Panobinostat plus bortezomib and dexamethasone versus placebo plus bortezomib and dexamethasone in patients with relapsed or relapsed and refractory multiple myeloma: a multicentre, randomised, double-blind phase 3 trial

scientific article

Panobinostat plus bortezomib and dexamethasone versus placebo plus bortezomib and dexamethasone in patients with relapsed or relapsed and refractory multiple myeloma: a multicentre, randomised, double-blind phase 3 trial is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/S1470-2045(14)70440-1
P698PubMed publication ID25242045
P5875ResearchGate publication ID267271456

P50authorWieslaw JedrzejczakQ9373502
Krzysztof WarzochaQ11749787
Hermann EinseleQ1610986
Jesús San MiguelQ5930658
Joan BladéQ87885218
Lugui QiuQ88013660
Wenming ChenQ88054219
Peter GimsingQ89084681
Jonathan L KaufmanQ89455185
Kwee L YongQ90710845
Vania HungriaQ91273829
Robert SchlossmanQ114300414
Jamie D CavenaghQ114442098
Thanyaphong Na NakornQ117252337
Noppadol SiritanaratkulQ117252338
Claudia CorradoQ117252340
Bourras-Rezki BengoudifaQ117252342
Florence BinlichQ117252344
Athanasios DimopoulosQ26338766
Paolo CorradiniQ37838318
Javier de la RubiaQ42814411
Hareth NahiQ56421057
Meral BeksacQ57078421
Hans SalwenderQ57159225
Monika SopalaQ60140073
Ashraf ElghandourQ60324814
Enrique M OcioQ60324819
Sagar LonialQ66431075
Paul G. RichardsonQ87712102
Philippe MoreauQ87734443
P2093author name stringJe-Jung Lee
Sung-Soo Yoon
Jae Hoon Lee
Jian Hou
Andreas Günther
Suporn Chuncharunee
Ming-Chung Wang
Sang Kyun Sohn
Richard LeBlanc
Tontanai Numbenjapon
Daryl Tan
Stefano Pulini
Darrell White
Tatiana Shelekhova
Ljupco Veskovski
P2860cites workInternational Myeloma Working Group consensus statement for the management, treatment, and supportive care of patients with myeloma not eligible for standard autologous stem-cell transplantationQ27002668
A phase 2 study of bortezomib in relapsed, refractory myelomaQ33348702
Randomized phase III study of pegylated liposomal doxorubicin plus bortezomib compared with bortezomib alone in relapsed or refractory multiple myeloma: combination therapy improves time to progressionQ33376149
Lenalidomide plus dexamethasone for relapsed or refractory multiple myelomaQ33377526
Lenalidomide, bortezomib, and dexamethasone combination therapy in patients with newly diagnosed multiple myelomaQ33389111
Subcutaneous versus intravenous administration of bortezomib in patients with relapsed multiple myeloma: a randomised, phase 3, non-inferiority studyQ33394981
Superiority of the triple combination of bortezomib-thalidomide-dexamethasone over the dual combination of thalidomide-dexamethasone in patients with multiple myeloma progressing or relapsing after autologous transplantation: the MMVAR/IFM 2005-04 RQ33401216
A phase 2 study of single-agent carfilzomib (PX-171-003-A1) in patients with relapsed and refractory multiple myelomaQ33402536
PANORAMA 2: panobinostat in combination with bortezomib and dexamethasone in patients with relapsed and bortezomib-refractory myelomaQ33409825
Pomalidomide plus low-dose dexamethasone versus high-dose dexamethasone alone for patients with relapsed and refractory multiple myeloma (MM-003): a randomised, open-label, phase 3 trialQ33410172
Phase Ib study of panobinostat and bortezomib in relapsed or relapsed and refractory multiple myeloma.Q33410225
Vorinostat or placebo in combination with bortezomib in patients with multiple myeloma (VANTAGE 088): a multicentre, randomised, double-blind studyQ33410481
Lenalidomide plus dexamethasone for relapsed multiple myeloma in North AmericaQ34585268
Criteria for evaluating disease response and progression in patients with multiple myeloma treated by high-dose therapy and haemopoietic stem cell transplantation. Myeloma Subcommittee of the EBMT. European Group for Blood and Marrow TransplantQ34753416
Bortezomib plus melphalan and prednisone for initial treatment of multiple myelomaQ34815786
Improved survival in multiple myeloma and the impact of novel therapiesQ36478461
Phase I study of vorinostat in combination with bortezomib for relapsed and refractory multiple myelomaQ37379984
Development of the pan-DAC inhibitor panobinostat (LBH589): successes and challengesQ37432654
European Myeloma Network recommendations on the evaluation and treatment of newly diagnosed patients with multiple myelomaQ37552008
Mechanism of action of proteasome inhibitors and deacetylase inhibitors and the biological basis of synergy in multiple myelomaQ37954600
Association of response endpoints with survival outcomes in multiple myelomaQ38122624
In vitro and in vivo rationale for the triple combination of panobinostat (LBH589) and dexamethasone with either bortezomib or lenalidomide in multiple myelomaQ39768627
