An Update on the Synthesis of Pyrrolo[1,4]benzodiazepines

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An Update on the Synthesis of Pyrrolo[1,4]benzodiazepines is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.3390/MOLECULES21020154
P932PMC publication ID6273195
P698PubMed publication ID26828475
P5875ResearchGate publication ID292177056

P2093author name stringGeorge Varvounis
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A phase I trial of SJG-136 (NSC#694501) in advanced solid tumorsQ33385770
Limazepines A-F, pyrrolo[1,4]benzodiazepine Antibiotics from an Indonesian Micrococcus sp.Q33434057
Sugar-based enantiomeric and conformationally constrained pyrrolo[2,1-c][1,4]-benzodiazepines as potential GABAA ligandsQ33818550
Synthesis of aryl-substituted naphthalene-linked pyrrolobenzodiazepine conjugates as potential anticancer agents with apoptosis-inducing ability.Q33952790
Observation of a single-stranded DNA/pyrrolobenzodiazepine adduct.Q34022046
Design and synthesis of benzo[c,d]indolone-pyrrolobenzodiazepine conjugates as potential anticancer agentsQ34114979
Interaction of pyrrolobenzodiazepine (PBD) ligands with parallel intermolecular G-quadruplex complex using spectroscopy and ESI-MS.Q34256936
Optimization of the antitumor activity of sequence-specific pyrrolobenzodiazepine derivatives based on their affinity for ABC transportersQ34293696
Enterotoxicity of a nonribosomal peptide causes antibiotic-associated colitis.Q34583682
An extended pyrrolobenzodiazepine-polyamide conjugate with selectivity for a DNA sequence containing the ICB2 transcription factor binding site.Q34867943
A potent anti-CD70 antibody-drug conjugate combining a dimeric pyrrolobenzodiazepine drug with site-specific conjugation technology.Q50871095
SGN-CD33A: a novel CD33-targeting antibody-drug conjugate using a pyrrolobenzodiazepine dimer is active in models of drug-resistant AML.Q50904360
Isolation and Characterization of Anthramycin, a New Antitumor AntibioticQ53900646
O-Debenzylation of a Pyrrolo[2,1-c][1,4]benzodiazepine in the Presence of a Carbinolamine Functionality: Synthesis of DC-81Q56485891
Pharmacokinetics, pharmacodynamics and metabolism of the dimeric pyrrolobenzodiazepine SJG-136 in ratsQ58641838
Research on nitrogen containing heterocyclic compounds.XX. Synthesis of 8H-Imidazo[5,1-c]pyrrolo[1,2-a][1,4]benzodiazepine and its 6-derivativesQ58961022
Novel C8-linked pyrrolobenzodiazepine (PBD)–heterocycle conjugates that recognize DNA sequences containing an inverted CCAAT boxQ60026462
Studies on synthetic drugs. II. Syntheses of pyrrolo[1,i-d][1,4]-benzodiazepine derivatives (author's transl)Q67011484
Pyrrolo[1,4]benzodiazepine antitumor antibiotics: relationship of DNA alkylation and sequence specificity to the biological activity of natural and synthetic compoundsQ70075186
Total synthesis of anthramycinQ72109889
Identification and synthesis of major metabolites of Vasopressin V2-receptor agonist WAY-151932, and antagonist, LixivaptanQ81249679
Observation of the reversibility of a covalent pyrrolobenzodiazepine (PBD) DNA adduct by HPLC/MS and CD spectroscopyQ83257464
Nuclear magnetic resonance solution structures of inter- and intrastrand adducts of DNA cross-linker SJG-136Q83848571
Iridium catalyzed asymmetric hydrogenation of cyclic imines of benzodiazepinones and benzodiazepinesQ84576320
γ-Turn Mimicry with Benzodiazepinones and Pyrrolobenzodiazepinones Synthesized from a Common Amino Ketone IntermediateQ85497098
Intramolecular azide to alkene cycloadditions for the construction of pyrrolobenzodiazepines and azetidino-benzodiazepinesQ85829558
Mutasynthesis of a potent anticancer sibiromycin analogueQ36035377
SG2285, a novel C2-aryl-substituted pyrrolobenzodiazepine dimer prodrug that cross-links DNA and exerts highly potent antitumor activityQ36496775
DNA interstrand crosslink repair and cancerQ36576047
Biosynthesis, synthesis, and biological activities of pyrrolobenzodiazepinesQ37764802
Synthesis of DNA-interactive pyrrolo[2,1-c][1,4]benzodiazepines (PBDs).Q37821888
The development of pyrrolobenzodiazepines as antitumour agentsQ37860342
Small molecule drugs - optimizing DNA damaging agent-based therapeuticsQ38002595
