Mechanisms of intrahepatic triglyceride accumulation

scientific article

Mechanisms of intrahepatic triglyceride accumulation is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.3748/WJG.V22.I4.1664
P932PMC publication ID4721997
P698PubMed publication ID26819531
P5875ResearchGate publication ID291846510

P50authorSusanne KaserQ43166190
P2093author name stringClaudia Ress
P2860cites workComparative proteomic study reveals 17β-HSD13 as a pathogenic protein in nonalcoholic fatty liver diseaseQ24300844
Evidence for a role of nonalcoholic steatohepatitis in hepatitis C: a prospective studyQ43039600
The impact of liver fat vs visceral fat in determining categories of prediabetesQ43184911
Liver injury in acute fatty liver of pregnancy: possible link to placental mitochondrial dysfunction and oxidative stress.Q43208286
SIRT1 mediates the effect of GLP-1 receptor agonist exenatide on ameliorating hepatic steatosisQ43412126
Prospective screening for pediatric mitochondrial trifunctional protein defects in pregnancies complicated by liver diseaseQ44202802
Alcoholic liver injury in the rat is associated with reduced expression of peroxisome proliferator-alpha (PPARalpha)-regulated genes and is ameliorated by PPARalpha activationQ44797080
A prospective national study of acute fatty liver of pregnancy in the UK.Q46336995
Leptin reverses nonalcoholic steatohepatitis in patients with severe lipodystrophyQ46405084
Liver X receptor in cooperation with SREBP-1c is a major lipid synthesis regulator in nonalcoholic fatty liver disease.Q46442905
Alcohol-related problems in Taiwan with particular emphasis on alcoholic liver diseasesQ47759121
Perilipin 5 improves hepatic lipotoxicity by inhibiting lipolysis.Q52653330
Enhanced expression of pro-inflammatory mediators and liver X-receptor-regulated lipogenic genes in non-alcoholic fatty liver disease and hepatitis CQ59273491
The role of apolipoprotein A5 in non-alcoholic fatty liver diseaseQ61451349
Epidemiology of alcoholic liver diseaseQ68135451
Effects of free fatty acids on the metabolic response to oral fructose in lean healthy humansQ71115803
Acetaldehyde adducts and autoantibodies against VLDL and LDL in alcoholicsQ72922446
Nonalcoholic steatohepatitisQ74424858
Host- and disease-specific factors affecting steatosis in chronic hepatitis CQ77169958
Liver failure during pregnancyQ80234921
Energy expenditure and adaptive responses to an acute hypercaloric fat load in humans with lipodystrophyQ81185058
Evaluation and management of non-alcoholic steatohepatitisQ81545126
Lipoprotein lipase expression in livers of morbidly obese patients could be responsible for liver steatosisQ83508734
Apolipoprotein A5 internalized by human adipocytes modulates cellular triglyceride contentQ84424543
Perilipin 5: from fatty liver to hepatic lipodystrophy?Q86047296
Peroxisomal-proliferator-activated receptor alpha activates transcription of the rat hepatic malonyl-CoA decarboxylase gene: a key regulation of malonyl-CoA levelQ38347572
NAFLD: a multisystem disease.Q38446387
Apolipoprotein A5: Extracellular and Intracellular Roles in Triglyceride MetabolismQ38509473
The small GTPase Rab7 as a central regulator of hepatocellular lipophagyQ38922472
Pharmacological activation of aldehyde dehydrogenase 2 by Alda-1 reverses alcohol-induced hepatic steatosis and cell death in mice.Q38925122
Hepatitis C virus nonstructural protein 5A favors upregulation of gluconeogenic and lipogenic gene expression leading towards insulin resistance: a metabolic syndromeQ39062412
Hepatitis C virus induced up-regulation of microRNA-27: a novel mechanism for hepatic steatosis.Q39118328
SOCS3 and IRS-1 gene expression differs between genotype 1 and genotype 2 hepatitis C virus-infected HepG2 cellsQ39791492
Silencing of hepatic fatty acid transporter protein 5 in vivo reverses diet-induced non-alcoholic fatty liver disease and improves hyperglycemiaQ39975300
Impaired expression of the peroxisome proliferator-activated receptor alpha during hepatitis C virus infection.Q40463023
Adaptation of hepatic mitochondrial function in humans with non-alcoholic fatty liver is lost in steatohepatitisQ40960591
Role of oxidative stress and antioxidant therapy in alcoholic and nonalcoholic liver diseases.Q41191940
Alcoholic liver disease: natural historyQ41623292
Hepatitis C viral proteins perturb metabolic liver zonation.Q41739888
The LXR inverse agonist SR9238 suppresses fibrosis in a model of non-alcoholic steatohepatitisQ42010216
Glyceroneogenesis is the dominant pathway for triglyceride glycerol synthesis in vivo in the ratQ42088454
Hepatitis C virus dysregulates glucose homeostasis by a dual mechanism involving induction of PGC1α and dephosphorylation of FoxO1.Q42249714
Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease.Q42462295
A single residue in the C1 domain sensitizes novel protein kinase C isoforms to cellular diacylglycerol productionQ42503419
Liver specific inactivation of carboxylesterase 3/triacylglycerol hydrolase decreases blood lipids without causing severe steatosis in miceQ42508123
Elevated lipogenesis and diminished cholesterol synthesis in patients with hepatitis C viral infection compared to healthy humansQ42989310
Genotype 3 is associated with accelerated fibrosis progression in chronic hepatitis C.Q42990025
Steatosis accelerates the progression of liver damage of chronic hepatitis C patients and correlates with specific HCV genotype and visceral obesityQ43031928
Fibrosis in genotype 3 chronic hepatitis C and nonalcoholic fatty liver disease: Role of insulin resistance and hepatic steatosisQ43034053
Aldehyde dedydrogenase-2 plays a beneficial role in ameliorating chronic alcohol-induced hepatic steatosis and inflammation through regulation of autophagyQ35108275
The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in miceQ35108391
Review article: Nutritional therapy in alcoholic liver diseaseQ35206697
Minireview: the AMP-activated protein kinase cascade: the key sensor of cellular energy status.Q35213694
Mammalian triacylglycerol metabolism: synthesis, lipolysis, and signalingQ35235426
Cellular mechanism of insulin resistance in nonalcoholic fatty liver diseaseQ35239565
Cost-effectiveness of sofosbuvir in the treatment of patients with hepatitis CQ35522668
Peroxisome Proliferator-Activated Receptors, Fatty Acid Oxidation, Steatohepatitis and HepatocarcinogenesisQ35550462