Aggresome induction by proteasome inhibitor bortezomib and alpha-tubulin hyperacetylation by tubulin deacetylase (TDAC) inhibitor LBH589 are synergistic in myeloma cellsQ42156460
Efficacy and safety of once-weekly bortezomib in multiple myeloma patients.Q42921022
Bortezomib or high-dose dexamethasone for relapsed multiple myelomaQ46549268
Phase II trial of the pan-deacetylase inhibitor panobinostat as a single agent in advanced relapsed/refractory multiple myelomaQ83358859
P433issue11
P921main subjectplaceboQ269829
dexamethasoneQ422252
multicenter clinical trialQ6934595
phase III clinical trialQ42824827
P1104number of pages12
P304page(s)1195-1206
P577publication date2014-09-18
P1433published inLancet Oncology CommissionQ13747613
P1476titlePanobinostat plus bortezomib and dexamethasone versus placebo plus bortezomib and dexamethasone in patients with relapsed or relapsed and refractory multiple myeloma: a multicentre, randomised, double-blind phase 3 trial
P478volume15

Reverse relations

cites work (P2860)
Q39147132A chemical probe toolbox for dissecting the cancer epigenome
Q28067148A clinical update on the role of carfilzomib in the treatment of relapsed or refractory multiple myeloma
Q40763491A comparison of salvage infusional chemotherapy regimens for recurrent/refractory multiple myeloma
Q30239781A look backward and forward in the regulatory and treatment history of multiple myeloma: Approval of novel-novel agents, new drug development, and longer patient survival
Q37705920A novel histone deacetylase inhibitor, CKD5, has potent anti-cancer effects in glioblastoma
Q47584543A phase 1 trial of the HDAC inhibitor AR-42 in patients with multiple myeloma and T- and B-cell lymphomas
Q89777245A phase 2 study of panobinostat with lenalidomide and weekly dexamethasone in myeloma
Q88364699A selective histone deacetylase inhibitor for myeloma
Q37210896AACR Cancer Progress Report 2015
Q26739689Action mechanisms of histone deacetylase inhibitors in the treatment of hematological malignancies
Q38630472Advances in targeted therapy for the treatment of patients with relapsed/refractory multiple myeloma
Q36000415Allogeneic hematopoietic cell transplantation for multiple myeloma in Europe: trends and outcomes over 25 years. A study by the EBMT Chronic Malignancies Working Party
Q36751751An immediate transcriptional signature associated with response to the histone deacetylase inhibitor Givinostat in T acute lymphoblastic leukemia xenografts
Q38765451An overview of investigational Histone deacetylase inhibitors (HDACis) for the treatment of non-Hodgkin's lymphoma
Q38561373An update in treatment options for multiple myeloma in nontransplant eligible patients
Q100395010Anti-bacterial and anti-viral nanchangmycin displays anti-myeloma activity by targeting Otub1 and c-Maf
Q90029028Approach to the treatment of the older, unfit patient with myeloma from diagnosis to relapse: perspectives of a US hematologist and a geriatric hematologist
Q92276353Assessment and monitoring of patients receiving chemotherapy for multiple myeloma: strategies to improve outcomes
Q90185321Association of adverse events and associated cost with efficacy for approved relapsed and/or refractory multiple myeloma regimens: A Bayesian network meta-analysis of phase 3 randomized controlled trials
Q48272362Award Winner in the Young Investigator Category, 2017 Society for Biomaterials Annual Meeting and Exposition, Minneapolis, MN, April 05-08, 2017: Lymph node stiffness-mimicking hydrogels regulate human B-cell lymphoma growth and cell surface recepto
Q42378528BET inhibitors as novel therapeutic agents in breast cancer.
Q64978883Barriers and Facilitators of Using Sensored Medication Adherence Devices in a Diverse Sample of Patients With Multiple Myeloma: Qualitative Study.
Q92812162Bone Marrow Stromal Cells-Induced Drug Resistance in Multiple Myeloma
Q40047253Bortezomib and low-dose dexamethasone with or without continuous low-dose oral cyclophosphamide for primary refractory or relapsed multiple myeloma: a randomized phase III study
Q93144918Bortezomib for the Treatment of Hematologic Malignancies: 15 Years Later
Q52686509Bortezomib plus dexamethasone vs thalidomide plus dexamethasone for relapsed or refractory multiple myeloma.
Q90012167Bortezomib, lenalidomide, and dexamethasone with panobinostat for front-line treatment of patients with multiple myeloma who are eligible for transplantation: a phase 1 trial
Q52812971Bortezomib, thalidomide, dexamethasone, and panobinostat for patients with relapsed multiple myeloma (MUK-six): a multicentre, open-label, phase 1/2 trial.
