Platinum Compounds: a New Class of Potent Antitumour Agents

scientific article

Platinum Compounds: a New Class of Potent Antitumour Agents is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1001455608
P356DOI10.1038/222385A0
P953full work available at URLhttp://www.nature.com/articles/222385a0
http://www.nature.com/articles/222385a0.pdf
P698PubMed publication ID5782119
P5875ResearchGate publication ID17404231

P2093author name stringB. Rosenberg
J. E. Trosko
VanCamp L
L. VanCamp
V. H. Mansour
P2860cites workEffectiveness of nitrogen mustards in retarding the growth of sarcoma 180 with reference to route of administration, age of tumors, food intake, and weight loss of the miceQ47449659
INHIBITION OF CELL DIVISION IN ESCHERICHIA COLI BY ELECTROLYSIS PRODUCTS FROM A PLATINUM ELECTRODEQ28202030
P433issue5191
P407language of work or nameEnglishQ1860
P921main subjectplatinumQ880
P304page(s)385-386
P577publication date1969-04-01
P1433published inNatureQ180445
P1476titlePlatinum compounds: a new class of potent antitumour agents
Platinum Compounds: a New Class of Potent Antitumour Agents
P478volume222

Reverse relations

cites work (P2860)
Q438191703-D QSAR studies on new dibenzyltin(IV) anticancer agents by comparative molecular field analysis (CoMFA).
Q387823653-octadecylcarbamoylacrylic acid-cisplatin nanocomplexes for the development of novel liposome formulation
Q67290762A Circular Dichroism Study of DNA . Platinum Complexes. Differentiation between Monofunctional. cis-Bidentate and trans-Bidentate Platinum Fixation on a Series of DNAs
Q91761770A Comprehensive Review on the Synthesis, Characterization, and Biomedical Application of Platinum Nanoparticles
Q92632504A New Look into the Mode of Action of Metal-Based Anticancer Drugs
Q38953565A TrxR inhibiting gold(I) NHC complex induces apoptosis through ASK1-p38-MAPK signaling in pancreatic cancer cells.
Q28546961A better experimental method to detect the sensitivity of cancer cells to anticancer drugs after adenovirus-mediated introduction of two kinds of p53 in vivo
Q39570737A bifunctional organometallic ruthenium drug with multiple modes of inducing apoptosis
Q54486007A cDNA microarray analysis identifies 52 genes associated with cis-diamminedichloroplatinum susceptibility in head and neck squamous cell carcinoma cell lines.
Q51140866A comprehensive biological insight of trinuclear copper(II)-tin(IV) chemotherapeutic anticancer drug entity: in vitro cytotoxicity and in vivo systemic toxicity studies.
Q43411545A core cross-linked polymeric micellar platium(IV) prodrug with enhanced anticancer efficiency
Q40202099A crystalline platinum blue: its molecular structure, chemical reactivity, and possible relevance to the mode of action of antitumor platinum drugs
Q40774280A crystallographic study of metal-binding to yeast phenylalanine transfer RNA
Q58921543A dinuclear cyclometalated gold(iii)–phosphine complex targeting thioredoxin reductase inhibits hepatocellular carcinoma in vivo
Q44320923A fluorescent probe for investigating the activation of anticancer platinum(IV) prodrugs based on the cisplatin scaffold.
Q40162812A glucose derivative as natural alternative to the cyclohexane-1,2-diamine ligand in the anticancer drug oxaliplatin?
Q45260669A kinetic and mechanistic study into the substitution behaviour of platinum(II) polypyridyl complexes with a series of azole ligands
Q54066529A molecular cytogenetic approach to studying platinum resistance.
Q36785185A new anticancer platinum compound, (-)-(R)-2-aminomethyl-pyrrolidine(1,1-cyclobutanedicarboxylato) platinum(II): DNA interstrand crosslinking, repair and lethal effects in normal human, Fanconi's anaemia and xeroderma pigmentosum cells
Q42043312A new, semi-automated system for the micro-scale synthesis of [195mPt]cisplatin suitable for clinical studies
Q46474564A note from history: Landmarks in history of cancer, Part 6.
Q28484947A novel and selective poly (ADP-ribose) polymerase inhibitor ameliorates chemotherapy-induced painful neuropathy
Q38984020A novel manganese complex LMnAc selectively kills cancer cells by induction of ROS-triggered and mitochondrial-mediated cell death
Q86044072A novel ruthenium(II)-polypyridyl complex inhibits cell proliferation and induces cell apoptosis by impairing DNA damage repair
Q41912667A pH responsive complexation-based drug delivery system for oxaliplatin
Q33494306A phase I study of 1,2-diamminomethyl-cyclobutane-platinum (II)-lactate (D-19466; lobaplatin) administered daily for 5 days.
Q39214856A polymer-(tandem drugs) conjugate for enhanced cancer treatment
Q39173607A potential rhodium cancer therapy: studies of a cytotoxic organorhodium(I) complex that binds DNA.
Q35868560A review of selected anti-tumour therapeutic agents and reasons for multidrug resistance occurrence
Q42464258A semiquantitative analysis of the effects of cisplatin on the rat stria vascularis
Q37905280A strategy for the development of two clinically active cisplatin analogs: CBDCA and CHIP.
Q38792102A survey of the mechanisms of action of anticancer transition metal complexes
Q39557153A tetrazolato-bridged dinuclear platinum(II) complex exhibits markedly high in vivo antitumor activity against pancreatic cancer.
Q78179609Absorbed doses to patients from 191Pt-, 193mPt- and 195mPt-cisplatin
Q105245784Aciculatin, a novel flavone-C-glycoside with DNA binding activity from chrysopogon aciculatis
Q90859353Acquired SETD2 mutation and impaired CREB1 activation confer cisplatin resistance in metastatic non-small cell lung cancer
Q46874152Activity of two platinum-linked phosphonic acids against autochthonous rat colorectal cancer as well as in two human colon-cancer cell lines
Q38412888Acute and sub-chronic toxicity of four cytostatic drugs in zebrafish.
Q64033563Adduct formation of cis-(NH3)2PtX2 (X = Cl−, I−) with formamides and the crystal structures of cis-(NH3)2PtCl2·(CH3)2NCHO. Application for the purification of the antitumor agent cisplatin
Q33385228Adenoviral-mediated pHyde gene transfer and cisplatin additively inhibit human prostate cancer growth by enhancing apoptosis
Q28072577Advances and Challenges in Viability Detection of Foodborne Pathogens
Q39653970Advances in platinum cancer chemotherapy. Advances in the design of cisplatin analogues
Q47274509Aerobic reactions of antitumor active dirhodium(II) tetraacetate Rh2(CH3COO)4 with glutathione
Q36396542Altered DNA binding and amplification of human breast cancer suppressor gene BRCA1 induced by a novel antitumor compound, [Ru(η(6)-p-phenylethacrynate)Cl(2)(pta)].
Q46088554An experimental and theoretical investigation into the hydrolysis of dichloro(ethylenediamine)platinum(II) via electrospray mass spectrometry and density functional theory
Q28080615An integrated view of cisplatin-induced nephrotoxicity and ototoxicity
Q38975452An integrative view of cisplatin-induced renal and cardiac toxicities: Molecular mechanisms, current treatment challenges and potential protective measures
Q30855124An unusual ligand coordination gives rise to a new family of rhodium metalloinsertors with improved selectivity and potency
Q92586137Analysing central metabolism in ultra-high resolution: At the crossroads of carbon and nitrogen
Q57552230Analysis of the Current Situation of Antitumor Drug Use in China
Q39738527Anionic linear-globular dendrimer-cis-platinum (II) conjugates promote cytotoxicity in vitro against different cancer cell lines
Q28344764Anti-Candida activity of a new platinum derivative
Q40796522Anti-HIV and cytotoxic activities of Ru(II)/Ru(III) polypyridyl complexes containing 2,6-(2'-benzimidazolyl)-pyridine/chalcone as co-ligand
Q28553698Anti-Invasive and Anti-Proliferative Synergism between Docetaxel and a Polynuclear Pd-Spermine Agent
Q38203819Anti-cancer palladium complexes: a focus on PdX2L2, palladacycles and related complexes
Q36292954Anti-proliferative activity and mechanism of action of titanocene dichloride
Q39961719Anti-tumour activity of heavy transition metal complexes against hepatoma cells
Q59101621Anticancer Activities of Mononuclear Ruthenium(II) Coordination Complexes
Q47827072Anticancer Activity of Copper Complex of (4R)-(-)-2-Thioxo-4-thiazolidinecarboxylic Acid and 3-Rhodaninepropionic Acid on Prostate and Breast Cancer Cells by Fluorescent Microscopic Imaging.
Q90334551Anticancer Ruthenium(III) Complexes and Ru(III)-Containing Nanoformulations: An Update on the Mechanism of Action and Biological Activity
Q39732972Anticancer activity of a chelating nitrogen mustard bearing tetrachloridoplatinum(iv) complex: better stability yet equipotent to the Pt(ii) analogue.
Q37833099Anticancer activity of metal complexes: involvement of redox processes
Q30515979Anticancer activity of methyl-substituted oxaliplatin analogs
Q39387194Anticancer activity of silver-N-heterocyclic carbene complexes: caspase-independent induction of apoptosis via mitochondrial apoptosis-inducing factor (AIF).
Q36639291Anticancer drug discovery and pharmaceutical chemistry: a history
Q39029785Anticancer potential of (pentamethylcyclopentadienyl)chloridoiridium(III) complexes bearing κP and κP,κS-coordinated Ph2 PCH2 CH2 CH2 S(O)x Ph (x=0-2) ligands.
Q67240403Antileukaemic and Nephrotoxic Properties of Platinum Compounds
Q41774809Antileukemic Efficacy of Monomeric Manganese-Based Metal Complex on KG-1A and K562 Cell Lines
Q51551365Antileukemic activity and cellular effects of rhodium(III) crown thiaether complexes.
Q39496661Antineoplastic drugs: clinical pharmacology and therapeutic use.
Q99632123Antioxidant effect of acetyl-l-carnitine against cisplatin-induced cardiotoxicity
Q59229108Antiproliferative Activity of PtII Complexes with Carboxylated Phosphanes in Chelated or Ring-Opened Forms
Q39619138Antiproliferative activity of chelating N,O- and N,N-ruthenium(II) arene functionalised poly(propyleneimine) dendrimer scaffolds
Q45159072Antitumor activity and cellular accumulation of a new platinum complex, (-)-(R)-2-aminomethylpyrrolidine(1,1-cyclobutanedicarboxylato)platinum( II) monohydrate, in cisplatin-sensitive and -resistant murine P388 leukemia cells
Q37481696Antitumor activity and toxicity of salts of inorganic group 3a metals: aluminum, gallium, indium, and thallium
Q69491820Antitumor activity of imidazolium-bisimidazole-tetrachlororuthenate (III). A representative of a new class of inorganic antitumor agents
Q54098993Antitumour activity of oxaliplatin in neuroblastoma cell lines.