Regulation of hepatic lipin-1 by ethanol: role of AMP-activated protein kinase/sterol regulatory element-binding protein 1 signaling in miceQ35659167
Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetesQ35837720
Drinking habits as cofactors of risk for alcohol induced liver damage. The Dionysos Study GroupQ35841368
Relationship between body fat mass and free fatty acid kinetics in men and women.Q35871368
Reduction of TIP47 improves hepatic steatosis and glucose homeostasis in miceQ35900825
The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndromeQ35901803
Reversal of muscle insulin resistance by weight reduction in young, lean, insulin-resistant offspring of parents with type 2 diabetesQ35991365
Opposing roles of cell death-inducing DFF45-like effector B and perilipin 2 in controlling hepatic VLDL lipidationQ36145221
PPARalpha activation is essential for HCV core protein-induced hepatic steatosis and hepatocellular carcinoma in miceQ36330881
Skeletal muscle insulin resistance promotes increased hepatic de novo lipogenesis, hyperlipidemia, and hepatic steatosis in the elderlyQ36339529
Intrahepatic diacylglycerol content is associated with hepatic insulin resistance in obese subjectsQ36588248
Histological assessment of non-alcoholic fatty liver diseaseQ36634377
Hepatitis C virus infection activates an innate pathway involving IKK-α in lipogenesis and viral assemblyQ36913366
Non-alcoholic fatty liver disease: the mist gradually clearsQ37096332
Insulin resistance, inflammation, and non-alcoholic fatty liver diseaseQ37301920
Deletion of SIRT1 from hepatocytes in mice disrupts lipin-1 signaling and aggravates alcoholic fatty liverQ37619753
Forkhead box transcription factor regulation and lipid accumulation by hepatitis C virusQ37713887
Pharmacological and non-pharmacological treatment of non-alcoholic fatty liver disease.Q37768230
Sphingolipids: agents provocateurs in the pathogenesis of insulin resistanceQ37862117
Pathogenesis of alcohol-induced liver disease: classical concepts and recent advancesQ37872342
Drug-induced hepatic steatosisQ38216273
Recent advances in understanding proteins involved in lipid droplet formation, growth and fusion.Q38217400
A potential treatment of non-alcoholic fatty liver disease with SIRT1 activators.Q38255465
Dietary models of insulin resistanceQ38274138
Hepatitis C virus and lipid droplets: finding a nicheQ38286433
Insulin resistance, non-alcoholic fatty liver disease and hepatitis C virus infection.Q38290690
Reduction of hepatosteatosis and lipid levels by an adipose differentiation-related protein antisense oligonucleotide.Q38302026
Hepatitis C virus differentially modulates activation of forkhead transcription factors and insulin-induced metabolic gene expressionQ24606745
Endoplasmic reticulum stress and the inflammatory basis of metabolic diseaseQ24633352
Insulin-induced phosphorylation of FKHR (Foxo1) targets to proteasomal degradationQ24673179
Drug-induced liver injury in obesityQ26828462
Role of mitochondria in nonalcoholic fatty liver diseaseQ27028142
Insulin resistance is a cause of steatosis and fibrosis progression in chronic hepatitis CQ27477981
Advances in understanding and treating liver diseases during pregnancy: A reviewQ28080792
Hepatic lipid droplet biology: Getting to the root of fatty liverQ28087033
Absence of perilipin 2 prevents hepatic steatosis, glucose intolerance and ceramide accumulation in alcohol-fed miceQ28240106
Effect of ethanol on hydrogen peroxide-induced AMPK phosphorylationQ28569249
Inhibition of protein kinase Cepsilon prevents hepatic insulin resistance in nonalcoholic fatty liver diseaseQ28571421
Ethanol induces fatty acid synthesis pathways by activation of sterol regulatory element-binding protein (SREBP)Q28575163
Autophagy regulates lipid metabolismQ29547421
Steatohepatitis: a tale of two "hits"?Q29547771
Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver diseaseQ29614897
Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicityQ29614932
Molecular mediators of hepatic steatosis and liver injuryQ29616709
PPARs and the complex journey to obesityQ29619271
Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver diseaseQ29619334
Long-term follow-up of patients with NAFLD and elevated liver enzymesQ29620024
Defective TNF-alpha-mediated hepatocellular apoptosis and liver damage in acidic sphingomyelinase knockout miceQ30881683
Relationship between steatosis, inflammation, and fibrosis in chronic hepatitis C: a meta-analysis of individual patient data.Q31040495
The transcriptional and DNA binding activity of peroxisome proliferator-activated receptor alpha is inhibited by ethanol metabolism. A novel mechanism for the development of ethanol-induced fatty liverQ31449696
Modulation of fatty acid and bile acid metabolism by peroxisome proliferator-activated receptor α protects against alcoholic liver diseaseQ33717578
Hepatitis C virus core protein abrogates the DDX3 function that enhances IPS-1-mediated IFN-beta inductionQ33775699
A fetal fatty-acid oxidation disorder as a cause of liver disease in pregnant womenQ33863717
Pregnancy-related liver disordersQ33978151
Endoplasmic reticulum stress links hepatitis C virus RNA replication to wild-type PGC-1α/liver-specific PGC-1α upregulationQ34057855
Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophyQ34129374
Peroxisomal beta-oxidation and peroxisome proliferator-activated receptor alpha: an adaptive metabolic systemQ34262892
Epidemiology of alcoholic liver diseaseQ34345871
Alcoholic disease: liver and beyond.Q34405030
Adipose triglyceride lipase is a major hepatic lipase that regulates triacylglycerol turnover and fatty acid signaling and partitioningQ34511046
ATGL-catalyzed lipolysis regulates SIRT1 to control PGC-1α/PPAR-α signalingQ35004298
Sirtuin 1 (SIRT1) protein degradation in response to persistent c-Jun N-terminal kinase 1 (JNK1) activation contributes to hepatic steatosis in obesityQ35063067
Acute fatty liver of pregnancy: over six months follow-up study of twenty-five patientsQ35069517
Hepatitis C virus infection and its clearance alter circulating lipids: implications for long-term follow-upQ35090649
P433issue4
P407language of work or nameEnglishQ1860
P921main subjecttriglycerideQ186319
P304page(s)1664-1673
P577publication date2016-01-28
P1433published inWorld Journal of GastroenterologyQ15708885
P1476titleMechanisms of intrahepatic triglyceride accumulation
P478volume22

