Heat Shock Protein-Peptide and HSP-Based Immunotherapies for the Treatment of Cancer

scientific article

Heat Shock Protein-Peptide and HSP-Based Immunotherapies for the Treatment of Cancer is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.3389/FIMMU.2016.00171
P3181OpenCitations bibliographic resource ID1979437
P932PMC publication ID4850156
P698PubMed publication ID27199993

P50authorMaxim ShevtsovQ59689890
Gabriele MulthoffQ47813083
P2093author name stringGabriele Multhoff
Maxim Shevtsov
P2860cites workHeat shock protein gp96 is a master chaperone for toll-like receptors and is important in the innate function of macrophagesQ24609722
Heat Shock Protein 70 (Hsp70) Peptide Activated Natural Killer (NK) Cells for the Treatment of Patients with Non-Small Cell Lung Cancer (NSCLC) after Radiochemotherapy (RCTx) - From Preclinical Studies to a Clinical Phase II TrialQ26858884
The heterodimeric assembly of the CD94-NKG2 receptor family and implications for human leukocyte antigen-E recognitionQ27649331
Emerging roles for scavenger receptor SREC-I in immunityQ28080847
Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone functionQ28218547
Tumor rejection antigen gp96/grp94 is an ATPase: implications for protein folding and antigen presentationQ28646520
Targeting membrane heat-shock protein 70 (Hsp70) on tumors by cmHsp70.1 antibodyQ30497901
Cell surface-bound heat shock protein 70 (Hsp70) mediates perforin-independent apoptosis by specific binding and uptake of granzyme B.Q30967103
A phase I trial of intratumoral administration of recombinant oncolytic adenovirus overexpressing HSP70 in advanced solid tumor patientsQ33382497
Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cellsQ33604925
Induction of tumor-specific immune response by gene transfer of Hsp70-cell-penetrating peptide fusion protein to tumors in mice.Q33730763
Pilot study of intratumoral injection of recombinant heat shock protein 70 in the treatment of malignant brain tumors in childrenQ33800747
Heat shock proteins in cancer: diagnostic, prognostic, predictive, and treatment implicationsQ33899708
Interaction of heat shock proteins with peptides and antigen presenting cells: chaperoning of the innate and adaptive immune responsesQ34115645
A phase I pilot study of autologous heat shock protein vaccine HSPPC-96 in patients with resected pancreatic adenocarcinomaQ34617610
Gene vaccinesQ35095112
Cellular requirements for tumor-specific immunity elicited by heat shock proteins: tumor rejection antigen gp96 primes CD8+ T cells in vivoQ35154049
A mouse tumor-specific transplantation antigen is a heat shock-related proteinQ35603985
Tumor rejection antigens of chemically induced sarcomas of inbred miceQ35605797
Heat shock proteins: biological functions and clinical application as personalized vaccines for human cancer.Q35613124
Initiation of the Immune Response by Extracellular Hsp72: Chaperokine Activity of Hsp72Q35792444
Vaccination of Metastatic Melanoma Patients With Autologous Tumor-Derived Heat Shock Protein gp96-Peptide Complexes: Clinical and Immunologic FindingsQ57570391
A mechanism for the specific immunogenicity of heat shock protein-chaperoned peptidesQ60307732
Radiation combined with hyperthermia induces HSP70-dependent maturation of dendritic cells and release of pro-inflammatory cytokines by dendritic cells and macrophagesQ61893828
Membrane-bound heat shock protein 70 (Hsp70) in acute myeloid leukemia: a tumor specific recognition structure for the cytolytic activity of autologous NK cellsQ61893852
Heat shock protein 70 (Hsp70) stimulates proliferation and cytolytic activity of natural killer cellsQ61893857
A stress-inducible 72-kDa heat-shock protein (HSP72) is expressed on the surface of human tumor cells, but not on normal cellsQ61893867
Purification of immunogenic heat shock protein 70-peptide complexes by ADP-affinity chromatographyQ73457700
HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokineQ73606601
CD91: a receptor for heat shock protein gp96Q73615235
Vaccination with autologous tumor-derived heat-shock protein gp96 after liver resection for metastatic colorectal cancerQ73910273
Saturation, competition, and specificity in interaction of heat shock proteins (hsp) gp96, hsp90, and hsp70 with CD11b+ cellsQ74183154
Vaccination of melanoma patients with peptide- or tumor lysate-pulsed dendritic cellsQ74310288
Induction of systemic antitumor immunity by gene transfer of mammalian heat shock protein 70.1 into tumors in situQ77462833
A vaccine for renal cancerQ79754768
Therapeutic cancer vaccinesQ82495300
Cancer immunologyQ95819282
Heat shock protein-based cancer vaccinesQ35843630
Role of membrane Hsp70 in radiation sensitivity of tumor cellsQ35879762
Heat shock protein 70-associated peptides elicit specific cancer immunityQ36362368
The dual nature of specific immunological activity of tumor-derived gp96 preparationsQ36368193
Heat shock protein-peptide complexes, reconstituted in vitro, elicit peptide-specific cytotoxic T lymphocyte response and tumor immunityQ36380745
The CD94/NKG2 family of receptors: from molecules and cells to clinical relevance.Q36685564
Human natural killer receptors, co-receptors, and their ligands.Q37399014
