Peroxisome Proliferator-Activated Receptor-γ Is Critical to Cardiac Fibrosis

scientific article

Peroxisome Proliferator-Activated Receptor-γ Is Critical to Cardiac Fibrosis is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1155/2016/2198645
P3181OpenCitations bibliographic resource ID1668991
P932PMC publication ID4880703
P698PubMed publication ID27293418
P5875ResearchGate publication ID303028879

P2093author name stringZheng Yang
Qi-Zhu Tang
Hai-Han Liao
Huang-Jun Liu
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Rosiglitazone, a peroxisome proliferator-activated receptor-gamma, inhibits the Jun NH(2)-terminal kinase/activating protein 1 pathway and protects the heart from ischemia/reperfusion injuryQ43972557
PPAR-γ activation by rosiglitazone suppresses angiotensin II-mediated proliferation and phenotypictransition in cardiac fibroblasts via inhibition of activation of activator protein 1.Q44203460
Pioglitazone, a peroxisome proliferator-activated receptor-gamma agonist, attenuates left ventricular remodeling and failure after experimental myocardial infarctionQ44243308
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The PPARgamma-activator rosiglitazone does not alter remodeling but increases mortality in rats post-myocardial infarctionQ44472847
Peroxisome proliferator-activated receptor-alpha and receptor-gamma activators prevent cardiac fibrosis in mineralocorticoid-dependent hypertensionQ44513157
Up-regulation of peroxisome proliferator-activated receptor gamma in radiation-induced heart injury in ratsQ44793448
Diabetes drugs tied to fractures in womenQ44968221
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Pioglitazone, a peroxisome proliferator-activated receptor gamma activator, ameliorates experimental autoimmune myocarditis by modulating Th1/Th2 balanceQ45255881
Osthole regulates TGF-β1 and MMP-2/9 expressions via activation of PPARα/γ in cultured mouse cardiac fibroblasts stimulated with angiotensin II.Q45817713
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Pioglitazone, a peroxisome proliferator-activated receptor-gamma activator, attenuates atrial fibrosis and atrial fibrillation promotion in rabbits with congestive heart failureQ46723268
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Beneficial effects of pioglitazone on hypertensive cardiovascular injury are enhanced by combination with candesartanQ46833898
Beneficial effects of pioglitazone on left ventricular hypertrophy in genetically hypertensive ratsQ46882639
PPARgamma gene transfer sustains apoptosis, inhibits vascular smooth muscle cell proliferation, and reduces neointima formation after balloon injury in ratsQ46902316
Pioglitazone limits myocardial infarct size, activates Akt, and upregulates cPLA2 and COX-2 in a PPAR-γ-independent mannerQ47388835
Increased connective tissue growth factor relative to brain natriuretic peptide as a determinant of myocardial fibrosisQ48235274
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Cellular and molecular mechanisms of fibrosisQ24648892
Peroxisome proliferator-activated receptors and their ligands: nutritional and clinical implications--a reviewQ26866784
Traditional Chinese Medication Qiliqiangxin attenuates cardiac remodeling after acute myocardial infarction in mice.Q27309112
Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancerQ30476541
PPAR gamma 2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolismQ33283063
Simvastatin inhibited cardiac hypertrophy and fibrosis in apolipoprotein E-deficient mice fed a "Western-style diet" by increasing PPAR α and γ expression and reducing TC, MMP-9, and Cat S levels.Q33577634
Whole grape intake impacts cardiac peroxisome proliferator-activated receptor and nuclear factor kappaB activity and cytokine expression in rats with diastolic dysfunctionQ34088823
Synergism in hyperhomocysteinemia and diabetes: role of PPAR gamma and tempolQ34149341
Cardiac fibrosis in end-stage human heart failure and the cardiac natriuretic peptide guanylyl cyclase system: regulation and therapeutic implicationsQ34150487
Peroxisome proliferator-activated receptors for hypertensionQ34179017
Curcumin attenuates cardiac fibrosis in spontaneously hypertensive rats through PPAR-γ activationQ34295008
PPAR Gamma Expression Levels during Development of Heart Failure in Patients with Coronary Artery Disease after Coronary Artery Bypass-Grafting.Q34412608
Telomere biology in cardiovascular disease - role of insulin sensitivity in diabetic heartsQ34467089
Atrial fibrosis: mechanisms and clinical relevance in atrial fibrillation.Q34588710
Effect of aleglitazar on cardiovascular outcomes after acute coronary syndrome in patients with type 2 diabetes mellitus: the AleCardio randomized clinical trialQ34660831
The origin of fibroblasts and mechanism of cardiac fibrosisQ34994036
Cardiac protective effects of irbesartan via the PPAR-gamma signaling pathway in angiotensin-converting enzyme 2-deficient miceQ34997831
Inhibition of TGF-β by a novel PPAR-γ agonist, chrysin, salvages β-receptor stimulated myocardial injury in rats through MAPKs-dependent mechanismQ35177115
New insights into insulin resistance in the diabetic heartQ35243945
Angiopoietin-1 protects heart against ischemia/reperfusion injury through VE-cadherin dephosphorylation and myocardiac integrin-β1/ERK/caspase-9 phosphorylation cascadeQ35287105
Role of peroxisome proliferator-activated receptors gene polymorphisms in type 2 diabetes and metabolic syndromeQ35613936
Thiazolidinedione use, fluid retention, and congestive heart failure: a consensus statement from the American Heart Association and American Diabetes AssociationQ35615572
Peroxisome proliferator-activated receptors, metabolic syndrome and cardiovascular diseaseQ35636191
