| scholarly article | Q13442814 |
| P356 | DOI | 10.1007/S125-002-8248-Z |
| P698 | PubMed publication ID | 11845227 |
| P2093 | author name string | Wada R | |
| Yagihashi N | |||
| Mizukami H | |||
| Yagihashi S | |||
| Sakuraba H | |||
| Hanyu C | |||
| P433 | issue | 1 | |
| P921 | main subject | patient | Q181600 |
| P304 | page(s) | 85-96 | |
| P577 | publication date | 2002-01-01 | |
| P1433 | published in | Diabetologia | Q5270140 |
| P1476 | title | Reduced beta-cell mass and expression of oxidative stress-related DNA damage in the islet of Japanese Type II diabetic patients. | |
| P478 | volume | 45 |
| Q55100432 | A Mouse Model of Beta-Cell Dysfunction as Seen in Human Type 2 Diabetes. |
| Q90629107 | A novel fast-slow model of diabetes progression: Insights into mechanisms of response to the interventions in the Diabetes Prevention Program |
| Q35942505 | A simple matter of life and death-the trials of postnatal Beta-cell mass regulation |
| Q36800711 | A systematic review of oxidative stress and safety of antioxidants in diabetes: focus on islets and their defense |
| Q37221760 | Abnormalities in insulin secretion in type 2 diabetes mellitus |
| Q35432420 | Activation of the NLRP3 inflammasome complex is not required for stress-induced death of pancreatic islets |
| Q46421527 | Adaptation to intermittent stress promotes maintenance of beta-cell compensation: comparison with food restriction |
| Q38364481 | Advances in pathology of diabetes from pancreatic islets to neuropathy--a tribute to Paul Langerhans |
| Q24609292 | Adverse effect of high glucose concentration on stem cell therapy |
| Q33628658 | Age-associated changes of islet endocrine cells and the effects of body mass index in Japanese |
| Q28565844 | Aging correlates with decreased beta-cell proliferative capacity and enhanced sensitivity to apoptosis: a potential role for Fas and pancreatic duodenal homeobox-1 |
| Q46555146 | Alleviation of oxidative damage in multiple tissues in rats with streptozotocin-induced diabetes by rice bran oil supplementation |
| Q28083933 | Alogliptin benzoate for management of type 2 diabetes |
| Q26799155 | Alpha-, Delta- and PP-cells: Are They the Architectural Cornerstones of Islet Structure and Co-ordination? |
| Q36112058 | An immune origin of type 2 diabetes? |
| Q33558360 | An islet in distress: β cell failure in type 2 diabetes |
| Q47402416 | Androgen signaling expands β-cell mass in male rats and β-cell androgen receptor is degraded under high-glucose conditions. |
| Q52576428 | Angiotensin II receptor blocker provides pancreatic beta-cell protection independent of blood pressure lowering in diabetic db/db mice. |
| Q96219622 | Annual decline in β-cell function in patients with type 2 diabetes in China |
| Q36793521 | Anonymous sources: where do adult β cells come from? |
| Q46580273 | Anti-apoptotic and cytoprotective effect of Enicostemma littorale against oxidative stress in Islets of Langerhans |
| Q36918173 | Anti-diabetic functions of soy isoflavone genistein: mechanisms underlying its effects on pancreatic β-cell function |
| Q58795255 | Antidiabetic Effects of Isolated Triterpene Glycoside Fraction from |
| Q38761197 | Antidiabetic Mechanisms of Rosa canina Fruits: An In Vitro Evaluation. |
| Q46933169 | Antioxidants N-acetyl-L-cysteine and manganese(III)tetrakis (4-benzoic acid)porphyrin do not prevent beta-cell dysfunction in rat islets cultured in high glucose for 1 wk. |
| Q35644730 | Apolipoprotein CIII links islet insulin resistance to β-cell failure in diabetes |
| Q58201197 | Association of a microsatellite in FASL to type II diabetes and of the FAS-670G>A genotype to insulin resistance |
