Cellular Energetics as a Target for Tumor Cell Elimination

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Cellular Energetics as a Target for Tumor Cell Elimination is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P6179Dimensions Publication ID1036364878
P356DOI10.1134/S0006297916020012
P698PubMed publication ID27260387

P2093author name stringA V Kulikov
B D Zhivotovsky
V G Gogvadze
P V Maximchik
P2860cites workBax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondriaQ22008484
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Reactive oxygen species mediate caspase activation and apoptosis induced by lipoic acid in human lung epithelial cancer cells through Bcl-2 down-regulationQ23914984
Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic functionQ24293924
Hexokinase II: cancer's double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondriaQ24595940
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Hexokinase II detachment from the mitochondria potentiates cisplatin induced cytotoxicity through a caspase-2 dependent mechanismQ24634709
Determinants of BH3 Binding Specificity for Mcl-1 versus Bcl-xLQ27660407
p53 regulates mitochondrial respirationQ28242400
Interleukin-3-induced phosphorylation of BAD through the protein kinase AktQ28255373
Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosisQ28283313
A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growthQ28283339
Energy metabolism in tumor cellsQ28288377
Regulation of cancer cell metabolismQ28303890
Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and BakQ28572925
The pathophysiology of mitochondrial cell deathQ29547893
Absolute oxygen tension (pO(2)) in murine fatty and muscle tissue as determined by EPR.Q47694426
Decreased affinity for oxygen of cytochrome-c oxidase in Leigh syndrome caused by SURF1 mutationsQ47952796
Oxidative metabolism and glycolysis in benign brain tumorsQ48216195
The energy blockers 3-bromopyruvate and lonidamine: effects on bioenergetics of brain mitochondriaQ48560205
Acetoacetate metabolism in AS-30D hepatoma cells.Q51594509
Bid, but not Bax, regulates VDAC channels.Q53849605
On the mechanism of the crabtree effect in mouse ascites tumor cellsQ67014148
Role of acetoin on the regulation of intermediate metabolism of Ehrlich ascites tumor mitochondria: its contribution to membrane cholesterol enrichment modifying passive proton permeabilityQ68656978
Regulation of cellular energy metabolism: the Crabtree effectQ71259962
Understanding the dynamics of cellular responsiveness to modifications of metabolic substrates in perifusionQ72037241
Occurrence of the Crabtree effect in HeLa cellsQ74687772
Tumor hypoxia and gene expression--implications for malignant progression and therapyQ77709035
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Glycolysis inhibition targets Mcl-1 to restore sensitivity of lymphoma cells to ABT-737-induced apoptosisQ82468263
The combination of metformin and 2-deoxyglucose inhibits autophagy and induces AMPK-dependent apoptosis in prostate cancer cellsQ95804869
Greater cell cycle inhibition and cytotoxicity induced by 2-deoxy-d-glucose in tumor cells treated under hypoxic vs aerobic conditionsQ44647527
A novel Bim-BH3-derived Bcl-XL inhibitor: biochemical characterization, in vitro, in vivo and ex-vivo anti-leukemic activityQ45357282
Immuno- and hepato-toxicity of dichloroacetic acid in MRL(+/+) and B(6)C(3)F(1) miceQ46287362
Inhibition of energy-producing pathways of HepG2 cells by 3-bromopyruvateQ46302698
Glucose metabolism heterogeneity in human and mouse malignant glioma cell linesQ46727509
Aerobic glycolysis: meeting the metabolic requirements of cell proliferationQ29615178
Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addictionQ29616653
c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolismQ29617213
Spatial heterogeneity and oxygen dependence of glucose consumption in R3230Ac and fibrosarcomas of the Fischer 344 rat.Q33217203
Oncogenic alterations of metabolismQ33546892
Akt/Protein kinase B inhibits cell death by preventing the release of cytochrome c from mitochondriaQ33959022
BH3 mimetics: status of the field and new developmentsQ34037924
Targeting mitochondria for cancer therapyQ34115304
Nitric oxide inhibition of respiration involves both competitive (heme) and noncompetitive (copper) binding to cytochrome c oxidaseQ34270791
Energy substrate modulates mitochondrial structure and oxidative capacity in cancer cellsQ34297004
Hexokinase 1 blocks apoptotic signals at the mitochondriaQ34369759
Effect of extracellular AMP on cell proliferation and metabolism of breast cancer cell lines with high and low glycolytic ratesQ34416216
3-Thiomorpholin-8-oxo-8H-acenaphtho [1,2-b] pyrrole-9-carbonitrile (S1) derivatives as pan-Bcl-2-inhibitors of Bcl-2, Bcl-xL and Mcl-1.Q34498717
Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells.Q34645070
Bcl-xL promotes the open configuration of the voltage-dependent anion channel and metabolite passage through the outer mitochondrial membraneQ34647032
Mitochondrial intermembrane junctional complexes and their involvement in cell deathQ34648830
Hypoxia-inducible factor-1alpha and the glycolytic phenotype in tumors.Q34768392
BCL-2 family antagonists for cancer therapyQ34891196
Multiple BH3 mimetics antagonize antiapoptotic MCL1 protein by inducing the endoplasmic reticulum stress response and up-regulating BH3-only protein NOXA.Q35107469
PI3K/Akt and apoptosis: size mattersQ35603373
Cancer metabolism: facts, fantasy, and fictionQ35617179
The TCA cycle and tumorigenesis: the examples of fumarate hydratase and succinate dehydrogenase.Q35622053
Deviant energetic metabolism of glycolytic cancer cellsQ35653177
