Mucin-Type O-Glycosylation in Gastric Carcinogenesis

scientific article

Mucin-Type O-Glycosylation in Gastric Carcinogenesis is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.3390/BIOM6030033
P3181OpenCitations bibliographic resource ID4592245
P932PMC publication ID5039419
P698PubMed publication ID27409642

P50authorDaniela P FreitasQ59674935
Ana MagalhãesQ82158704
Henrique O DuarteQ87886034
Celso A. ReisQ37831414
P2093author name stringJoana Gomes
Catarina Gomes
P2860cites workTerminal alpha1,4-linked N-acetylglucosamine in Helicobacter pylori-associated intestinal metaplasia of the human stomach and gastric carcinoma cell linesQ40291475
Expression of Lea in gastric cancer cell lines depends on FUT3 expression regulated by promoter methylationQ40326698
Thomsen-Friedenreich antigen expression in gastric carcinomas is associated with MUC1 mucin VNTR polymorphism.Q40480034
Role of the human ST6GalNAc-I and ST6GalNAc-II in the synthesis of the cancer-associated sialyl-Tn antigenQ40507967
Natural antibiotic function of a human gastric mucin against Helicobacter pylori infection.Q40525525
CDX2 homeoprotein is involved in the regulation of ST6GalNAc-I gene in intestinal metaplasia.Q41081633
CD44: structure, function, and association with the malignant process.Q41438683
Loss of Differentiation in Intestinal Metaplasia in Cancerous Stomachs.A Comparative Morphologic StudyQ41704526
Fut2-null mice display an altered glycosylation profile and impaired BabA-mediated Helicobacter pylori adhesion to gastric mucosaQ42015583
Helicobacter pylori CagA protein targets the c-Met receptor and enhances the motogenic responseQ42064313
Peripheral alpha-linked N-acetylglucosamine on the carbohydrate moiety of mucin derived from mammalian gastric gland mucous cells: epitope recognized by a newly characterized monoclonal antibodyQ42086138
Regulation of Helicobacter pylori adherence by gene conversionQ42187297
Role of fucosyltransferases in the association between apomucin and Lewis antigen expression in normal and malignant gastric epitheliumQ42274023
Expression pattern of polypeptide N-acetylgalactosaminyltransferase-10 in gastric carcinomaQ42417033
Reciprocal Modulation of Terminal Sialylation and Bisecting N-Glycans: A New Axis of Cancer-Cell Glycome Regulation?Q42911192
Human trefoil factor 2 is a lectin that binds α-GlcNAc-capped mucin glycans with antibiotic activity against Helicobacter pylori.Q42926733
Expression of UDP-N-acetyl-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase-6 in gastric mucosa, intestinal metaplasia, and gastric carcinoma.Q43225298
Dimeric sialyl-Le(x) expression in gastric carcinoma correlates with venous invasion and poor outcomeQ43512005
Polymorphisms of two fucosyltransferase genes (Lewis and Secretor genes) involving type I Lewis antigens are associated with the presence of anti-Helicobacter pylori IgG antibody.Q43727854
The clinical significance of sialyl Lewis antigen expression in the spread of gastric cancer. Flow cytometric DNA analysisQ44425750
Simple mucin-type carbohydrate antigens (Tn, sialosyl-Tn and T) in gastric mucosa, carcinomas and metastasesQ44568970
Close correlation between increased sialyl-Lewisx expression and metastasis in human gastric carcinomaQ45102566
Infection by Helicobacter pylori expressing the BabA adhesin is influenced by the secretor phenotypeQ46580526
Expression of fully and under-glycosylated forms of MUC1 mucin in gastric carcinoma.Q47705298
The expression pattern of UDP-N-acetyl-alpha-d-galactosamine: polypeptide N-acetylgalactosaminyl transferase-3 in early gastric carcinomaQ47867942
A family of UDP-GalNAc: polypeptide N-acetylgalactosaminyl-transferases control the initiation of mucin-type O-linked glycosylationQ48060342