| Q89590339 | Association of glucose tolerance status with pancreatic β- and α-cell mass in community-based autopsy samples of Japanese individuals: The Hisayama Study |
| Q33729788 | Association of telomere length with type 2 diabetes, oxidative stress and UCP2 gene variation |
| Q39081292 | Association study of mitochondrial DNA polymorphisms with type 2 diabetes in Tunisian population |
| Q34455014 | Associations of dietary flavonoids with risk of type 2 diabetes, and markers of insulin resistance and systemic inflammation in women: a prospective study and cross-sectional analysis |
| Q37369071 | At pharmacologically relevant concentrations intravenous iron preparations cause pancreatic beta cell death |
| Q46781567 | Augmented beta cell loss and mitochondrial abnormalities in sucrose-fed GK rats |
| Q33585719 | Augmented reduction of islet β-cell mass in Goto-Kakizaki rats fed high-fat diet and its suppression by pitavastatin treatment |
| Q40197944 | Autocrine anti-apoptotic and proliferative effects of insulin in pancreatic beta-cells |
| Q34043054 | Baicalein Protects against Type 2 Diabetes via Promoting Islet β-Cell Function in Obese Diabetic Mice. |
| Q59789573 | Beneficial Effects of Resveratrol Administration-Focus on Potential Biochemical Mechanisms in Cardiovascular Conditions |
| Q88399061 | Beta cell stress in a 4-year follow-up of patients with type 2 diabetes: A longitudinal analysis of the BetaDecline Study |
| Q36798634 | Beta cells in type 2 diabetes - a crucial contribution to pathogenesis |
| Q35852835 | Beta-cell mass plasticity in type 2 diabetes. |
| Q35946606 | Beta-cells in type 2 diabetes: a loss of function and mass |
| Q84199219 | Biliverdin protects against the deterioration of glucose tolerance in db/db mice |
| Q57294537 | Characterization of Apoptosis, Autophagy and Oxidative Stress in Pancreatic Islets Cells and Intestinal Epithelial Cells Isolated from Equine Metabolic Syndrome (EMS) Horses |
| Q36514898 | Chromosomal telomere attrition as a mechanism for the increased risk of epithelial cancers and senescent phenotypes in type 2 diabetes |
| Q33812782 | Chronic high fat feeding restricts islet mRNA translation initiation independently of ER stress via DNA damage and p53 activation |
| Q30423466 | Chronic resveratrol treatment protects pancreatic islets against oxidative stress in db/db mice |
| Q39403167 | Clinical staging of type 2 diabetes: The time has come |
| Q37193371 | Consequences of exposure to light at night on the pancreatic islet circadian clock and function in rats. |
| Q35874941 | DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients |
| Q35651511 | Decreased beta-cell mass in diabetes: significance, mechanisms and therapeutic implications |
| Q81348403 | Deletion of Cdkn1b ameliorates hyperglycemia by maintaining compensatory hyperinsulinemia in diabetic mice |
| Q40863210 | Delta cell death in the islet of Langerhans and the progression from normal glucose tolerance to type 2 diabetes in non-human primates (baboon, Papio hamadryas). |
| Q42498849 | Destruction of pancreatic beta-cells by transgenic induction of prostaglandin E2 in the islets |
| Q35580004 | Development of a nongenetic mouse model of type 2 diabetes |
| Q34777247 | Development of type 2 diabetes following intrauterine growth retardation in rats is associated with progressive epigenetic silencing of Pdx1. |
| Q35078465 | Developmental aspects of the endocrine pancreas |
| Q35977992 | Developmental origins of adult disease |
| Q38165184 | Diabetes and beta cell function: from mechanisms to evaluation and clinical implications |