Q33428423Carfilzomib and dexamethasone versus bortezomib and dexamethasone for patients with relapsed or refractory multiple myeloma (ENDEAVOR): a randomised, phase 3, open-label, multicentre study
Q37652953Carfilzomib boosted combination therapy for relapsed multiple myeloma
Q38989789Carfilzomib for the treatment of patients with relapsed and/or refractory multiple myeloma
Q49931866Carfilzomib-dexamethasone versus subcutaneous or intravenous bortezomib in relapsed or refractory multiple myeloma: secondary analysis of the phase 3 ENDEAVOR study
Q92233485Characteristics and risk factors of bortezomib induced peripheral neuropathy: A systematic review of phase III trials
Q93269619Chidamide epigenetically represses autophagy and exerts cooperative antimyeloma activity with bortezomib
Q91756067Chidamide, a histone deacetylase inhibitor, induces growth arrest and apoptosis in multiple myeloma cells in a caspase-dependent manner
Q33443179Clinical Pharmacokinetics and Pharmacodynamics of Panobinostat
Q90293639Clinical and biological characteristics of myeloma patients influence response to elotuzumab combination therapy
Q26795696Clinical characteristics of patients with relapsed multiple myeloma
Q26747768Clinical developments in the treatment of relapsed or relapsed and refractory multiple myeloma: impact of panobinostat, the first-in-class histone deacetylase inhibitor
Q26745930Clinical use and applications of histone deacetylase inhibitors in multiple myeloma
Q60920589Combining carfilzomib and panobinostat to treat relapsed/refractory multiple myeloma: results of a Multiple Myeloma Research Consortium Phase I Study
Q49949477Common Adverse Effects of Novel Therapies for Multiple Myeloma (MM) and Their Management Strategies.
Q59807925Comparison of the antifibrotic effects of the pan-histone deacetylase-inhibitor panobinostat versus the IPF-drug pirfenidone in fibroblasts from patients with idiopathic pulmonary fibrosis
Q26782868Consensus Conference on Salvage Hematopoietic Cell Transplantation in Patients with Relapsed Multiple Myeloma (short title)
Q36480589Cost of Treatment for Relapsed/Refractory Multiple Myeloma
Q64098082Cost of peripheral neuropathy in patients receiving treatment for multiple myeloma: a US administrative claims analysis
Q47348957Current and New Therapeutic Strategies for Relapsed and Refractory Multiple Myeloma: An Update.
Q38672091Current and developing synthetic pharmacotherapy for treating relapsed/refractory multiple myeloma
Q38658649Current and emerging triplet combination therapies for relapsed and refractory multiple myeloma.
Q38412189Current therapeutic strategies for multiple myeloma
Q38271032Current treatment landscape for relapsed and/or refractory multiple myeloma
Q38959138Current treatments for renal failure due to multiple myeloma
Q26749421DNA Methylation and Chromatin Remodeling: The Blueprint of Cancer Epigenetics
Q52676395DNMTi/HDACi combined epigenetic targeted treatment induces reprogramming of myeloma cells in the direction of normal plasma cells.
Q60922662DOT1L inhibition blocks multiple myeloma cell proliferation by suppressing IRF4-MYC signaling
Q59797151Daratumumab plus bortezomib and dexamethasone versus bortezomib and dexamethasone in relapsed or refractory multiple myeloma: updated analysis of CASTOR
Q38996881Daratumumab, Elotuzumab, and the Development of Therapeutic Monoclonal Antibodies in Multiple Myeloma
Q33438321Deacetylase inhibitors: an advance in myeloma therapy?
Q89222569Death by a thousand cuts: the slow demise of chemotherapy
Q36572408Dinutuximab and Panobinostat
Q36178810Discovery of selective small-molecule HDAC6 inhibitor for overcoming proteasome inhibitor resistance in multiple myeloma
Q92771675EHA evaluation of the ESMO-Magnitude of Clinical Benefit Scale version 1.1 (ESMO-MCBS v1.1) for haematological malignancies
Q86915321ENDEAVOR to change treatment for multiple myeloma?
Q36494358Effective use of panobinostat in combination with other active agents in myeloma in a novel five-drug combination: Case report and interesting observations
Q33432845Efficacy and Safety of Panobinostat in Relapsed or/and Refractory Multiple Myeloma: Meta Analyses of Clinical Trials and Systematic Review
Q104268535Efficacy and safety of oral panobinostat plus subcutaneous bortezomib and oral dexamethasone in patients with relapsed or relapsed and refractory multiple myeloma (PANORAMA 3): an open-label, randomised, phase 2 study
Q33443417Efficacy and tolerability of the histone deacetylase inhibitor panobinostat in clinical practice.
Q92298135Efficacy and toxicity of histone deacetylase inhibitors in relapsed/refractory multiple myeloma: Systematic review and meta-analysis of clinical trials
Q64972393Efficacy of retreatment with immunomodulatory drugs and proteasome inhibitors following daratumumab monotherapy in relapsed and refractory multiple myeloma patients.
Q41694198Emerging drugs and combinations to treat multiple myeloma
Q92150213Emerging epigenetic-modulating therapies in lymphoma
Q47340203Emerging options in multiple myeloma: targeted, immune, and epigenetic therapies.
