| review article | Q7318358 |
| scholarly article | Q13442814 |
| P356 | DOI | 10.1038/NRC1587 |
| P2888 | exact match | https://scigraph.springernature.com/pub.10.1038/nrc1587 |
| P8608 | Fatcat ID | release_ixchtpiwhbbc5kdxtzgqniappq |
| P698 | PubMed publication ID | 15803155 |
| P5875 | ResearchGate publication ID | 7933291 |
| P2093 | author name string | Stephen Neidle | |
| David E Thurston | |||
| P2860 | cites work | Crystal structure of parallel quadruplexes from human telomeric DNA | Q22122125 |
| Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone | Q24299505 | ||
| Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain | Q24314763 | ||
| A census of human cancer genes | Q24647081 | ||
| In vivo activation of the p53 pathway by small-molecule antagonists of MDM2 | Q27642888 | ||
| Specific Association of Human Telomerase Activity with Immortal Cells and Cancer | Q27860801 | ||
| High-throughput screening of small molecules in miniaturized mammalian cell-based assays involving post-translational modifications | Q28137594 | ||
| Recognition of the DNA minor groove by pyrrole-imidazole polyamides | Q28182798 | ||
| INHIBITION OF CELL DIVISION IN ESCHERICHIA COLI BY ELECTROLYSIS PRODUCTS FROM A PLATINUM ELECTRODE | Q28202030 | ||
| DNA crosslinking and biological activity of a hairpin polyamide-chlorambucil conjugate | Q28208906 | ||
| Generating Diverse Skeletons of Small Molecules Combinatorially | Q28212236 | ||
| Synthesis of the thapsigargins | Q28269487 | ||
| Measurement of the critical DNA lesions produced by antibody-directed enzyme prodrug therapy (ADEPT) in vitro, in vivo and in clinical material | Q28366622 | ||
| Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings | Q28842973 | ||
| Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors | Q29618610 | ||
| Overriding imatinib resistance with a novel ABL kinase inhibitor | Q30014844 | ||
| Development of natural product-derived receptor tyrosine kinase inhibitors based on conservation of protein domain fold | Q30778612 | ||
| Simple selection criteria for drug-like chemical matter | Q30990966 | ||
| Chemical genetics: ligand-based discovery of gene function | Q31881396 | ||
| Nuclear localization of pyrrole–imidazole polyamide–fluorescein conjugates in cell culture | Q33193534 | ||
| Kinases, Homology Models, and High Throughput Docking | Q33193967 | ||
| Receptor-mediated and enzyme-dependent targeting of cytotoxic anticancer drugs | Q33746856 | ||
| Chemoinformatics - predicting the physicochemical properties of 'drug-like' molecules | Q33840254 | ||
| Monoclonal antibodies to the myeloid stem cells: therapeutic implications of CMA-676, a humanized anti-CD33 antibody calicheamicin conjugate | Q33864566 | ||
| Cell senescence and telomere shortening induced by a new series of specific G-quadruplex DNA ligands. | Q34013958 | ||
| Glivec (STI571, imatinib), a rationally developed, targeted anticancer drug | Q34139151 | ||
| Property distributions: differences between drugs, natural products, and molecules from combinatorial chemistry | Q34172646 | ||
| Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia | Q34235776 | ||
| Platinum Compounds: a New Class of Potent Antitumour Agents | Q34239433 | ||
| The process of structure-based drug design | Q34266765 | ||
| The PDBbind database: collection of binding affinities for protein-ligand complexes with known three-dimensional structures | Q34323005 | ||
| Prodrug strategies in cancer therapy | Q34400910 | ||
| Selective activation of anticancer prodrugs by monoclonal antibody-enzyme conjugates | Q34463640 | ||
| DNA and its associated processes as targets for cancer therapy | Q34625003 | ||
| Nitroreductase-based GDEPT. | Q34673965 | ||
| Telomere maintenance as a target for anticancer drug discovery | Q34743340 | ||
| Chemical and biological profile of dual Cdk1 and Cdk2 inhibitors | Q35101040 | ||
| Systematic discovery of multicomponent therapeutics | Q35147474 | ||
| Protein kinase inhibitors: insights into drug design from structure. | Q35697409 | ||
| Of mice and men: values and liabilities of the athymic nude mouse model in anticancer drug development | Q35761426 | ||