| Q38109814 | Diabetes and its comorbidities--where East meets West |
| Q33490595 | Diabetic beta-cells can achieve self-protection against oxidative stress through an adaptive up-regulation of their antioxidant defenses. |
| Q46124642 | Diabetic kidney lesions of GIPRdn transgenic mice: podocyte hypertrophy and thickening of the GBM precede glomerular hypertrophy and glomerulosclerosis |
| Q46831972 | Diabetic modifier QTLs in F(2) intercrosses carrying homozygous transgene of TGF-beta |
| Q55311614 | Dietary Flavonoids in the Prevention of T2D: An Overview. |
| Q41042241 | Distinct Levels of Reactive Oxygen Species Coordinate Metabolic Activity with Beta-cell Mass Plasticity |
| Q53352969 | Distinct effects of dipeptidyl peptidase-4 inhibitor and glucagon-like peptide-1 receptor agonist on islet morphology and function. |
| Q55195388 | Divergent antioxidant capacity of human islet cell subsets: A potential cause of beta-cell vulnerability in diabetes and islet transplantation. |
| Q35008131 | Do plants mediate their anti-diabetic effects through anti-oxidant and anti-apoptotic actions? an in vitro assay of 3 Indian medicinal plants |
| Q27026480 | Does disruption of circadian rhythms contribute to beta-cell failure in type 2 diabetes? |
| Q37973874 | Does interference with the renin-angiotensin system protect against diabetes? Evidence and mechanisms |
| Q26752746 | Dynamic pathology of islet endocrine cells in type 2 diabetes: β-Cell growth, death, regeneration and their clinical implications |
| Q36764954 | ESCI Award 2006. Mitochondrial function and endocrine diseases |
| Q33920106 | Eating glutinous brown rice twice a day for 8 weeks improves glycemic control in Japanese patients with diabetes mellitus |
| Q58039682 | Effect of combining rosiglitazone with either metformin or insulin on β-cell mass and function in an animal model of Type 2 diabetes characterized by reduced β-cell mass at birth |
| Q39517749 | Effect of environmental contaminants on Beta cell function |
| Q36209136 | Effect of sitagliptin on blood glucose control in patients with type 2 diabetes mellitus who are treatment naive or poorly responsive to existing antidiabetic drugs: the JAMP study |
| Q88538234 | Effect of the sodium-glucose cotransporter 2 inhibitor luseogliflozin on pancreatic beta cell mass in db/db mice of different ages |
| Q37133517 | Effects of 4-hydroxynonenal on vascular endothelial and smooth muscle cell redox signaling and function in health and disease |
| Q37057949 | Effects of Obesity and Diabetes on α- and β-Cell Mass in Surgically Resected Human Pancreas |
| Q36625097 | Effects of macronutrient excess and composition on oxidative stress: relevance to diabetes and cardiovascular disease |
| Q46164585 | Effects of palmitate on ER and cytosolic Ca2+ homeostasis in beta-cells |
| Q50106732 | Effects of subchronic acrylamide treatment on the endocrine pancreas of juvenile male Wistar rats |
| Q37860493 | Endoplasmic reticulum stress and pancreatic β-cell death |
| Q37288073 | Endoplasmic reticulum stress: its role in disease and novel prospects for therapy |
| Q28273485 | Epidemic obesity and type 2 diabetes in Asia |
| Q33767089 | Epigenetic mechanisms in the development of type 2 diabetes |
| Q26823288 | Epigenetics: the missing link to understanding β-cell dysfunction in the pathogenesis of type 2 diabetes |
| Q37661239 | Executioners of apoptosis in pancreatic {beta}-cells: not just for cell death |
| Q41531028 | Exendin-4 suppresses SRC activation and reactive oxygen species production in diabetic Goto-Kakizaki rat islets in an Epac-dependent manner |