Tumor Mitochondria and the Bioenergetics of Cancer CellsQ35681852
Transformation of human mesenchymal stem cells increases their dependency on oxidative phosphorylation for energy productionQ35748754
Stressing out over survival: glutamine as an apoptotic modulator.Q36254208
The role of the mitochondrial permeability transition in cell deathQ36578744
Rheostat control of gene expression by metabolitesQ36612424
Glucose metabolism and cancerQ36625786
Mitochondria-targeted drugs synergize with 2-deoxyglucose to trigger breast cancer cell deathQ36979129
Mitocans: mitochondrial targeted anti-cancer drugs as improved therapies and related patent documentsQ37066949
Mitochondria in cancer cells: what is so special about them?Q37093125
Alpha-tocopheryl succinate induces apoptosis by targeting ubiquinone-binding sites in mitochondrial respiratory complex II.Q37158312
Regulation of hexokinase binding to VDACQ37235994
Roles of p53, MYC and HIF-1 in regulating glycolysis - the seventh hallmark of cancerQ37259237
Metabolic transformation in cancer.Q37423585
Proapoptotic N-truncated BCL-xL protein activates endogenous mitochondrial channels in living synaptic terminalsQ37535121
Pyruvate into lactate and back: from the Warburg effect to symbiotic energy fuel exchange in cancer cells.Q37552177
The Warburg effect and mitochondrial stability in cancer cellsQ37648867
Bioenergetic pathways in tumor mitochondria as targets for cancer therapy and the importance of the ROS-induced apoptotic triggerQ37660632
Rethinking the Warburg effect with Myc micromanaging glutamine metabolismQ37677940
The pivotal roles of mitochondria in cancer: Warburg and beyond and encouraging prospects for effective therapiesQ37728362
Waves of gene regulation suppress and then restore oxidative phosphorylation in cancer cellsQ37749030
Mitochondrially targeted anti-cancer agentsQ37769939
Oxidative phosphorylation in cancer cellsQ37789810
Choosing between glycolysis and oxidative phosphorylation: A tumor's dilemma?Q37801026
Pro-apoptotic activity of BH3-only proteins and BH3 mimetics: from theory to potential cancer therapyQ37977487
Many players in BCL-2 family affairsQ38185804
Small molecule Mcl-1 inhibitors for the treatment of cancerQ38244767
Mitochondrial substrates in cancer: drivers or passengers?Q38245420
Mitochondrially targeted vitamin E succinate modulates expression of mitochondrial DNA transcripts and mitochondrial biogenesisQ38921197
Why to compare absolute numbers of mitochondria.Q38980806
3-Bromopyruvate induces apoptosis in breast cancer cells by downregulating Mcl-1 through the PI3K/Akt signaling pathwayQ39027590
Targeting cisplatin-resistant human tumor cells with metabolic inhibitorsQ39042043
Impact of 2-deoxy-D-glucose on the target metabolome profile of a human endometrial cancer cell lineQ39067055
Glutamine deprivation enhances antitumor activity of 3-bromopyruvate through the stabilization of monocarboxylate transporter-1.Q39317923
The BH3 mimetic S1 induces autophagy through ER stress and disruption of Bcl-2/Beclin 1 interaction in human glioma U251 cellsQ39349641
Targeting mitochondria by α-tocopheryl succinate kills neuroblastoma cells irrespective of MycN oncogene expressionQ39404881
Targeting cancer cell metabolism: the combination of metformin and 2-deoxyglucose induces p53-dependent apoptosis in prostate cancer cellsQ39730167
Inhibition of glycolysis enhances cisplatin-induced apoptosis in ovarian cancer cellsQ39742722
The role of high rates of glycolysis and glutamine utilization in rapidly dividing cellsQ39826882
Glucose metabolism inhibits apoptosis in neurons and cancer cells by redox inactivation of cytochrome c.Q39912742
Mitochondrial-targeted active Akt protects SH-SY5Y neuroblastoma cells from staurosporine-induced apoptotic cell deathQ39961067
Increased ROS generation and p53 activation in alpha-lipoic acid-induced apoptosis of hepatoma cells.Q40202620
pO2- and pH-gradients in multicellular spheroids and their relationship to cellular metabolism and radiation sensitivity of malignant human tumor cells.Q40647638
Characterization of porin isoforms expressed in tumor cellsQ40853637
Glucose and phosphate inhibit respiration and oxidative metabolism in cultured hamster eight-cell embryos: evidence for the "crabtree effect".Q41171991
VDAC closure increases calcium ion fluxQ41816375
The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.Q42064781
Apoptosis of B-cell chronic lymphocytic leukemia cells induced by a novel BH3 peptidomimeticQ42448236
Oxidative phosphorylation is impaired by prolonged hypoxia in breast and possibly in cervix carcinomaQ42960308
Akt activation protects hippocampal neurons from apoptosis by inhibiting transcriptional activity of p53.Q43508981
Cytochrome c release occurs via Ca2+-dependent and Ca2+-independent mechanisms that are regulated by Bax.Q43551075
Multisite control of the Crabtree effect in ascites hepatoma cells.Q43572428
Role of protonatable groups of bovine heart bc(1) complex in ubiquinol binding and oxidationQ43808628
Bcl-2 and Bax regulate the channel activity of the mitochondrial adenine nucleotide translocatorQ44273379
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)65-79
P577publication date2016-02-01
P1433published inBiochemistryQ4086944
P1476titleCellular Energetics as a Target for Tumor Cell Elimination
P478volume81

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cites work (P2860)
Q58792872Aqueous Extracts of Kob Induce Apoptosis to Exert Anticancer Activity
Q60930189Mitochondrial Substrate-Level Phosphorylation as Energy Source for Glioblastoma: Review and Hypothesis

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