Dynamic pathology of islet endocrine cells in type 2 diabetes: β-Cell growth, death, regeneration and their clinical implications

scientific article

Dynamic pathology of islet endocrine cells in type 2 diabetes: β-Cell growth, death, regeneration and their clinical implications is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1111/JDI.12424
P932PMC publication ID4773678
P698PubMed publication ID27042265

P2093author name stringHiroki Mizukami
Soroku Yagihashi
Wataru Inaba
P2860cites workImmunoassay of endogenous plasma insulin in manQ22306302
Significant human beta-cell turnover is limited to the first three decades of life as determined by in vivo thymidine analog incorporation and radiocarbon datingQ28742133
Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetesQ29615593
Interleukin-1-receptor antagonist in type 2 diabetes mellitusQ29619001
Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetesQ29619192
β-Cell failure in type 2 diabetesQ33588325
Age-associated changes of islet endocrine cells and the effects of body mass index in JapaneseQ33628658
Ontogeny, differentiation and growth of the endocrine pancreasQ33985105
Reduced beta-cell mass and expression of oxidative stress-related DNA damage in the islet of Japanese Type II diabetic patients.Q53979441
Resident macrophages mediate islet amyloid polypeptide-induced islet IL-1β production and β-cell dysfunction.Q54614933
Cell cycle control of β-cell replication in the prenatal and postnatal human pancreasQ54638182
Selective β-Cell Loss and α-Cell Expansion in Patients with Type 2 Diabetes Mellitus in KoreaQ57214866
Early phase glucagon and insulin secretory abnormalities, but not incretin secretion, are similarly responsible for hyperglycemia after ingestion of nutrientsQ57591270
Obesity and type 2 diabetes in Japanese patientsQ58207650
Immunochemical Distinction between Insulins with Identical Amino-Acid SequencesQ59000512
Expression of an islet regenerating (reg) gene in isolated rat islets: effects of nutrient and non-nutrient growth factorsQ67534160
Cellular composition of the human diabetic pancreasQ70269326
DNA synthesis in cultured neonatal rat islets — a comparison of two methodsQ71864464
Quantitation of Endocrine Cell Content in the Pancreas of Nondiabetic and Diabetic HumansQ72546157
Quantitative estimation of the pancreatic islet tissue in diabetic subjectsQ73849716
Macrophages and pancreatic islet amyloidosisQ74483148
Involvement of oxidative stress-induced DNA damage, endoplasmic reticulum stress, and autophagy deficits in the decline of β-cell mass in Japanese type 2 diabetic patientsQ87622984
Paracrinology of islets and the paracrinopathy of diabetesQ34136529
Glucagonocentric restructuring of diabetes: a pathophysiologic and therapeutic makeoverQ34244209
Islet amyloid with macrophage migration correlates with augmented β-cell deficits in type 2 diabetic patientsQ34336126
Pancreatic alpha cell mass in European subjects with type 2 diabetesQ35031657
Islet amyloid polypeptide demonstrates a persistent capacity to disrupt membrane integrityQ35034994
β-cell loss and β-cell apoptosis in human type 2 diabetes are related to islet amyloid depositionQ35070534
Human-IAPP disrupts the autophagy/lysosomal pathway in pancreatic β-cells: protective role of p62-positive cytoplasmic inclusionsQ35092842
Reduced Ki67 Staining in the Postmortem State Calls Into Question Past Conclusions About the Lack of Turnover of Adult Human β-CellsQ35532309
Islet amyloid: a complication of islet dysfunction or an aetiological factor in Type 2 diabetes?Q35628614
Quo vadis: Where have the β-cells gone?Q35879292
Pathophysiologic differences among Asians, native Hawaiians, and other Pacific Islanders and treatment implicationsQ35898378
Formation of a human β-cell population within pancreatic islets is set early in lifeQ36201514
Pancreatic β cell dedifferentiation as a mechanism of diabetic β cell failureQ36241895
β-cell mass and turnover in humans: effects of obesity and agingQ36477911
Expansion of beta-cell mass in response to pregnancyQ36768314
Beta-cell replication is the primary mechanism subserving the postnatal expansion of beta-cell mass in humansQ36971500
Adult diffuse nesidioblastosis: genetically or environmentally induced?Q37028417
Amyloid formation in human IAPP transgenic mouse islets and pancreas, and human pancreas, is not associated with endoplasmic reticulum stressQ37324652
Insulin resistance alters islet morphology in nondiabetic humansQ37597046
Amyloid in the islets of Langerhans: thoughts and some historical aspectsQ37864338
Longevity of human islet α- and β-cellsQ37913504
Inflammation in obesity and diabetes: islet dysfunction and therapeutic opportunity.Q38112934
Macrophages and islet inflammation in type 2 diabetesQ38134112
Down-regulation of pancreatic transcription factors and incretin receptors in type 2 diabetesQ38174889
Clinical staging of type 2 diabetes: The time has comeQ39403167
Participation of Akt, menin, and p21 in pregnancy-induced beta-cell proliferationQ39793341
Beta-cell development and turnover during prenatal life in humansQ39917634
High expression rates of human islet amyloid polypeptide induce endoplasmic reticulum stress mediated beta-cell apoptosis, a characteristic of humans with type 2 but not type 1 diabetesQ40137823
Differential volumetry of A,B and D cells in the pancreatic islets of diabetic and nondiabetic subjectsQ41151495
THE RELATION OE DIABETES MELLITUS TO LESIONS OF THE PANCREAS. HYALINE DEGENERATION OF THE ISLANDS OE LANGERHANS.Q41786170
Accelerated loss of islet beta cells in sucrose-fed Goto-Kakizaki rats, a genetic model of non-insulin-dependent diabetes mellitusQ41810412
Mechanisms of impaired fasting glucose and glucose intolerance induced by an approximate 50% pancreatectomyQ42498875
The determination of blood-sugar: Critical analysis of the reduction of alkaline copper reagents by glucose and other substancesQ42573099
Prevalence and clinicopathological characteristics of islet amyloid in chinese patients with type 2 diabetesQ44631818
Change in β-cell mass in Japanese nondiabetic obese individuals.Q45984989
Pancreatic beta-cell mass in European subjects with type 2 diabetesQ46332814
Partial pancreatectomy in adult humans does not provoke beta-cell regenerationQ46932707
p27 Regulates the transition of beta-cells from quiescence to proliferationQ46941946
WHO diagnostic criteria as a validation tool for the diagnosis of diabetes mellitus: a study in five European countries.Q51489018
The long lifespan and low turnover of human islet beta cells estimated by mathematical modelling of lipofuscin accumulation.Q51780558
Type 2 diabetes-a matter of beta-cell life and death?Q53873519
P275copyright licenseCreative Commons Attribution-NonCommercial-NoDerivativesQ6937225
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectpathologyQ7208
cell growthQ189159
islet of LangerhansQ728309
type 2 diabetesQ3025883
insulin-secreting cellsQ70229258
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)155-65
P577publication date2016-03-01
P1433published inJournal of Diabetes InvestigationQ28207066
P1476titleDynamic pathology of islet endocrine cells in type 2 diabetes: β-Cell growth, death, regeneration and their clinical implications
P478volume7