| Q38703932 | Fucoidan ameliorates pancreatic β-cell death and impaired insulin synthesis in streptozotocin-treated β cells and mice via a Sirt-1-dependent manner |
| Q52602460 | GPR119 Agonist DS-8500a Effects on Pancreatic β-Cells in Japanese Type 2 Diabetes Mellitus Patients. |
| Q33320681 | Genetic deficiency of glycogen synthase kinase-3beta corrects diabetes in mouse models of insulin resistance |
| Q33993882 | Genistein induces pancreatic beta-cell proliferation through activation of multiple signaling pathways and prevents insulin-deficient diabetes in mice |
| Q28261829 | Gliclazide protects human islet beta-cells from apoptosis induced by intermittent high glucose |
| Q36861036 | Glucolipotoxicity: fuel excess and beta-cell dysfunction. |
| Q37403983 | Glucose-dependent insulinotropic polypeptide (Gastric Inhibitory Polypeptide; GIP). |
| Q93015063 | Glucose-lowering effect of Gryllus bimaculatus powder on streptozotocin-induced diabetes through the AKT/mTOR pathway |
| Q35065639 | Glucotoxicity and beta-cell failure in type 2 diabetes mellitus |
| Q46910852 | Glutathione peroxidase protein expression and activity in human islets isolated for transplantation |
| Q33610661 | Goals of treatment for type 2 diabetes: beta-cell preservation for glycemic control |
| Q55262468 | HX-1171 attenuates pancreatic β-cell apoptosis and hyperglycemia-mediated oxidative stress via Nrf2 activation in streptozotocin-induced diabetic model. |
| Q46169591 | Heterogeneity in distribution of amyloid-positive islets in type-2 diabetic patients |
| Q64264027 | Heterogeneity of Metabolic Defects in Type 2 Diabetes and Its Relation to Reactive Oxygen Species and Alterations in Beta-Cell Mass |
| Q39882740 | High beta-cell mass prevents streptozotocin-induced diabetes in thioredoxin-interacting protein-deficient mice. |
| Q33890987 | High glucose inhibits glucose-6-phosphate dehydrogenase, leading to increased oxidative stress and beta-cell apoptosis |
| Q89085811 | High-fat-diet-induced remission of diabetes in a subset of KATP -GOF insulin-secretory-deficient mice |
| Q42974125 | Histologic studies of islets of Langerhans in transplanted pancreata from marginal donors in Japan |
| Q37832964 | Histone deacetylase (HDAC) inhibition as a novel treatment for diabetes mellitus |
| Q35932755 | Human Islet Morphology Revisited: Human and Rodent Islets Are Not So Different After All |
| Q41689680 | Human beta cell mass and function in diabetes: Recent advances in knowledge and technologies to understand disease pathogenesis |
| Q33757031 | Hyperactivation of Akt/mTOR and deficiency in tuberin increased the oxidative DNA damage in kidney cancer patients with diabetes |
| Q41126026 | Hyperglycemia decreases preoxiredoxin-2 expression in a middle cerebral artery occlusion model |
| Q91831011 | Hypoglycemic Effects of sesquiterpene lactones from Byrsonima crassifolia |
| Q64325535 | IAPP/amylin deposition, which is correlated with expressions of ASC and IL-1β in β-cells of Langerhans' islets, directly initiates NLRP3 inflammasome activation |
| Q39012899 | Immunomodulation by helminths: Similar impact on type 1 and type 2 diabetes? |
| Q37531511 | Impact of obesity severity and duration on pancreatic β- and α-cell dynamics in normoglycemic non-human primates. |
| Q37179931 | Impaired autophagic function in rat islets with aging |
| Q38341934 | Implications of ghrelin and hexarelin in diabetes and diabetes-associated heart diseases |
| Q35667116 | Importance of Beta Cell Function for the Treatment of Type 2 Diabetes |
| Q45413460 | Increase in the free radical scavenging capability of bitter gourd by a heat-drying process |
