Androgen signaling expands β-cell mass in male rats and β-cell androgen receptor is degraded under high-glucose conditions.

scientific article published on 14 November 2017

Androgen signaling expands β-cell mass in male rats and β-cell androgen receptor is degraded under high-glucose conditions. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1152/AJPENDO.00211.2017
P698PubMed publication ID29138225

P50authorNobuaki ShirakiQ42857744
Naoki HaradaQ51504389
Kenji KaiQ51527485
P2093author name stringYuji Takahashi
Hiroshi Inui
Ryoichi Yamaji
Tatsuya Masuda
Takahiro Katsuki
Yasuhiro Yoda
Yusuke Yotsumoto
P2860cites workThe decline of androgen levels in elderly men and its clinical and therapeutic implicationsQ28251483
Impaired insulin secretion and glucose tolerance in beta cell-selective Ca(v)1.2 Ca2+ channel null miceQ28587870
Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetesQ29619192
Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell linesQ29619317
Calmodulin protects androgen receptor from calpain-mediated breakdown in prostate cancer cellsQ30500293
Androgen receptor (AR) coregulators: a diversity of functions converging on and regulating the AR transcriptional complexQ34007618
Castration-induced testosterone deficiency increases fasting glucose associated with hepatic and extra-hepatic insulin resistance in adult male ratsQ34478412
Sex differences of endogenous sex hormones and risk of type 2 diabetes: a systematic review and meta-analysisQ34502187
Development of a novel class of glucose transporter inhibitorsQ36032683
Partial pancreatectomy in the rat and subsequent defect in glucose-induced insulin releaseQ36989349
Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitusQ37141727
Sex steroids effects on the endocrine pancreas.Q37767921
Androgen receptor silences thioredoxin-interacting protein and competitively inhibits glucocorticoid receptor-mediated apoptosis in pancreatic β-CellsQ38914454
Sex differences in the multiple-dose streptozotocin model of diabetesQ39877050
ARA24/Ran enhances the androgen-dependent NH2- and COOH-terminal interaction of the androgen receptorQ39970676
Glyceraldehyde-3-phosphate dehydrogenase enhances transcriptional activity of androgen receptor in prostate cancer cellsQ40123008
Calmodulin-androgen receptor (AR) interaction: calcium-dependent, calpain-mediated breakdown of AR in LNCaP prostate cancer cellsQ40192902
Androgens induce prostate cancer cell proliferation through mammalian target of rapamycin activation and post-transcriptional increases in cyclin D proteinsQ40248475
Isolation of INS-1-derived cell lines with robust ATP-sensitive K+ channel-dependent and -independent glucose-stimulated insulin secretionQ40871524
Transcription factor Ets-1 links glucotoxicity to pancreatic beta cell dysfunction through inhibiting PDX-1 expression in rodent modelsQ41126946
Testosterone protects against glucotoxicity-induced apoptosis of pancreatic β-cells (INS-1) and male mouse pancreatic isletsQ42443592
Renal function and renal disease in males or females--vive la petite differenceQ43451686
Reduced β-cell mass and altered glucose sensing impair insulin-secretory function in βIRKO miceQ44602874
Cytochrome P-450(17alpha) in beta-cells of rat pancreas and its local steroidogenesisQ46538167
Distribution of 17 beta-hydroxysteroid dehydrogenase gene expression and activity in rat and human tissuesQ48524479
Reduced beta-cell mass and expression of oxidative stress-related DNA damage in the islet of Japanese Type II diabetic patients.Q53979441
P433issue3
P304page(s)E274-E286
P577publication date2017-11-14
P1433published inAmerican Journal of Physiology - Endocrinology and MetabolismQ15765671
P1476titleAndrogen signaling expands β-cell mass in male rats and β-cell androgen receptor is degraded under high-glucose conditions
P478volume314

Reverse relations

Q97422028Implicating androgen excess in propagating metabolic disease in polycystic ovary syndromecites workP2860