Modern Radiotherapy Concepts and the Impact of Radiation on Immune Activation

scientific article

Modern Radiotherapy Concepts and the Impact of Radiation on Immune Activation is …
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scholarly articleQ13442814

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P356DOI10.3389/FONC.2016.00141
P3181OpenCitations bibliographic resource ID657060
P932PMC publication ID4913083
P698PubMed publication ID27379203

P50authorRainer FietkauQ64584867
Benjamin FreyQ38326649
P2093author name stringUdo S Gaipl
Josefin Hartmann
Anja Derer
Lisa Deloch
P2860cites workLow and moderate doses of ionizing radiation up to 2 Gy modulate transmigration and chemotaxis of activated macrophages, provoke an anti-inflammatory cytokine milieu, but do not impact upon viability and phagocytic functionQ87677634
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Emergence of stereotactic body radiation therapy and its impact on current and future clinical practiceQ27015651
Radiotherapy and the tumor stroma: the importance of dose and fractionationQ27022685
Death and anti-death: tumour resistance to apoptosisQ28217065
Ionizing radiation inhibition of distant untreated tumors (abscopal effect) is immune mediatedQ28245528
DNA damage and the balance between survival and death in cancer biologyQ28271163
Past, present, and future of radiotherapy for the benefit of patientsQ28280008
Signatures of mutational processes in human cancerQ29547191
How does radiation kill cells?Q33533818
Radiation-induced survival responses promote immunogenic modulation to enhance immunotherapy in combinatorial regimens.Q33878572
Abscopal effects of radiotherapy on advanced melanoma patients who progressed after ipilimumab immunotherapy.Q33930593
Radiation-induced apoptosisQ33992363
Radiation therapy: state of the art and the futureQ34105161
Radiation-induced cell death mechanismsQ34116777
Necrosis: a specific form of programmed cell death?Q34174765
The sensitivity of lymphocytes to ionising radiationQ34231156
The role of biologically effective dose (BED) in clinical oncologyQ34262045
???Q95395760
Autophagy promotes radiation-induced senescence but inhibits bystander effects in human breast cancer cells.Q34373081
Defining molecular signature of pro-immunogenic radiotherapy targets in human prostate cancer cellsQ34438000
Combinations of immunotherapy and radiation in cancer therapy.Q34582640
Lack of p53 function promotes radiation-induced mitotic catastrophe in mouse embryonic fibroblast cellsQ34682107
Stereotactic Radiation Therapy Augments Antigen-Specific PD-1-Mediated Antitumor Immune Responses via Cross-Presentation of Tumor AntigenQ35328111
Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapyQ35540109
Human monocytes are severely impaired in base and DNA double-strand break repair that renders them vulnerable to oxidative stressQ35641503
Maximizing Tumor Immunity With Fractionated RadiationQ35916615
Ablative Tumor Radiation Can Change the Tumor Immune Cell Microenvironment to Induce Durable Complete RemissionsQ35958252
The in vitro immunogenic potential of caspase-3 proficient breast cancer cells with basal low immunogenicity is increased by hypofractionated irradiationQ36069982
The controversial abscopal effectQ36143531
Final results of local-regional control and late toxicity of RTOG 9003: a randomized trial of altered fractionation radiation for locally advanced head and neck cancerQ36332315
Genetic landscape of metastatic and recurrent head and neck squamous cell carcinoma.Q36430737
Synergy of topical toll-like receptor 7 agonist with radiation and low-dose cyclophosphamide in a mouse model of cutaneous breast cancerQ36476394
Hyperfractionated or accelerated radiotherapy in head and neck cancer: a meta-analysisQ36584651
Immunosuppressive effects of radiation on human dendritic cells: reduced IL-12 production on activation and impairment of naive T-cell primingQ36616735
Cancer immunoediting: antigens, mechanisms, and implications to cancer immunotherapyQ36829161
Clearance of apoptotic cells by phagocytesQ36850155
Chemotherapy-induced immunogenic modulation of tumor cells enhances killing by cytotoxic T lymphocytes and is distinct from immunogenic cell death.Q36874767
Many faces of DAMPs in cancer therapyQ36907117
Normal tissue reactions to radiotherapy: towards tailoring treatment dose by genotypeQ37162103
Therapeutic effects of ablative radiation on local tumor require CD8+ T cells: changing strategies for cancer treatmentQ37268974
Fractionated but not single-dose radiotherapy induces an immune-mediated abscopal effect when combined with anti-CTLA-4 antibodyQ37351567
Definition of stereotactic body radiotherapy: principles and practice for the treatment of stage I non-small cell lung cancerQ37468265
STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors.Q37502349
Irradiation and anti-PD-L1 treatment synergistically promote antitumor immunity in mice.Q37524200
Systemic effects of local radiotherapyQ37539309
Current concepts in clinical radiation oncologyQ37603804
Exploiting sensitization windows of opportunity in hyper and hypo-fractionated radiation therapyQ37670422
Radiation-Induced Vascular Damage in Tumors: Implications of Vascular Damage in Ablative Hypofractionated Radiotherapy (SBRT and SRS)Q37974257