Q50330020Endoplasmic reticulum stress in the development of multiple myeloma and drug resistance
Q55433291Epigenetic Regulators in the Development, Maintenance, and Therapeutic Targeting of Acute Myeloid Leukemia.
Q28072370Epigenetic Therapeutics: A New Weapon in the War Against Cancer
Q38895512Epigenetic mechanisms of cell adhesion-mediated drug resistance in multiple myeloma.
Q38838643Epigenetic modifiers in immunotherapy: a focus on checkpoint inhibitors
Q39261435Epigenetic regulatory mutations and epigenetic therapy for multiple myeloma
Q48236958Epigenetic repression of miR-375 is the dominant mechanism for constitutive activation of the PDPK1/RPS6KA3 signalling axis in multiple myeloma.
Q39137683Epigenetic strategies to reverse drug resistance in heterogeneous multiple myeloma
Q41064275Epigenetic targeting drugs potentiate chemotherapeutic effects in solid tumor therapy
Q38275276Epigenetic targets for novel therapies of lung diseases
Q39009379Epigenetic therapy approaches in non-small cell lung cancer: Update and perspectives
Q26773803Epigenetic treatment of solid tumours: a review of clinical trials
Q38542620Epigenetics and Lymphoma: Can We Use Epigenetics to Prime or Reset Chemoresistant Lymphoma Programs?
Q35726371Epigenetics in diagnosis, prognostic assessment and treatment of cancer: an update
Q38770916Epigenetics: A primer for clinicians
Q35809982Estimating the Costs of Therapy in Patients with Relapsed and/or Refractory Multiple Myeloma: A Model Framework.
Q42384490Evidence of long-term disease control with panobinostat maintenance in patients with relapsed multiple myeloma.
Q27026478Evolving Paradigms in the Management of Multiple Myeloma: Novel Agents and Targeted Therapies
Q26771331Evolving paradigms in the treatment of relapsed/refractory multiple myeloma: increased options and increased complexity
Q53099556Factors associated with second-line triplet therapy in routine care in relapsed/refractory multiple myeloma.
Q93082000Feasibility, Tolerability and Efficacy of Carfilzomib in Combination with Lenalidomide and Dexamethasone in Relapsed Refractory Myeloma Patients: A Retrospective Real-Life Survey of the Sicilian Myeloma Network
Q52724347Functional transcriptomic annotation and protein-protein interaction analysis identify EZH2 and UBE2C as key upregulated proteins in ovarian cancer.
Q64928553HDAC Inhibitors Exert Anti-Myeloma Effects through Multiple Modes of Action.
Q43246885HDAC3 regulates DNMT1 expression in multiple myeloma: therapeutic implications
Q33834432HDAC5 controls the functions of Foxp3(+) T-regulatory and CD8(+) T cells
Q38799515Histone Deacetylase Inhibitors Enhance the Therapeutic Potential of Reovirus in Multiple Myeloma
Q28082536Histone acetyltransferases and histone deacetylases in B- and T-cell development, physiology and malignancy
Q37277238Histone deacetylase inhibitor panobinostat induces calcineurin degradation in multiple myeloma
Q38813504Histone deacetylase inhibitors in multiple myeloma: from bench to bedside
Q59798907Identification of Jun loss promotes resistance to histone deacetylase inhibitor entinostat through Myc signaling in luminal breast cancer
Q38572855Impact of Histone Deacetylase Inhibitors on microRNA Expression and Cancer Therapy: A Review
Q36115680Impact of prior treatment and depth of response on survival in MM-003, a randomized phase 3 study comparing pomalidomide plus low-dose dexamethasone versus high-dose dexamethasone in relapsed/refractory multiple myeloma.
Q38910971In vivo treatment with epigenetic modulating agents induces transcriptional alterations associated with prognosis and immunomodulation in multiple myeloma.
Q49375952Incidence of neutropenia and use of granulocyte colony-stimulating factors in multiple myeloma: is current clinical practice adequate?
Q49244147Incidence, Diagnosis, and Management of QT Prolongation Induced by Cancer Therapies: A Systematic Review.
Q33648440Individual patient oesophageal cancer 3D models for tailored treatment
Q42399891Innovations in treatment and response evaluation in multiple myeloma
Q92736173Insights into novel emerging epigenetic drugs in myeloid malignancies
Q46754093Integration of Novel Agents into the Care of Patients with Multiple Myeloma
Q58560605Interpreting clinical trial data in multiple myeloma: translating findings to the real-world setting
Q48126631Intra-patient dose escalation of panobinostat in patients with relapsed/refractory multiple myeloma.
Q95661294Isatuximab plus pomalidomide and dexamethasone in relapsed/refractory multiple myeloma patients with renal impairment: ICARIA-MM subgroup analysis
Q92003943Key actors in cancer therapy: epigenetic modifiers
Q60952711Lenalidomide and Low Dose Dexamethasone Plus Elotuzumab or Carfilzomib for Relapsed or Refractory Multiple Myeloma: A Comparison of Progression-Free Survival with Reconstructed Individual Participant Data
Q38791113Long term, continuous exposure to panobinostat induces terminal differentiation and long term survival in the TH-MYCN neuroblastoma mouse model
Q64099073Management of cardiovascular risk in patients with multiple myeloma
Q38874675Management of high-risk Myeloma: an evidence-based review of treatment strategies
Q49989003Management of multiple myeloma in the relapsed/refractory patient.
