Combination therapy for the improvement of long-term macrovascular and microvascular outcomes in type 2 diabetes: Rationale and evidence for early initiation

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Combination therapy for the improvement of long-term macrovascular and microvascular outcomes in type 2 diabetes: Rationale and evidence for early initiation is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/J.JDIACOMP.2016.03.010
P698PubMed publication ID27149916

P2093author name stringSteven Milligan
P2860cites workDiabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studiesQ24608301
Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational studyQ24652963
Heart failure outcomes with empagliflozin in patients with type 2 diabetes at high cardiovascular risk: results of the EMPA-REG OUTCOME® trialQ27301948
Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) GroupQ27860882
Management of hyperglycemia in type 2 diabetes, 2015: a patient-centered approach: update to a position statement of the American Diabetes Association and the European Association for the Study of DiabetesQ28254549
Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitusQ28297680
Alogliptin after acute coronary syndrome in patients with type 2 diabetesQ28297690
Risk of cardiovascular and all-cause mortality in individuals with diabetes mellitus, impaired fasting glucose, and impaired glucose tolerance: the Australian Diabetes, Obesity, and Lifestyle Study (AusDiab)Q28306815
Intensive blood glucose control and vascular outcomes in patients with type 2 diabetesQ29547541
Effects of intensive glucose lowering in type 2 diabetesQ29547736
10-year follow-up of intensive glucose control in type 2 diabetesQ29615973
Glucose control and vascular complications in veterans with type 2 diabetesQ29619213
Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomised controlled trialQ29619886
Effects of intensive glycaemic control on ischaemic heart disease: analysis of data from the randomised, controlled ACCORD trialQ30840447
Acarbose for prevention of type 2 diabetes mellitus: the STOP-NIDDM randomised trialQ33425402
Rationale, design, and baseline characteristics of a randomized, placebo-controlled cardiovascular outcome trial of empagliflozin (EMPA-REG OUTCOME™)Q33812170
Long-term effects of intensive glucose lowering on cardiovascular outcomesQ33851861
Initial combination of linagliptin and metformin improves glycaemic control in type 2 diabetes: a randomized, double-blind, placebo-controlled studyQ83489553
Initial combination of empagliflozin and linagliptin in subjects with type 2 diabetesQ86623452
Randomized clinical trial of quick-release bromocriptine among patients with type 2 diabetes on overall safety and cardiovascular outcomesQ33932712
Effect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes: an analysis of the ACCORD randomised trialQ34008233
Follow-up of blood-pressure lowering and glucose control in type 2 diabetesQ34042084
Diabetes mellitus, prediabetes, and incidence of subclinical myocardial damageQ34345083
Effect of Sitagliptin on Cardiovascular Outcomes in Type 2 DiabetesQ34670462
Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 DiabetesQ34673134
Initial combination of linagliptin and metformin in patients with type 2 diabetes: efficacy and safety in a randomised, double-blind 1-year extension studyQ34804865
Rosiglitazone evaluated for cardiovascular outcomes in oral agent combination therapy for type 2 diabetes (RECORD): a multicentre, randomised, open-label trialQ34985342
Effect of early intensive multifactorial therapy on 5-year cardiovascular outcomes in individuals with type 2 diabetes detected by screening (ADDITION-Europe): a cluster-randomised trialQ35106580
Prevalence of neuropathy and peripheral arterial disease and the impact of treatment in people with screen-detected type 2 diabetes: the ADDITION-Denmark studyQ35225473
Effect of bromocriptine-QR (a quick-release formulation of bromocriptine mesylate) on major adverse cardiovascular events in type 2 diabetes subjectsQ36522638
Rationale and design of the glycemia reduction approaches in diabetes: a comparative effectiveness study (GRADE).Q37022623
Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitusQ37141727
Rosiglitazone and outcomes for patients with diabetes mellitus and coronary artery disease in the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) trialQ37275571
Cardiovascular outcome trials in type 2 diabetes and the sulphonylurea controversy: rationale for the active-comparator CAROLINA trialQ38085534
Early combination therapy for the treatment of type 2 diabetes mellitus: systematic review and meta-analysisQ38160887
