Enterotoxicity of a nonribosomal peptide causes antibiotic-associated colitis.

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Enterotoxicity of a nonribosomal peptide causes antibiotic-associated colitis. is …
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scholarly articleQ13442814

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P819ADS bibcode2014PNAS..11113181S
P356DOI10.1073/PNAS.1403274111
P932PMC publication ID4246982
P698PubMed publication ID25157164
P5875ResearchGate publication ID267756848

P50authorRoland BückerQ42414925
Stefan SchildQ42612986
Rolf BreinbauerQ42663469
Christoph HögenauerQ43196341
Ellen L. ZechnerQ39412280
Gregor GorkiewiczQ39412321
P2093author name stringSandro Roier
Hansjörg Weber
Hanno Troeger
Jakob Pletz
Georg Schneditz
Kathrin A T Herzog
Jana Rentner
P2860cites workDiversity of the human intestinal microbial floraQ24544241
Microbial exposure during early life has persistent effects on natural killer T cell functionQ24604308
beta-Lactamases in laboratory and clinical resistanceQ24669605
The shikimate pathway as an entry to aromatic secondary metabolismQ24673312
Pyrrolo(1,4)benzodiazepine antitumor antibiotics. Comparative aspects of anthramycin, tomaymycin and sibiromycinQ39639868
Escherichia coli induces DNA double-strand breaks in eukaryotic cells.Q40244785
A novel integrative and conjugative element (ICE) of Escherichia coli: the putative progenitor of the Yersinia high-pathogenicity islandQ41464046
The high-pathogenicity island of Yersinia pseudotuberculosis can be inserted into any of the three chromosomal asn tRNA genesQ41483783
Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretomeQ42257409
Circumdatin H, a new inhibitor of mitochondrial NADH oxidase, from Aspergillus ochraceusQ46697950
Mechanisms and management of antibiotic-associated diarrheaQ50128861
Role of Klebsiella oxytoca in antibiotic-associated diarrhea.Q53452316
'Blooming' in the gut: how dysbiosis might contribute to pathogen evolutionQ63968591
Cytotoxic component(s) of Klebsiella oxytoca on HEp-2 cellsQ68798169
Production of a unique cytotoxin by Klebsiella oxytocaQ69431403
Structure-cytotoxicity relationship of tilivalline derivativesQ72142308
Stereoselective Synthesis of Tilivalline(1)Q74838855
Circumdatins D, E, and F: further fungal benzodiazepine analogues from aspergillus ochraceusQ77966952
Klebsiella oxytoca as an agent of antibiotic-associated hemorrhagic colitisQ79770453
Pathobionts of the gastrointestinal microbiota and inflammatory diseaseQ27008113
THE ENZYMIC CONVERSION OF 3-DEOXY-D-ARABINO-HEPTULOSONIC ACID 7-PHOSPHATE TO 5-DEHYDROQUINATEQ28155951
THE SHIKIMATE PATHWAYQ28249499
Klebsiella oxytoca as a causative organism of antibiotic-associated hemorrhagic colitisQ28277603
The gut microbiota--masters of host development and physiologyQ28286102
Pyrrolo[1,4]benzodiazepine antibiotics. Biosynthesis of the antitumor antibiotic sibiromycin by Streptosporangium sibiricumQ28330712
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesityQ28512778
The gut microbiota shapes intestinal immune responses during health and diseaseQ29547727
Chapter 8. Methods for in silico prediction of microbial polyketide and nonribosomal peptide biosynthetic pathways from DNA sequence dataQ33431525
Genotoxic Klebsiella pneumoniae in TaiwanQ33650052
Escherichia coli induces DNA damage in vivo and triggers genomic instability in mammalian cellsQ33953217
Gut metagenome in European women with normal, impaired and diabetic glucose controlQ34347521
Escherichia coli producing colibactin triggers premature and transmissible senescence in mammalian cellsQ34377079
The specificity-conferring code of adenylation domains in nonribosomal peptide synthetasesQ34504359
Assembly-line enzymology for polyketide and nonribosomal Peptide antibiotics: logic, machinery, and mechanisms.Q34555236
Benzodiazepine biosynthesis in Streptomyces refuineus.Q34640414
Colonic bacterial metabolites and human healthQ34654550
Lethal inflammasome activation by a multidrug-resistant pathobiont upon antibiotic disruption of the microbiotaQ36319423
Characterization of integrative and conjugative element ICEKp1-associated genomic heterogeneity in a Klebsiella pneumoniae strain isolated from a primary liver abscessQ36422212
Intestinal inflammation targets cancer-inducing activity of the microbiota.Q36819342
Biosynthesis of sibiromycin, a potent antitumor antibioticQ37191100
Cloning and characterization of the biosynthetic gene cluster for tomaymycin, an SJG-136 monomeric analogQ37191113
Genetic structure and distribution of the colibactin genomic island among members of the family Enterobacteriaceae.Q37410263
Working outside the protein-synthesis rules: insights into non-ribosomal peptide synthesisQ37614351
Genotypes of Klebsiella oxytoca isolates from patients with nosocomial pneumonia are distinct from those of isolates from patients with antibiotic-associated hemorrhagic colitis.Q37713661
Biosynthesis, synthesis, and biological activities of pyrrolobenzodiazepinesQ37764802
The development of pyrrolobenzodiazepines as antitumour agentsQ37860342
Interactions between the intestinal microbiome and liver diseasesQ38179779
Pyrrolo(1,4)benzodiazepine antitumor antibiotics In vitro interaction of anthramycin, sibiromycin and tomaymycin with DNA using specifically radiolabelled moleculesQ39143374
Cytotoxic effects of Klebsiella oxytoca strains isolated from patients with antibiotic-associated hemorrhagic colitis or other diseases caused by infections and from healthy subjectsQ39412029
P433issue36
P407language of work or nameEnglishQ1860
P304page(s)13181-13186
P577publication date2014-08-25
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleEnterotoxicity of a nonribosomal peptide causes antibiotic-associated colitis
P478volume111