Reverse relations

cites work (P2860)
Q64096895A Pathophysiological Model of Non-Alcoholic Fatty Liver Disease Using Precision-Cut Liver Slices
Q92578120Adipocytes as lipid sensors of oleic acid transport through a functional Caco-2/HT29-MTX intestinal barrier
Q90708084Curcumin Recovers Intracellular Lipid Droplet Formation Through Increasing Perilipin 5 Gene Expression in Activated Hepatic Stellate Cells In Vitro
Q55282555Effect of Toxicants on Fatty Acid Metabolism in HepG2 Cells.
Q47670676Hepatic Lipid Accumulation and Nrf2 Expression following Perinatal and Peripubertal Exposure to Bisphenol A in a Mouse Model of Nonalcoholic Liver Disease.
Q54226744Hepatitis C in Pregnancy.
Q48127350Inhibition of exendin-4-induced steatosis by protein kinase A in cultured HepG2 human hepatoma cells
Q64226476Jwa Kum Whan Attenuates Nonalcoholic Fatty Liver Disease by Modulating Glucose Metabolism and the Insulin Signaling Pathway
Q42758574Mechanisms Involved in Disruption of Adipose Tissue Mass Resulting from Chronic Unhealthy Alcohol Consumption
Q59792894MicroRNA-124 Regulates Fatty Acid and Triglyceride Homeostasis
Q91863612Mitochondrial disease disrupts hepatic allostasis and lowers the threshold for immune-mediated liver toxicity
Q58551494Niacin-Induced Anicteric Microvesicular Steatotic Acute Liver Failure
Q91871168Orotic acid-treated hepatocellular carcinoma cells resist steatosis by modification of fatty acid metabolism
Q94570524Pemafibrate, a selective PPARα modulator, prevents non-alcoholic steatohepatitis development without reducing the hepatic triglyceride content
Q38834079Resveratrol alleviates FFA and CCl4 induced apoptosis in HepG2 cells via restoring endoplasmic reticulum stress
Q92533825S100A16-induced adipogenesis is associated with up-regulation of 11 β-hydroxysteroid dehydrogenase type 1 (11β-HSD1)
Q51245978Serum lipids as an indicator for the alteration of liver function in patients with hepatitis B.
Q46093623Systems biology of personalized nutrition

Search more.