Induction of abscopal anti-tumor immunity and immunogenic tumor cell death by ionizing irradiation - implications for cancer therapies.Q37993183
How does ionizing irradiation contribute to the induction of anti-tumor immunity?Q38030920
Effects of ionizing radiation on the immune system with special emphasis on the interaction of dendritic and T cells.Q38039442
Dying cell clearance and its impact on the outcome of tumor radiotherapyQ38042950
Apoptosis in radiation therapy: a double-edged swordQ38052398
Contribution of the immune system to bystander and non-targeted effects of ionizing radiationQ38153979
The four faces of autophagy: implications for cancer therapyQ38181453
Kill and spread the word: stimulation of antitumor immune responses in the context of radiotherapyQ38217593
The autophagic response to radiation: relevance for radiation sensitization in cancer therapyQ38245753
Radiotherapy and immunogenic cell deathQ38284085
Myeloid-derived cells in tumors: effects of radiationQ38284087
Building immunity to cancer with radiation therapyQ38319687
Cell death by autophagy: emerging molecular mechanisms and implications for cancer therapyQ38331755
Lung cancer: the immune system and radiation.Q38540827
Anthracyclines induce DNA damage response-mediated protection against severe sepsis.Q38549117
Immune-modulating properties of ionizing radiation: rationale for the treatment of cancer by combination radiotherapy and immune checkpoint inhibitorsQ38641806
Fractionated radiotherapy is the main stimulus for the induction of cell death and of Hsp70 release of p53 mutated glioblastoma cell linesQ38868168
PD-1 Restrains Radiotherapy-Induced Abscopal Effect.Q38907646
Norm- and hypo-fractionated radiotherapy is capable of activating human dendritic cellsQ39025449
Treatment of triple-negative breast cancer using anti-EGFR-directed radioimmunotherapy combined with radiosensitizing chemotherapy and PARP inhibitorQ39169737
Turning T cells on: epigenetically enhanced expression of effector T-cell costimulatory molecules on irradiated human tumor cellsQ39575992
Accelerated fractionation in the radiation treatment of head and neck cancer. A critical comparison of different strategiesQ39650657
Accelerated senescence: an emerging role in tumor cell response to chemotherapy and radiationQ39957013
Gene expression profiling of breast, prostate, and glioma cells following single versus fractionated doses of radiation.Q40144504
Dose fractionation, dose rate and iso-effect relationships for normal tissue responses.Q40251054
Local radiation therapy of B16 melanoma tumors increases the generation of tumor antigen-specific effector cells that traffic to the tumorQ40412166
Radiation-induced apoptosis: Relevance to radiotherapyQ40433820
Stereotactic body radiation therapy and intensity modulated radiation therapy induce different plasmatic cytokine changes in non-small cell lung cancer patients: a pilot study.Q41034587
Local radiotherapy and granulocyte-macrophage colony-stimulating factor to generate abscopal responses in patients with metastatic solid tumours: a proof-of-principle trial.Q41653193
Interpretation of some results from radiotherapy and an attempt to determine a rational treatment technique. 1906.Q42030151
Abscopal effect of radiation on lung metastases of hepatocellular carcinoma: a case reportQ42062177
Radiation fosters dose-dependent and chemotherapy-induced immunogenic cell deathQ42115292
Fears over radiotherapy fractionation regimens in breast cancer. Proposed Uk trial needs to define techniques as well as numbers of treatmentsQ42757647
Trial Watch: Radioimmunotherapy for oncological indicationsQ43104064
Local irradiation of murine melanoma affects the development of tumour-specific immunity.Q46022196
Stereotactic body radiotherapy for colorectal liver metastases: a pooled analysisQ46159777
Late effects of hyperfractionated radiotherapy for advanced head and neck cancer: long-term follow-up results of RTOG 83-13.Q46248787
The UK Standardisation of Breast Radiotherapy (START) trials of radiotherapy hypofractionation for treatment of early breast cancer: 10-year follow-up results of two randomised controlled trials.Q46425805
Volumetric modulated arc therapy for delivery of prostate radiotherapy: comparison with intensity-modulated radiotherapy and three-dimensional conformal radiotherapyQ46502316
Radiation abscopal antitumor effect is mediated through p53Q47965289
Gamma irradiation of human dendritic cells influences proliferation and cytokine profile of T cells in autologous mixed lymphocyte reactionQ48035956
Nomenclature of modified fractionation protocols in radiotherapyQ48785691
The characterization of tumor apoptosis after experimental radiosurgeryQ48962259
Safety and efficacy of stereotactic body radiotherapy for stage 1 non-small-cell lung cancer in routine clinical practice: a patterns-of-care and outcome analysis.Q50736160
P407language of work or nameEnglishQ1860
P921main subjectadaptive radiation therapyQ180507
P304page(s)141
P577publication date2016-01-01
P13046publication type of scholarly workreview articleQ7318358
P1433published inFrontiers in OncologyQ26839986
P1476titleModern Radiotherapy Concepts and the Impact of Radiation on Immune Activation
P478volume6

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cites work (P2860)
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