| Q41486793 | Increased T cell immunoglobulin and mucin domain containing 4 (TIM-4) is negatively correlated with serum concentrations of interleukin-1β in type 2 diabetes |
| Q33806981 | Increased ectodomain shedding of cell adhesion molecule 1 from pancreatic islets in type 2 diabetic pancreata: correlation with hemoglobin A1c levels |
| Q46134848 | Increased insulin demand promotes while pioglitazone prevents pancreatic beta cell apoptosis in Wfs1 knockout mice |
| Q46802250 | Increased pancreatic beta-cell apoptosis following fetal and neonatal exposure to nicotine is mediated via the mitochondria |
| Q35184167 | Inflammatory mediators and islet beta-cell failure: a link between type 1 and type 2 diabetes |
| Q40180167 | Inhibition of GSK3 promotes replication and survival of pancreatic beta cells |
| Q38914937 | Inhibitor of differentiation proteins protect against oxidative stress by regulating the antioxidant-mitochondrial response in mouse beta cells |
| Q39521067 | Inhibitory effect of unsaturated fatty acids on saturated fatty acid-induced apoptosis in human pancreatic β-cells: activation of caspases and ER stress induction. |
| Q36910693 | Initiation and execution of lipotoxic ER stress in pancreatic beta-cells |
| Q42756047 | Insulin concerns and promises |
| Q41480990 | Insulin, glucagon and somatostatin stores in the pancreas of subjects with type-2 diabetes and their lean and obese non-diabetic controls. |
| Q39508542 | Intermittent high glucose enhances apoptosis in INS-1 cells |
| Q26830871 | Interventions to preserve beta-cell function in the management and prevention of type 2 diabetes |
| Q43913993 | Intracellular pathways of pancreatic β-cell apoptosis in type 1 diabetes |
| Q34336126 | Islet amyloid with macrophage migration correlates with augmented β-cell deficits in type 2 diabetic patients |
| Q24791201 | Islet expression of the DNA repair enzyme 8-oxoguanosine DNA glycosylase (Ogg1) in human type 2 diabetes |
| Q38038650 | Islet function in obese adolescents. |
| Q43248047 | Islets in type 2 diabetes: in honor of Dr. Robert C. Turner |
| Q28571937 | Lactogens protect rodent and human beta cells against glucolipotoxicity-induced cell death through Janus kinase-2 (JAK2)/signal transducer and activator of transcription-5 (STAT5) signalling |
| Q37679230 | Linking metabolic abnormalities to apoptotic pathways in Beta cells in type 2 diabetes |
| Q28546996 | Liraglutide improves pancreatic Beta cell mass and function in alloxan-induced diabetic mice |
| Q39446700 | Macrophage migration inhibitory factor deficiency protects pancreatic islets from palmitic acid-induced apoptosis |
| Q36750464 | Maternal antioxidants prevent β-cell apoptosis and promote formation of dual hormone-expressing endocrine cells in male offspring following fetal and neonatal nicotine exposure |
| Q36200213 | Maternal diabetes triggers DNA damage and DNA damage response in neurulation stage embryos through oxidative stress. |
| Q44864538 | Mathematical models of diabetes progression |
| Q46797069 | Measurements of insulin responses as predictive markers of pancreatic beta-cell mass in normal and beta-cell-reduced lean and obese Göttingen minipigs in vivo. |
| Q46373924 | Mechanism of Generation of Oxidative Stress and Pathophysiology of Type 2 Diabetes Mellitus: How Are They Interlinked? |
| Q36906325 | Mechanism of oxidative DNA damage in diabetes: tuberin inactivation and downregulation of DNA repair enzyme 8-oxo-7,8-dihydro-2'-deoxyguanosine-DNA glycosylase |
| Q45045299 | Metabolic adaptations to chronic glucose infusion in rats |
| Q37110569 | Metabolic dysregulation and adipose tissue fibrosis: role of collagen VI. |