Q43918428Antitumour and toxic effects on Wistar rats of two new platinum complexes
Q34632511Anvirzel™ in combination with cisplatin in breast, colon, lung, prostate, melanoma and pancreatic cancer cell lines
Q40280745Apoptosis of human breast carcinoma cells in the presence of cis-platin and L-/D-PPMP: IV. Modulation of replication complexes and glycolipid: Glycosyltransferases
Q46941824Apoptosis-inducing ability of silver(I) cyanide-phosphines useful for anti-cancer studies
Q39706669Arene ruthenium complexes as anticancer agents
Q57007836Assessment of exposure to platinum-group metals in urban children
Q43247159Astrocyte elevated gene-1 regulates osteosarcoma cell invasion and chemoresistance via endothelin-1/endothelin A receptor signaling
Q39264801Atomic level rendering of DNA-drug encounter.
Q57983113BAMLET kills chemotherapy-resistant mesothelioma cells, holding oleic acid in an activated cytotoxic state
Q34509157BODIPY-phosphane as a versatile tool for easy access to new metal-based theranostics.
Q88981142Bacterial Cytological Profiling Reveals the Mechanism of Action of Anticancer Metal Complexes
Q36379523Base-pair substitution hotspots in GAG and GCG nucleotide sequences in Escherichia coli K-12 induced by cis-diamminedichloroplatinum (II).
Q58864978Behind platinum's sparkle
Q39095158Bidentate ligands on osmium(VI) nitrido complexes control intracellular targeting and cell death pathways
Q41258864Bifunctional binding of cisplatin to DNA: why does cisplatin form 1,2-intrastrand cross-links with ag but not with GA?
Q34188228Binding of cis - and trans -Dichlorodiammineplatinum(II) to DNA: Evidence for Unwinding and Shortening of the Double Helix
Q33985189Binding of cis - and trans -dichlorodiammineplatinum(II) to the nucleosome core
Q33842478Binding of kinetically inert metal ions to RNA: the case of platinum(II).
Q60389814Bio-Metallodendrimers - Emerging Strategies in Metal-Based Drug Design
Q46504867Bioactive gold(i) complexes with 4-mercaptoproline derivatives
Q39773819Biochemical significance of the hard and soft acids and bases principle
Q70288533Biochemical studies on the potentiation of antitumor activity of cisplatin by adriamycin
Q54607960Biologic activity of a dinuclear Pd(II)-spermine complex toward human breast cancer.
Q39723723Biological activity of enantiomeric complexes [PtCl(2)L (2)] (L (2) is aromatic bisphosphanes and aromatic diamines).
Q41117364Biological activity of metal complexes. I. Interaction of Pt(II), Pd(II) and Rh(I) complexes with E. coli strains and with mice LS fibroblasts in vitro
Q39586908Biological activity of organometallic bismuth compounds
Q38872477Biologically active [Pd2L4](4+) quadruply-stranded helicates: stability and cytotoxicity.
Q43222524Biophysical studies on the stability of DNA intrastrand cross-links of transplatin.
Q60609930Bis(acetato)bis(1-methyl-4,5-diphenylimidazole)copper(II): Preparation, characterization, crystal structure, DNA strand breakage and cytogenetic effect
Q34184381Block copolymer micelles for drug delivery: design, characterization and biological significance
Q35615163Bmi1 essentially mediates podocalyxin-enhanced Cisplatin chemoresistance in oral tongue squamous cell carcinoma
Q39450806BnRCH gene inhibits cell growth of Hela cells through increasing the G2 phase of cell cycle
Q95841419Breathing New Life into the Mechanisms of Platinum Resistance in Lung Adenocarcinoma
Q38560599Bringing inorganic chemistry to life with inspiration from R. J. P. Williams
Q69636086CAP therapy for advanced, recurrent and/or metastatic malignant tumors of the head and neck
Q61817973Cancer Prevention and Therapy of Two Types of Gap Junctional Intercellular Communication⁻Deficient "Cancer Stem Cell"
Q24657512Cancer chemotherapy: past, present, and future--Part I
Q66971318Cancer of the ovary
Q46401371Cancer-Specific, Intracellular, Reductive Activation of Anticancer PtIV Prodrugs.
Q39047919Carbohydrate linked organotin(IV) complexes as human topoisomerase Iα inhibitor and their antiproliferative effects against the human carcinoma cell line
Q48250957Carboplatin ototoxicity: an animal model
Q70284489Carcinogenic effect of cisplatin (cis-diammine-dichloroplatinum (II), CDDP) in BD IX rats
Q71088174Carcinostatic effect of caffeine-8-ether-platinum-complexes
Q36611057Catalytic nanomedicine technology: copper complexes loaded on titania nanomaterials as cytotoxic agents of cancer cell
Q39206559Cationic arene ruthenium(II) complexes with chelating P-functionalized alkyl phenyl sulfide and sulfoxide ligands as potent anticancer agents.
Q54351595Cell response of Escherichia coli to cisplatin-induced stress.
Q58766014Cellular Pharmacology of Palladinum(III) Hematoporphyrin IX Complexes: Solution Stability, Antineoplastic and Apoptogenic Activity, DNA Binding, and Processing of DNA-Adducts
Q34089685Cellular Responses to Cisplatin‐Induced DNA Damage
Q68157850Changes in the cytoskeleton pattern of tumor cells by cisplatin in vitro
Q69414883Changes in the hydrodynamic properties of DNA induced by interaction with platinum (II) compounds
Q83202080Characteristic effect of an anticancer dinuclear platinum(II) complex on the higher-order structure of DNA
Q58135589Characterization and Purity Determination of Trans (±) 1,2-Diaminocyclohexane Platinum (Iv) Tetrachloride Using Liquid Chromatography With A Platinum Selective Detector
Q46103622Characterizing Pt-derived anticancer drugs from first principles: the case of oxaliplatin in aqueous solution
Q36085630Chemical approaches to the discovery and development of cancer therapies
Q36093381Chemistry and biology
Q28540744Chemopreventive evaluation of a Schiff base derived copper (II) complex against azoxymethane-induced colorectal cancer in rats
Q38779413Chemotherapeutic response to cisplatin-like drugs in human breast cancer cells probed by vibrational microspectroscopy.
Q51608334Chemotherapy of the squamous cell lung cancer LC-12 with 5-fluorouracil, cisplatin, carboplatin or iproplatin combinations.
Q68631789Chromatographic analysis of anticancer drugs
Q33788519Chronic cisplatin treatment promotes enhanced damage repair and tumor progression in a mouse model of lung cancer
Q34618357Circumventing tumor resistance to chemotherapy by nanotechnology
Q39718529Cis-diamminedichloroplatinum(II). A new antineoplastic agent derived from the group of heavy metal complexes (author's transl)
Q69796384Cis-dichlorodiammineplatinum (II): suppression of adjuvant-induced arthritis in rats
Q39798603Cisplatin (cis-diamminedichloroplatinum II)
Q38123245Cisplatin : an old drug with a newfound efficacy -- from mechanisms of action to cytotoxicity
Q48265802Cisplatin Binding to Biological Ligands Revealed at the Encounter Complex Level by IR Action Spectroscopy.
Q64063299Cisplatin Synergistically Enhances Antitumor Potency of Conditionally Replicating Adenovirus via p53 Dependent or Independent Pathways in Human Lung Carcinoma
Q30447637Cisplatin and aminoglycoside antibiotics: hearing loss and its prevention
Q92908024Cisplatin and beyond: molecular mechanisms of action and drug resistance development in cancer chemotherapy
Q83427382Cisplatin as a cornerstone of modern chemotherapy
Q53756401Cisplatin increases sensitivity of human leukemic blasts to triazene compounds.
Q36893886Cisplatin induces differentiation of breast cancer cells
Q83984819Cisplatin prevents high mobility group box 1 release and is protective in a murine model of hepatic ischemia/reperfusion injury
Q36548702Cisplatin resistance in gastric cancer cells is associated with HER2 upregulation-induced epithelial-mesenchymal transition
Q90149375Cisplatin-Based Chemotherapy of Human Cancers
Q33833882Cisplatin-based therapy: a neurological and neuropsychological review
Q38247492Cisplatin-induced antitumor immunomodulation: a review of preclinical and clinical evidence
Q54284519Cisplatin-induced injury of the renal distal convoluted tubule is associated with hypomagnesaemia in mice.
Q37989844Cisplatin-induced nephrotoxicity and targets of nephroprotection: an update
Q96135177Cisplatin-induced renal toxicity in elderly people
Q36039437Cisplatin-loaded porous Si microparticles capped by electroless deposition of platinum
Q37380106Cisplatin: a review of toxicities and therapeutic applications
Q34348474Cisplatin: from DNA damage to cancer chemotherapy.
Q39835716Cisplatin: synthesis, antitumour activity and mechanism of action
Q45361492Citrate inhibition of cisplatin reaction with DNA studied using fluorescently labeled oligonucleotides: implication for selectivity towards guanine
Q60212683Classical and Non-Classical Ruthenium-Based Anticancer Drugs: Towards Targeted Chemotherapy
Q41965116Clinical oncology and chemical thermodynamics
Q37551919Clinical overview on Lipoplatin: a successful liposomal formulation of cisplatin
Q39061133Co-delivery of oxaliplatin and demethylcantharidin via a polymer-drug conjugate
Q90139060Cobalt(II) Diphenylazodioxide Complexes Induce Apoptosis in SK-HEP-1 Cells
Q33798999Combination Platinum-based and DNA Damage Response-targeting Cancer Therapy: Evolution and Future Directions
Q46379865Combination therapeutic effect of cisplatin along with Solanum trilobatum on benzo(a)pyrene induced experimental lung carcinogenesis
Q33495298Comparative adverse effect profiles of platinum drugs.
Q39941240Comparative effects of alkylating agents and other anti-tumour agents on the intracellular level of adenosine 3′,5′-monophosphate in Walker carcinoma
Q40005317Comparison of the electronic properties, and thermodynamic and kinetic parameters of the aquation of selected platinum(II) derivatives with their anticancer IC50 indexes.
Q46604481Complexes of dibromo(ethylenediamine)-palladium(II) observed from aqueous solutions by electrospray mass spectrometry
Q50696009Complexes of dichloro(ethylenediamine)palladium(II) observed from aqueous solutions by electrospray mass spectrometry.
Q40648722Complexes of metals other than platinum as antitumour agents
Q39712535Comprehensive Vibrational Spectroscopic Investigation of trans,trans,trans-[Pt(N3)2(OH)2(py)2], a Pt(IV) Diazido Anticancer Prodrug Candidate
Q44712236Computational evidence for structural consequences of kiteplatin damage on DNA.