Aberrant expression of human mucin gene MUC5B in gastric carcinoma and cancer cells. Identification and regulation of a distal promoterQ48373208
Intestinal metaplasia with colonic-type sulphomucins in the gastric mucosa; its association with gastric carcinoma.Q50943375
Glycoengineered cell models for the characterization of cancer O-glycoproteome: an innovative strategy for biomarker discovery.Q50961166
ST6GalNAc-I controls expression of sialyl-Tn antigen in gastrointestinal tissues.Q51767552
CDw75 antigen expression in human gastric carcinoma and adjacent mucosa.Q53478477
Lewis system alterations in gastric carcinogenesis.Q53504569
Genetic activation of the MET pathway and prognosis of patients with high-risk, radically resected gastric cancer.Q54341358
Altered mRNA expressions of sialyltransferases in human gastric cancer tissues.Q54398386
Management of precancerous conditions and lesions in the stomach (MAPS): guideline from the European Society of Gastrointestinal Endoscopy (ESGE), European Helicobacter Study Group (EHSG), European Society of Pathology (ESP), and the Sociedade PortugQ57698678
Influence of the amino acid sequence on the MUC5AC motif peptide O-glycosylation by human gastric UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase(s)Q58160867
Intestinal metaplasia of human stomach displays distinct patterns of mucin (MUC1, MUC2, MUC5AC, and MUC6) expressionQ59182772
T (Thomsen?Friedenreich) antigen and other simple mucin-type carbohydrate antigens in precursor lesions of gastric carcinomaQ59182870
Helicobacter pylori cagpathogenicity island-positive strains induce syndecan-4 expression in gastric epithelial cellsQ59892803
The LacdiNAc-Specific Adhesin LabA Mediates Adhesion of Helicobacter pylori to Human Gastric MucosaQ60403350
Expression of mucins (MUC1, MUC2, MUC5AC, and MUC6) and type 1 Lewis antigens in cases with and withoutHelicobacter pyloricolonization in metaplastic glands of the human stomachQ60444903
Substrate specificities of three members of the human UDP-N-acetyl-alpha-D-galactosamine:Polypeptide N-acetylgalactosaminyltransferase family, GalNAc-T1, -T2, and -T3Q24311744
Characterization of a novel human UDP-GalNAc transferase, pp-GalNAc-T10Q24315839
Mucins in cancer: function, prognosis and therapyQ24633765
Helicobacter pylori SabA adhesin in persistent infection and chronic inflammationQ24650188
Polymorphisms in mucin genes in the development of gastric cancerQ26776186
Clinical significance of MET in gastric cancerQ26776190
Control of mucin-type O-glycosylation: a classification of the polypeptide GalNAc-transferase gene familyQ26864268
Targeting receptor tyrosine kinases in gastric cancerQ27013050
Interactions between Hyaluronan and Its Receptors (CD44, RHAMM) Regulate the Activities of Inflammation and CancerQ27021261
Prognostic significance of MET amplification and expression in gastric cancer: a systematic review with meta-analysisQ27027981
The Three-dimensional Structure of the Extracellular Adhesion Domain of the Sialic Acid-binding Adhesin SabA fromHelicobacter pyloriQ27681123
Cloning of a human UDP-N-acetyl-alpha-D-Galactosamine:polypeptide N-acetylgalactosaminyltransferase that complements other GalNAc-transferases in complete O-glycosylation of the MUC1 tandem repeatQ28118379
CD44 in cancerQ28217782
Mucins in cancer: protection and control of the cell surfaceQ28235006
CD44 is the principal cell surface receptor for hyaluronateQ28261336
Management of Helicobacter pylori infection--the Maastricht IV/ Florence Consensus ReportQ28264077
Functional adaptation of BabA, the H. pylori ABO blood group antigen binding adhesinQ28273716
Global eradication rates for Helicobacter pylori infection: systematic review and meta-analysis of sequential therapyQ28296156
Glycomic and sialoproteomic data of gastric carcinoma cells overexpressing ST3GAL4.Q31076830
