Insulin, glucagon and somatostatin stores in the pancreas of subjects with type-2 diabetes and their lean and obese non-diabetic controls.

scientific article published on 8 September 2017

Insulin, glucagon and somatostatin stores in the pancreas of subjects with type-2 diabetes and their lean and obese non-diabetic controls. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/S41598-017-10296-Z
P932PMC publication ID5591190
P698PubMed publication ID28887444

P50authorJean-Claude HenquinQ88048572
P2093author name stringJacques Rahier
Majeed M Ibrahim
P2860cites workBeta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetesQ29619192
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Unique arrangement of alpha- and beta-cells in human islets of LangerhansQ33803474
Immunochemical glucagon in human pancreas, gut, and plasma.Q51229035
C-peptide immunoreactivity and insulin content in the diabetic human pancreas and the relation to the stability of diabetic serum glucose level.Q51632257
Islet amyloid, increased A-cells, reduced B-cells and exocrine fibrosis: quantitative changes in the pancreas in type 2 diabetes.Q52490197
Studies of human insulin from nondiabetic and diabetic pancreas.Q53729618
Reduced beta-cell mass and expression of oxidative stress-related DNA damage in the islet of Japanese Type II diabetic patients.Q53979441
Selective β-Cell Loss and α-Cell Expansion in Patients with Type 2 Diabetes Mellitus in KoreaQ57214866
Documentation of hyperglucagonemia throughout the day in nonobese and obese patients with noninsulin-dependent diabetes mellitusQ68917267
Circulating amino acids and pancreatic endocrine function after ingestion of a protein-rich meal in obese subjectsQ69503366
Molecular forms of glucagon-like peptide-1 in human pancreas and glucagonomasQ70093213
Pancreatic polypeptide in islet cell tumors. Morphologic and functional correlationsQ70095944
Time course of content of insulin, glucagon and pancreatic polypeptide in human pancreatic tissue obtained by surgeryQ70196217
Cellular composition of the human diabetic pancreasQ70269326
Decrease of Pancreatic Somatostatin in Neonatal NesidiobiastosisQ72456621
Quantitation of Endocrine Cell Content in the Pancreas of Nondiabetic and Diabetic HumansQ72546157
Extractable insulin of pancreas; correlation with pathological and clinical findings in diabetic and nondiabetic casesQ76163537
Prolonged exposure of human beta-cells to high glucose increases their release of proinsulin during acute stimulation with glucose or arginineQ77312670
Involvement of oxidative stress-induced DNA damage, endoplasmic reticulum stress, and autophagy deficits in the decline of β-cell mass in Japanese type 2 diabetic patientsQ87622984
MEASUREMENT OF SMALL QUANTITIES OF INSULIN-LIKE ACTIVITY WITH RAT ADIPOSE TISSUE. IV. SERUM INSULIN-LIKE ACTIVITY AND TUMOR INSULIN CONTENT IN PATIENTS WITH FUNCTIONING ISLET-CELL TUMORS.Q33948689
Altered islet composition and disproportionate loss of large islets in patients with type 2 diabetesQ34079298
Aging and insulin secretionQ35027205
Pancreatic alpha cell mass in European subjects with type 2 diabetesQ35031657
Composition and function of macroencapsulated human embryonic stem cell-derived implants: comparison with clinical human islet cell graftsQ35245232
Quantitative study of insulin secretion and clearance in normal and obese subjectsQ35809498
beta-cell function in obesity: effects of weight loss.Q35961983
γ-Aminobutyric acid (GABA) signalling in human pancreatic islets is altered in type 2 diabetesQ36013568
β-cell mass and turnover in humans: effects of obesity and agingQ36477911
The role of alpha-cell dysregulation in fasting and postprandial hyperglycemia in type 2 diabetes and therapeutic implicationsQ36780425
Effects of Obesity and Diabetes on α- and β-Cell Mass in Surgically Resected Human PancreasQ37057949
Regulation of glucagon secretion by glucose: paracrine, intrinsic or both?Q37913517
The role of dysregulated glucagon secretion in type 2 diabetesQ37913523
Nutrient regulation of glucagon secretion: involvement in metabolism and diabetes.Q38203645
ATP-regulated potassium channels and voltage-gated calcium channels in pancreatic alpha and beta cells: similar functions but reciprocal effects on secretionQ38218351
Insulin, Proinsulin, Glucagon and Gastrin in Pancreatic Tumors and in Plasma of Patients with Organic Hyperinsulinism1Q39140583
The Pathophysiology of Hyperglycemia in Older Adults: Clinical Considerations.Q39191733
Infant Human Pancreas: A Potential Source of Islet Tissue for TransplantationQ40026785
Insulin deficiency and insulin resistance in the pathogenesis of NIDDM: is a divorce possible?Q40432875
Pancreatic β-Cells From Mice Offset Age-Associated Mitochondrial Deficiency With Reduced KATP Channel Activity.Q40955156
THE INSULIN AND THE ZINC CONTENT OF NORMAL AND DIABETIC PANCREAS.Q40971671
Differential volumetry of A,B and D cells in the pancreatic islets of diabetic and nondiabetic subjectsQ41151495
beta-Cell function in subjects spanning the range from normal glucose tolerance to overt diabetes: a new analysisQ45105931
Pancreatic islets from type 2 diabetic patients have functional defects and increased apoptosis that are ameliorated by metformin.Q45142823
Regional distribution and concentration of pancreatic polypeptide in the human and canine pancreasQ45197125
Change in β-cell mass in Japanese nondiabetic obese individuals.Q45984989
Pancreatic beta-cell mass in European subjects with type 2 diabetesQ46332814
Insulin and Proinsulin Content of Pancreases from Diabetic and Nondiabetic SubjectsQ47909970
Research-Focused Isolation of Human Islets From Donors With and Without Diabetes at the Alberta Diabetes Institute IsletCoreQ47943702
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectpancreasQ9618
obesityQ12174
glucagonQ28163629
P304page(s)11015
P577publication date2017-09-08
P1433published inScientific ReportsQ2261792
P1476titleInsulin, glucagon and somatostatin stores in the pancreas of subjects with type-2 diabetes and their lean and obese non-diabetic controls
P478volume7

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cites work (P2860)
Q89478076Inadequate β-cell mass is essential for the pathogenesis of type 2 diabetes
Q52656651Influence of organ donor attributes and preparation characteristics on the dynamics of insulin secretion in isolated human islets.
Q57280241The Difference δ-Cells Make in Glucose Control
Q89723300Wolfram syndrome 1 gene regulates pathways maintaining beta-cell health and survival

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