Q55844210Computational methods for the description of pharmacologically relevant platinum complexes – molecular structure and bond dissociation
Q33776520Confocal fluorescence microscopy studies of a fluorophore-labeled dirhodium compound: visualizing metal-metal bonded molecules in lung cancer (A549) cells
Q27666340Consequences of Cisplatin Binding on Nucleosome Structure and Dynamics
Q35128594Control and utilization of ruthenium and rhodium metal complex excited states for photoactivated cancer therapy
Q42576712Controlling Platinum, Ruthenium and Osmium Reactivity for Anticancer Drug Design.
Q39246803Coordination of Gly-Tyr · Pd(II) complex to ATP and ADP nucleotides
Q38667138Copper (II) complexes of bidentate ligands exhibit potent anti-cancer activity regardless of platinum sensitivity status
Q37855898Copper, gold and silver compounds as potential new anti-tumor metallodrugs
Q35133330Copper-free click-chemistry platform to functionalize cisplatin prodrugs.
Q39898547Correlation between the toxicity of platinum drugs to L1210 leukaemia cells and their mutagenic properties
Q36044721Criteria for the selection of second-generation platinum compounds
Q59096780Cross-linking of Complementary Strands of DNA in Mammalian Cells by Antitumour Platinum Compounds
Q64033545Crystal structures of three thiourea (tu) complexes of Pt(II): trans-[(tu)2Pt(NH3)2]Cl2, trans-[(tu)2Pt(CH3NH2)2]Cl2·3H2O and [Pt(tu)4]Cl2
Q64033546Crystal structures of two Pt(II) diamine compounds: trans-Pt(CH3NH2)2Cl2 and cis-Pt[(CH3)2NH]2Cl2
Q58588998Current Developments in Pt(IV) Prodrugs Conjugated with Bioactive Ligands
Q92917085Current State of Platinum Complexes for the Treatment of Advanced and Drug-Resistant Breast Cancers
Q34612225Current status and future perspectives in the treatment of advanced testicular cancer
Q50122993Cyclometalated Pt(ii) complexes with a bidentate Schiff-base ligand displaying unexpected cis/trans isomerism: synthesis, structures and electronic properties.
Q51423158Cyclometallated iridium complexes inducing paraptotic cell death like natural products: synthesis, structure and mechanistic aspects.
Q40631806Cyclopalladated compounds as chemotherapeutic agents: Antitumor activity against a murine melanoma cell line
Q69414675Cyclophosphamide, tetrahydropyranyl-adriamycin, and cis-platinum in the treatment of head and neck adenocarcinoma
Q72597362Cytologic observations on the effects of metallocene dichlorides on human fibroblasts cultivated in vitro
Q40743027Cytotoxic effects of metal complexes of biogenic polyamines. I. Platinum(II) spermidine compounds: prediction of their antitumour activity.
Q73599284Cytotoxicity assessment of three therapeutic agents, cyclosporin-A, cisplatin and doxorubicin, with the ciliated protozoan Tetrahymena pyriformis
Q33696556Cytotoxicity of Pyrazine-Based Cyclometalated (C^Npz^C)Au(III) Carbene Complexes: Impact of the Nature of the Ancillary Ligand on the Biological Properties
Q35882449Cytotoxicity of a Ti(IV) compound is independent of serum proteins
Q35095042Cytotoxicity of cyclometalated platinum complexes based on tridentate NCN and CNN-coordinating ligands: remarkable coordination dependence
Q39548349Cytotoxicity of gold(I) N-heterocyclic carbene complexes assessed by using human tumor cell lines
Q39869132DFT-based QSAR and QSPR models of several cis-platinum complexes: solvent effect
Q45811861DNA binding and oxidative DNA cleavage activity of (mu-oxo)diiron(iii) complexes in visible light.
Q38293573DNA cleavage and binding selectivity of a heterodinuclear Pt-Cu(3-Clip-Phen) complex
Q50902552DNA interaction of europium(III) complex containing 2,2'-bipyridine and its antimicrobial activity.
Q34725611DNA modifications by antitumor platinum and ruthenium compounds: their recognition and repair.
Q35531287DNA repair mechanisms in cancer development and therapy
Q29615572DNA repair pathways as targets for cancer therapy
Q67322647DNA-platinum interactions in vitro with trans- and cis- Pt(NH3)2Cl2
Q39992907David A. Karnofsky memorial lecture. Thoughts on chemical therapy
Q46165983Decomposition of Intermolecular Interactions in the Crystal Structure of Some Diacetyl Platinum(II) Complexes: Combined Hirshfeld, AIM, and NBO Analyses.
Q42946056Decursin Prevents Cisplatin-Induced Apoptosis via the Enhancement of Antioxidant Enzymes in Human Renal Epithelial Cells
Q40110955Degradable cisplatin-releasing core-shell nanogels from zwitterionic poly(beta -aminoester)-graft-PEG for cancer chemotherapy
Q39169444Degradation Kinetics of a Novel Antimitogenic and Antiviral Palladium(II) Coordination Compound
Q55165857Design, Synthesis, and Biological Evaluation of Benzimidazole-Derived Biocompatible Copper(II) and Zinc(II) Complexes as Anticancer Chemotherapeutics.
Q51307878Design, synthesis and biological evaluation of a novel series of glycosylated platinum(iv) complexes as antitumor agents.
Q52788217Design, synthesis, MTT assay, DNA interaction studies of platinum(II) complexes.
Q38974558Designing metallodrugs with nuclease and protease activity.
Q34088322Determination of hypersensitivity to genotoxic agents among Escherichia coli single gene knockout mutants
Q28484446Detoxifying antitumoral drugs via nanoconjugation: the case of gold nanoparticles and cisplatin
Q50576820Development of cis-platinum-induced hearing loss in guinea pigs.
Q47672975Differences in cisplatin distribution in sensitive and resistant ovarian cancer cells: a TEM/NanoSIMS study.
Q92154985Different Effects of Cisplatin and Transplatin on the Higher-Order Structure of DNA and Gene Expression
Q42854210Differential effect of cis-platinum (cis-diamminedichloroplatinum) on regulation of liver and kidney haem and haemoprotein metabolism. Possible involvement of gamma-glutamyl-cycle enzymes
Q47142435Dihydroartemisinin inhibits EMT induced by platinum-based drugs via Akt-Snail pathway
Q48058684Direct measurement of interaction forces between a platinum dichloride complex and DNA molecules.
Q66955456Dissociation of double-stranded poly(I) · poly(C) by cis-diammine-dichloro-Pt(II)
Q39540757Distinct mechanisms contribute to acquired cisplatin resistance of urothelial carcinoma cells.
Q36229392Drug Repurposing for Cancer Therapy.
Q37845248Drug therapy of cancer
Q90351538Dual Photoreactivity of a New Rh2(II,II) Complex for Biological Applications
Q30993331Effect of Different Z-Inducers on the Stabilization of Z Portion in BZ-DNA Sequence: Correlation Between Experimental and Simulation Data.
Q38014817Effect of cis-platinum on heme, drug, and steroid metabolism pathways: possible involvement in nephrotoxicity and infertility
Q40026912Effect of cis-platinum(II)diamminodichloride on cell division of Hyphomicrobium and Caulobacter
Q36767060Effect of cis-platinum(II)diamminodichloride on wild type and deoxyribonucleic acid repair deficient mutants of Escherichia coli
Q67552719Effect of coadministration of selenite on the toxicity and antitumor activity of cis-diamminedichloroplatinum (II) given repeatedly to mice
Q47715751Effect of rhodium (III) complex on experimental carcinogenesis in the livers of rats treated with thioacetamide
Q51674397Effect of whole body hyperthermia on cis-diamminedichloroplatinum (II)-induced antitumour activity and tissue Pt-distribution: do anaesthetics influence the therapeutic ratio?
Q42373306Effective prevention of the nephrotoxicity of cis-platin (CDDP) by administration of sodium 2-mercaptoethane-sulfonate (MESNA) in rats
Q37628495Effects of 1,25(OH)₂D₃ on Cancer Cells and Potential Applications in Combination with Established and Putative Anti-Cancer Agents.
Q52480589Effects of carboplatin on the testis. A histological study.
Q59649953Effects of cobalt (III) complexes on growth and metabolism of Escherichia coli
Q43334087Effects of granisetron and its combination with dexamethasone on cisplatin-induced delayed emesis in the ferret
Q72065588Effects of intralesional injection of cisplatin dissolved in urografin and lipiodol on Ehrlich ascites tumor and normal tissues of CD-1 mice
Q34393918Effects of monofunctional platinum agents on bacterial growth: a retrospective study
Q85570391Effects of platinic chloride on Tetrahymena pyriformis GL
Q52277315Effects on the development of offspring of female mice exposed to platinum sulfate or sodium hexachloroplatinate during pregnancy or lactation.
Q60909024Efficacy and tolerability of BP-C1 in metastatic breast cancer: a Phase II, randomized, double-blind, and placebo-controlled Thai multi-center study
Q43969526Electrolytic ablation as an adjunct to liver resection: experimental studies of predictability and safety
Q24804655Electrolytic ablation of the rat pancreas: a feasibility trial
Q51205603Electron scattering from gas phase cis-diamminedichloroplatinum(II): quantum analysis of resonance dynamics.
Q36069093Electron transfer-based combination therapy of cisplatin with tetramethyl-p-phenylenediamine for ovarian, cervical, and lung cancers.
Q33612466Electrospun Poly(ε-caprolactone) Composite Nanofibers with Controlled Release of Cis-Diamminediiodoplatinum for a Higher Anticancer Activity
Q64268057Elucidation of the Mechanism of Action for Metal Based Anticancer Drugs by Mass Spectrometry-Based Quantitative Proteomics
Q55172138Emerging role of long non-coding RNAs in cisplatin resistance.
Q35000093Encapsulation of Pt(IV) Prodrugs within a Pt(II) Cage for Drug Delivery
Q35242640Endothelin-1 promotes osteosarcoma cell invasion and survival against cisplatin-induced apoptosis
Q71236723Energy-dispersive X-ray fluorescence determination of platinum in plasma, urine, and cerebrospinal fluid of patients administered cis-dichlorodiammineplatinum(II)
Q41488663Enhanced inhibition of both cellular protein synthesis and malate dehydrogenase by aged aquoplatinum(II) complexes
Q39081353Enhancement of cisplatin cytotoxicity in combination with herniarin in vitro
Q34704011Enhancing chemotherapy response with Bmi-1 silencing in ovarian cancer
Q37085878Enhancing the efficacy of cisplatin in ovarian cancer treatment - could arsenic have a role.