Q38896473Management of relapsed and refractory multiple myeloma in modern times: Incorporating new agents into decision-making.
Q47283493Management of relapsed and refractory multiple myeloma: novel agents, antibodies, immunotherapies and beyond
Q38681463Management of relapsed multiple myeloma: recommendations of the International Myeloma Working Group
Q38900024Managing renal complications in multiple myeloma
Q38725415Mechanisms of Acquired Drug Resistance to the HDAC6 Selective Inhibitor Ricolinostat Reveals Rational Drug-Drug Combination with Ibrutinib
Q39185604Mechanisms of Resistance in Multiple Myeloma
Q38860769Mechanisms of action and resistance for multiple myeloma novel drug treatments
Q64065815Metformin Augments Panobinostat's Anti-Bladder Cancer Activity by Activating AMP-Activated Protein Kinase
Q26768653Minimal Residual Disease Assessment in the Context of Multiple Myeloma Treatment
Q47423761Model-Based Meta-Analysis for Multiple Myeloma: A Quantitative Drug-Independent Framework for Efficient Decisions in Oncology Drug Development
Q38756800Modern multiple myeloma therapy: deep, sustained treatment response and good clinical outcomes
Q103723880Modulating proteasome inhibitor tolerance in multiple myeloma: an alternative strategy to reverse inevitable resistance
Q90544939Monoclonal Antibodies versus Histone Deacetylase Inhibitors in Combination with Bortezomib or Lenalidomide plus Dexamethasone for the Treatment of Relapsed or Refractory Multiple Myeloma: An Indirect-Comparison Meta-Analysis of Randomized Controlled
Q45057327Moving Beyond Maximum Tolerated Dose for Targeted Oncology Drugs: Use of Clinical Utility Index to Optimize Venetoclax Dosage in Multiple Myeloma Patients
Q55476446Multiple Liver Nodules Mimicking Metastatic Disease as Initial Presentation of Multiple Myeloma.
Q89682913Multiple Myeloma: Available Therapies and Causes of Drug Resistance
Q55119496Multiple Myeloma: Diagnosis and Treatment.
Q64883977Multiple Myeloma: Updates on Diagnosis and Management.
Q100316249Multiple myeloma current treatment algorithms
Q36725401Multiple myeloma in the marrow: pathogenesis and treatments.
Q37623809Multiple myeloma: 2016 update on diagnosis, risk-stratification, and management
Q58565204Multiple myeloma: 2018 update on diagnosis, risk‐stratification, and management
Q37394605Multiple myeloma: patient outcomes in real-world practice
Q36470699Myeloma today: Disease definitions and treatment advances
Q47625488NCCN Guidelines Insights: Multiple Myeloma, Version 3.2016.
Q45043445NICE guidance on panobinostat for patients with multiple myeloma after at least two previous treatments
Q48269862Natural history of relapsed myeloma, refractory to immunomodulatory drugs and proteasome inhibitors: a multicenter IMWG study
Q64901832Navigating the treatment landscape in multiple myeloma: which combinations to use and when?
Q89777946Network meta-analysis of randomized trials in multiple myeloma: efficacy and safety in relapsed/refractory patients
Q55283646New Treatment Strategies Making an Impact in Multiple Myeloma.
Q38598891New developments in the management of relapsed/refractory multiple myeloma - the role of ixazomib
Q28071551New investigational drugs with single-agent activity in multiple myeloma
Q38673764New pharmacotherapy options for multiple myeloma
Q58798742Next-Generation Drugs and Probes for Chromatin Biology: From Targeted Protein Degradation to Phase Separation
Q38981247Next-generation multiple myeloma treatment: a pharmacoeconomic perspective
Q39234159Novel Proteasome Inhibitors and Histone Deacetylase Inhibitors: Progress in Myeloma Therapeutics
Q51761449Novel Treatments for Multiple Myeloma: What Role Do They Have in Older Adults?
Q51188342Novel histone deacetylase 6 (HDAC6) selective inhibitors: a patent evaluation (WO2014181137).
Q38764510Novel therapeutic approaches in chondrosarcoma.
Q45873027Novel treatment opportunities for sulfur mustard-related cancers: genetic and epigenetic perspectives
Q47125228Novel tropolones induce the unfolded protein response pathway and apoptosis in multiple myeloma cells
Q42046604Olaptesed pegol, an anti-CXCL12/SDF-1 Spiegelmer, alone and with bortezomib-dexamethasone in relapsed/refractory multiple myeloma: a Phase IIa Study
Q38780843Outcome of autologous hematopoietic stem cell transplantation in refractory multiple myeloma.