Muscle ring finger-3 protects against diabetic cardiomyopathy induced by a high fat diet.Q35716907
ERK/GSK3β/Snail signaling mediates radiation-induced alveolar epithelial-to-mesenchymal transition.Q35783218
Transforming growth factor-β inhibits myocardial PPARγ expression in pressure overload-induced cardiac fibrosis and remodeling in miceQ35885246
MuRF2 regulates PPARγ1 activity to protect against diabetic cardiomyopathy and enhance weight gain induced by a high fat dietQ35920226
Reversal of systemic hypertension-associated cardiac remodeling in chronic pressure overload myocardium by ciglitazoneQ35989215
The cardiac fibroblast: therapeutic target in myocardial remodeling and failureQ36094597
Fibrosis, Connexin-43, and Conduction Abnormalities in the Brugada Syndrome.Q36245208
Peroxisome Proliferator-Activated Receptors and the Heart: Lessons from the Past and Future DirectionsQ36261125
Corepressors of agonist-bound nuclear receptorsQ36288161
Peroxisome proliferator-activated receptor gamma as a drug target in the pathogenesis of insulin resistanceQ36321335
Galectin-3, a marker of cardiac fibrosis, predicts incident heart failure in the communityQ36439679
Actions of peroxisome proliferator-activated receptors-gamma agonists explaining a possible blood pressure-lowering effectQ36491985
Pioglitazone attenuates valvular calcification induced by hypercholesterolemiaQ36612212
Molecular and metabolic mechanisms of cardiac dysfunction in diabetes.Q36674142
Agonists at PPAR-gamma suppress angiotensin II-induced production of plasminogen activator inhibitor-1 and extracellular matrix in rat cardiac fibroblastsQ36734442
Reactivation of Snail genes in renal fibrosis and carcinomas: a process of reversed embryogenesis?Q36765406
Peroxisome proliferator-activated receptors (PPARs) and their agonists for hypertension and heart failure: are the reagents beneficial or harmful?Q37201071
Defective peroxisomal proliferators activated receptor gamma activity due to dominant-negative mutation synergizes with hypertension to accelerate cardiac fibrosis in miceQ37201578
Identification and regulation of novel PPAR-gamma splice variants in human THP-1 macrophagesQ37395127
Cardiac fibroblasts: at the heart of myocardial remodelingQ37491524
PPARs and adipocyte function.Q37601619
Snail as a potential target molecule in cardiac fibrosis: paracrine action of endothelial cells on fibroblasts through snail and CTGF axisQ37636881
Reperfusion injury, microvascular dysfunction, and cardioprotection: the "dark side" of reperfusionQ37637606
Telmisartan attenuates isoproterenol-induced cardiac remodeling in rats via regulation of cardiac adiponectin expressionQ37727413
Potential therapeutic targets for cardiac fibrosis: TGFbeta, angiotensin, endothelin, CCN2, and PDGF, partners in fibroblast activationQ37764239
Use of clinically available PPAR agonists for heart failure; do the risks outweigh the potential benefits?Q37961919
PPAR agonists for the treatment of cardiovascular disease in patients with diabetesQ37996437
Effect of a new PPAR-gamma agonist, lobeglitazone, on neointimal formation after balloon injury in rats and the development of atherosclerosis.Q38422501
Peroxisome proliferator-activated receptor (PPAR) gamma in cardiovascular disorders and cardiovascular surgery.Q38527229
Management of cardiac fibrosis in diabetic rats; the role of peroxisome proliferator activated receptor gamma (PPAR-gamma) and calcium channel blockers (CCBs)Q39766035
PEDF and 34-mer inhibit angiogenesis in the heart by inducing tip cells apoptosis via up-regulating PPAR-γ to increase surface FasL.Q40373354
Simvastatin activates the PPARγ-dependent pathway to prevent left ventricular hypertrophy associated with inhibition of RhoA signalingQ40581719
PPAR-γ agonist attenuates inflammation in aortic aneurysm patientsQ40693751
Peroxisome proliferator activated-receptor agonism and left ventricular remodeling in mice with chronic myocardial infarctionQ41843180
Hepatocyte-derived Snail1 propagates liver fibrosis progressionQ41865587
A pilot study of circulating PPAR-γ receptor protein in elderly patients with atrial fibrillationQ41955585
DIOL triterpenes block profibrotic effects of angiotensin II and protect from cardiac hypertrophyQ41990989
Combination of a peroxisome proliferator-activated receptor-gamma agonist and an angiotensin II receptor blocker attenuates myocardial fibrosis and dysfunction in type 2 diabetic ratsQ42258153
Reduction of isoprenaline-induced myocardial TGF-β1 expression and fibrosis in osthole-treated miceQ42727456
Cardiac fibrosis in diabetic rats: regulation and mechanism of activation of the PPARgamma signal pathway.Q42728839
Angiotensin type 1 receptor blockers induce peroxisome proliferator-activated receptor-gamma activityQ42829351
Pharmacogenomic, physiological, and biochemical investigations on safety and efficacy biomarkers associated with the peroxisome proliferator-activated receptor-gamma activator rosiglitazone in rodents: a translational medicine investigationQ43046058
Rosiglitazone reverses cardiac adverse remodeling (fibrosis and vascularization) in perinatal low protein rat offspring.Q43071641
Ameliorative role of rosiglitazone in hyperhomocysteinemia-induced experimental cardiac hypertrophy.Q43115444
Peroxisome proliferator-activated receptor-gamma activation attenuates cardiac fibrosis in type 2 diabetic rats: the effect of rosiglitazone on myocardial expression of receptor for advanced glycation end products and of connective tissue growth facQ43245112
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectdrug discoveryQ1418791
P304page(s)2198645
P577publication date2016-01-01
P1433published inPPAR ResearchQ15756406
P1476titlePeroxisome Proliferator-Activated Receptor-γ Is Critical to Cardiac Fibrosis
P478volume2016