Q36377590Enzyme-Instructed Intracellular Molecular Self-Assembly to Boost Activity of Cisplatin against Drug-Resistant Ovarian Cancer Cells
Q64238257Evaluation of Polymer Nanoformulations in Hepatoma Therapy by Established Rodent Models
Q39663017Evaluation of a Schiff base copper complex compound as potent anticancer molecule with multiple targets of action
Q37344013Evolution of energy metabolism, stem cells and cancer stem cells: how the warburg and barker hypotheses might be linked.
Q90292067Exonuclease 1 (Exo1) Participates in Mammalian Non-Homologous End Joining and Contributes to Drug Resistance in Ovarian Cancer
Q44011744Expeditious syntheses of two carbohydrate-linked cisplatin analogs
Q57816479Exploration of biological activities of alkyne arms containing Cu(ii) and Ni(ii) complexes: syntheses, crystal structures and DFT calculations
Q52349456Exploration of selected electronic characteristics of half-sandwich organoruthenium(II) β-diketonate complexes.
Q70714242Ferricenium complexes: a new type of water-soluble antitumor agent
Q24236119Fluid and diuretic therapy for preventing cisplatin-induced nephrotoxicity
Q24242032Fluid and diuretic therapy for preventing cisplatin-induced nephrotoxicity
Q38863948Fluorescent mixed ligand copper(II) complexes of anthracene-appended Schiff bases: studies on DNA binding, nuclease activity and cytotoxicity
Q56978022Folding Kinetics of Single Human Telomeric G-Quadruplex Affected by Cisplatin
Q64390093Formation and stability of interstrand cross-links induced by cis- and trans-diamminedichloroplatinum (II) in the DNA of Saccharomyces cerevisiae strains differing in repair capacity
Q53029341Fosfomycin Does not Reduce Cytostatic Activity of Cis-Platinum Against Human Osteosarcoma Cell Lines in Vitro
Q35593353From cisplatin to artificial nucleases--the role of metal ion-nucleic acid interactions in biology
Q52739129Functional metal complexes from CuAAC "click" bidentate and tridentate pyridyl-1,2,3-triazole ligands.
Q39761093Gadolinium texaphyrin (Gd-Tex)-malonato-platinum conjugates: synthesis and comparison with carboplatin in normal and Pt-resistant cell lines
Q42131038Gap Junction Enhancer Potentiates Cytotoxicity of Cisplatin in Breast Cancer Cells
Q39428059Genetic variation in the DNA repair pathway as a potential determinant of response to platinum-based chemotherapy in breast cancer.
Q40807070Genomic imbalances associated with acquired resistance to platinum analogues
Q26851196Genotoxic anti-cancer agents and their relationship to DNA damage, mitosis, and checkpoint adaptation in proliferating cancer cells
Q28378257Gold(I) complexes as antimicrobial agents
Q58921526Gold(iii) complexes inhibit growth of cisplatin-resistant ovarian cancer in association with upregulation of proapoptotic PMS2 gene
Q47447102Green synthesis palladium nanoparticles mediated by white tea (Camellia sinensis) extract with antioxidant, antibacterial, and antiproliferative activities toward the human leukemia (MOLT-4) cell line
Q38043422Group-10 metal complexes of biological molecules and related ligands: structural and functional properties
Q77636528Growth and differentiation of bone marrow hematopoietic cells in mice bearing Ehrlich ascite tumor and treated with Dicyclopentadienildichlorotitanium (IV)
Q90376633HOXB7 mediates cisplatin resistance in esophageal squamous cell carcinoma through involvement of DNA damage repair
Q46521670HPMA copolymer platinates as novel antitumour agents: in vitro properties, pharmacokinetics and antitumour activity in vivo
Q36082052Half-sandwich RuCl2(η(6)-p-cymene) core complexes containing sulfur donor aroylthiourea ligands: DNA and protein binding, DNA cleavage and cytotoxic studies
Q54056992HeLa cell transformants overproducing mouse metallothionein show in vivo resistance to cis-platinum in nude mice.
Q42130456Heteroleptic Copper(I) Complexes of "Scorpionate" Bis-pyrazolyl Carboxylate Ligand with Auxiliary Phosphine as Potential Anticancer Agents: An Insight into Cytotoxic Mode.
Q62082145Highly Water-Soluble Cyclopentadienyl and Indenyl Molybdenum(II) Complexes - Second Generation of Molybdenum-Based Cytotoxic Agents
Q35756295Highly and Broad-Spectrum In Vitro Antitumor Active cis-Dichloridoplatinum(II) Complexes with 7-Azaindoles
Q34297886Highly potent metallopeptide analogues of luteinizing hormone-releasing hormone.
Q39864467Highly selective apoptotic cell death induced by halo-salane titanium complexes
Q28484603Histological changes in kidney and liver of rats due to gold (III) compound [Au(en)Cl(2)]Cl
Q44631406How Strong Can the Bend Be on a DNA Helix from Cisplatin? DFT and MP2 Quantum Chemical Calculations of Cisplatin-Bridged DNA Purine Bases
Q39185517Human cancerous and healthy cell cytotoxicity studies of a chiral μ-dicarbene-digold(I) metallamacrocycle
Q62140985Hydration of cis- and trans-platin: A pseudopotential treatment in the frame of a G3-type theory for platinum complexes
Q34531571Hydrogel Nanoparticles with Thermally Controlled Drug Release
Q38000483Hyphenated techniques as tools for speciation analysis of metal-based pharmaceuticals: developments and applications
Q61799902Hypoxia-targeted drug delivery
Q34052005Identification of chemoresistant factors by protein expression analysis with iTRAQ for head and neck carcinoma
Q67797213Immediate (type I) allergic responses to platinum compounds
Q40461128Immunological and spectroscopic studies of poly(dG-dC).poly(dG-dC) modified by cis-diamminedichloroplatinum(II).
Q41430824Immunosuppression by Platinum Diamines
Q40886027Immunosuppression with cis -Platinum (II) Diammino-dichloride: Effect on Antibody Plaque-Forming Spleen Cells
Q56763984Impact of drug formulation and free platinum/cisplatin ratio on hypersensitivity reactions to cisplatin: formulation matters
Q88917536Impact of various lipophilic substituents on ruthenium(II), rhodium(III) and iridium(III) salicylaldimine-based complexes: synthesis, in vitro cytotoxicity studies and DNA interactions
Q43029692Improvements in the Synthesis and Understanding of the Iodo-bridged Intermediate en Route to the Pt(IV) Prodrug Satraplatin
Q58079350In Vitro Anti-Atherogenic Properties of N-Heterocyclic Carbene Aurate(I) Compounds
Q36001231In Vitro and In Vivo Studies of Non-Platinum-Based Halogenated Compounds as Potent Antitumor Agents for Natural Targeted Chemotherapy of Cancers
Q42292369In situ generated D-peptidic nanofibrils as multifaceted apoptotic inducers to target cancer cells
Q70813836In the search for new anticancer drugs. VII. Platinum complexes of diaziridines and azetidine
Q35216231In vitro and in vivo antitumor activities and DNA binding mode of five coordinated cyclometalated organoplatinum(II) complexes containing biphosphine ligands
Q58838263In vitro and in vivo studies into the biological activities of 1,10-phenanthroline, 1,10-phenanthroline-5,6-dione and its copper(ii) and silver(i) complexes
Q39952629In vitro anticancer activity and biologically relevant metabolization of organometallic ruthenium complexes with carbohydrate-based ligands
Q39027164In vitro cytotoxic activities, DNA-, and BSA-binding studies of a new dinuclear copper(II) complex with N-[3-(dimethylamino)propyl]-N'-(2-carboxylatophenyl)-oxamide as ligand
Q41503822In vitro plasma binding of some second generation antitumor platinum complexes
Q53116557In vitro studies on cisplatin focusing on kinetic aspects of intracellular chemistry by LC-ICP-MS.
Q53028113In vitro studies on genotoxicity and cytotoxicity of the anticancer drugs cisplatin and cofplaton, a caffeine-8-ether plus cisplatinum compound
Q39782222In vivo comparative study of the cytotoxicity of a liposomal formulation of cisplatin (lipoplatin™).
Q67716194Increased mitochondrial uptake of rhodamine 123 by CDDP treatment
Q38806350Induction of intrinsic and extrinsic apoptosis through oxidative stress in drug-resistant cancer by a newly synthesized Schiff base copper chelate
Q46912600Inelastic neutron scattering study of Pt(II) complexes displaying anticancer properties
Q62274210Influence of DFT Functionals and Solvation Models on the Prediction of Far-Infrared Spectra of Pt-Based Anticancer Drugs: Why Do Different Complexes Require Different Levels of Theory?
Q62851949Influence of antineoplastic drugs on morphine analgesia and on morphine tolerance
Q68671238Influence of frusemide on cis-dichlorodiammineplatinum (II) pharmaco-kinetics
Q60212615Influence of the Diketonato Ligand on the Cytotoxicities of [Ru(η6-p-cymene)(R2acac)(PTA)]+ Complexes (PTA = 1,3,5-triaza-7-phosphaadamantane)
Q45060673Influence of time and chloride ions on the interaction of cisplatin with human albumin in-vitro
Q45811404Inhibition of Cold VarIant of Influenza Virus by Selected Chemicals
Q34249679Inhibition of avian myeloblastosis virus reverse transcriptase and virus inactivation by metal complexes of isonicotinic acid hydrazide
Q38981537Inhibition of cancer derived cell lines proliferation by synthesized hydroxylated stilbenes and new ferrocenyl-stilbene analogs. Comparison with resveratrol.
Q70439651Inhibition of cell division by sodium chloroiridate
Q55060877Inhibition of cisplatin-mediated DNA damage in vitro by ribonucleotides.
Q70456367Inhibition of leucine aminopeptidase and malate dehydrogenase by aquoplatinum (II) complexes
Q70586156Inhibition of lymphocyte blastogenesis by platinum compounds
Q37364815Inhibition of transcription by platinum antitumor compounds
Q72605126Inhibitory studies of DNA, RNA and protein synthesis in Escherichia coli by platinum containing complexes
Q42118007Innovative Use of Palladium Compounds to Selectively Detect Live Enterobacteriaceae Cells in Milk by Polymerase Chain Reaction
Q91971712Inositol-triphosphate 3-kinase B confers cisplatin resistance by regulating NOX4-dependent redox balance
Q36959078Insights into RNA binding by the anticancer drug cisplatin from the crystal structure of cisplatin-modified ribosome
Q64945054Insulin Release Mechanism Modulated by Toxins Isolated from Animal Venoms: From Basic Research to Drug Development Prospects.
Q42592163Interaction of 5'-Guanosine Monophosphate with Organotin(IV) Moieties: Synthesis, Structural Characterization, and Anti-Inflammatory Activity
Q40048032Interaction of Pt(II) complexes with DNAs from various sources. A circular dichroism study
Q44637765Interaction of anticancer drug cisplatin with guanine: Density functional theory and surface‐enhanced Raman spectroscopy study
Q41141577Interaction of cis-diamminedichloroplatinum(II) with phi X174 DNA.
