High glucose inhibits glucose-6-phosphate dehydrogenase, leading to increased oxidative stress and beta-cell apoptosis

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High glucose inhibits glucose-6-phosphate dehydrogenase, leading to increased oxidative stress and beta-cell apoptosis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1096/FJ.09-136572
P932PMC publication ID2879949
P698PubMed publication ID20032314
P5875ResearchGate publication ID40767803

P50authorJoseph LoscalzoQ64498968
P2093author name stringChong Wee Liew
Rohit N Kulkarni
Yingyi Zhang
Robert C Stanton
Jane A Leopold
Ji Hu
Zhaoyun Zhang
Lili Guo
Diane E Handy
P2860cites workImportance of glucose-6-phosphate dehydrogenase activity for cell growthQ28268412
Oxidative stress as a major culprit in kidney disease in diabetesQ28281957
Glucose-6-phosphate dehydrogenase activity and NADPH/NADP+ ratio in liver and pancreas are dependent on the severity of hyperglycemia in ratQ28583459
A glucose-6-phosphate dehydrogenase (G6PD) splice site consensus sequence mutation associated with G6PD enzyme deficiencyQ28586870
Targeted disruption of the housekeeping gene encoding glucose 6-phosphate dehydrogenase (G6PD): G6PD is dispensable for pentose synthesis but essential for defense against oxidative stressQ28589916
X-linked glucose-6-phosphate dehydrogenase deficiency in Mus musculusQ28592759
Importance of glucose-6-phosphate dehydrogenase activity in cell deathQ28646889
Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetesQ29619192
Glucose-6-phosphate dehydrogenase overexpression decreases endothelial cell oxidant stress and increases bioavailable nitric oxideQ30890753
Glucose-6-phosphate dehydrogenase modulates vascular endothelial growth factor-mediated angiogenesisQ30939997
A role for glutathione peroxidase in protecting pancreatic beta cells against oxidative stress in a model of glucose toxicityQ34156113
Oxidative stress-mediated, post-translational loss of MafA protein as a contributing mechanism to loss of insulin gene expression in glucotoxic beta cellsQ34387108
A pyruvate cycling pathway involving cytosolic NADP-dependent isocitrate dehydrogenase regulates glucose-stimulated insulin secretionQ34557756
Diabetes, oxidative stress, and antioxidants: a reviewQ35077717
Beta-cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetesQ35641724
Chronic oxidative stress as a central mechanism for glucose toxicity in pancreatic islet beta cells in diabetesQ35838612
beta-cell failure in diabetes and preservation by clinical treatmentQ36757992
Update in type 1 diabetesQ36872654
Caspase-3 activation is a critical determinant of genotoxic stress-induced apoptosisQ37050795
Oxidative stress: the vulnerable beta-cellQ37164516
Beta-cell apoptosis in type 2 diabetes: quantitative and functional consequences.Q37221767
Proliferation markersQ38478831
Protection of insulin-secreting INS-1 cells against oxidative stress through adenoviral-mediated glutathione peroxidase overexpressionQ40647894
Adenovirus-mediated catalase gene transfer reduces oxidant stress in human, porcine and rat pancreatic isletsQ41006022
A new lease of life for an old enzymeQ41076880
Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-producing cellsQ41081642
Signal transduction proteins that associate with the platelet-derived growth factor (PDGF) receptor mediate the PDGF-induced release of glucose-6-phosphate dehydrogenase from permeabilized cellsQ41467294
Glucose-6-phosphate dehydrogenase deficiency decreases vascular superoxide and atherosclerotic lesions in apolipoprotein E(-/-) miceQ42489998
Pancreatic islet beta-cell and oxidative stress: the importance of glutathione peroxidaseQ42585037
The murine Ki-67 cell proliferation antigen accumulates in the nucleolar and heterochromatic regions of interphase cells and at the periphery of the mitotic chromosomes in a process essential for cell cycle progressionQ42818281
Increase in glucose-6-phosphate dehydrogenase in adipocytes stimulates oxidative stress and inflammatory signalsQ42834215
Enhanced expression of glucose-6-phosphate dehydrogenase in human cells sustaining oxidative stressQ42986449
Glucose-6-phosphate dehydrogenase modulates cytosolic redox status and contractile phenotype in adult cardiomyocytesQ44493380
Pancreatic islets from type 2 diabetic patients have functional defects and increased apoptosis that are ameliorated by metformin.Q45142823
Diabetes causes inhibition of glucose-6-phosphate dehydrogenase via activation of PKA, which contributes to oxidative stress in rat kidney cortexQ46547434
Differentially expressed proteins in the pancreas of diet-induced diabetic miceQ46551319
Prevention of oxidative stress by adenoviral overexpression of glutathione-related enzymes in pancreatic isletsQ46613184
The role of the pentose phosphate shunt in glucose induced insulin release: in vitro studies with 6-aminonicotinamide, methylene blue, NAD + , NADH, NADP + , NADPH and nicotinamide on isolated pancreatic rat islets.Q50965972
Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues.Q53787751
Reduced beta-cell mass and expression of oxidative stress-related DNA damage in the islet of Japanese Type II diabetic patients.Q53979441
Effect of 6-aminonicotinamide on insulin release and C-14 glucose oxidation by isolated pancreatic rat islets: difference between glucose, tolbutamide and aminophylline.Q54144263
6-Amnionicotinamide (6-AN) as a diabetogenic agent. In vitro and in vivo studies in the ratQ68761868
An improved method for isolation of mouse pancreatic isletsQ70103136
High glucose inhibits glucose-6-phosphate dehydrogenase via cAMP in aortic endothelial cellsQ73010828
Complementary action of antioxidant enzymes in the protection of bioengineered insulin-producing RINm5F cells against the toxicity of reactive oxygen speciesQ77349161
Mechanisms of protection of catalase by NADPH. Kinetics and stoichiometryQ77726403
Role of oxidative stress in diabetic complications: a new perspective on an old paradigmQ77804864
Enhanced glutathione levels and oxidoresistance mediated by increased glucose-6-phosphate dehydrogenase expressionQ77896835
Upregulation of glucose-6-phosphate dehydrogenase and NAD(P)H oxidase activity increases oxidative stress in failing human heartQ80734999
Chronic oxidative stress as a mechanism for glucose toxicity of the beta cell in type 2 diabetesQ80820435
P4510describes a project that usesImageJQ1659584
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectapoptotic processQ14599311
P304page(s)1497-1505
P577publication date2009-12-23
P1433published inFASEB JournalQ520194
P1476titleHigh glucose inhibits glucose-6-phosphate dehydrogenase, leading to increased oxidative stress and beta-cell apoptosis
P478volume24