Heat-shock protein peptide complex-96 vaccination for recurrent glioblastoma: a phase II, single-arm trialQ37492175
Activating and inhibitory receptors of natural killer cellsQ37766751
The role of heat shock proteins in antigen cross presentationQ38008364
Intracellular and extracellular Hsp70 chaperone as a target for cancer therapy.Q38120836
Heat-shock proteins-based immunotherapy for advanced melanoma in the era of target therapies and immunomodulating agents.Q38199545
Exogenously delivered heat shock protein 70 displaces its endogenous analogue and sensitizes cancer cells to lymphocytes-mediated cytotoxicityQ38998531
Investigating receptors for extracellular heat shock proteinsQ39478462
Enhanced generation of cytotoxic T lymphocytes by heat shock protein 70 fusion proteins harboring both CD8(+) T cell and CD4(+) T cell epitopesQ39669582
T cell activation by heat shock protein 70 vaccine requires TLR signaling and scavenger receptor expressed by endothelial cells-1Q39819170
Heat shock protein 70-reactivity is associated with increased cell surface density of CD94/CD56 on primary natural killer cellsQ39958463
The heat shock protein HSP70 promotes mouse NK cell activity against tumors that express inducible NKG2D ligandsQ40073011
Scavenger receptor-A mediates gp96/GRP94 and calreticulin internalization by antigen-presenting cellsQ40240250
Dacarbazine (DTIC) versus vaccination with autologous peptide-pulsed dendritic cells (DC) in first-line treatment of patients with metastatic melanoma: a randomized phase III trial of the DC study group of the DeCOG.Q40357536
Heat shock protein 70 surface-positive tumor exosomes stimulate migratory and cytolytic activity of natural killer cellsQ40408986
Definition of extracellular localized epitopes of Hsp70 involved in an NK immune responseQ40425157
Heat shock protein-mediated cross-presentation of exogenous HIV antigen on HLA class I and class II.Q40533110
Heat shock proteins in immune response to cancer: the Fourth ParadigmQ40648771
Interaction of heat shock protein 70 peptide with NK cells involves the NK receptor CD94.Q40658554
Tumor-derived heat shock protein 70 peptide complexes are cross-presented by human dendritic cells.Q40691520
CD40, an extracellular receptor for binding and uptake of Hsp70-peptide complexesQ40700550
Immunization of cancer patients with autologous cancer-derived heat shock protein gp96 preparations: a pilot studyQ40746131
HSP70 as endogenous stimulus of the Toll/interleukin-1 receptor signal pathwayQ40751242
Novel signal transduction pathway utilized by extracellular HSP70: role of toll-like receptor (TLR) 2 and TLR4.Q40751982
Cutting edge: receptor-mediated endocytosis of heat shock proteins by professional antigen-presenting cells.Q40960957
A 14-mer Hsp70 peptide stimulates natural killer (NK) cell activityQ40969222
Purification of heat shock protein-peptide complexes for use in vaccination against cancers and intracellular pathogensQ41108048
Heat shock protein 72 on tumor cells: a recognition structure for natural killer cellsQ41114467
Dendritic cells transfected with heat-shock protein 70 messenger RNA for patients with hepatitis C virus-related hepatocellular carcinoma: a phase 1 dose escalation clinical trialQ41733152
CD91-Dependent Modulation of Immune Responses by Heat Shock Proteins: A Role in Autoimmunity.Q42283936
CD91 is a common receptor for heat shock proteins gp96, hsp90, hsp70, and calreticulinQ43566795
Treatment of colon and lung cancer patients with ex vivo heat shock protein 70-peptide-activated, autologous natural killer cells: a clinical phase i trial.Q44917998
HSP70 vaccine in combination with gene therapy with plasmid DNA encoding sPD-1 overcomes immune resistance and suppresses the progression of pulmonary metastatic melanomaQ45855370
Phase III comparison of vitespen, an autologous tumor-derived heat shock protein gp96 peptide complex vaccine, with physician's choice of treatment for stage IV melanoma: the C-100-21 Study Group.Q46748085
Immune modulation with high-dose heat-shock protein gp96: therapy of murine autoimmune diabetes and encephalomyelitisQ47897499
Plasma exosomes protect the myocardium from ischemia-reperfusion injury.Q48674766
What ASCO does for its membersQ49274143
70-kDa heat shock protein coated magnetic nanocarriers as a nanovaccine for induction of anti-tumor immune response in experimental glioma.Q50698276
Antitumor effects of combined therapy of recombinant heat shock protein 70 and hyperthermia using magnetic nanoparticles in an experimental subcutaneous murine melanomaQ51813573
Effective immunotherapy of rat glioblastoma with prolonged intratumoral delivery of exogenous heat shock protein Hsp70.Q55461040
A phase II trial of vaccination with autologous, tumor-derived heat-shock protein peptide complexes Gp96, in combination with GM-CSF and interferon-α in metastatic melanoma patientsQ57570360
P407language of work or nameEnglishQ1860
P921main subjectimmunotherapyQ1427096
P304page(s)171
P577publication date2016-04-29
P1433published inFrontiers in ImmunologyQ27723748
P1476titleHeat Shock Protein-Peptide and HSP-Based Immunotherapies for the Treatment of Cancer
P478volume7