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cites work (P2860)
Q427007245-HT induces PPAR γ reduction and proliferation of pulmonary artery smooth muscle cells via modulating GSK-3β/β-catenin pathway
Q89304971Abnormalities of Mitochondrial Dynamics in the Failing Heart: Normalization Following Long-Term Therapy with Elamipretide
Q93199229Effect of fish oil on circulating asymmetric dimethylarginine and adiponectin in overweight or obese patients with atrial fibrillation
Q49908591Interrelationship between diabetes mellitus and heart failure: the role of peroxisome proliferator-activated receptors in left ventricle performance.
Q47136571MicroRNA-130a, a Potential Antifibrotic Target in Cardiac Fibrosis
Q48247479PPAR-γ Agonists and Their Role in Primary Cicatricial Alopecia.
Q90324378PPARγ Agonist PGZ Attenuates OVA-Induced Airway Inflammation and Airway Remodeling via RGS4 Signaling in Mouse Model
Q37694630Targeting EZH1 and EZH2 contributes to the suppression of fibrosis-associated genes by miR-214-3p in cardiac myofibroblasts
Q37171547Telmisartan improves cardiac fibrosis in diabetes through peroxisome proliferator activated receptor δ (PPARδ): from bedside to bench
Q33717198Traditional Chinese Medication Qiliqiangxin Protects Against Cardiac Remodeling and Dysfunction in Spontaneously Hypertensive Rats

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