Heart failure, saxagliptin, and diabetes mellitus: observations from the SAVOR-TIMI 53 randomized trialQ38424163
Initial Combination Therapy With Canagliflozin Plus Metformin Versus Each Component as Monotherapy for Drug-Naïve Type 2 DiabetesQ40826432
Follow-up of glycemic control and cardiovascular outcomes in type 2 diabetesQ40873421
CONSENSUS STATEMENT BY THE AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY ON THE COMPREHENSIVE TYPE 2 DIABETES MANAGEMENT ALGORITHM--2016 EXECUTIVE SUMMARY.Q41000321
Lixisenatide in Patients with Type 2 Diabetes and Acute Coronary SyndromeQ41078909
Heart failure and mortality outcomes in patients with type 2 diabetes taking alogliptin versus placebo in EXAMINE: a multicentre, randomised, double-blind trialQ41234478
Basal insulin and cardiovascular and other outcomes in dysglycemiaQ42507791
Addition of either pioglitazone or a sulfonylurea in type 2 diabetic patients inadequately controlled with metformin alone: impact on cardiovascular events. A randomized controlled trialQ42672645
Acarbose treatment and the risk of cardiovascular disease and hypertension in patients with impaired glucose tolerance: the STOP-NIDDM trialQ43606926
Development and progression of nephropathy in type 2 diabetes: the United Kingdom Prospective Diabetes Study (UKPDS 64).Q44242786
Multifactorial intervention and cardiovascular disease in patients with type 2 diabetesQ44295713
Vildagliptin plus metformin combination therapy provides superior glycaemic control to individual monotherapy in treatment-naive patients with type 2 diabetes mellitusQ46075201
The effect of alogliptin and pioglitazone combination therapy on various aspects of β-cell function in patients with recent-onset type 2 diabetesQ46134952
Baseline characteristics of the patient population in the Saxagliptin Assessment of Vascular Outcomes Recorded in patients with diabetes mellitus (SAVOR)-TIMI 53 trialQ46164104
Dapagliflozin, metformin XR, or both: initial pharmacotherapy for type 2 diabetes, a randomised controlled trialQ46595958
Effect of a multifactorial intervention on mortality in type 2 diabetesQ46767642
Similarity of the impact of type 1 and type 2 diabetes on cardiovascular mortality in middle-aged subjectsQ46847408
Rationale, design, and baseline characteristics of the Canagliflozin Cardiovascular Assessment Study (CANVAS)--a randomized placebo-controlled trialQ47909934
Efficacy and safety of initial combination therapy with alogliptin plus metformin versus either as monotherapy in drug-naïve patients with type 2 diabetes: a randomized, double-blind, 6-month study.Q51328925
A treatment strategy implementing combination therapy with sitagliptin and metformin results in superior glycaemic control versus metformin monotherapy due to a low rate of addition of antihyperglycaemic agents.Q51373947
Initial combination therapy with saxagliptin and metformin provides sustained glycaemic control and is well tolerated for up to 76 weeks.Q51378688
The duration of diabetes affects the response to intensive glucose control in type 2 subjects: the VA Diabetes TrialQ57213806
Intensive Glycemic Control and the Prevention of Cardiovascular Events: Implications of the ACCORD, ADVANCE, and VA Diabetes TrialsQ59624463
Initial combination of linagliptin and metformin compared with linagliptin monotherapy in patients with newly diagnosed type 2 diabetes and marked hyperglycaemia: a randomized, double-blind, active-controlled, parallel group, multinational clinical tQ61684764
Changes in diabetes-related complications in the United States, 1990-2010Q64125961
Intensified multifactorial intervention in patients with type 2 diabetes mellitus and microalbuminuria: the Steno type 2 randomised studyQ74464563
Diabetic retinopathyQ80795176
Efficacy and safety of initial combination therapy with sitagliptin and metformin in patients with type 2 diabetes: a 54-week studyQ83386003
P433issue6
P407language of work or nameEnglishQ1860
P921main subjecttype 2 diabetesQ3025883
P304page(s)1177-85
P577publication date2016-08-01
P1433published inJournal of Diabetes and its ComplicationsQ15763696
P1476titleCombination therapy for the improvement of long-term macrovascular and microvascular outcomes in type 2 diabetes: Rationale and evidence for early initiation
P478volume30

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cites work (P2860)
Q39408293Insulin Glargine/Lixisenatide: A Review in Type 2 Diabetes
Q39189383SGLT2 inhibitor/DPP-4 inhibitor combination therapy - complementary mechanisms of action for management of type 2 diabetes mellitus

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