| Q36392253 | Methylglyoxal Impairs Insulin Secretion of Pancreatic β-Cells through Increased Production of ROS and Mitochondrial Dysfunction Mediated by Upregulation of UCP2 and MAPKs. |
| Q38027961 | MicroRNA expression profiling of human islets from individuals with and without type 2 diabetes: promises and pitfalls |
| Q37459532 | Mild exposure of RIN-5F β-cells to human islet amyloid polypeptide aggregates upregulates antioxidant enzymes via NADPH oxidase-RAGE: an hormetic stimulus. |
| Q34511749 | Mitochondrial dynamics in diabetes |
| Q35550591 | Mitochondrial dysfunction and β-cell failure in type 2 diabetes mellitus |
| Q28576650 | Modulation of neuronal pentraxin 1 expression in rat pancreatic β-cells submitted to chronic glucotoxic stress |
| Q50527927 | Modulation of palmitate-induced endoplasmic reticulum stress and apoptosis in pancreatic β-cells by stearoyl-CoA desaturase and Elovl6. |
| Q34403650 | Monogenic syndromes of abnormal glucose homeostasis: clinical review and relevance to the understanding of the pathology of insulin resistance and beta cell failure. |
| Q34828414 | Multiple nonglycemic genomic loci are newly associated with blood level of glycated hemoglobin in East Asians |
| Q26996084 | New experimental models of diabetic nephropathy in mice models of type 2 diabetes: efforts to replicate human nephropathy |
| Q39407505 | Novel protective mechanism of reducing renal cell damage in diabetes: Activation AMPK by AICAR increased NRF2/OGG1 proteins and reduced oxidative DNA damage |
| Q37234084 | OGG1 is degraded by calpain following oxidative stress and cisplatin exposure |
| Q91904863 | Organoids from the Human Fetal and Adult Pancreas |
| Q37774895 | Oxidative stress and beta-cell dysfunction |
| Q35621286 | Oxidative stress as a therapeutic target in diabetes: revisiting the controversy |
| Q38207007 | Oxidative stress in the etiology of age-associated decline in glucose metabolism |
| Q40605303 | Oxidative stress is a mediator of glucose toxicity in insulin-secreting pancreatic islet cell lines |
| Q37286230 | Oxidative stress is induced by islet amyloid formation and time-dependently mediates amyloid-induced beta cell apoptosis |
| Q30235154 | Paediatric type 2 diabetes in China-Pandemic, progression, and potential solutions |
| Q33549736 | Palmitate induces a pro-inflammatory response in human pancreatic islets that mimics CCL2 expression by beta cells in type 2 diabetes |
| Q39052404 | Pancreas Volume and Fat Deposition in Diabetes and Normal Physiology: Consideration of the Interplay Between Endocrine and Exocrine Pancreas |
| Q37188492 | Pancreas volumes in humans from birth to age one hundred taking into account sex, obesity, and presence of type-2 diabetes |
| Q30903914 | Pancreatic adipose tissue infiltration, parenchymal steatosis and beta cell function in humans |
| Q35031657 | Pancreatic alpha cell mass in European subjects with type 2 diabetes |
| Q45205491 | Pancreatic beta cell senescence contributes to the pathogenesis of type 2 diabetes in high-fat diet-induced diabetic mice |
| Q33825167 | Pancreatic fat accumulation, fibrosis, and acinar cell injury in the Zucker diabetic fatty rat fed a chronic high-fat diet |
| Q42585037 | Pancreatic islet beta-cell and oxidative stress: the importance of glutathione peroxidase |
| Q41054906 | Pancreatic β cell dedifferentiation in diabetes and redifferentiation following insulin therapy |
| Q37832150 | Pancreatic β-Cell Mass as a Pharmacologic Target in Diabetes |
| Q38951177 | Pancreatic β-cell identity in diabetes. |
| Q94600515 | Pancreatic β-cells in type 1 and type 2 diabetes mellitus: different pathways to failure |