Expression of ST3GAL4 leads to SLe(x) expression and induces c-Met activation and an invasive phenotype in gastric carcinoma cellsQ31121236
Identification of common and unique peptide substrate preferences for the UDP-GalNAc:polypeptide alpha-N-acetylgalactosaminyltransferases T1 and T2 derived from oriented random peptide substratesQ33254101
SabA is the H. pylori hemagglutinin and is polymorphic in binding to sialylated glycansQ33264403
Role of ABO secretor status in mucosal innate immunity and H. pylori infectionQ33313489
Pathobiology of Helicobacter pylori-Induced Gastric CancerQ33361550
Comparative genomics of Helicobacter pylori: analysis of the outer membrane protein familiesQ33597903
Polypeptide N-acetylgalactosaminyltransferase 2 regulates cellular metastasis-associated behavior in gastric cancerQ33703870
Molecular studies into the role of CD44 variants in metastasis in gastric cancerQ33706667
The structure and assembly of secreted mucinsQ33763293
MUC1 and cancerQ33778447
Tyrosine kinases and gastric cancerQ34103663
Polypeptide GalNAc-transferases, ST6GalNAc-transferase I, and ST3Gal-transferase I expression in gastric carcinoma cell lines.Q34198013
Clinical relevance of sialyltransferases ST6GAL-I and ST3GAL-III in gastric cancerQ34224371
Precancerous lesions in the stomach: from biology to clinical patient management.Q34354090
Regulation of mucin and glycoconjugate expression: from normal epithelium to gastric tumorsQ34386340
Expression of CD44 and its variants on gastric epithelial cells of patients with Helicobacter pylori colonisationQ34409537
Signaling properties of hyaluronan receptorsQ34444928
Helicobacter pylori adhesin binding fucosylated histo-blood group antigens revealed by retaggingQ34452414
Translocation of Helicobacter pylori CagA into gastric epithelial cells by type IV secretionQ34507324
Glycoproteomic analysis of serum from patients with gastric precancerous lesionsQ34546096
Protein glycosylation in cancerQ35413473
CD44 plays a functional role in Helicobacter pylori-induced epithelial cell proliferation.Q35556818
Human gastric carcinogenesis: a multistep and multifactorial process--First American Cancer Society Award Lecture on Cancer Epidemiology and PreventionQ35570715
Life at the margins: modulation of attachment proteins in Helicobacter pyloriQ35577892
Probing the O-glycoproteome of gastric cancer cell lines for biomarker discovery.Q35692128
Helicobacter pylori outer membrane proteins and gastroduodenal diseaseQ35760550
CD44 is required for two consecutive steps in HGF/c-Met signaling.Q35805198
Association Between Helicobacter pylori Eradication and Gastric Cancer Incidence: A Systematic Review and Meta-analysis.Q35912196
MET in gastric carcinomas: comparison between protein expression and gene copy number and impact on clinical outcomeQ36089948
Helicobacter pylori chronic infection and mucosal inflammation switches the human gastric glycosylation pathwaysQ36263451
Porcine submaxillary gland apomucin contains tandemly repeated, identical sequences of 81 residues.Q36298649
Interaction of CagA with Crk plays an important role in Helicobacter pylori-induced loss of gastric epithelial cell adhesionQ36403673
Clinical relevance of the Helicobacter pylori gene for blood-group antigen-binding adhesinQ36556507
Clinicopathologic significance of sialyl Le(x) expression in advanced gastric carcinomaQ36621614
Helicobacter pylori induces beta3GnT5 in human gastric cell lines, modulating expression of the SabA ligand sialyl-Lewis xQ36655027
Structural Insights into Polymorphic ABO Glycan Binding by Helicobacter pyloriQ36690768
MUC6 apomucin shows a distinct normal tissue distribution that correlates with Lewis antigen expression in the human stomachQ36692591
MUC1-C oncoprotein as a target in breast cancer: activation of signaling pathways and therapeutic approachesQ36753508