Q52996234Interaction of cis-dichlorodiammineplatinum (II) with DNA
Q39584594Interaction of rac-[M(diimine)3]2+ (M=Co, Ni) complexes with CT DNA: role of 5,6-dmp ligand on DNA binding and cleavage and cytotoxicity
Q67018850Interaction of rhodium(III) with DNA
Q73295356Interaction of sodium chloroplatinate and iproplatin with metallothionein in vivo
Q67324954Interactions of Cis- and Trans-platinum(II) complexes with dehydrogenase enzymes in the presence of different mono- and polynucleotides: Evidence for a ternary complex
Q47906101Interactions of an antitumor platinum compound with deoxyribonucleic acid, histones, l-amino acids, poly-l-amino acids, nucleosides and nucleotides
Q27687736Interactions of gold-based drugs with proteins: crystal structure of the adduct formed between ribonuclease A and a cytotoxic gold(III) compound
Q54252471Interactions of platinum complexes, peptides, methionine and dehydrogenases.
Q34663069Interactions of platinum metals and their complexes in biological systems
Q50210771Interactions of the "piano-stool" [ruthenium(II)(η(6) -arene)(quinolone)Cl](+) complexes with water; DFT computational study.
Q39140230Intracellular water - an overlooked drug target? Cisplatin impact in cancer cells probed by neutrons.
Q41722709Introduction and overview of noninvasive drug monitoring
Q39407436Investigational drugs under study by the United States National Cancer Institute
Q67428098Investigations into the mechanisn of action of antitumour platinum compounds: Time- and dose-dependent changes in the alkaline sucrose gradient sedimentation profiles of DNA from hamster cells treated with cis-platinum(II) diamminedichloride
Q39371239Involvement of cytochrome P450 in cisplatin treatment: implications for toxicity
Q43856063Ionic rhenocene derivatives with antitumor activity
Q69609843Ionic titanocene complexes: a new type of antitumor agent
Q38710506Is matching ruthenium with dithiocarbamato ligands a potent chemotherapeutic weapon in oncology?
Q40586878Isomer abundance of bis(beta-diketonato) complexes of titanium(IV). Crystal structures of the antitumor compound budotitane [Ti(IV)(bzac)(2)(OEt)(2)] and of its dichloro-derivative [Ti(IV)(bzac)(2)Cl(2)] (bzac=1-phenylbutane-1,3-dionate).
Q36291991JWA reverses cisplatin resistance via the CK2-XRCC1 pathway in human gastric cancer cells
Q30972381Kinetic study of azole-bridged dinuclear platinum(II) complexes reacting with a hairpin-stabilized double-stranded oligonucleotide
Q52076226Kinetics and mechanism for reduction of anticancer-active tetrachloroam(m)ine platinum(IV) compounds by glutathione.
Q38298266Kinetics of cisplatin binding to short r(GG) containing miRNA mimics - influence of Na(+)versus K(+), temperature and hydrophobicity on reactivity
Q68239828Leukemia and the reducing property of viruses
Q58063439Ligation of anti-cancer drugs to self-assembling ultrashort peptides by click chemistry for localized therapy
Q57345360Light Harvesting and Photoemission by Nanoparticles for Photodynamic Therapy
Q50909229Lipid Flip-Flop and Pore Nucleation on Zwitterionic Bilayers are Asymmetric under Ionic Imbalance.
Q52535446Lipophilic gold(I) complexes with 1,3,4-oxadiazol-2-thione or 1,3-thiazolidine-2-thione moieties: synthesis and their cytotoxic and antimicrobial activities.
Q89622527Long Non-coding RNAs Involved in Resistance to Chemotherapy in Ovarian Cancer
Q41504946Long term effect of Cis-Diamminedichloride platinum (CDDP) on renal function and structure in man
Q38814705Luminescent bioactive NHC-metal complexes to bring light into cells
Q39528351M2L4 coordination capsules with tunable anticancer activity upon guest encapsulation.
Q39687663MDR1 mediated chemoresistance: BMI1 and TIP60 in action
Q41194560Matrix Density Engineering of Hydrogel Nanoparticles with Simulation-Guided Synthesis for Tuning Drug Release and Cellular Uptake
Q36904002Mechanism elucidation of the cis-trans isomerization of an azole ruthenium-nitrosyl complex and its osmium counterpart
Q26996320Mechanisms of Cisplatin nephrotoxicity
Q64390568Mechanisms of cisplatin (cis-diamminodichloroplatinum II)-induced cytotoxicity and genotoxicity in yeast
Q37392185Mechanistic Studies of the Anticancer Activity of An Octahedral Hexanuclear Pt(II) Cage.
Q38034439Mechanistic studies on the reactions of platinum(II) complexes with nitrogen- and sulfur-donor biomolecules
Q34514293Medicinal agents incorporating the 1,2-diamine functionality
Q39270889Melanoma tumor inhibition by tetrachlorido(O,O'-dibutyl-ethylenediamine-N,N'-di-3-propionate)platinum(IV) complex: in vitro and in vivo investigations.
Q45174087Mercaptoalkylamine Coordination Compounds of Platinum(II) and Palladium(II) and Their Anticancer Activity
Q69015737Metabolism of platinum [14cethylenediamine dichloride in the rat
Q48185242Metal Ions Effectively Ablate the Action of Botulinum Neurotoxin A.
Q35836648Metal and metalloid containing natural products and a brief overview of their applications in biology, biotechnology and biomedicine.
Q38271731Metal complex interactions with DNA.
Q91913177Metal complexes driven from Schiff bases and semicarbazones for biomedical and allied applications: a review
Q68286163Metallothionein induction prevents toxic side effects of cisplatin and adriamycin used in combination
Q91685000Methionine Binding to Dirhodium(II) Tetraacetate
Q36467141Metoclopramide enhances the effect of cisplatin on xenografted squamous cell carcinoma of the head and neck
Q42241395Microbial growth inhibition by alternating electric fields
Q37467770Mind the gap: a survey of how cancer drug carriers are susceptible to the gap between research and practice.
Q33564338Mitaplatin, a potent fusion of cisplatin and the orphan drug dichloroacetate
Q39052398Mitochondria are the primary target in the induction of apoptosis by chiral ruthenium(II) polypyridyl complexes in cancer cells
Q39638924Mitochondrial mode of action of a thymidine-based cisplatin analogue breaks resistance in cancer cells
Q39993736Mixed ligand ruthenium(II) complexes of bis(pyrid-2-yl)-/bis(benzimidazol-2-yl)-dithioether and diimines: study of non-covalent DNA binding and cytotoxicity.
Q38969205Mixed-ligand ruthenium polypyridyl complexes as apoptosis inducers in cancer cells, the cellular translocation and the important role of ROS-mediated signaling
Q37843695Mode of action and biosynthesis of the azabicycle-containing natural products azinomycin and ficellomycin.
Q73481429Modified rice bran beneficial for weight loss of mice as a major and acute adverse effect of Cisplatin
Q73335667Modifying the properties of platinum (IV) complexes in order to increase biological effectiveness
Q35758048Molecular mechanisms of resistance and toxicity associated with platinating agents
Q31630775Molecular structure and cytotoxicity of 3D-transition metal complexes capable to form a stable metal-nitrogen bond
Q38823861Mono- and di-bromo platinum(IV) prodrugs via oxidative bromination: synthesis, characterization, and cytotoxicity.
Q37282213Monofunctional and higher-valent platinum anticancer agents.
Q50063144Monomeric and dimeric coordinatively saturated and substitutionally inert Ru(ii) polypyridyl complexes as anticancer drug candidates.
Q57752749Mononuclear copper(ii) complexes with 3,5-substituted-4-salicylidene-amino-3,5-dimethyl-1,2,4-triazole: synthesis, structure and potent inhibition of protein tyrosine phosphatases
Q38829453Mononuclear iron(iii) complexes of tridentate ligands with efficient nuclease activity and studies of their cytotoxicity
Q38310005More pronounced salt dependence and higher reactivity for platination of the hairpin r(CGCGUUGUUCGCG) compared with d(CGCGTTGTTCGCG).
Q64033408Multiplicity of metal ion binding patterns to nucleobases
Q30883067Multivalent Antibiotics via Metal Complexes: Potent Divalent Vancomycins against Vancomycin-Resistant Enterococci
Q66894876Mutagenic properties of CIS-Platinum(II)diammino-dichloride in Escherichia coli
Q38980214N-Polybenzylated alicyclic 1,2-diamines: cytotoxicity and G1 phase arrest in cancer cell line
Q39138998N6-benzyladenosine derivatives as novel N-donor ligands of platinum(II) dichlorido complexes.
Q34338695Nanocarriers for delivery of platinum anticancer drugs.
Q37042860Nanoparticle encapsulation of mitaplatin and the effect thereof on in vivo properties
Q38723829Nanoparticle formulations of cisplatin for cancer therapy
Q52744411Nanoparticles of metal-organic cages designed to encapsulate platinum-based anticancer agents.
Q42361372Nanotoxicology and Metalloestrogens: Possible Involvement in Breast Cancer
Q34690068Nephrotoxicity induced by cancer chemotherapy with special emphasis on cisplatin toxicity
Q42368069Neuro-protective effect of rutin against Cisplatin-induced neurotoxic rat model
Q46487990New Insights into the Reactivity of Cisplatin with Free and Restrained Nucleophiles: Microsolvation Effects and Base Selectivity in Cisplatin-DNA Interactions.
Q40491603New cisplatin analogues in development. A review
Q34914365New clues for platinum antitumor chemistry: kinetically controlled metal binding to DNA.
Q33859961New oral chemotherapeutic agents for lung cancer
Q40149023New platinum complexes in clinical trials
Q34215909New platinum complexes with anti-tumour activity
Q39717597Noble Metal Complexes in Cancer Chemotherapy
Q36985163Non-DNA-binding platinum anticancer agents: Cytotoxic activities of platinum-phosphato complexes towards human ovarian cancer cells
Q42155449Non-traditional platinum compounds for improved accumulation, oral bioavailability, and tumor targeting
Q33852968Noninvasive measurements for studying the tumoral pharmacokinetics of platinum anticancer drugs in solid tumors
Q39031995Novel heterobimetallic radiotheranostic: preparation, activity, and biodistribution
Q48015270Novel nanocrystals as a platinum-delivery vehicle for chemotherapy
Q53636499Novel oxaliplatin derivatives with 1-(substituted benzyl)azetidine-3,3-dicarboxylate anions. Synthesis, cytotoxicity, and interaction with DNA.