| Predictive ADMET studies, the challenges and the opportunities | Q35853056 | ||
| Structure-based design of selective and potent G quadruplex-mediated telomerase inhibitors | Q35853278 | ||
| High-throughput X-ray crystallography for drug discovery | Q35879836 | ||
| Strategies to overcome resistance to targeted protein kinase inhibitors | Q35968384 | ||
| Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death | Q36742412 | ||
| Molecular characterization of the hdm2-p53 interaction | Q36871109 | ||
| The G-quadruplex-interactive molecule BRACO-19 inhibits tumor growth, consistent with telomere targeting and interference with telomerase function. | Q40453766 | ||
| The novel sequence-specific DNA cross-linking agent SJG-136 (NSC 694501) has potent and selective in vitro cytotoxicity in human B-cell chronic lymphocytic leukemia cells with evidence of a p53-independent mechanism of cell kill | Q40514651 | ||
| SJG-136 (NSC 694501), a novel rationally designed DNA minor groove interstrand cross-linking agent with potent and broad spectrum antitumor activity: part 2: efficacy evaluations | Q40514657 | ||
| SJG-136 (NSC 694501), a novel rationally designed DNA minor groove interstrand cross-linking agent with potent and broad spectrum antitumor activity: part 1: cellular pharmacology, in vitro and initial in vivo antitumor activity | Q40514663 | ||
| A nonpeptidic sulfonamide inhibits the p53-mdm2 interaction and activates p53-dependent transcription in mdm2-overexpressing cells | Q40528623 | ||
| Linker length modulates DNA cross-linking reactivity and cytotoxic potency of C8/C8' ether-linked C2-exo-unsaturated pyrrolo[2,1-c][1,4]benzodiazepine (PBD) dimers. | Q40588353 | ||
| Solid-phase synthesis of the cyclic peptide portion of chlorofusin, an inhibitor of p53-MDM2 interactions. | Q40606162 | ||
| Design, synthesis, and evaluation of a novel pyrrolobenzodiazepine DNA-interactive agent with highly efficient cross-linking ability and potent cytotoxicity | Q40819330 | ||
| Antitumor imidazotetrazines. 1. Synthesis and chemistry of 8-carbamoyl-3-(2-chloroethyl)imidazo[5,1-d]-1,2,3,5-tetrazin-4(3 H)-one , a novel broad-spectrum antitumor agent | Q42255336 | ||
| Isolation and structure elucidation of Chlorofusin, a novel p53-MDM2 antagonist from a Fusarium sp. | Q43677077 | ||
| Binding of an inhibitor of the p53/MDM2 interaction to MDM2. | Q44338543 | ||
| Trisubstituted acridine derivatives as potent and selective telomerase inhibitors. | Q44604134 | ||
| Structural basis for the autoinhibition and STI-571 inhibition of c-Kit tyrosine kinase | Q44881257 | ||
| NMR-driven discovery of benzoylanthranilic acid inhibitors of far upstream element binding protein binding to the human oncogene c-myc promoter. | Q45060205 | ||
| Discovery of N-(2-chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4- ylamino)thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays. | Q45198729 | ||
| Calculation of ligand-nucleic acid binding free energies with the generalized-born model in DOCK. | Q46895699 | ||
| Assessing scoring functions for protein-ligand interactions | Q47429905 | ||
| Characteristic physical properties and structural fragments of marketed oral drugs. | Q52005766 | ||
| Inhibition of telomerase limits the growth of human cancer cells. | Q52536487 | ||
| Timeline: Chemotherapy and the war on cancer. | Q53313789 | ||
| Targeting enzymes to cancers--new developments. | Q53619323 | ||
| Natural products in cancer chemotherapy: past, present and future | Q73121945 | ||
| Synthesis of the chlorofusin cyclic peptide: assignment of the asparagine stereochemistry | Q75187834 | ||
| A small molecule transcriptional activation domain | Q80487705 | ||
| P433 | issue | 4 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 285-296 | |
| P577 | publication date | 2005-04-01 | |
| P1433 | published in | Nature Reviews Cancer | Q641657 |
| P1476 | title | Chemical approaches to the discovery and development of cancer therapies | |
| P478 | volume | 5 |
| Q34043354 | "One ring to bind them all"-part I: the efficiency of the macrocyclic scaffold for g-quadruplex DNA recognition |