Deregulation of MUC4 in gastric adenocarcinoma: potential pathobiological implication in poorly differentiated non-signet ring cell type gastric cancerQ36882675
Carcinogenesis of Helicobacter pyloriQ36903152
MET amplification as a potential therapeutic target in gastric cancer.Q36984821
Mucin glycosylating enzyme GALNT2 suppresses malignancy in gastric adenocarcinoma by reducing MET phosphorylationQ36998213
Polypeptide N-acetylgalactosaminyl transferase 3 independently predicts high-grade tumours and poor prognosis in patients with renal cell carcinomas.Q37040588
HER2 in gastric cancer: a new prognostic factor and a novel therapeutic targetQ37149210
Relevance of MUC1 mucin variable number of tandem repeats polymorphism in H pylori adhesion to gastric epithelial cells.Q37220689
A subset of gastric cancers with EGFR amplification and overexpression respond to cetuximab therapyQ37240838
Expression of the Helicobacter pylori adhesin SabA is controlled via phase variation and the ArsRS signal transduction systemQ37274259
Lewis antigen alterations in gastric cancer precursorsQ67732513
Expression of Blood Group-Related Antigens, ABH, Lewisa, Lewisb, Lewisx, Lewisy, CA19-9, and CSLEX1 in Early Cancer, Intestinal Metaplasia, and Uninvolved Mucosa of the StomachQ68179534
Subunit structure of porcine submaxillary mucinQ69718472
Expression of Lewisa, Lewisb, Lewisx, Lewisy, siayl-Lewisa, and sialyl-Lewisx blood group antigens in human gastric carcinoma and in normal gastric tissueQ69936076
Lewis blood group-related antigen expression in normal gastric epithelium, intestinal metaplasia, gastric adenoma, and gastric carcinomaQ70740933
The mucin profiles of normal gastric mucosa, intestinal metaplasia and its variants and gastric carcinomaQ71097848
Prognostic significance of T antigen expression in patients with gastric carcinomaQ71116832
T and Tn, general carcinoma autoantigensQ71372455
Schistosomes, liver flukes and Helicobacter pylori. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Lyon, 7-14 June 1994Q72152032
Mucin gene expression in normal, preneoplastic, and neoplastic human gastric epitheliumQ72312433
Fucosyltransferase-producing sialyl Le(a) and sialyl Le(x) carbohydrate antigen in benign and malignant gastrointestinal mucosaQ72674365
Immunohistochemical study of MUC5AC expression in human gastric carcinomas using a novel monoclonal antibodyQ73081862
Immunohistochemical study of the expression of MUC6 mucin and co-expression of other secreted mucins (MUC5AC and MUC2) in human gastric carcinomasQ73462707
Histopathological subtypes and prognosis of gastric cancer are correlated with the expression of mucin-associated sialylated antigens: Sialosyl-Lewis(a), Sialosyl-Lewis(x) and sialosyl-TnQ77564890
Expression of MUC1 and MUC2 mucins in gastric carcinomas: its relationship with the prognosis of the patientsQ77603489
Helicobacter pylori infection produces reversible glycosylation changes to gastric mucinsQ77669427
The aberrant expression of Lewis a antigen in intestinal metaplastic cells of gastric mucosa is caused by augmentation of Lewis enzyme expressionQ77740638
Mucins MUC1, MUC2, MUC5AC and MUC6 expression in the evaluation of differentiation and clinico-biological behaviour of gastric carcinomaQ77755083
Disseminated cancer cells in the blood and expression of sialylated antigen in gastric cancerQ79150076
Sweet receptors mediate the adhesion of the gastric pathogen Helicobacter pylori: glycoproteomic strategiesQ84381610
Synthesis of bivalent glycoclusters containing GlcNAc as hexasaccharide mimetics. Bactericidal activity against Helicobacter pyloriQ84969930
Helicobacter pyloriQ85652456
Role of sulfated O-glycans expressed by high endothelial venule-like vessels in pathogenesis of chronic inflammatory gastrointestinal diseasesQ37283590