Q39280492Overall survival of patients with relapsed multiple myeloma treated with panobinostat or placebo plus bortezomib and dexamethasone (the PANORAMA 1 trial): a randomised, placebo-controlled, phase 3 trial
Q38765760PD-1/PD-L1 inhibitors in multiple myeloma: The present and the future
Q36848015Panobinostat (Farydak): A Novel Option for the Treatment of Relapsed Or Relapsed and Refractory Multiple Myeloma
Q33426983Panobinostat PK/PD profile in combination with bortezomib and dexamethasone in patients with relapsed and relapsed/refractory multiple myeloma
Q36109802Panobinostat Plus Bortezomib Versus Lenalidomide in Patients with Relapsed and/or Refractory Multiple Myeloma: A Matching-Adjusted Indirect Treatment Comparison of Survival Outcomes using Patient-level Data
Q37711782Panobinostat acts synergistically with ibrutinib in diffuse large B cell lymphoma cells with MyD88 L265 mutations.
Q55064105Panobinostat and Multiple Myeloma in 2018.
Q38806260Panobinostat for the management of multiple myeloma
Q85350362Panobinostat for the treatment of multiple myeloma
Q26778674Panobinostat for the treatment of multiple myeloma: the evidence to date
Q38616807Panobinostat for the treatment of relapsed or relapsed/refractory multiple myeloma: pharmacology and clinical outcomes
Q33428575Panobinostat in combination with bortezomib in patients with relapsed or refractory peripheral T-cell lymphoma: an open-label, multicentre phase 2 trial
Q89339834Panobinostat in combination with rituximab in heavily pretreated diffuse large B-cell lymphoma: Results of a phase II study
Q88761558Panobinostat in multiple myeloma
Q54682248Panobinostat plus bortezomib and dexamethasone for relapsed myeloma.
Q33428098Panobinostat plus bortezomib and dexamethasone in previously treated multiple myeloma: outcomes by prior treatment
Q33443001Panobinostat plus bortezomib and dexamethasone: impact of dose intensity and administration frequency on safety in the PANORAMA 1 trial.
Q38716460Panobinostat: A Review in Relapsed or Refractory Multiple Myeloma
Q33430925Panobinostat: A histone deacetylase inhibitor for the treatment of relapsed or refractory multiple myeloma
Q38519497Panobinostat: a novel pan-deacetylase inhibitor for the treatment of relapsed or relapsed and refractory multiple myeloma
Q38269612Panobinostat: a review of trial results and future prospects in multiple myeloma
Q38403118Panobinostat: first global approval
Q41602673Patterns of relapse and outcome of elderly multiple myeloma patients treated as front-line therapy with novel agents combinations
Q36703448Phase 1 trial of carfilzomib (PR-171) in combination with vorinostat (SAHA) in patients with relapsed or refractory B-cell lymphomas
Q37150016Phase 2 study of panobinostat with or without rituximab in relapsed diffuse large B-cell lymphoma
Q33437811Phase 2 study of tabalumab, a human anti-B-cell activating factor antibody, with bortezomib and dexamethasone in patients with previously treated multiple myeloma.
Q33423168Phase I study of carfilzomib, lenalidomide, vorinostat, and dexamethasone in patients with relapsed and/or refractory multiple myeloma
Q88402159Phase I trial of histone deacetylase inhibitor panobinostat in addition to glucocorticoids for primary therapy of acute graft-versus-host disease
Q49853764Phase I/II study of mocetinostat in combination with gemcitabine for patients with advanced pancreatic cancer and other advanced solid tumors
Q35571044Phase I/II study of the combination of panobinostat and carfilzomib in patients with relapsed/refractory multiple myeloma
Q43753697Phase I/II study of the deacetylase inhibitor panobinostat after allogeneic stem cell transplantation in patients with high-risk MDS or AML (PANOBEST trial).
Q42940540Phase II study of bendamustine, bortezomib and dexamethasone as second-line treatment for elderly patients with multiple myeloma: the Intergroupe Francophone du Myelome 2009-01 trial
Q92088331Pomalidomide, bortezomib, and dexamethasone for patients with relapsed or refractory multiple myeloma previously treated with lenalidomide (OPTIMISMM): a randomised, open-label, phase 3 trial
Q42425704Pooled analysis of the reports of carfilzomib, panobinostat, and elotuzumab combinations in patients with refractory/relapsed multiple myeloma
Q37737800Posttransplant maintenance therapy in multiple myeloma: the changing landscape
Q52674773Potential of oncolytic viruses in the treatment of multiple myeloma.
Q38742700Practical Approaches to the Management of Dual Refractory Multiple Myeloma
Q41088379Preclinical anti-myeloma activity of EDO-S101, a new bendamustine-derived molecule with added HDACi activity, through potent DNA damage induction and impairment of DNA repair
Q92572416Predictive Factors for Early Relapse in Multiple Myeloma after Autologous Hematopoietic Stem Cell Transplant
Q52801394Prevention and management of adverse events of novel agents in multiple myeloma: a consensus of the European Myeloma Network.
