Clinical developments in the treatment of relapsed or relapsed and refractory multiple myeloma: impact of panobinostat, the first-in-class histone deacetylase inhibitor

scientific article

Clinical developments in the treatment of relapsed or relapsed and refractory multiple myeloma: impact of panobinostat, the first-in-class histone deacetylase inhibitor is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.2147/OTT.S87962
P3181OpenCitations bibliographic resource ID1734251
P932PMC publication ID4869663
P698PubMed publication ID27274274

P2093author name stringShannon M Hough
Erika M Price
Kimberly A Redic
P2860cites workClinical use of proteasome inhibitors in the treatment of multiple myelomaQ28080999
Phase II trial of the pan-deacetylase inhibitor panobinostat as a single agent in advanced relapsed/refractory multiple myelomaQ83358859
Histone deacetylases and cancerQ28240447
Structure and mechanism of the Hsp90 molecular chaperone machineryQ29615146
Phase Ia/II, two-arm, open-label, dose-escalation study of oral panobinostat administered via two dosing schedules in patients with advanced hematologic malignancies.Q33405714
PANORAMA 2: panobinostat in combination with bortezomib and dexamethasone in patients with relapsed and bortezomib-refractory myelomaQ33409825
Phase Ib study of panobinostat and bortezomib in relapsed or relapsed and refractory multiple myeloma.Q33410225
Panobinostat plus bortezomib and dexamethasone versus placebo plus bortezomib and dexamethasone in patients with relapsed or relapsed and refractory multiple myeloma: a multicentre, randomised, double-blind phase 3 trialQ33417762
Small-molecule inhibition of proteasome and aggresome function induces synergistic antitumor activity in multiple myelomaQ33854012
Controlling the double helixQ34172152
New insights into the treatment of multiple myeloma with histone deacetylase inhibitorsQ34224278
Reduced expression of class II histone deacetylase genes is associated with poor prognosis in lung cancer patients.Q34340318
Intrinsic apoptotic and thioredoxin pathways in human prostate cancer cell response to histone deacetylase inhibitorQ35070323
The proteasome: structure, function, and role in the cellQ35124091
Phase I/II study of the combination of panobinostat and carfilzomib in patients with relapsed/refractory multiple myelomaQ35571044
Vorinostat Combined with High-Dose Gemcitabine, Busulfan, and Melphalan with Autologous Stem Cell Transplantation in Patients with Refractory Lymphomas.Q36660672
Combined proteasome and histone deacetylase inhibition: A promising synergy for patients with relapsed/refractory multiple myelomaQ37753391
Mechanism of action of proteasome inhibitors and deacetylase inhibitors and the biological basis of synergy in multiple myelomaQ37954600
Histone deacetylase inhibitors in multiple myeloma: rationale and evidence for their use in combination therapyQ38115884
Current strategies for treatment of relapsed/refractory multiple myelomaQ38182683
Multiple myeloma: Updates for pharmacists in the treatment of relapsed and refractory diseaseQ38360962
Panobinostat: first global approvalQ38403118
The future of therapy for relapsed/refractory multiple myeloma: emerging agents and novel treatment strategiesQ39596244
In vitro and in vivo rationale for the triple combination of panobinostat (LBH589) and dexamethasone with either bortezomib or lenalidomide in multiple myelomaQ39768627
Histone deacetylase inhibitor panobinostat induces clinical responses with associated alterations in gene expression profiles in cutaneous T-cell lymphomaQ40070617
Aggresome induction by proteasome inhibitor bortezomib and alpha-tubulin hyperacetylation by tubulin deacetylase (TDAC) inhibitor LBH589 are synergistic in myeloma cellsQ42156460
The histone deacetylase inhibitor MS-275 promotes differentiation or apoptosis in human leukemia cells through a process regulated by generation of reactive oxygen species and induction of p21CIP1/WAF1 1.Q42163084
Molecular sequelae of histone deacetylase inhibition in human malignant B cellsQ44280918
Clinical course of patients with relapsed multiple myelomaQ44544763
Disease-specific survival for patients with multiple myeloma: significant improvements over time in all age groupsQ48084283
P275copyright licenseCreative Commons Attribution-NonCommercial 3.0 UnportedQ18810331
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P304page(s)2783-93
P577publication date2016-01-01
P1433published inOncoTargets and TherapyQ7092081
P1476titleClinical developments in the treatment of relapsed or relapsed and refractory multiple myeloma: impact of panobinostat, the first-in-class histone deacetylase inhibitor
P478volume9

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cites work (P2860)
Q49315568Breakthroughs in modern cancer therapy and elusive cardiotoxicity: Critical research-practice gaps, challenges, and insights
Q39234159Novel Proteasome Inhibitors and Histone Deacetylase Inhibitors: Progress in Myeloma Therapeutics
Q88761558Panobinostat in multiple myeloma

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