| Q45959242 | A "dual-function" photocage releasing nitric oxide and an anthrylmethyl cation with a single wavelength light. |
| Q34955056 | A Discovery Funnel for Nucleic Acid Binding Drug Candidates |
| Q28547489 | A New Epigenetic Mechanism of Temozolomide Action in Glioma Cells |
| Q64122665 | A New Generation of Minor-Groove-Binding-Heterocyclic Diamidines That Recognize G·C Base Pairs in an AT Sequence Context |
| Q37080928 | A hitchhiker's guide to G-quadruplex ligands |
| Q54419281 | A label-free and colorimetric turn-on assay for coralyne based on coralyne-induced formation of peroxidase-mimicking split DNAzyme. |
| Q48113343 | A modular design for minor groove binding and recognition of mixed base pair sequences of DNA. |
| Q38293827 | A novel G-quadruplex-forming GGA repeat region in the c-myb promoter is a critical regulator of promoter activity |
| Q34036087 | A novel bisindole-PBD conjugate causes DNA damage induced apoptosis via inhibition of DNA repair pathway. |
| Q38299927 | A platinum-quinacridine hybrid as a G-quadruplex ligand |
| Q37681844 | A selective and label-free strategy for rapid screening of telomere-binding Ligands via fluorescence regulation of DNA/silver nanocluster |
| Q39926626 | Amino acetate functionalized Schiff base organotin(IV) complexes as anticancer drugs: synthesis, structural characterization, and in vitro cytotoxicity studies |
| Q37691491 | An efficient and practical radiosynthesis of [11C]temozolomide |
| Q36047250 | Antiproliferative activities of halogenated thieno[3,2-d]pyrimidines |
| Q52875210 | Antiproliferative activity of bicyclic benzimidazole nucleosides: synthesis, DNA-binding and cell cycle analysis. |
| Q36407244 | Antiprotease therapy in cancer: hot or not? |
| Q33244983 | Atomic force microscopy study of the specific adhesion between a colloid particle and a living melanoma cell: Effect of the charge and the hydrophobicity of the particle surface |
| Q33298617 | Chemical groups that adhere to the surfaces of living malignant cells |
| Q40066154 | Chiral salicyl diamines: potent anticancer molecules |
| Q35996040 | Chromatin structure determines accessibility of a hairpin polyamide-chlorambucil conjugate at histone H4 genes in pancreatic cancer cells |
| Q48290499 | Control of the DNA-Binding and Antiproliferative Properties of Hydroxybenzo[b]quinolizinium Derivatives with pH and Light. |
| Q45049803 | DLJ14, a novel chemo-sensitization agent, enhances therapeutic effects of adriamycin against MCF-7/A cells both in vitro and in vivo |
| Q36748138 | Design, synthesis, crystallization and biological evaluation of new symmetrical biscationic compounds as selective inhibitors of human Choline Kinase α1 (ChoKα1) |
| Q37188627 | Direct detection and quantification of abasic sites for in vivo studies of DNA damage and repair |
| Q37347859 | Discovery of 8-methoxypyrazino[1,2-a]indole as a New Potent Antiproliferative Agent Against Human Leukemia K562 Cells. A Structure-Activity Relationship Study |
| Q28487714 | Early Chk1 phosphorylation is driven by temozolomide-induced, DNA double strand break- and mismatch repair-independent DNA damage |
| Q34428294 | Ethyl 1,6-dimethyl-2-oxo-4-(quinolin-4-yl)-1,2,3,4-tetra-hydro-pyrimidine-5-carboxyl-ate. |
| Q53078142 | FDG-PET/CT assessment of differential chemotherapy effects upon skeletal muscle metabolism in patients with melanoma. |
| Q27644231 | G-quadruplex recognition by quinacridines: a SAR, NMR, and biological study |
| Q41863980 | Halogenated pentamethine cyanine dyes exhibiting high fidelity for G-quadruplex DNA. |
| Q37397991 | Heterocyclic dications as a new class of telomeric G-quadruplex targeting agents |
| Q35003819 | Identification of new natural DNA G-quadruplex binders selected by a structure-based virtual screening approach. |
| Q35785923 | Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists |
| Q38358509 | Interaction between cationic zinc porphyrin and lead ion induced telomeric guanine quadruplexes: evidence for end-stacking |
| Q24815275 | Intercalator conjugates of pyrimidine locked nucleic acid-modified triplex-forming oligonucleotides: improving DNA binding properties and reaching cellular activities. |