Reverse relations

cites work (P2860)
Q47226956A comparison of cell survival and heat shock protein expression after radiation in normal dermal fibroblasts, microvascular endothelial cells, and different head and neck squamous carcinoma cell lines
Q48145688A comparison of two sources of methionine supplemented at different levels on heat shock protein 70 expression and oxidative stress product of Peking ducks subjected to heat stress.
Q91731105Advancements in Prophylactic and Therapeutic Nanovaccines
Q55291915Alpha-Fetoprotein and Hepatocellular Carcinoma Immunity.
Q60909641Application of built-in adjuvants for epitope-based vaccines
Q37587724B-Cell-Based and Soluble Biomarkers in Body Liquids for Predicting Acute/Chronic Graft-versus-Host Disease after Allogeneic Hematopoietic Stem Cell Transplantation
Q39451757Cancer immunotherapy: moving forward with peptide T cell vaccines
Q92837698Cloning, expression of a truncated HSP110 protein that augments the activities of tumor antigen-specific cytotoxic and apoptosis via tHSP110-peptide complex vaccines
Q90145195Combined intracavitary thermotherapy with iron oxide nanoparticles and radiotherapy as local treatment modality in recurrent glioblastoma patients
Q42328475Editorial: The HSP70 Molecular Chaperone Machines
Q38662422Endogenous Heat-Shock Protein Induction with or Without Radiofrequency Ablation or Cryoablation in Patients with Stage IV Melanoma.
Q58568805Heat Shock Proteins as Immunomodulants
Q55190074Heat shock protein 70 protects mouse against post-infection irritable bowel syndrome via up-regulating intestinal γδ T cell's Th17 response.
Q52558324Heat shock proteins expressed in the marsupial Tasmanian devil are potential antigenic candidates in a vaccine against devil facial tumour disease.
Q87944374Immune modulatory effects of radiotherapy as basis for well-reasoned radioimmunotherapies
Q58729712Immunogenic Effect of Hyperthermia on Enhancing Radiotherapeutic Efficacy
Q39043413Immunotherapy of colorectal cancer: new perspectives after a long path.
Q64232509Impact of a Heat Shock Protein Impurity on the Immunogenicity of Biotherapeutic Monoclonal Antibodies
Q57179194Influence of hyperthermal regimes on experimental teratoma development in vitro
Q61798268Local immunomodulation combined to radiofrequency ablation results in a complete cure of local and distant colorectal carcinoma
Q64231695Membrane Hsp70-supported cell-to-cell connections via tunneling nanotubes revealed by live-cell STED nanoscopy
Q39370805Metabolism of the Endocannabinoid Anandamide: Open Questions after 25 Years
Q61809072Phenotype and Function of Activated Natural Killer Cells From Patients With Prostate Cancer: Patient-Dependent Responses to Priming and IL-2 Activation
Q92487370Role of heat shock proteins in bladder cancer: potential biomarkers for treatment response and oncological prognosis
Q90417081T-Cell based therapies for overcoming neuroanatomical and immunosuppressive challenges within the glioma microenvironment
Q41660505Targeting Heat Shock Proteins in Cancer: A Promising Therapeutic Approach
Q60907513The Autoantigenic Proinsulin B-Chain Peptide B11-23 Synergises with the 70 kDa Heat Shock Protein DnaK in Macrophage Stimulation
Q96304342The expression profiles and prognostic values of HSPs family members in Head and neck cancer
Q93018120Transcriptomic Analysis Provides Novel Insights into Heat Stress Responses in Sheep
Q39281019Unconventional Secretion of Heat Shock Proteins in Cancer
Q47583155Vaccination in the immunotherapy of glioblastoma

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