| Q44136348 | Pathogenesis of type 2 diabetes mellitus |
| Q39413300 | Personalized management of hyperglycemia in type 2 diabetes: reflections from a Diabetes Care Editors' Expert Forum |
| Q89050027 | Phytonutrient genistein is a survival factor for pancreatic β-cells via GPR30-mediated mechanism |
| Q34999753 | Place of pitavastatin in the statin armamentarium: promising evidence for a role in diabetes mellitus |
| Q33983473 | Postnatal development of numbers and mean sizes of pancreatic islets and beta-cells in healthy mice and GIPR(dn) transgenic diabetic mice |
| Q90438416 | Primary study on the hypoglycemic mechanism of 5rolGLP-HV in STZ-induced type 2 diabetes mellitus mice |
| Q34541669 | Pro-oxidant/antioxidant balance controls pancreatic β-cell differentiation through the ERK1/2 pathway |
| Q38062439 | Progression of β-cell dysfunction in obese youth |
| Q33585856 | Progressive deterioration of insulin secretion in Japanese type 2 diabetic patients in comparison with those who carry the S20G mutation of the islet amyloid polypeptide gene: A long-term follow-up study |
| Q44620062 | Protective Effects of Probucol Treatment on Pancreatic .BETA.-cell Function of SZ-induced Diabetic APA Hamsters |
| Q37128184 | Protective efficacy of folic acid and vitamin B12 against nicotine-induced toxicity in pancreatic islets of the rat. |
| Q42460121 | Quantification of the relationship between glycemia and beta-cell mass adaptation in vivo |
| Q42393663 | Quantitative analysis of cell composition and purity of human pancreatic islet preparations |
| Q46112916 | Quantitative histopathological assessment of retardation of islets of langerhans degeneration in rosiglitazone-dosed obese ZDF rats using combined insulin and collagens (I and III) immunohistochemistry with automated image analysis and statistical m |
| Q35879292 | Quo vadis: Where have the β-cells gone? |
| Q36263001 | Reactive oxygen species, reactive nitrogen species and antioxidants in etiopathogenesis of diabetes mellitus type-2 |
| Q53207032 | Reduction of both beta cell death and alpha cell proliferation by dipeptidyl peptidase-4 inhibition in a streptozotocin-induced model of diabetes in mice. |
| Q37603286 | Regulation of insulin synthesis and secretion and pancreatic Beta-cell dysfunction in diabetes |
| Q36267776 | Regulation of pancreatic beta-cell mass |
| Q36034329 | Relationship between beta-cell mass and diabetes onset. |
| Q36131766 | Role of impaired insulin secretion and insulin resistance in the pathogenesis of type 2 diabetes mellitus |
| Q57214866 | Selective β-Cell Loss and α-Cell Expansion in Patients with Type 2 Diabetes Mellitus in Korea |
| Q46740173 | Selenoprotein P-neutralizing antibodies improve insulin secretion and glucose sensitivity in type 2 diabetes mouse models |
| Q60923458 | Single-cell gene expression analysis reveals β-cell dysfunction and deficit mechanisms in type 2 diabetes |
| Q51301524 | Sleeve gastrectomy, but not duodenojejunostomy, preserves total beta-cell mass in Goto-Kakizaki rats evaluated by three-dimensional optical projection tomography. |
| Q35630601 | Small Molecule Kaempferol Promotes Insulin Sensitivity and Preserved Pancreatic β -Cell Mass in Middle-Aged Obese Diabetic Mice |
| Q36846424 | Small molecule kaempferol modulates PDX-1 protein expression and subsequently promotes pancreatic β-cell survival and function via CREB. |
| Q46617148 | Src activation generates reactive oxygen species and impairs metabolism-secretion coupling in diabetic Goto-Kakizaki and ouabain-treated rat pancreatic islets |