Q88797028Prevention and treatment of relapse after stem cell transplantation in lymphoid malignancies
Q53831599Prognostic value of antigen expression in multiple myeloma: a PETHEMA/GEM study on 1265 patients enrolled in four consecutive clinical trials.
Q44694137Progress and Paradigms in Multiple Myeloma
Q48178842Prolonged survival after second autologous transplantation and lenalidomide maintenance for salvage treatment of myeloma patients at first relapse after prior autograft
Q42581682Promising therapies in multiple myeloma
Q53752929Proteasome inhibitors in cancer therapy.
Q35408665Proteotoxic crisis, the ubiquitin-proteasome system, and cancer therapy
Q33429115Quisinostat, bortezomib, and dexamethasone combination therapy for relapsed multiple myeloma
Q38967891RECQ1 helicase is involved in replication stress survival and drug resistance in multiple myeloma
Q36989576Randomized phase 2 study: elotuzumab plus bortezomib/dexamethasone vs bortezomib/dexamethasone for relapsed/refractory MM.
Q35750491Rational Combinations of Targeted Agents in AML
Q64242177Real-World Treatment Patterns, Outcomes, and Healthcare Resource Utilization in Relapsed or Refractory Multiple Myeloma: Evidence from a Medical Record Review in France
Q39690253Real-world treatment patterns and associated progression-free survival in relapsed/refractory multiple myeloma among US community oncology practices
Q28074521Recent advances in multiple myeloma: a Korean perspective
Q28070331Recent advances in understanding multiple myeloma
Q38757067Recent progress in relapsed multiple myeloma therapy: implications for treatment decisions.
Q92914144Relapsed refractory multiple myeloma: a comprehensive overview
Q53786308Relationship of response and survival in patients with relapsed and refractory multiple myeloma treated with pomalidomide plus low-dose dexamethasone in the MM-003 trial randomized phase III trial (NIMBUS).
Q98177216Restoring MLL reactivates latent tumor suppression-mediated vulnerability to proteasome inhibitors
Q38895216Rewiring the solid tumor epigenome for cancer therapy
Q33167710Ricolinostat plus lenalidomide, and dexamethasone in relapsed or refractory multiple myeloma: a multicentre phase 1b trial
Q39040044Ricolinostat, the First Selective Histone Deacetylase 6 Inhibitor, in Combination with Bortezomib and Dexamethasone for Relapsed or Refractory Multiple Myeloma
Q37199772Role of Histone Deacetylase Inhibitors in Relapsed Refractory Multiple Myeloma: A Focus on Vorinostat and Panobinostat
Q38455740Romidepsin for the treatment of non-Hodgkin's lymphoma
Q33438732Safety and efficacy of abexinostat, a pan-histone deacetylase inhibitor, in non-Hodgkin lymphoma and chronic lymphocytic leukemia: results of a phase II study
Q58793830Safety and efficacy of vorinostat, bortezomib, doxorubicin and dexamethasone in a phase I/II study for relapsed or refractory multiple myeloma (VERUMM study: vorinostat in elderly, relapsed and unfit multiple myeloma)
Q39100317Safety issues and management of toxicities associated with new treatments for multiple myeloma.
Q39404809Safety of ixazomib for the treatment of multiple myeloma
Q26740359Salvage therapies in relapsed and/or refractory myeloma: what is current and what is the future?
Q40454277Salvage therapy in first relapse: a retrospective study in a large patient population with multiple myeloma.
Q42348465Salvage use of allogeneic hematopoietic stem cell transplantation after reduced intensity conditioning from unrelated donors in multiple myeloma. A study by the Plasma Cell Disorders subcommittee of the European Group for Blood and Marrow Transplant
Q39013620Second primary malignancies in multiple myeloma: an overview and IMWG consensus
Q90669066Seeking Convergence and Cure with New Myeloma Therapies
Q36242646Selective Inhibitors of Histone Deacetylases 1 and 2 Synergize with Azacitidine in Acute Myeloid Leukemia
Q49068138Sensitization of retinoids and corticoids to epigenetic drugs in MYC-activated lung cancers by antitumor reprogramming.
Q39027826Sequencing of nontransplant treatments in multiple myeloma patients with active disease
Q89777982Should minimal residual disease negativity be the end point of myeloma therapy?
Q38783055Sorafenib for the treatment of multiple myeloma.
Q38820565Specialty pharmacy for hematologic malignancies
Q50326769Synergistic Immunostimulatory Effects and Therapeutic Benefit of Combined Histone Deacetylase and Bromodomain Inhibition in Non-Small Cell Lung Cancer
Q33441476Systematic review and meta-analysis of the efficacy and safety of novel monoclonal antibodies for treatment of relapsed/refractory multiple myeloma
Q38989377Targeting Deubiquitinating Enzymes in Glioblastoma Multiforme: Expectations and Challenges.
Q38728585Targeting plasma cells: are we any closer to a panacea for diseases of antibody-secreting cells?