Q39459292Novel platinum(II) and palladium(II) complexes of thiosemicarbazones derived from 5-substitutedthiophene-2-carboxaldehydes and their antiviral and cytotoxic activities
Q37461061Novel strategies for reversing platinum resistance
Q45162711Novel thiocyanato complexes with potent cytotoxic and antimicrobial properties
Q68045195Novel, quinone-thiosemicarbazone hybrid (QTSCHY) non-platinum antitumor agents: inhibition of DNA biosynthesis in P388 lymphocytic cells by coordinatively unsaturated copper(II) and iron(III) complexes of naphthoquinone thiosemicarbazones
Q40121686Occupational asthma: Review of present clinical and immunologic status
Q38767028Oligonucleotide structure: a decade of results from single crystal X-ray diffraction studies
Q39399932On the binding modes of metal NHC complexes with DNA secondary structures: implications for therapy and imaging
Q35665803Oncology: its scope and prospects
Q28829576One-dimensional Magnus-type platinum double salts
Q39229950Organometallic anticancer agents that interfere with cellular energy processes: a subtle approach to inducing cancer cell death
Q42555974Organometallic cis-Dichlorido Ruthenium(II) Ammine Complexes
Q38848959Overcoming tumor resistance to cisplatin through micelle-mediated combination chemotherapy
Q90371047Oxaliplatin Pt(IV) prodrugs conjugated to gadolinium-texaphyrin as potential antitumor agents
Q37242664Oxaliplatin-based chemotherapy in the management of colorectal cancer
Q33761590Oxidative DNA double strand breaks and autophagy in the antitumor effect of sterically hindered platinum(II) complexes in NSCLCs
Q43051494Oxidative halogenation of cisplatin and carboplatin: synthesis, spectroscopy, and crystal and molecular structures of Pt(IV) prodrugs
Q33594393Oxoaporphine Metal Complexes (CoII, NiII, ZnII) with High Antitumor Activity by Inducing Mitochondria-Mediated Apoptosis and S-phase Arrest in HepG2.
Q69571206Pattern of toxicity by titanocene dichloride in mice. Blood and urine chemical parameters
Q41915835Pentamethylcyclopentadienyl-rhodium and iridium complexes containing (N^N and N^O) bound chloroquine analogue ligands: synthesis, characterization and antimalarial properties
Q38870736Peptide Bioconjugates of Electron-Poor Metallocenes: Synthesis, Characterization, and Anti-Proliferative Activity
Q38166233Personalizing colon cancer therapeutics: targeting old and new mechanisms of action.
Q37946235Perspective: the potential of pyrazole-based compounds in medicine
Q38330216Pharmacogenetics of chemotherapy-induced nausea and vomiting
Q47309064Pharmacogenetics of platinum-based chemotherapy in non-small cell lung cancer: predictive validity of polymorphisms of ERCC1.
Q61828298Pharmacokinetics and Tissue Distribution of Cisplatin and Conjugates of Cisplatin with Carboxymethyldextran and A5B7 Monoclonal Antibody in CD1 Mice
Q38275908Pharmacokinetics and tissue distribution of novel platinum containing anticancer agent BP-C1 studied in rabbits using sector field inductively coupled plasma mass spectrometry
Q33426796Pharmacokinetics of (glycolate-0,0')-diammine platinum (II), a new platinum derivative, in comparison with cisplatin and carboplatin
Q35112827Pharmacological and molecular effects of platinum(II) complexes involving 7-azaindole derivatives.
Q33670435Pharmacological applications of inorganic complexes
Q69358010Phase I clinical trial of combined therapy with 5-FU (NSC 19893) and cis-platinum (II) diaminedichloride (NSC 119875)
Q51199413Photochemistry and DNA photocleavage by a new unsupported dirhodium(II,II) complex.
Q35147166Photoinduced interactions of two dirhodium complexes with d(GTCGAC)2 probed by 2D NOESY.
Q30806098Photoinduced intercalation and coordination of a dirhodium complex to DNA: dual DNA binding
Q77811663Physicochemical factors for cytotoxic activity in platinum dinuclear complexes with pyrimidine and imide ligands
Q56659409Platin-Komplexe in der Krebstherapie
Q58486684Platinum Complexes as Anti-Cancer Drugs: Modeling of Structure, Activation and Function
Q58993871Platinum and Palladium Polyamine Complexes as Anticancer Agents: The Structural Factor
Q36322728Platinum antitumour agents: a review of (bio)analysis
Q43620915Platinum carboxylato-pendant-arm macrocycles: structure, redox properties and anti-cancer potential
Q38791247Platinum complexes as light promoted anticancer agents: a redefined strategy for controlled activation
Q67234080Platinum complexes inhibit ATP‐driven basic dye uptake in lysosomes from rat liver
Q53728172Platinum coordination complexes in cancer chemotherapy.
Q39428343Platinum nanoparticles in nanobiomedicine.
Q44485929Platinum(II) catalysis and radical intervention in reductions of platinum(IV) antitumor drugs by ascorbic acid
Q92268928Platinum(IV)-Ferrocene Conjugates and Their Cyclodextrin Host-Guest Complexes
Q41007441Platinum-conjugated antibodies for application in mass cytometry
Q90049509Poly(3-hydroxi-butyrate-co-3-hydroxy-valerate) (PHB-HV) microparticles loaded with holmium acetylacetonate as potential contrast agents for magnetic resonance images
Q55286461Polyethylene glycol-conjugated HER2-targeted peptides as a nuclear imaging probe for HER2-overexpressed gastric cancer detection in vivo.
Q36253687Polymeric Micelle-Mediated Delivery of DNA-Targeting Organometallic Complexes for Resistant Ovarian Cancer Treatment
Q37211504Polymeric micelles from poly(ethylene glycol)-poly(amino acid) block copolymer for drug and gene delivery
Q33506479Polyvalent oligonucleotide gold nanoparticle conjugates as delivery vehicles for platinum(IV) warheads
Q50649669Possible involvement of the lipoxygenase and leukotriene signaling pathways in cisplatin-mediated renal toxicity.
Q39888799Post-translational and transcriptional regulation of glycolipid glycosyltransferase genes in apoptotic breast carcinoma cells: VII. Studied by DNA-microarray after treatment with L-PPMP.
Q42281419Potent antitumour activity of (-)-(R)-2-aminomethylpyrrolidine (1,1-cyclobutanedicarboxylato)platinum(II) monohydrate (DWA2114R) against advanced L1210 leukaemia in mice
Q39452671Potent inhibition of protein tyrosine phosphatases by quinquedentate binuclear copper complexes: synthesis, characterization and biological activities.
Q40864105Potential Carcinostatic Activity of Metal Complexes
Q39175635Potentially cytotoxic new copper(II) hydrazone complexes: synthesis, crystal structure and biological properties
Q92637158Preclinical Evaluation of 1,2-Diamino-4,5-Dibromobenzene in Genetically Engineered Mouse Models of Pancreatic Cancer
Q41704067Prediction of the antitumor activity of new platinum analogs based on their ex vivo pharmacodynamics as determined by bioassay
Q64889081Preferential Interstrand Cross-Linking of DNA Rich in Guanine and Cytosine by cis-Dichlorodiammineplatinum(II)
Q33465444Preliminary clinical experience withcis-diamminedichloroplatinum (II) (NSC 119875, CACP)
Q71463869Preliminary studies on the inhibitory effect of novel Pd(II) complexes of vitamin B6 on cell divisions
Q37395694Preparation of mammalian expression vectors incorporating site-specifically platinated-DNA lesions.
Q98293128Probing DNA-Cleavage Efficiencies of Copper(II) Complexes: A Computational Perspective
Q45145537Probing the biological evaluations of a new designed Pt(II) complex using spectroscopic and theoretical approaches: human hemoglobin as a target.
Q37276239Promotion of DNA strand breaks, interstrand cross-links and apoptotic cell death in A2780 human ovarian cancer cells by transplatinum planar amine complexes
Q50213472Prophage induction and mutagenecity of a series of anti-tumour platinum(II) and platinum(IV) co-ordination complexes
Q69405199Protection against cisplatin nephrotoxicity by prochlorperazine
Q58911169Pt(II) Complexes with Linear Diamines—Part I: Vibrational Study of Pt-Diaminopropane
Q57599961Pt(II) complexes of amino acids and peptides II. Structural analysis of trans-[Cl2-Pt-(H-Aib-OH)2n] and trans-[Pt-(H-Aib-O−)2]
Q51931934Pt-bridges in various single-strand and double-helix DNA sequences. DFT and MP2 study of the cisplatin coordination with guanine, adenine, and cytosine.
Q38760811Pyrithione-based ruthenium complexes as inhibitors of aldo-keto reductase 1C enzymes and anticancer agents
Q58486657QM/MM description of platinum–DNA interactions: comparison of binding and DNA distortion of five drugs
Q45934645QM/MM investigation into binding of square-planar platinum complexes to DNA fragments.
Q51141636Quantitative analysis of the flexibility effect of cisplatin on circular DNA.
Q46326842Quantitative subcellular distribution of platinum in rat tissues following i.v. bolus and i.v. infusion of cisplatin
Q39827612Radiation and platinum drug interaction
Q37628986Radio-frequency plasma polymerized biodegradable carrier for in vivo release of cis-platinum
Q41572976Reaction of cis-diamminedichloroplatinum (II) and DNA in B or Z conformation
Q38002872Reactions and structural characterization of gold(III) complexes with amino acids, peptides and proteins.
Q40472204Reactions of the UVRABC excision nuclease with DNA damaged by diamminedichloroplatinum(II).
Q39689828Rearrangement of a 1,3-trans-[Pt(NH3)2[(GXG)-N7G,N7G]] intrastrand cross-link into interstrand cross-links within RNA duplexes
Q97646049Recent Advances of Gold Compounds in Anticancer Immunity
Q53139745Recent Developments in the Medicinal Applications of Silver-NHC Complexes and Imidazolium Salts.
Q101578696Recent advances in the discovery of multi-targeted tyrosine kinase inhibitors as anticancer agents
Q34282236Recognition of cisplatin adducts by cellular proteins
Q39304159Reduced Newcastle disease virus-induced oncolysis in a subpopulation of cisplatin-resistant MCF7 cells is associated with survivin stabilization
Q47830147Reduction Process of Tetraplatin in the Presence of Deoxyguanosine Monophosphate (dGMP): A Computational DFT Study.
Q89870493Regulation and New Treatment Strategies in Breast Cancer
Q91949964Relations between approved platinum drugs and non-coding RNAs in mesothelioma
Q40168599Relationships between functionality and genetic toxicology of selected DNA-damaging agents
Q40783611Relative efficiencies of a series of square-planar platinum(II) compounds on Salmonella mutagenesis
Q72711040Renal immunolocalization of kallikrein in cisplatin nephrotoxicity in rats
Q71808266Renal insufficiency induced by cisplatin in rats is ameliorated by cyclosporin A
Q48321401Renal toxicity and chemotherapy in children with cancer.