Alpha1,4GlcNAc-capped mucin-type O-glycan inhibits cholesterol alpha-glucosyltransferase from Helicobacter pylori and suppresses H. pylori growth.Q37378007
The engagement of selectins and their ligands in colorectal cancer liver metastasesQ37559776
Clinical significance of polypeptide N-acetylgalactosaminyl transferase-5 (GalNAc-T5) expression in patients with gastric cancerQ37711697
Alterations in glycosylation as biomarkers for cancer detectionQ37721665
Selectins promote tumor metastasis.Q37746080
Helicobacter pylori: gastric cancer and beyondQ37760037
MSP-RON signalling in cancer: pathogenesis and therapeutic potentialQ38116308
Mucins in pancreatic cancer and its microenvironmentQ38121746
Gastric cancer: adding glycosylation to the equationQ38128077
Attachment of Helicobacter pylori to human gastric epithelium mediated by blood group antigensQ38313312
Structural diversity and specific distribution of O-glycans in normal human mucins along the intestinal tractQ38336832
Glycosylation in cancer: mechanisms and clinical implicationsQ38569702
Bacteria-targeted biomaterials: Glycan-coated microspheres to bind Helicobacter pylori.Q38799885
Glycomic analysis of gastric carcinoma cells discloses glycans as modulators of RON receptor tyrosine kinase activation in cancerQ38807457
Bacterial-binding chitosan microspheres for gastric infection treatment and preventionQ39114565
A human model of gastric carcinogenesis.Q39644851
De novo expression of CD44 variants in sporadic and hereditary gastric cancerQ39653487
Differential expression of alpha-2,3-sialyltransferases and alpha-1,3/4-fucosyltransferases regulates the levels of sialyl Lewis a and sialyl Lewis x in gastrointestinal carcinoma cells.Q39795184
CagA associates with c-Met, E-cadherin, and p120-catenin in a multiproteic complex that suppresses Helicobacter pylori-induced cell-invasive phenotypeQ39825147
Mucous glycoproteins: a gel of a problemQ39827428
Identification of gastric cancer stem cells using the cell surface marker CD44.Q39856772
MUC2 mucin is a major carrier of the cancer-associated sialyl-Tn antigen in intestinal metaplasia and gastric carcinomas.Q39940364
Helicobacter pylori induces gastric epithelial cell invasion in a c-Met and type IV secretion system-dependent mannerQ40228842
Biological significance of cancer-associated sialyl-Tn antigen: modulation of malignant phenotype in gastric carcinoma cells.Q40233254
P275copyright licenseCreative Commons AttributionQ6905323
P6216copyright statuscopyrightedQ50423863
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectstomach neoplasmQ4335552
mucinQ410862
glycosylationQ898365
carcinogenesisQ1637543
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P577publication date2016-07-11
P1433published inBiomoleculesQ23929963
P1476titleMucin-Type O-Glycosylation in Gastric Carcinogenesis
P478volume6

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cites work (P2860)
Q89475533C1GALT1 is associated with poor survival and promotes soluble Ephrin A1-mediated cell migration through activation of EPHA2 in gastric cancer
Q90589038Deficiency in the glycosyltransferase Gcnt1 increases susceptibility to tuberculosis through a mechanism involving neutrophils
Q49185043Drug resistance related to aberrant glycosylation in colorectal cancer
Q92063533Esophageal, gastric and colorectal cancers: Looking beyond classical serological biomarkers towards glycoproteomics-assisted precision oncology
Q60949584Functional Roles of -Glycosylation
Q55517393GalNAc-T15 in gastric adenocarcinoma: Characterization according to tissue architecture and cellular location.
Q90240459The structure of the colorectal cancer-associated enzyme GalNAc-T12 reveals how nonconserved residues dictate its function

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