Q38821103Targeting the cancer epigenome for therapy
Q28067187The Danish National Multiple Myeloma Registry
Q37150733The Diagnosis and Treatment of Multiple Myeloma
Q60960086The Epigenome in Multiple Myeloma: Impact on Tumor Cell Plasticity and Drug Response
Q47344797The European Medicines Agency Review of Panobinostat (Farydak) for the Treatment of Adult Patients with Relapsed and/or Refractory Multiple Myeloma
Q49349840The Future of Combination Therapies for Peripheral T Cell Lymphoma (PTCL).
Q38687570The HDAC inhibitor panobinostat (LBH589) exerts in vivo anti-leukaemic activity against MLL-rearranged acute lymphoblastic leukaemia and involves the RNF20/RNF40/WAC-H2B ubiquitination axis
Q38873902The Role of Intracellular Signaling Pathways in the Pathogenesis of Multiple Myeloma and Novel Therapeutic Approaches.
Q28069789The Role of Panobinostat Plus Bortezomib and Dexamethasone in Treating Relapsed or Relapsed and Refractory Multiple Myeloma: A European Perspective
Q95642034The Synergistic Antitumor Activity of Chidamide in Combination with Bortezomib on Gastric Cancer
Q58792448The Therapeutic Strategy of HDAC6 Inhibitors in Lymphoproliferative Disease
Q58718492The biological significance of histone modifiers in multiple myeloma: clinical applications
Q47375990The effect of novel therapies in high-molecular-risk multiple myeloma
Q91806716The fragility of phase 3 trials supporting FDA-approved anticancer medicines: a retrospective analysis
Q40153567The molecular pathogenesis of the NUP98-HOXA9 fusion protein in acute myeloid leukemia
Q30248534The next generation of novel therapies for the management of relapsed multiple myeloma
Q38685108The potential of ixazomib, a second-generation proteasome inhibitor, in the treatment of multiple myeloma
Q47339695The proteasome and proteasome inhibitors in multiple myeloma
Q95650650The proteasome as a druggable target with multiple therapeutic potentialities: Cutting and non-cutting edges
Q92356557The role of CXCR4 in multiple myeloma: Cells' journey from bone marrow to beyond
Q55513961The use of single armed observational data to closing the gap in otherwise disconnected evidence networks: a network meta-analysis in multiple myeloma.
Q39177792Therapy for Relapsed Multiple Myeloma: Guidelines From the Mayo Stratification for Myeloma and Risk-Adapted Therapy
Q47812117Three cases of relapsed/refractory multiple myeloma under hemodialysis treated with panobinostat/bortezomib/dexamethasone (FVD).
Q64886671Towards Molecular Profiling in Multiple Myeloma: A Literature Review and Early Indications of Its Efficacy for Informing Treatment Strategies.
Q50281172Treatment of HIV-Infected Individuals with the Histone Deacetylase Inhibitor Panobinostat Results in Increased Numbers of Regulatory T Cells and Limits Ex Vivo Lipopolysaccharide-Induced Inflammatory Responses
Q38970597Treatment of Relapsed/Refractory Multiple Myeloma
Q64068728Treatment of patients with multiple myeloma progressing on frontline-therapy with lenalidomide
Q26749180Treatment of relapsed and refractory multiple myeloma
Q58729834Treatment options for refractory/relapsed multiple myeloma: an updated evidence synthesis by network meta-analysis
Q39369772Treatment options for relapse after autograft in multiple myeloma - report from an EBMT educational meeting.
Q47552083Treatment-free interval as a metric of patient experience and a health outcome of value for advanced multiple myeloma: the case for the histone deacetylase inhibitor panobinostat, a next-generation novel agent
Q38342281Treatment-related symptom management in patients with multiple myeloma: a review
Q30238893Triplet combinations in relapsed/refractory myeloma: update on recent phase 3 trials
Q47770089Triplet vs. doublet drug regimens for managing multiple myeloma.
Q93189824Understanding Cancer Through the Lens of Epigenetic Inheritance, Allele-Specific Gene Expression, and High-Throughput Technology
Q59798196Update on PD-1/PD-L1 Inhibitors in Multiple Myeloma
Q92603982Update on elotuzumab for the treatment of relapsed/refractory multiple myeloma: patients' selection and perspective
Q33440007Update on the optimal use of bortezomib in the treatment of multiple myeloma
Q50166078Updated results of a phase 2 study of panobinostat combined with melphalan, thalidomide and prednisone (MPT) in relapsed/refractory multiple myeloma.
Q92218684Updates on Hematologic Malignancies in the Older Adult: Focus on Acute Myeloid Leukemia, Chronic Lymphocytic Leukemia, and Multiple Myeloma
Q92276379Use of carfilzomib in second-line therapy and beyond for relapsed multiple myeloma
Q38826861VEGF-mediated cell survival in non-small-cell lung cancer: implications for epigenetic targeting of VEGF receptors as a therapeutic approach
Q38970612Waldenstrom Macroglobulinemia: Genomic Aberrations and Treatment
Q38733592Which therapies will move to the front line for multiple myeloma?
Q52817414[Multiple myeloma : What has been confirmed in therapy?]

Search more.