properties of globular proteins from their atomic-level structureQ29620591
Calculation of hydrodynamic properties of small nucleic acids from their atomic structureQ30686123
Platinum cross-linking of adenines and guanines on the quadruplex structures of the AG3(T2AG3)3 and (T2AG3)4 human telomere sequences in Na+ and K+ solutionsQ31134580
Modern applications of analytical ultracentrifugationQ33689917
Targeting multi-stranded DNA structuresQ33818493
G-quadruplexes as targets for drug designQ33876849
G-quadruplex DNA: a potential target for anti-cancer drug designQ33877249
Tiny telomere DNAQ33892005
DNA G-quadruplexes, telomere-specific proteins and telomere-associated enzymes as potential targets for new anticancer drugsQ33945457
Fluorescence studies of nucleotides and polynucleotides. I. Formycin, 2-aminopurine riboside, 2,6-diaminopurine riboside, and their derivatives.Q34238979
Low-energy circular dichroism of 2-aminopurine dinucleotide as a probe of local conformation of DNA and RNA.Q34302342
Studies on the structure and dynamics of the human telomeric G quadruplex by single-molecule fluorescence resonance energy transferQ34382392
Secondary DNA structures as molecular targets for cancer therapeuticsQ34439504
Quadruplex structures in nucleic acidsQ34464208
G-quadruplexes as therapeutic targetsQ34464217
Biophysical studies by ultracentrifugationQ34489516
DNA and its associated processes as targets for cancer therapyQ34625003
Telomere maintenance as a target for anticancer drug discoveryQ34743340
"...the tyranny of the lattice...".Q35184071
Chemical approaches to the discovery and development of cancer therapiesQ36085630
Helix formation by guanylic acidQ36397431
Telomere loss: mitotic clock or genetic time bomb?Q36706939
Intramolecular quadruplex conformation of human telomeric DNA assessed with 125I-radioprobingQ37592329
Telomestatin and diseleno sapphyrin bind selectively to two different forms of the human telomeric G-quadruplex structureQ38324328
The cationic porphyrin TMPyP4 down-regulates c-MYC and human telomerase reverse transcriptase expression and inhibits tumor growth in vivoQ38359848
Reconciliation of the X-ray and NMR structures of the thrombin-binding aptamer d(GGTTGGTGTGGTTGG).Q38361323
P433issue14
P407language of work or nameEnglishQ1860
P304page(s)4649-4659
P577publication date2005-08-16
P1433published inNucleic Acids ResearchQ135122
P1476titleNot so crystal clear: the structure of the human telomere G-quadruplex in solution differs from that present in a crystal
P478volume33

Reverse relations

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