| Q39031412 | Mechanism of the malabaricone C-induced toxicity to the MCF-7 cell line |
| Q38165863 | Molecular basis of pharmacological therapy in Cushing's disease |
| Q34340777 | Molecular docking studies of anti-cancerous candidates in Hippophae rhamnoides and Hippophae salicifolia |
| Q48156129 | Molecular dynamics simulations and binding free energy analysis of DNA minor groove complexes of curcumin |
| Q59300895 | Naphthylnitrobutadienes as pharmacologically active molecules: evaluation of the in vivo antitumour activity |
| Q24813445 | Not so crystal clear: the structure of the human telomere G-quadruplex in solution differs from that present in a crystal |
| Q90439922 | Novel Chemo-Photothermal Therapy in Breast Cancer Using Methotrexate-Loaded Folic Acid Conjugated Au@SiO2 Nanoparticles |
| Q34514081 | Novel G-quadruplex stabilizing agents: in-silico approach and dynamics |
| Q37137649 | Novel metals and metal complexes as platforms for cancer therapy |
| Q51325771 | One-step gene delivery into the cytoplasm in a fusion-dependent manner based on a new membrane fusogenic lipid. |
| Q92353593 | Oxoisoaporphines and Aporphines: Versatile Molecules with Anticancer Effects |
| Q38798715 | Pharmacokinetics and Pharmacodynamics in Breast Cancer Animal Models. |
| Q64914030 | Phytochemical analysis and antiproliferative activity of the aerial parts of Scrophularia subaphylla. |
| Q53219322 | QS-ZYX-1-61 induces apoptosis through topoisomerase II in human non-small-cell lung cancer A549 cells. |
| Q47987033 | Rapid and simple flow injection analysis tandem mass spectrometric method for the quantification of melphalan in a lipid-based drug delivery system. |
| Q28486104 | Re-directing an alkylating agent to mitochondria alters drug target and cell death mechanism |
| Q38074601 | Recent advances in the development of 1,8-naphthalimide based DNA targeting binders, anticancer and fluorescent cellular imaging agents. |
| Q37804383 | Receptor-targeted nanocarriers for therapeutic delivery to cancer |
| Q25257441 | Sequence- and structural-selective nucleic acid binding revealed by the melting of mixtures. |
| Q36647759 | Small molecules targeting histone H4 as potential therapeutics for chronic myelogenous leukemia |
| Q36293541 | Strategies and methodologies for identifying molecular targets in sarcomas and other tumors |
| Q33804219 | Structural insight for the recognition of G-quadruplex structure at human c-myc promoter sequence by flavonoid Quercetin |
| Q36345568 | Synthesis and DNA-binding affinity studies of glycosylated intercalators designed as functional mimics of the anthracycline antibiotics |
| Q34025044 | Synthesis and Evaluation of Haloacetyl, α-Bromoacryloyl and Nitrooxyacetyl Benzo[b]furan and Benzo[b]thiophene Derivatives as Potent Antiproliferative Agents Against Leukemia L1210 and K562 Cells. |
| Q53038908 | Synthesis and cytotoxicity evaluation of naphthalimide derived N-mustards. |
| Q50250628 | Synthesis and photophysical evaluation of a pyridinium 4-amino-1,8-naphthalimide derivative that upon intercalation displays preference for AT-rich double-stranded DNA. |
| Q89286232 | Synthesis, docking and anticancer activity of azo-linked hybrids of 1,3,4-thia-/oxadiazoles with cyclic imides |
| Q55370601 | Temozolomide and Pituitary Tumors: Current Understanding, Unresolved Issues, and Future Directions. |
| Q38010032 | Temozolomide in aggressive pituitary adenomas and carcinomas. |
| Q37955091 | Temozolomide responsiveness in aggressive corticotroph tumours: a case report and review of the literature |
| Q36548809 | Temperature-feedback upconversion nanocomposite for accurate photothermal therapy at facile temperature |
| Q50125296 | Tetrazolylpyrene unnatural nucleoside as a human telomeric multimeric G-quadruplex selective switch-on fluorescent sensor. |
| Q44502621 | The effect of the 4-amino functionality on the photophysical and DNA binding properties of alkyl-pyridinium derived 1,8-naphthalimides. |
| Q37789267 | Treatment of pituitary neoplasms with temozolomide: a review. |
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