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cites work (P2860)
Q64951986Assessment of insulin sensitivity and secretion in patients with fibrocalculous pancreatic diabetes.
Q39069908Clinical relevance of epigenetics in the onset and management of type 2 diabetes mellitus
Q41147348Culturing and transcriptome profiling of progenitor-like colonies derived from adult mouse pancreas
Q57300294Effectiveness of Coenzyme Q10 Supplementation for Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis
Q55394333Host-Parasite Interactions in Individuals with Type 1 and 2 Diabetes Result in Higher Frequency of Ascaris lumbricoides and Giardia lamblia in Type 2 Diabetic Individuals.
Q93029127Pancreatic Islet Hyperplasia: A Potential Marker for Anabolic-Androgenic Steroid Use
Q49795312Pancreatic and Islet Remodeling in Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Knockout Ferrets
Q92926186Proinsulin is sensitive to reflect glucose intolerance
Q42876331Renoprotective Effects of the Dipeptidyl Peptidase-4 Inhibitor Sitagliptin: A Review in Type 2 Diabetes
Q64103626Repetition of Prediabetes Enhances the Risk of Developing Diabetes
Q89426717Reply to the comment of Wilbrink et al. on Retrospective analysis of liraglutide and basal insulin combination therapy in Japanese type 2 diabetes: The association between remaining β-cell function and the achievement of the HbA1c target 1 year afte
Q42696994Sodium glucose co-transporter 2 inhibitor, tofogliflozin, shows better improvements of blood glucose and insulin secretion in patients with high insulin levels at baseline

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