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cites work (P2860)
Q41991724A tricyclic pyrrolobenzodiazepine produced by Klebsiella oxytoca is associated with cytotoxicity in antibiotic-associated hemorrhagic colitis.
Q26772938An Update on the Synthesis of Pyrrolo[1,4]benzodiazepines
Q92624751An anaerobic bacterium host system for heterologous expression of natural product biosynthetic gene clusters
Q41987403Antibiotics and specialized metabolites from the human microbiota
Q38618414Bioactive natural products from novel microbial sources.
Q47424110Biosynthesis of the Enterotoxic Pyrrolobenzodiazepine Natural Product Tilivalline
Q38620301Causes of hematochezia and hemorrhagic antibiotic-associated colitis in children and adolescents
Q48113441Gut microbiome: a new player in gastrointestinal disease
Q26799980HUMAN MICROBIOTA. Small molecules from the human microbiota
Q58770854Klebsiella oxytoca expands in cancer cachexia and acts as a gut pathobiont contributing to intestinal dysfunction
Q96835042Making and breaking leupeptin protease inhibitors in pathogenic gammaproteobacteria
Q35625314Microbial inhibition of oral epithelial wound recovery: potential role for quorum sensing molecules?
Q64064650Molecular typing of cytotoxin-producing Klebsiella oxytoca isolates by 16S-23S internal transcribed spacer PCR
Q46290229Natural product diversity associated with the nematode symbionts Photorhabdus and Xenorhabdus
Q36200942Natural products as mediators of disease.
Q89147783Natural products from thioester reductase containing biosynthetic pathways
Q87166461Natural products: Hunting microbial metabolites
Q38808285New Concept of the Biosynthesis of 4-Alkyl-L-Proline Precursors of Lincomycin, Hormaomycin, and Pyrrolobenzodiazepines: Could a γ-Glutamyltransferase Cleave the C-C Bond?
Q36316177Nonribosomal Peptide Synthesis-Principles and Prospects
Q55248458Novel pathway of 3-hydroxyanthranilic acid formation in limazepine biosynthesis reveals evolutionary relation between phenazines and pyrrolobenzodiazepines.
Q90739257Signaling Natural Products from Human Pathogenic Bacteria
Q97905672Sulfamethoxazole drug stress upregulates antioxidant immunomodulatory metabolites in Escherichia coli
Q35694112The Microbes inside Us and the Race for Colibactin
Q39633344The Toxin-Producing Pathobiont Klebsiella oxytoca Is Not Associated with Flares of Inflammatory Bowel Diseases.
Q90730093The association of surface adhesin genes and the biofilm formation among Klebsiella oxytoca clinical isolates
Q55052940The benzodiazepine-like natural product tilivalline is produced by the entomopathogenic bacterium Xenorhabdus eapokensis.
Q35844576The colibactin warhead crosslinks DNA.
Q64235113enterotoxins tilimycin and tilivalline have distinct host DNA-damaging and microtubule-stabilizing activities

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