| Q40307509 | Stimulation of β-adrenergic receptors plays a protective role via increased expression of RAF-1 and PDX-1 in hyperglycemic rat pancreatic islet (RIN-m5F) cells |
| Q37091579 | Targeting beta-cell mass in type 2 diabetes: promise and limitations of new drugs based on incretins |
| Q38548027 | Targeting fatty acid metabolism to improve glucose metabolism. |
| Q38790584 | Telomere attrition and diabetes mellitus |
| Q64987978 | The Anti-Inflammatory and Anti-Oxidant Mechanisms of the Keap1/Nrf2/ARE Signaling Pathway in Chronic Diseases. |
| Q37675505 | The NLRP3 inflammasome: a sensor for metabolic danger? |
| Q41623135 | The Nrf2/Keap1/ARE Pathway and Oxidative Stress as a Therapeutic Target in Type II Diabetes Mellitus. |
| Q34870188 | The Ser(326)Cys polymorphism of 8-oxoguanine glycosylase 1 (OGG1) is associated with type 2 diabetes in Mexican Americans |
| Q37325272 | The antiinflammatory cytokine interleukin-1 receptor antagonist protects from high-fat diet-induced hyperglycemia |
| Q37424895 | The beta cell lesion in type 2 diabetes: there has to be a primary functional abnormality. |
| Q48224585 | The effects of green cardamom supplementation on blood glucose, lipids profile, oxidative stress, sirtuin-1 and irisin in type 2 diabetic patients: a study protocol for a randomized placebo-controlled clinical trial. |
| Q80442170 | The pathophysiological basis for intensive insulin replacement |
| Q37680167 | The proapoptotic BH3-only proteins Bim and Puma are downstream of endoplasmic reticulum and mitochondrial oxidative stress in pancreatic islets in response to glucotoxicity |
| Q36288928 | The protective effect of peroxiredoxin II on oxidative stress induced apoptosis in pancreatic β-cells |
| Q26995759 | The role of peroxidation of mitochondrial membrane phospholipids in pancreatic β -cell failure |
| Q24541464 | The unique cytoarchitecture of human pancreatic islets has implications for islet cell function |
| Q57476570 | The α-cell in diabetes mellitus |
| Q46371926 | Thrombospondin 1 protects pancreatic β-cells from lipotoxicity via the PERK-NRF2 pathway. |
| Q37083241 | Time-resolved studies define the nature of toxic IAPP intermediates, providing insight for anti-amyloidosis therapeutics. |
| Q36962205 | Type 2 diabetes - a matter of failing beta-cell neogenesis? Clues from the GK rat model. |
| Q33803474 | Unique arrangement of alpha- and beta-cells in human islets of Langerhans |
| Q50569941 | Urinary markers of nucleic acid oxidation in Danish overweight/obese children and youths. |
| Q33585873 | Utility of indices using C-peptide levels for indication of insulin therapy to achieve good glycemic control in Japanese patients with type 2 diabetes |
| Q42409734 | Vascular endothelial growth factor-mediated islet hypervascularization and inflammation contribute to progressive reduction of β-cell mass. |
| Q46380847 | Vasculopathy in type 2 diabetes mellitus: role of specific angiogenic modulators |
| Q92832878 | WWP1 knockout in mice exacerbates obesity-related phenotypes in white adipose tissue but improves whole-body glucose metabolism |
| Q35646939 | cJUN N-terminal kinase (JNK) activation mediates islet amyloid-induced beta cell apoptosis in cultured human islet amyloid polypeptide transgenic mouse islets. |
| Q33588325 | β-Cell failure in type 2 diabetes |
| Q27692665 | β-cell dysfunction: Its critical role in prevention and management of type 2 diabetes |
| Q35070534 | β-cell loss and β-cell apoptosis in human type 2 diabetes are related to islet amyloid deposition |
| Q33558395 | β-cell mass in people with type 2 diabetes |
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