Q73186773Renal toxicity caused by cisplatinum in glutathione-depleted metallothionein-null mice
Q40308378Renaturation effects of cis and trans platinum II and IV compounds on calf thymus deoxyribonucleic acid
Q36364916Repair of cis-platinum-DNA adducts by ABC excinuclease in vivo and in vitro
Q38984857Repurposing platinum-based chemotherapies for multi-modal treatment of glioblastoma
Q36458492Response of murine erythroleukemia cells to cis- and trans-diamminedichloroplatinum (II).
Q41488608Response of two strains of L5178Y cells to cis-dichlorobis-(cyclopentylamine)platinum(II). I. cross-sensitivity to cis-PAD and UV light
Q33781389Rho kinase inhibitor Y-27632 facilitates recovery from experimental peripheral neuropathy induced by anti-cancer drug cisplatin
Q34671630Rhodium and its compounds as potential agents in cancer treatment
Q38690083Rhodium complexes as therapeutic agents
Q39095650Robust structure and reactivity of aqueous arsenous acid-platinum(II) anticancer complexes
Q37230238Role of oxaliplatin in the treatment of colorectal cancer
Q33811929Role of p53 in the ability of 1,2-diaminocyclohexane-diacetato-dichloro-Pt(IV) to circumvent cisplatin resistance
Q42834264Ruthenium(II) [3 + 2 + 1] mixed ligand complexes: substituent effect on photolability, photooxidation of bases, photocytotoxicity and photonuclease activity
Q70545681Scandium, Chromium(VI), Gallium, Yttrium, Rhodium, Palladium, Indium in Mice: Effects on Growth and Life Span
Q55006915Self-Assembly of a [1 + 1] Ionic Hexagonal Macrocycle and Its Antiproliferative Activity.
Q39257995Self-assembled metalla-rectangles bearing azodipyridyl ligands: synthesis, characterization and antitumor activity
Q60585078Separation of platinated derivatives of nucleic acid bases on Sephadex G10
Q72683670Severe exfoliative dermatitis associated with hand ischemia during cisplatin therapy
Q35688494Similar binding of the carcinostatic drugs cis-[Pt[NH3)2] and [Ru(NH3)5Cl] Cl2to tRNApheand a comparison with the binding of the inactivetrans-[Pt(NH3)2Cl2] complex - reluctance in binding to Watson-Crick base pain within doable helix
Q41718006Single nucleotide polymorphisms of nucleotide excision repair pathway are significantly associated with outcomes of platinum-based chemotherapy in lung cancer
Q47411821Solvent and Copper Ion-Induced Synthesis of Pyridyl-Pyrazole-3-One Derivatives: Crystal Structure, Cytotoxicity
Q70249798Some effects of combination chemotherapy with cis-platinum on renal function in patients with nonseminomatous testicular carcinoma
Q53364302Sonochemical Synthesis and Characterization of the Copper(II) Nanocomplex: DNA- and BSA-Binding, Cell Imaging, and Cytotoxicity Against the Human Carcinoma Cell Lines.
Q35864802Special Agents Hunting Down Women Silent Killer: The Emerging Role of the p38α Kinase
Q48264159Special issue: practical applications of metal complexes.
Q77916486Spectroscopic evidence for cis-[PtCl(2)(NH(3))(2)]-erythrocyte membrane interaction
Q30398128Spectroscopic investigation of Bovine Liver Catalase interactions with a novel phen-imidazole derivative of platinum.
Q58242834Stimuli-responsive Pd2L4metallosupramolecular cages: towards targeted cisplatin drug delivery
Q64116999Store-Operated Calcium Entry Contributes to Cisplatin-Induced Cell Death in Non-Small Cell Lung Carcinoma
Q27678705Structural basis of human DNA polymerase η-mediated chemoresistance to cisplatin.
Q38710830Structurally related hydrazone-based metal complexes with different antitumor activities variably induce apoptotic cell death
Q38797478Structure Effect of Some New Anticancer Pt(II) Complexes of Amino Acid Derivatives with Small Branched or Linear Hydrocarbon Chains on Their DNA Interaction
Q67242450Structure and activity relationships of platinum complexes with anti-tumour activity
Q27662176Structure of duplex DNA containing the cisplatin 1,2-{Pt(NH3)2}2+-d(GpG) cross-link at 1.77Å resolution
Q38740869Structure, function and carcinogenicity of metabolites of methylated and non-methylated polycyclic aromatic hydrocarbons: a comprehensive review
Q39485992Structure-activity relationships for organometallic osmium arene phenylazopyridine complexes with potent anticancer activity
Q49687144Structure-activity relationships for ruthenium and osmium anticancer agents - towards clinical development.
Q40544638Studies on cis-dichlorodiammineplatinum (II) as a radiosensitizer
Q39428358Study of the anticancer properties of tin(IV) carboxylate complexes on a panel of human tumor cell lines
Q30723906Study of the coordination of amino acids with metals using [trans-en2Os(eta2-H2)L]2+ as a 1H NMR probe
Q32103947Study of the interaction of DNA with cisplatin and other Pd(II) and Pt(II) complexes by atomic force microscopy
Q44025748Study on the amount of binding of anti-tumor metal complexes to different target sites of dGMP using trans-[en(2)Os(eta2-H(2))(CF(3)SO(3))](CF(3)SO(3)) in a competitive mode
Q45180822Study on the interaction between a water-soluble dinuclear nickel complex and bovine serum albumin by spectroscopic techniques
Q38833511Sugar-boronate ester scaffold tethered pyridyl-imine palladium(II) complexes: synthesis and their in vitro anticancer evaluation.
Q40728629Suppression of spleen lymphocyte mitogenesis in mice injected with platinum compounds
Q53944459Survival and SOS induction in cisplatin-treated Escherichia coli deficient in Pol II, RecBCD and RecFOR functions.
Q69270075Synergistic antitumor activity of cisplatin and UFT in nude mice bearing transplantable nasopharyngeal hybridoma
Q38990462Syntheses and structural investigation of some alkali metal ion-mediated LV(V)O2(-) (L(2-) = tridentate ONO ligands) species: DNA binding, photo-induced DNA cleavage and cytotoxic activities
Q58385411Syntheses, Characterization, and Antitumor Activities of Platinum(II) and Palladium(II) Complexes with Sugar-Conjugated Triazole Ligands
Q42141944Synthesis and Antiproliferative Activity of Steroidal Thiosemicarbazone Platinum (Pt(II)) Complexes
Q63247947Synthesis and Evaluation of the Antiproliferative Properties of a Tethered Tubercidin-Platinum(II) Complex
Q44616689Synthesis and Physicochemical, Antimitogenic, and Antiviral Properties of a Novel Palladium (II) Coordination Compound
Q38928386Synthesis and anticancer activities of a novel class of mono- and di-metallic Pt(II)(salicylaldiminato)(DMSO or Picolino)Cl complexes.
Q30358389Synthesis and anticancer activity of carbosilane metallodendrimers based on arene ruthenium(ii) complexes
Q41879977Synthesis and antitumor activity of a series of (aminoethylpyrrolidine) platinum complexes
Q32121495Synthesis and antitumour activity of platinum(II) and platinum(IV) complexes containing ethylenediamine-derived ligands having alcohol, carboxylic acid and acetate substituents. Crystal and molecular structure of [PtL4CL2].H20 where L4 is ethylenedi
Q39137763Synthesis and crystal structure of binuclear copper(II) complex bridged by N-(2-hydroxyphenyl)-N'-[3-(diethylamino)propyl]oxamide: in vitro anticancer activity and reactivity toward DNA and protein
Q38561236Synthesis and cytotoxic activity of dextran carrying cis-dichloro(cyclohexane-trans-l-1,2-diamine)platinum(II) complex
Q40246525Synthesis and cytotoxicity of enantiomerically pure [1,2-diamino-1-(4-fluorophenyl)-3-methylbutane]platinum(II) complexes
Q42461721Synthesis and pharmacological evaluation of modified adenosines joined to mono-functional platinum moieties.
Q94089335Synthesis of Platinum Complexes from N-Benzyl-1,3-Propane-diamine Derivatives, Potential Antineoplastic Agents
Q39162262Synthesis of antitumor azolato-bridged dinuclear platinum(ii) complexes with in vivo antitumor efficacy and unique in vitro cytotoxicity profiles
Q86838174Synthesis of enantiomeric pureCis-dichloroplatinum(II) amino acid complexes
Q67872690Synthesis, Antitumor Activity, and Nephrotoxicity of the Optical Isomers of 2-Aminomethylpyrrolidine(1,1-cyclobutane-dicarboxylato)platinum(II)
Q38716555Synthesis, Biological Evaluation, and Molecular Docking Studies on the DNA Binding Interactions of Platinum(II) Rollover Complexes Containing Phosphorus Donor Ligands.
Q41865609Synthesis, Characterization, and Cytotoxicity of the First Oxaliplatin Pt(IV) Derivative Having a TSPO Ligand in the Axial Position.
Q59172597Synthesis, Characterization, and In Vitro Antitumor Activity of New Amidineplatinum(II) Complexes Obtained by Addition of Ammonia to Coordinated Acetonitrile
Q30607784Synthesis, Characterization, and Interaction with Biomolecules of Platinum(II) Complexes with Shikimic Acid-Based Ligands
Q59867933Synthesis, Cytotoxicity and Antibacterial Studies of Novel Symmetrically and Nonsymmetrically 4-(Methoxycarbonyl)benzyl-Substituted N-Heterocyclic Carbene-Silver Acetate Complexes
Q38904045Synthesis, X-ray structure and in vitro cytotoxicity studies of Cu(I/II) complexes of thiosemicarbazone: special emphasis on their interactions with DNA.
Q44378286Synthesis, characterization and antitumor activity of novel octahedral Pt(IV) complexes
Q91787414Synthesis, characterization and biological activities of imidazo[1,2-a]pyridine based gold(III) metal complexes
Q31011200Synthesis, characterization and biological activity of trans-platinum(II) and trans-platinum(IV) complexes with 4-hydroxymethylpyridine.
Q35803993Synthesis, characterization and biological activity of trans-platinum(II) complexes with chloroquine
Q57843316Synthesis, characterization and biomolecule-binding properties of novel tetra-platinum(ii)-thiopyridylporphyrins
Q34396926Synthesis, characterization, DNA binding and cleavage, BSA interaction and anticancer activity of dinuclear zinc complexes
Q31056225Synthesis, characterization, DNA binding, cleavage activity, cytotoxicity and molecular docking of new nano water-soluble [M(5-CH₂PPh₃-3,4-salpyr)](ClO₄)₂ (M = Ni, Zn) complexes.