Antibody-drug conjugates for the treatment of cancerQ38068568
Effect of hairpin loop structure on reactivity, sequence preference and adduct orientation of a DNA-interactive pyrrolo[2,1-c][1,4]benzodiazepine (PBD) antitumour agentQ38300702
The minor groove-binding agent ELB-21 forms multiple interstrand and intrastrand covalent cross-links with duplex DNA and displays potent bactericidal activity against methicillin-resistant Staphylococcus aureusQ38336785
DNA Sequence Preference and Adduct Orientation of Pyrrolo[2,1-c][1,4]benzodiazepine Antitumor AgentsQ38339530
Dithiocarbamate/piperazine bridged pyrrolobenzodiazepines as DNA-minor groove binders: synthesis, DNA-binding affinity and cytotoxic activityQ38911469
GC-targeted C8-linked pyrrolobenzodiazepine-biaryl conjugates with femtomolar in vitro cytotoxicity and in vivo antitumor activity in mouse modelsQ39178091
Synthesis, anticancer activity and apoptosis inducing ability of bisindole linked pyrrolo[2,1-c][1,4]benzodiazepine conjugatesQ39439385
Synthesis and anticancer activity of chalcone-pyrrolobenzodiazepine conjugates linked via 1,2,3-triazole ring side-armed with alkane spacersQ39523980
Synthesis and biological evaluation of estradiol linked pyrrolo[2,1-c][1,4]benzodiazepine (PBD) conjugates as potential anticancer agentsQ39565636
DNA interstrand cross-linking and in vivo antitumor activity of the extended pyrrolo[2,1-c][1,4]benzodiazepine dimer SG2057.Q39579617
Hybrids of privileged structures benzothiazoles and pyrrolo[2,1-c] [1,4]benzodiazepin-5-one, and diversity-oriented synthesis of benzothiazolesQ39653628
Remarkable enhancement in the DNA-binding ability of C2-fluoro substituted pyrrolo[2,1-c][1,4]benzodiazepines and their anticancer potentialQ39891027
DC-81-Indole conjugate agent induces mitochondria mediated apoptosis in human melanoma A375 cellsQ40127572
Design, synthesis, and biophysical and biological evaluation of a series of pyrrolobenzodiazepine-poly(N-methylpyrrole) conjugatesQ40238058
Effect of base sequence on the DNA cross-linking properties of pyrrolobenzodiazepine (PBD) dimersQ42063199
Antistaphylococcal activity of DNA-interactive pyrrolobenzodiazepine (PBD) dimers and PBD-biaryl conjugates.Q42190109
[5-Aroyl-5,6-dihydro-4H-pyrrolo[1,2-a][1,4]benzodiazepin-4-carboxylic acids: synthesis and analgesic and neurobehavioral activity]Q42199357
Inhibition of DNA binding of the NF-Y transcription factor by the pyrrolobenzodiazepine-polyamide conjugate GWL-78.Q42813042
Furan ring opening-pyrrole ring closure: a new synthetic route to aryl(heteroaryl)-annulated pyrrolo[1,2-a][1,4]diazepinesQ43044594
Pyrrolobenzodiazepine and related systems. I. Synthesis and pharmacological evaluation of new 5,6-dihydro-4H-pyrrolo[1,2-a][1,4]benzodiazepine derivativesQ43587963
Correction: Interaction of Pyrrolobenzodiazepine (PBD) Ligands with Parallel Intermolecular G-Quadruplex Complex Using Spectroscopy and ESI-MS.Q46004902
Boseongazepines A-C, pyrrolobenzodiazepine derivatives from a Streptomyces sp. 11A057.Q46259712
Pyrrolo[1,2-a][1,4]benzodiazepine: a novel class of non-azole anti-dermatophyte anti-fungal agentsQ46540927
Computational studies support the role of the C7-sibirosamine sugar of the pyrrolobenzodiazepine (PBD) sibiromycin in transcription factor inhibitionQ46853969
Diazepines. 5. Synthesis and biological action of 6-phenyl-4H-pyrrolo[1,2-a][1,4]benzodiazepinesQ48207802
Pyrrolobenzodiazepines and related systems. 2. Synthesis and biological properties of isonoraptazepine derivativesQ48405829
P275copyright licenseCreative Commons AttributionQ6905323
P6216copyright statuscopyrightedQ50423863
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectantineoplasticQ2853144
pyrroleQ67954132
anti-HIV agentsQ50377208
P304page(s)154
P577publication date2016-01-28
P1433published inMoleculesQ151332
P1476titleAn Update on the Synthesis of Pyrrolo[1,4]benzodiazepines
P478volume21

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cites work (P2860)
Q37561359From Anthramycin to Pyrrolobenzodiazepine (PBD)-Containing Antibody-Drug Conjugates (ADCs).
Q48677630Novel pyrrolobenzodiazepine and pyrroloquinazoline scaffolds synthesized by a simple and highly selective Ugi/cyclization sequence.