Q36270717Synthesis, characterization, and evaluation of cis-diphenyl pyridineamine platinum(II) complexes as potential anti-breast cancer agents
Q39465410Synthesis, characterization, and in vitro antitumor properties of gold(III) compounds with the traditional Chinese medicine (TCM) active ingredient liriodenine
Q39293908Synthesis, characterization, cellular uptake, apoptosis, cytotoxicity, dna-binding, and antioxidant activity studies of ruthenium(II) complexes
Q86002412Synthesis, crystal structure, and biological activities of two chiral mononuclear Mn((III)) complexes
Q87383865Synthesis, cytotoxicity, induction of apoptosis, and interaction with DNA of dinuclear platinum(II) complexes
Q34933612Synthesis, photophysics, and reverse saturable absorption of platinum complexes bearing extended π-conjugated C^N^N ligands
Q37722632Synthetic methods for the preparation of platinum anticancer complexes
Q26863585Systems biology of cisplatin resistance: past, present and future
Q41908532TWIST interacts with endothelin-1/endothelin A receptor signaling in osteosarcoma cell survival against cisplatin
Q39217966TWIST interacts with β-catenin signaling on osteosarcoma cell survival against cisplatin
Q43122076Targeted Chemotherapy with Metal Complexes
Q34550075Targeted delivery of a cisplatin prodrug for safer and more effective prostate cancer therapy in vivo
Q36970889Targeted delivery of cisplatin to prostate cancer cells by aptamer functionalized Pt(IV) prodrug-PLGA-PEG nanoparticles
Q36877212Targeted single-wall carbon nanotube-mediated Pt(IV) prodrug delivery using folate as a homing device
Q39775092Tautomeric forms study of 1H-(2'-pyridyl)-3-methyl-5-hydroxypyrazole and 1H-(2'-pyridyl)-3-phenyl-5-hydroxypyrazole. Synthesis, structure, and cytotoxic activity of their complexes with palladium(II) ions
Q37523040Testicular Germ Cell Tumors: A Paradigm for the Successful Treatment of Solid Tumor Stem Cells
Q35116876The Chemical and Biological Effects of cis -Dichlorodiammineplatinum (II), an Antitumor Agent, on DNA
Q39798817The Crystal Structures of Metal Complexes of Nucleic Acids and Their Constituent
Q41150062The Mechanism of Action of Antitumor Platinum Compounds
Q91786131The Melding of Drug Screening Platforms for Melanoma
Q28066801The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs
Q54364011The anticancer drug, cisplatin, increases the naturally occurring cell-mediated lysis of tumor cells.
Q41579853The antitumor activity of the platinum complex D-17872 is associated with tumor cell differentiation
Q73714919The cellular distribution and oxidation state of platinum(II) and platinum(IV) antitumour complexes in cancer cells
Q55980246The detection of trace amounts of trans-Pt(NH3)2Cl2 in the presence of cis-Pt(NH3)2Cl2. A high performance liquid chromatographic application of kurnakow's test
Q77891517The effect of a Titanocene Dichloride derivative, Ti IV (C5H5)(2) NCS(2), on the haematopoietic response of Ehrlich tumour-bearing mice
Q54761524The effect of cis-dichlorodiammineplatinum(II) on Escherichia coli B the role of fil, exr and hcr markers
Q77923864The effect of cobalt chloride on serum protein electrophoretic patterns in mice
Q36068602The effect of combined treatment with a platinum complex and ionizing radiation on chinese hamster ovary cells in vitro
Q39929512The effect of heavy metal chelators on the renal accumulation of platinum after cis-dichlorodiammineplatinum II administration to the rat.
Q37171242The effect of ligand lipophilicity on the nanoparticle encapsulation of Pt(IV) prodrugs
Q38842569The effect of potential supramolecular-bond promoters on the DNA-interacting abilities of copper-terpyridine compounds
Q51765470The effects of anaesthetics on cisplatinum-induced toxicity at normal temperatures and during whole-body hyperthermia: the influence of NaCl concentration of the vehicle.
Q70039601The effects of cisplatin on rat spinal ganglia: a study by light and electron microscopy and by morphometry
Q39698183The effects of platinum complexes on seven enzymes
Q52931757The gas-phase chemistry of cis-diammineplatinum(II) complexes: a joint experimental and theoretical study.
Q39737590The in vivo inhibition of tumor growth by ruthenium red: its relationship with the metabolism of calcium in the tumor
Q44594192The interaction of platinum II compounds with bacteriophages T7 and R17
Q43624407The interaction of radiation and cis-diamminedichloroplatinum (II) in intestinal crypt cells
Q92100267The interaction of silver(II) complexes with biological macromolecules and antioxidants
Q51624154The interactions of cisplatin and DNA studied by atomic force microscopy
Q40943542The kinetics and cytotoxicity of cisplatin and its monohydrated complex
Q52527114The mutagenic effect of platinum compounds in Drosophila melanogaster.
Q34474051The phosphate clamp: a small and independent motif for nucleic acid backbone recognition
Q27729148The primary mode of binding of cisplatin to a B-DNA dodecamer: C-G-C-G-A-A-T-T-C-G-C-G
Q40532517The reaction of platinum(II) complexes with DNA. Kinetics of intrastrand crosslink formation in vitro
Q34649255The resurgence of platinum-based cancer chemotherapy
Q48157721The role of arsenic in the hydrolysis and DNA metalation processes in an arsenous acid-platinum(ii) anticancer complex
Q20906133The therapeutic potential of metal-based antimalarial agents: implications for the mechanism of action
Q54482434The tumor-inhibiting effect of isomeric dichloro(diphenylethylenediamine)platinum(II) complexes.
Q46336845The π-acceptor effect in the substitution reactions of tridentate N-donor ligand complexes of platinum(II): a detailed kinetic and mechanistic study
Q90268304Theranostic Lysosomal Targeting Anticancer and Antimetastatic Agents: Half-Sandwich Iridium(III) Rhodamine Complexes
Q104284185Theranostics through the synergistic cooperation of heterometallic complexes
Q38431547Therapeutic applications of spherical nucleic acids
Q38292983Therapeutic gold, silver, and platinum nanoparticles
Q40153857Therapeutic progress--review VIII. Do the newer cytotoxic drugs represent a significant advance in the treatment of cancer?
Q34063391Thermodynamic and kinetic behaviour of [Pt(2-methylthiomethylpyridine)(OH2)2]2+.
Q39933300Timed‐Release Depot for Anticancer Agents
Q61805438Tissue-Specific Chk1 Activation Determines Apoptosis by Regulating the Balance of p53 and p21
Q34671639Titanium complexes in cancer treatment
Q39611571Titanocene anticancer complexes and their binding mode of action to human serum albumin: a computational study
Q44020716Topoisomerase II antagonism and anticancer activity of coordinated derivatives of [RuCl(2)(C(6)H(6))(dmso)].
Q52248411Toxicity and antitumor activity of cis-bis-carboxylato(trans-R,R-1,2-diaminocyclohexane) platinum(II) complexes entrapped in liposomes.
Q39184839Transition metal complexes with oligopeptides: single crystals and crystal structures
Q98178472Triggering of Apoptosis in Osteosarcoma 143B Cell Line by Carbon Quantum Dots via the Mitochondrial Apoptotic Signal Pathway
Q33797148Ultrastructure of Chlamydomonas eugametos palmelloids induced by chloroplatinic acid treatment
Q34396623Understanding and improving platinum anticancer drugs--phenanthriplatin
Q69884769Unexpected mobilisation of lead during cisplatin chemotherapy
Q37868960Unique platinum-DNA interactions may lead to more effective platinum-based antitumor drugs
Q40954510Urinary TIMP2⋅IGFBP7 for the prediction of platinum-induced acute renal injury.
Q35317195Use of the comet assay technique for quick and reliable prediction of in vitro response to chemotherapeutics in breast and colon cancer.
Q34132691Using synthetic DNA interstrand crosslinks to elucidate repair pathways and identify new therapeutic targets for cancer chemotherapy
Q37026980Visualizing inhibition of nucleosome mobility and transcription by cisplatin-DNA interstrand crosslinks in live mammalian cells
Q40791052WR2721 as a modulator of cisplatin- and carboplatin-induced side effects in comparison with other chemoprotective agents: a molecular approach
Q39000939Water-soluble DNA minor groove binders as potential chemotherapeutic agents: synthesis, characterization, DNA binding and cleavage, antioxidation, cytotoxicity and HSA interactions
Q39768981Water-soluble organometallic analogues of oxaliplatin with cytotoxic and anticlonogenic activity
Q67313471X-ray photoelectron spectroscopy of DNA · Pt complexes Evidence of O6(Gua) · N7(Gua) chelation of DNA with cis-dichlorodiamine platinum(II)
Q42246601[Biological effects of coordination compounds of transitional metals. The beta-lactamase inhibitory effect of cis-platin, 2-aminopyridine palladium chloride, clavulanic acid and penicillanic acid sulfonate CP 45,899 in the nitrocefin test and Titert
Q54134785[Cytostatic non-platinum metal complexes: new perspectives for the treatment of cancer?].
Q69576604[Cytostatic platinum complexes: an unexpected discovery with considerable consequences]
Q73664263[Transient electrical birefringence study of the interaction between DNA and platinum compounds: cis-DDP, trans-DDP and TDP]
Q70646077[Tumor inhibition by metallocenes: effect of titanocene, zirconocene, and hafnocene dichlorides on Ehrlich ascites tumor in mice (author's transl)]
Q39805147cis-Diamminedichloroplatinum (II): A Metal Complex with Significant Anticancer Activity
Q36785141cis-Dichlorodiammineplatinum(II): cytological changes induced in Escherichia coli
Q41625727cis-Platinum in advanced gynecologic malignancy
Q50619101cis-Platinum ototoxicity.
Q50095469cis-Platinum pro-drug-attached CuFeS2 nanoplates for in vivo photothermal/photoacoustic imaging and chemotherapy/photothermal therapy of cancer.
Q44080713cis-dichlorodiammineplatinum(II): Hematopoietic effects in rats
Q36073424hsDNA groove binding, photocatalytic activity, and in vitro breast and colon cancer cell reducing function of greener SeNPs
Q37681865miR-33a is up-regulated in chemoresistant osteosarcoma and promotes osteosarcoma cell resistance to cisplatin by down-regulating TWIST.
Q39342904miR-34a is downregulated in cis-diamminedichloroplatinum treated sinonasal squamous cell carcinoma patients with poor prognosis.
Q42538506miR-96 induces cisplatin chemoresistance in non-small cell lung cancer cells by downregulating SAMD9.
Q64033092β-Diketones as Scaffolds for Anticancer Drug Design - From Organic Building Blocks to Natural Products and Metallodrug Components

Search more.